Rebecca H. Speltz

Thesis Advisor: Donald Simone, Ph.D.

Thesis Research

Alterations in the descending modulation of nociceptive signals in mouse models of chronic pain.

Publications (pubmed)

Uhelski ML, Bruce D, Speltz R, Wilcox GL, Simone DA. Topical Application of Loperamide/Oxymorphindole, Mu and Delta Opioid Receptor Agonists, Reduces Sensitization of C-fiber Nociceptors that Possess NaV1.8. Neuroscience. 2020 Oct 15;446:102-112. PMCID: PMC7532699

Speltz R, Lunzer MM, Shueb SS, Akgün E, Reed R, Kalyuzhny A, Portoghese PS, Simone DA. The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids. Pain. 2020 Sep 1;161(9):2041-2057. PMCID: PMC7606301

Shueb SS, Erb SJ, Lunzer MM, Speltz R, Harding-Rose C, Akgün E, Simone DA, Portoghese PS. Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5. Neuropharmacology. 2019 Dec 1;160:107690. PMCID: PMC7210724

Work prior to the UMN MSTP:

Leong ML, Speltz R, Wessendorf M. Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla. Neurosci Lett. 2016 Mar 23;617:82-7. PMCID: PMC4798916

Fairbanks CA, Peterson CD, Speltz RH, Riedl MS, Kitto KF, Dykstra JA, Braun PD, Sadahiro M, Salton SR, Vulchanova L. The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity. Pain. 2014 Jul;155(7):1229-37. PMCID: PMC4070220

Leong ML, Gu M, Speltz-Paiz R, Stahura EI, Mottey N, Steer CJ, Wessendorf M. Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain. J Neurosci. 2011 Nov 23;31(47):17028-39. PMCID: PMC3257180