Rebecca H. Speltz
Email: spel0048@umn.edu
Entering Class: 2013
Education:
Hamline University
Biochemistry major
B.S., 2010
University of Minnesota
Graduate Program in Neuroscience
Ph.D., 2020
MSTP Student Governance:
- Student Advisory Committee, 2017-2019
Thesis Advisor: Donald Simone, Ph.D.
Thesis Research
Alterations in the descending modulation of nociceptive signals in mouse models of chronic pain.
Publications (pubmed)
Speltz R, Lunzer MM, Shueb SS, Akgün E, Reed R, Kalyuzhny A, Portoghese PS, Simone DA. The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids. Pain. 2020 Apr 27. [Epub ahead of print]
Shueb SS, Erb SJ, Lunzer MM, Speltz R, Harding-Rose C, Akgün E, Simone DA, Portoghese PS. Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5. Neuropharmacology. 2019 Dec 1;160:107690.
Work prior to the UMN MSTP:
Leong ML, Speltz R, Wessendorf M. Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla. Neurosci Lett. 2016 Mar 23;617:82-7. PMCID: PMC4798916
Fairbanks CA, Peterson CD, Speltz RH, Riedl MS, Kitto KF, Dykstra JA, Braun PD, Sadahiro M, Salton SR, Vulchanova L. The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity. Pain. 2014 Jul;155(7):1229-37. PMCID: PMC4070220
Leong ML, Gu M, Speltz-Paiz R, Stahura EI, Mottey N, Steer CJ, Wessendorf M. Neuronal loss in the rostral ventromedial medulla in a rat model of neuropathic pain. J Neurosci. 2011 Nov 23;31(47):17028-39. PMCID: PMC3257180