C-QODE: Lab Meeting Presentation
Center for Quality Outcomes, Discovery & Evaluation (C-QODE)
Wednesday, March 23, 2022
@ 2:00 pm | via Zoom
“Recent Experiences Coordinating Trials using Bayesian Response Adaptive Randomization”
Presented By: Thomas Murray, PhD
Assistant Professor and Medtronic Faculty Fellow, Division of Biostatistics
Thomas will discuss his experiences coordinating two recent clinical trials in out-of-hospital cardiac arrest that used Bayesian response adaptive randomization designs, and present some methodological innovations to improve implementation and understand the potential benefit these designs offer. He will discuss the ACCESS trial (Clinicaltrials.gov ID: NCT03119571), which sought to compare the efficacy of two standards or care: direct admission to the cardiac catheter laboratory versus the ICU; and the ARREST trial (NCT03880565), which sought to evaluate the efficacy of in-transit ECMO facilitated resuscitation versus standard Advanced Cardiac Life Support (ACLS) resuscitation.