Lacher Lab Publishes Strategies to Dissect the Effects of Non-protein-coding DNA

Assistant professor, Dr. Sarah Lacher (pictured above), along with team members, Daniel Levings and Kirsten Shaw, publish their latest research on ways to dissect the effects of non-protein-coding DNA.

Previously referred to as "junk DNA", non-protein-coding DNA is essential for turning genes on or off. Non-protein coding DNA varies significantly between individuals and thousands of specific variations have been linked to disease risk. In this review, published in the May 2020 issue of the Journal of Toxicology, the team discusses a variety of strategies and tools available to dissect the effects of inter-individual variation in non-protein-coding DNA, specifically as it relates to exposure-linked disease.

Levings D, Shaw KE, Lacher SE. Genomic Resources for Dissecting the Role of Non-Protein Coding Variation in Gene-Environment Interactions [published online ahead of print, 2020 May 22]. Toxicology. 2020;152505. doi:10.1016/j.tox.2020.152505