A century of discovery
Virologist Robert G. Green, M.D., in his lab circa 1940. (Photo: University Archives)
Science fiction author Isaac Asimov once wrote, “Everything about microscopic life is terribly upsetting. How can things so small be so important?”
But “important” is almost too timid a word to describe the powerful microbes responsible for some of humankind’s most devastating diseases — tuberculosis, diphtheria, influenza, polio, HIV/AIDS, and staph and fungal infections, to name just a few.
Since the University of Minnesota’s Department of Microbiology and Immunology was established in 1918–19, scientists there — and in other departments, too — have contributed mightily to the world’s store of knowledge about the bacteria, fungi, and viruses that teem within and on humans, animals, and plants. In fact, the American Society for Microbiology recently recognized the university for its accomplishments over the past century with a prestigious “Milestones in Microbiology” award.
Many talented individuals from across the U have contributed seminal discoveries over the past 100 years. Here are a few standouts:
- Arthur T. Henrici, M.D. (1889–1943), called “America’s bacteriologist” in his day, did pioneering work on bacterial growth and structure, and provided one of the earliest descriptions of the biofilms that play key roles in dental plaques, infectious diseases, and antibiotic resistance.
- Robert G. Green, M.D. (1895–1947), is credited with saving the Midwest fur industry through his studies of viral infections in silver fox and mink, and for discovering the first adenovirus, canine hepatitis virus, and the vaccine that protected dogs and foxes from it.
- Robert A. Good, M.D. (1922–2003), helped lay the foundation for the first successful human bone marrow transplant, performed at the U of M in 1968.
- Lewis W. Wannamaker, M.D. (1923–1983), developed the strategies to prevent rheumatic fever and kidney disease following a strep infection that remain the standard of care today.
- Dennis W. Watson, Ph.D. (1914–2008), developed the anthrax vaccine used to protect soldiers in World War II, and was the first to identify the toxic component of Gram-negative bacteria, which can cause fever, diarrhea, and toxic shock.
- Martin Dworkin, Ph.D. (1927–2014), a pioneer in understanding how multicellular bacteria communicate and behave together, was among the first to apply mathematics modeling to microbial research.
Current department chair and Regents Professor Ashley Haase, M.D., two-time recipient of a National Institutes of Health MERIT Award for his work on HIV/AIDS, praises what he calls “a history of faculty excellence” in a department designed to teach students at every level, from undergrads to medical and graduate students.
Now at home in a new building in the U’s Biomedical Discovery District, the department prepares students to take on the 21st century’s greatest infectious diseases.
“Our rich, distinguished past has prepared us well to work on the great killers of our time,” says Haase, “including HIV/AIDS, TB, antibiotic resistance, and influenza.”