COVID-19 Update - April 6th
April 6, 2020
As a surgical department, we are innovators. As researchers, we are problem solvers. As learners, we are knowledge seekers.
Together we are fighting this virus. A parasite that disappears after 14-days without a host. The image to the left is an illustration of the COVID-19 virus receptors recognition mechanism included in a recent paper in Nature authored by our colleagues in the Department of Biochemistry, Molecular Biology, and Biophysics. Authors of the paper report, "A key to tackling this epidemic is to understand the virus's receptor recognition mechanism, which regulates its infectivity, pathogenesis and host range." Note the color structure of the diagram. The green part is the human receptor (ACE2), and the cyan and purple part is the SARS-CoV-2 receptor-binding protein (so-called spike protein). The cyan part is the core structure of the SARS-CoV-2 receptor-binding protein that functions as a scaffold for the protein. The purple part makes contact with the human receptor, and Fang Li in the Department of BMBB calls it the "receptor-binding motif" of the SARS-CoV-2 protein.