Spring Phcl Seminar Series - 10:00 AM
"Copper Dependent Kinases: Making Every Penny Count in Cancer"
Donita Brady, PhD
Harrison McCrea Dickson, M.D. and Clifford C. Baker, M.D. Presidential Assistant Professor
Department of Cancer Biology
Perelman School of Medicine
University of Pennsylvania
Dr. Donita C. Brady is a Harrison McCrea Dickson, M.D. and Clifford C. Baker, M.D. Presidential Assistant Professor of Cancer Biology at the University of Pennsylvania. She obtained her Ph.D. in Pharmacology in 2008 with Dr. Adrienne Cox at the University of North Carolina at Chapel Hill in 2008. For her postdoctoral studies, Dr. Brady joined the laboratory of Dr. Christopher Counter at Duke University, which focuses on pharmacologically accessible signaling pathways downstream of oncogenes, like RAS. Her independent laboratory at Penn is founded in a new paradigm in nutrient sensing and protein regulation, termed metalloallostery, where redox-active metals control kinase activity, and is advancing our knowledge in basic science and disease-focused areas. Their focus lies at the intersection of kinase signaling and copper (Cu) homeostasis with the goal of defining the mechanistic features of Cu-dependent kinases to target them in cancer via drug repurposing or development.