Stem Cell Institute member Dr. Elizabeth Bradley is awarded Regenerative Medicine Minnesota Grant
February 2, 2022
Regenerative Medicine Minnesota has announced the grants awarded for 2022 to 2024 and the list of grantees includes Elizabeth Bradley, PhD who is a member of the Stem Cell Institute. Dr. Bradley's funded research project will focus on "Epigenetic Reprogramming to Enhance Bone Regeneration in Type 2 Diabetes."
Type 2 diabetes is a common chronic condition that affects Minnesotans' quality of life. Reducing the body's own ability to heal is among its health impacts. Our work suggests that epigenetic reprogramming of innate immune cells enhances bone healing in pre-clinical, non-diabetic models. This project will evaluate the effects of epigenetic reprogramming to bone healing in a high fat diet (HFD)-induced model of type 2 diabetes. We will also determine if epigenetic programming limits enhanced commitment to bone resorbing osteoclasts observed in type 2 diabetes and if a novel regulator of cellular metabolism, Lipocalin 2, controls innate immune cell responses and glucose utilization.