Cancer & Infectious Diseases

Investigators from the department are working on the fundamental aspects of how cancer cells proliferate and metastasize, how inflammatory and immunological responses are modulated during infection and what the structural basis of virus host cell interaction are.

Down-modulation of S Phase with Anti-Estrogens in Lung PreneoplasiasModified from Stabile et al. Carcinogenesis, 33(2012)2181-9

Areas of focus are to understand how steroids and insulin-like growth factor (IGF-1) mediated signaling stimulates cancer cells to proliferate, migrate and metastasize. How cancer cells meet their metabolic demands by regulating cap-dependent translational initiation, DNA repair and replication. Another area of focus is to understand how cancer cells acquired blood supply angiogenesis, a fundamental step in the growth and metastasis of cancer. Learning from these studies, investigators are developing novel, targeted therapies to treat cancer. While cancer is considered as a wound that never heals, inflammatory responses during normal wound healing process are studied at the molecular, cellular and organismal level. Investigations are carried out on the structural basis of virus binding to cellular receptors and how it modulates infectivity.