Faculty

Bio

Expertise

• Gait-training and evaluation
• osteoclast biology

Professional Associations

• American Society for Bone and Mineral Research
• Association of Academic Physiatrists

Research Summary

Research Funding Grants

• R01 AR064793-01A1 (Battaglino)
  04/01/2015 – 03/31/2020
  NIH/NIAMS
  "Regulation of gastric and osteoclast acidification by Snx10"
  The specific aims to be addressed in this project are: 1) Determine the cellular mechanisms by which Snx10 regulates osteoclast function. 2) Determine the role of osteoclastic expression of Snx10 on bone homeostasis in vivo. 3) Determine the role of gastric expression of Snx10 on bone homeostasis in vivo.
  Role: PI
• W81XWH-14-SCIRP-CTA (Morse)
  09/01/2015-08/31/19
  Department of Defense
  "Effects of Ekso-assisted gait training on Bone Health and Quality of Life: A Randomized Clinical Trial"
  The goals of this project are to 1) determine whether exoskeleton-assisted gait training increases bone strength in the paralyzed lower extremity and 2) determine whether exoskeleton-assisted gait training improves quality of life after SCI. Secondarily, to determine whether gait training improves the following related outcomes and mediators of quality of life: mood, pain, and cortical activity of related emotional networks in the brain.
  Role: Site PI

Publications

2019

• Morse L, Troy K, Fang Y, Nguyen N, Battaglino R, Goldstein, Richard, Gupta R, Taylor J. Combination Therapy with Zoledronic Acid and FES-row Training Mitigates Bone Loss in the Paralyzed Legs: Results of a Randomized Comparative Clinical Trial. Submitted to JBMR PLUS.
• Battaglino R, NguyenN, MorseLR. Bisphosphonate use is associated with lower levels of the bone-derived hormone osteocalcin in men with spinal cord injury. Ricardo A., Nguyen,Leslie R. Submitted to Osteoporosis International.

2018

• Morse LR, Coker J, Battaglino R. Statins and Bone Health: A Mini Review. Actual. Osteol 14(1) :31:35, 2018
• Battaglino R, Jha P, Liu W, Morse LR. FKBP12: a partner of Snx10 required for vesicular trafficking in osteoclasts. Submitted, Journal Cellular Biochemistry.
• Liu W, Morse LR, Picotto G, Sultana F, Odgren P, Battaglino R. Snx10 and PIKfyve are Required for Lysosome Formation in Osteoclasts, Submitted, Journal of Bone and Mineral Research.
• Park AJ, Battaglino RA, Nguyen N, Morse LR. Associations between lean mass and leptin in men with chronic spinal cord injury: results from the FRASCI-muscle study. Accepted, PLOS One. 2018.
• Hirai K, FurushoH, KawashimaN, XuS, de BeerMC, Battaglino R, Van DykeT, StashenkoP, SasakiH. SAA contributes to the chronicity of periapical lesions via TLR2 and TLR4. Accepted, Journal of Dental Research. 2018.

2017

• Rivoira M, Rodríguez V, Picotto G, Battaglino R, Tolosa de Talamoni N. Naringin prevents bone loss in a rat model of type 1 Diabetes mellitus. Arch Biochem Biophys. 2018 Jan 1;637:56-63. doi: 10.1016/j.abb.2017.12.001. Epub 2017 Dec 5. PMID: 29208404
• Silva LAB, Azevedo LU, Consolaro A, Barnett F, Xu Y, Battaglino RA, Cañadas PS, de Oliveira KMH, Silva RAB. Novel endodontic sealers induce cell cytotoxicity and apoptosis in a dose-dependent behavior and favorable response in mice subcutaneous tissue. Clin Oral Investig. 2017 Dec 21(9):2851-2861. doi: 10.1007/s00784-017-2087-1. Epub 2017 Mar 9. PMID: 28281012

2016

• Morse LR, Nguyen N, Battaglino RA, Guarino AJ, Gagnon D, Zafonte R, Garshick E. Wheelchair use and Lipophilic Statin Medications May Influence Bone Loss in Chronic Spinal Cord Injury: Findings from the FRASCI Study. Osteoporos Int. 2016 Jul 13. [Epub ahead of print]. PMID: 27412619
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:27412619
• Sasaki H, Hirai K, Men Martins C, Furusho H, Battaglino R, Hashimoto K. Interrelationship between Periapical Lesion and Systemic Metabolic Disorders. Curr Pharm Des. 2016 Feb [Epub ahead of print]. PMID: 26881444
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:26881444

2015

• Guo F, He H, Fu ZC, Huang S, Chen T, Papasian CJ, Morse LR, Xu Y, Battaglino RA, Yang XF, Jiang Z, Xin HB, Fu M. Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling. Biochem J. 2015 Dec 15;472(3):309-18. doi: 10.1042/BJ20150019. Epub 2015 Oct 5. PMID: 26438880
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:26438880
• Xu Y; Morse LR; Bezerra da Silva R; Wang D, Battaglino RA. A Short Report: PAMM, a Novel Antioxidant Protein, Induced by Oxidative Stress. Redox Biol. 2015 Dec;6:446-453. PMID: 26402163.
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:26402163
• Ye L, Morse LR, Zhang L, Sasaki H, Mills J, Odgren P, Sibbel G, Zamarioli A, Battaglino RA. Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet. 2015 Mar 26;11(3):e1005057.
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:25811986

2014

• Tan C, Battaglino R, Doherty A, Gupta R, Lazzari A, Garshick E, Zafonte R, Morse LR. (2014) Adiponectin is Associated with Bone Strength and Fracture History in Paralyzed Men with Spinal Cord Injury. Osteoporos Int. 2014 Nov;25(11):2599-607.
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:24980185

2013

• Liang Ye, Leslie R Morse, Ricardo A Battaglino. Snx10: a newly identified locus associated with human osteopetrosis. IBMS BoneKEy (2013) 10, Article number: 421
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:25419438
• Saltzman JW, Battaglino R, Stott H, Morse LR. Neurotoxic or Neuroprotective? Current Controversies in SCI-Induced Autoimmunity. Curr Phys Med Rehabil Reports. 2013 Sep;1(3). PMID: 24416711
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:24416711
• Choi E, Carruthers K, Zhang L, Thomas N, Battaglino RA, Morse LR, Widrick JJ. Concurrent muscle and bone deterioration in a murine model of cancer cachexia. Physiol Rep. 2013 Nov;1(6): PMID: 24400146
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:24400146
• Doherty AL, Battaglino RA, Donovan J, Gagnon D, Lazzari AA, Garshick E, Zafonte R, Morse LR. Adiponectin is a candidate biomarker of lower extremity bone density in men with chronic spinal cord injury. J Bone Miner Res. 2013 Jun 20. PMID: 23787489
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23787489
• Tan CO, Battaglino RA, Morse LR. Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation Strategies. Int J Phys Med Rehabil. 2013;1. pii: 127. PMID: 25419534
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:25419534
• Zamarioli A, Battaglino RA, Morse LR, Sudhakar S, Maranho DA, Okubo R, Volpon JB, Shimano AC. Standing frame and electrical stimulation therapies partially preserve bone strength in a rodent model of acute spinal cord injury. Am J Phys Med Rehabil. 2013 May;92(5):402-10 PMID: 23478455
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23478455
• Lucisano MP, Nelson-Filho P, Morse L, Battaglino R, Watanabe PC, da Silva RA, da Silva LA. Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy. Braz Oral Res. 2013 May-Jun;27(3):252-7. PMID: 23739782
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23739782
• Saltzman JW, Battaglino R, Salles L, Jha P, Sudhakar S, Garshick E, Stott HL, Zafonte R, Morse LR. (2013). B-cell maturation antigen, a proliferation-inducing ligand, and B-cell activation factor are candidate mediators of spinal cord injury-induced autoimmunity. J. Neurotruama 30(6): 434-440.
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:23088438
• Morse LR, Sudhakar S, Tun C, Lazzari A, Garshick E, Zafonte R, Battaglino RA. (2013) Sclerostin: A candidate biomarker of SCI-induced osteoporosis. Osteoporos Int. 24(3): 961-968.
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22801952

2012

• Battaglino RA, Lazzari AA, Garshick E, Morse LR. Spinal cord injury-induced osteoporosis: pathogenesis and emerging therapies. Curr Osteoporos Rep. 2012 Dec;10(4):278-85. PMID: 22983921
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22983921
• Nelson-Filho P, Lucisano MP, Da Silva RA, Da Silva RS, Serra MC, Gerlach RF, Neto FC, Carneiro ZA, Zamarioli A, Morse L, Battaglino R. Systemically alendronate was incorporated into dental tissues but did not cause morphological or mechanical changes in rats teeth. Microsc Res Tech. 2012 Sep;75(9):1265-71. doi: 10.1002/jemt.22059. PMID: 22508272
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22508272
• Goy DP, Gorosito E, Costa HS, Mortarino P, Pedemonte NA, Toledo J, Mansur HS, Pereira MM, Battaglino R, Feldman S. Hybrid matrix grafts to favor tissue regeneration in rabbit femur bone lesions. Open Biomed Eng J. 2012;6:85-91. Epub 2012 Jul 10. PMID: 22848334
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22848334
• Battaglino RA, Sudhakar S, Lazzari A, Garshick E, Zafonte R, Morse LR. (2012). Circulating sclerostin is elevated in short-term and reduced in long-term SCI. Bone. May 7. [Epub ahead of print]. PMID: 22575440
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22575440

2011

• Morse LR, Xu Y, Solomon B, Boyle L, Yoganathan S, Stashenko P, Battaglino RA. Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction. Transl Stroke Res. 2011 Dec 1;2(4):643-50. doi: 10.1007/s12975-011-0118-9. PMID: 22368723
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22368723
• Morse LR, Sudhakar S, Danilack V, Tun C, Lazzari A, Gagnon DR, Garshick E, Battaglino RA. Association between sclerostin and bone density in chronic SCI. J Bone Miner Res. 2011 Oct 17. doi: 10.1002/jbmr.546. [Epub ahead of print] PMID: 22006831
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22006831
• Zhu Cuihua, Morse LR, Battaglino R. (2011) SNX10 is required for osteoclast formation and resorption activity. SNX10 is required for osteoclast formation and resorption activity. J Cell Biochem. 2011 Dec 15. doi: 10.1002/jcb.24029. [Epub ahead of print]. PMID: 22174188
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:22174188

2010

• Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino R. (2010) Mutational analysis of NHAcc/NHA2 in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1800(12): 1241-1247. PMCID: PMC2967667
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:20713131
• Sasaki H, Suzuki N, Alshwaimi E, Xu Y, Morse LR, Battaglino RA, Stashenko P. 18-beta-Glycyrrhetinic Acid Inhibits Periodontitis Via Glucocorticoid-independent NF-kB Inactivation In IL-10 Deficient Mice. J Periodontal Res. 2010 Dec;45(6):757-63. PMID: 20682015
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:20682015
• Xu Y, Morse LR, da Silva R, Odgren PR, Sasaki H, Stashenko P, Battaglino RA. PAMM: A redox regulatory protein that modulates osteoclast differentiation. Antioxid Redox Signal 2010 Jul 1;13(1):27-37. Antioxid Redox Signal. 2010 Jul 1;13(1):27-37. PMID: 19951071
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19951071

2009

• Xu Y, Young M, Battaglino RA, Morse LR, Fontana CR, Pagonis TC, Kent R, Stashenko P, Soukos NS. Endodontic antiomicrobial photodynamic therapy: Assessment of safety on fibroblasts and osteoblasts in vitro. J Endod. 2009 Nov;35(11):1567-72. PMID: 19840649
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19840649
• Morse LR, Lazzari A, Battaglino RA, Stolzmann K, Matthess K, Gagnon D, Davis S, Garshick E. Dual energy X-Ray absorptiometry of the distal femur may be more reliable than the proximal tibia in spinal cord injury. Arch Phys Med Rehabil 2009; 90:827-831. PMID: 19406303
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19406303
• Morse LR, Giangregori L, Battaglino RA, Holland R, Craven BC, Stolzmann K, Lazzari A, Sabharwal S, Garshick E. VA Based Survey of Osteoporosis Management in Spinal Cord Injury. PMR. 2009 Mar:1(3):240-244. PMID: 19627901
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:19627901
• Morse LR, Geller A, Battaglino RA, Stolzmann K, Matthess K, Lazzari A, Garshick E. Barriers to Providing Dual Energy X-ray Absorptiometry Services to Individuals with Spinal Cord Injury. Am J Phys Med Rehabil. 2009 Jan;88(1):57-60. PMID: 18824888
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:18824888
• Morse LR, Battaglino RA, Stolzmann K, Hallett L, Waddimba A, Gagnon D, Lazzari A, Garshick E. Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int. 2009 Mar;20(3):385-92. Epub 2008 Jun 26. PMID: 18581033
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:18581033

2008

• Morse LR, Nguyen HP, Jain N, Williams S, Tun CG, Battaglino RA, Stashenko P, Garshick E. (2008) Age and motor score predict osteoprotegerin level in chronic SCI. J. Musculoskelet. Neuronatal Interact. 8(1): 50-57. PMID: 18398265
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:18398265
• Morse L, Teng YD, Pham L, Newton K, Du Y, Liao WL, Kohler T, Müller R, Graves D, Stashenko P, Battaglino R. (2008) Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats. (SCI-induced bone loss in growing rats) Osteoporos Int. 19(3): 645-652. PMID: 17987335
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17987335
• Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P. (2008) NHA-oc/NHA2: A mitochondrial cation-proton antiporter selectively expressed in osteoclasts. Bone 42(1): 180-192. PMID: 17988971
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17988971

2007

• Pham L, Purcell P, Morse LR, Stashenko P, Battaglino RA. (2007) Expression Analysis of nha-oc/NHA2: a Novel Osteoclast-Specific Gene. Gene Expr. Patterns 7(8): 846-851. PMID: 17698421
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17698421
• Schulze-Späte U, Battaglino R, Fu J, Sharma A, Vokes M, Stashenko P. (2007) Brn3 Transcription factors control terminal osteoclastogenesis. J. Cell Biochem. 102(1): 1-12. PMID: 17668438
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17668438

2006

• Battaglino R, Vokes M, Spate U, Sharma A, Graves D, Kohler T, Muller R, Yoganathan S, Stashenko P. (2006) Fluoxetine treatment increases trabecular bone formation in mice. J. Cell. Biochem.100(6): 1387-1394. PMID: 17041947
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:17041947

2005

• Gyurko R, Shoji H, Battaglino RA, Boustany G, Gibson FC 3rd, Genco CA, Stashenko P, Van Dyke TE. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone 2005; Mar; 36(3):472-9. PMID: 15777672
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:15777672

2004

• Battaglino R, Fu J, Späte U, Ersoy U, Joe M, Sedaghat L, Stashenko P. Serotonin regulates osteoclasts differentiation via its transporter. Journal of Bone and Mineral Research 2004; 19(9):1420-1431. PMID: 15312242
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:15312242
• Okamatsu Y, Kim D, Battaglino R, Sasaki H, Späte U, Stashenko P. MIP-1g promotes receptor activator of NF-?B ligand-induced osteoclast formation and survival. Journal of Immunology 2004; 173(3):2084-2090. PMID: 15265944
  http://www.jimmunol.org/content/173/3/2084

2002

• Battaglino R, Kim D, Fu J, Vaage B, Fu XY, Stashenko P. c-myc is required for osteoclast differentiation. Journal of Bone and Mineral Research 2002; 17(5):763-773. PMID: 12009006
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:12009006

1998

• Xiong J, Battaglino R, Stuhlmann H. Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Developmental Dynamics 1998; 212(2):181-197. PMID: 9626494
  http://dy3uq8jh2v.search.serialssolutions.com/?sid=Entrez:PubMed&id=pmid:9626494
• Battaglino R. A Genetic Screen for Developmentally Regulated Genes in Mice (Ph.D. dissertation, 1998). University of New York.

1991

• Battaglino RA, Huergo M, Pilosof AMR, Bartholomai GB. (1991) Culture requirements for the production of protease by Aspergilius-oryzae in solid-state fermentation. Appl. Microbiol. Biotechnol. 35(3):292-296. 

Bio

Awards & Recognition

• Helen May Bradley Alumni Achievement Award, Maryville University of St. Louis, 2014
• Craig H. Neilsen Fellowship in Spinal Cord Injury Research, 2013-2015
• Bryan Robinson Neuroscience Endowment Doctoral Research Grant, 2010
• University of Florida Medical Guild Research Incentive Award, 2008

 

Professional Associations

• American Physiological Society
  • Central Nervous System Section 
• American Physical Therapy Association 
  • Research Section 
  • Academy of Neurologic Physical Therapy (formerly - Neurology Section)

Teaching Summary

Academic Interests and Focus

As an Assistant Professor in the Division of Physical Therapy, Dr. Brendan Dougherty is active in training students and serves on the Admissions Committee and New Faculty Search Committee.

Bio

Awards & Recognition

• K12 Scholar - Interdisciplinary Rehabilitation Engineering Career Development Program, 2016
• NIH Loan Repayment Program (LRP) Award Recipient, 2015
• NIH T32 Musculoskeletal Research Training Grant Post-Doctoral Fellow - Mayo Clinic, 2013-2015
• American Society of Biomechanics Young Scientist Pre-Doctoral Award, 2013
• NIH T32 Musculoskeletal Training Grant Post-Doctoral Fellow - University of Minnesota, 2011-2013
• University of Minnesota GAPSA Scholarly Travel Grant, 2012
• Doctoral Dissertation Fellowship - University of Minnesota (Declined), 2012
• The Schoofs Prize for Creativity design Competition, First Place, 2008
• RERC on AMI International Design Competition, Second Place, 2008
• Certification of Recognition for Undergraduate Research Efforts, 2008
• Biology in Engineering Certificate, University of Wisconsin - Madison, 2008
• Outstanding Performance in Biomedical Engineering Scholarship, 2008
• University of Wisconsin - College of Engineering Dean's List, 2004-2008 

Professional Associations

• American Society of Biomechanics
• Orthopaedic Research Society

Research Summary

Research Summary/Interests

Dr. Ellingson’s primary research focus is to detect biomechanical and imaging based biomarkers of spinal health. The diverse causes of back and neck pain lead to difficulties in differential diagnosis, hindering patient-specific individualized treatment. Dr. Ellingson’s multifaceted research strategy aims to overcome these limitations by identifying aberrant spinal motion patterns, quantifying intervertebral disc pathology, and isolating neuromuscular responses to pain. Ultimately, by integrating these approaches he strives to assess and enhance an individual’s functional ability in an effort to improve their quality of life.

Current Research Funding Grants

Scoliosis Research Society: Biomechanical and Mechanical Intervertebral Disc Profiles in Developmental Spinal Deformities

Selected Publications

• Ellingson AM, Shaw MN, Giambini H, An KN. Comparative Role of Disc Degeneration and Ligament Failure on Functional Mechanics of the Lumbar Spine. Computer Methods in Biomechanics and Biomedical Engineering. In Press
• Ellingson AM and Nuckley DJ. Helical Axes Patterns of the Lumbar Spine Altered by Severity of Intervertebral Disc Degeneration. Journal of Biomechanics, 2015. 48(2): 361-9.
• Ellingson AM, Nagel TM, Polly Jr. DW, Ellermann J, Nuckley DJ. Quantitative T2* (T2 star) Relaxation Times Predict Site Specific Proteoglycan Content and Residual Mechanics of the Intervertebral Disc Throughout Degeneration. Journal of Orthopaedic Research, 2014. 32(8): 1083-9.
• Schroeder D, Korsakov F, Knipe C, Thorson L, Ellingson AM, Nuckley D, Carlis J, Keefe DF. Trend-Centric Motion Visualization: Designing and Applying a New Strategy for Analyzing Scientific Motion Collections. Visualization and Computer Graphics, IEEE Transactions on.2014;20(12): 2644-2653.
• Ellingson AM, Mehta, H, Polly Jr. DW, Ellermann J, Nuckley DJ. Disc Degeneration Assessed by Quantitative T2* (T2 star) Correlated with Functional Lumbar Mechanics. Spine, 2013. 38(24): E1533-40.
• Ellingson AM, Yelisetti V, Schulz CA, Bronfort G, Downing J, Keefe DF, and Nuckley DJ. Instantaneous Helical Axis Methodology to Identify Aberrant Neck Motion. Clinical Biomechanics, 2013. 28(7):731-735.
• Dahl MC, Ellingson AM, Mehta HP, Huelman JH, Nuckley DJ. The Biomechanics of a Multilevel Lumbar Spine Hybrid Using Nucleus Replacement in Conjunction with Fusion. The Spine Journal, 2013(2): 175-183.
• Ellingson AM, Nuckley DJ. Intervertebral Disc Viscoelastic Parameters and Residual Mechanics Spatially Quantified using a Hybrid Confined / In Situ Indentation Method. Journal of Biomechanics, 2012. 45(3): 491-6.
• Mehta H, Santos E, Ledonio C, Sembrano J, Ellingson A, Pare P, Murrell B, and Nuckley DJ. Biomechanical Analysis of Pedicle Screw Thread Differential Design in an Osteoporotic Cadaver Model.Clinical Biomechanics, 2012. 27(3): 234-40.
• Coffey D, Korsakov F, Ewert M, Hagh-Shenas H, Thorson L, Ellingson A, Nuckley DJ, Keefe DF. Visualizing Motion Data in Virtual Reality: Understanding the Roles of Animation, Interaction, and Static Presentation. Computer Graphics Forum,2012. 31(3): 1215-24.
• Jackson B, Coffey D, Thorson L, Schroeder D, Ellingson AM, Nuckley DJ, Keefe DF. Toward Mixed Method Evaluations of Scientific Visualizations and Design Process as an Evaluation Tool.BELIV 2012: Beyond Time and Errors: Novel Evaluation Methods for Visualization, Workshop at IEEE VisWeek 2012, 2012.
• Wheeler DJ, Freeman AL, Ellingson AM, Nuckley DJ, Buckley JM, Scheer JK, Crawford NR, Bechtold JE. Inter-Laboratory Variability in in vitro Spinal Segment Flexibility Testing. Journal of Biomechanics, 2011. 44(13): 2383-7.

Teaching Summary

Clinical Biomechanics; Advanced Biomechanics; Human Kinetics

Bio

Dr. Fonkoue has joined the Physical Therapy Division as an Assistant Professor on the Tenure Track with a research focus. She received her medical degree at the University of Yaoundé Faculty of Medicine and Biomedical Sciences in Yaoundé, Cameroon. She went on to complete a PhD in Biological Sciences at Michigan Technological University in Houghton. Dr. Fonkoue also completed a postdoctoral fellowship at Emory University School of Medicine. She is currently finishing a Master of Science in Clinical Research (MSCR) at Emory University's Laney Graduate School in Atlanta, Georgia.Dr. Fonkoue's academic training and research experience have provided her with an excellent background in both clinical medicine and basic integrative physiology. While she practiced as a physician in Cameroon, she currently works as a translational researcher. Specifically, she is establishing a scientific niche focused on distinct neurocirculatory and hormonal mechanisms linking trauma and cardiovascular disease risk in women.In her free time, Dr. Fonkoue enjoys spending time with her family and being outdoors

Awards & Recognition

• New Investigator Award, Neural Control & Autonomic Regulation (NCAR), NCAR Section Awards, The American Physiological Society, 2021
• New Investigator Spotlight, International Society of Hypertension, December 2019
• The Caroline Tum Suden/Frances Hellebrandt Award for Meritorious Research, The American Physiological Society, 201, 2015
• Best Paper, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, APS Select, The American Physiological Society
• First Place, Young Investigator Award, Southern Society for Clinical Investigation, 2018
• Research Recognition Award, Neural Control & Autonomic Regulation (NCAR), NCAR Section Awards, The American Physiological Society, 2017
• Grand Prize for Best Poster, Life Science and Technology Institute Forum, 2016
• Outstanding Scholarship Award, Department of Biological Sciences, Michigan Technological University, 2016
• First Place Research Poster Presentation, Graduate Research Colloquium, Michigan Technological University, 2015
• Award for Outstanding Oral Presentation, Michigan Physiological Society 201.

Professional Associations

• American Autonomic Society
• American Heart Association
• American Physiological Society

Research Summary

Dr. Fonkoue's current research aims to determine if post-traumatic stress disorder (PTSD) in women causes vascular, neural, and hormonal changes linked to an increased risk of hypertension and cardiovascular disease. She has previously published data highlighting the autonomic dysregulation present in PTSD patients.

Research Funding Grants

1. VA Merit Review Park (PI), 07/1/2020-06/30/2024. Title: Mechanisms of Sympathetic Overactivity in Post-traumatic Stress Disorder (PTSD). Role: Co-Investigator. The major goals of this grant are to investigate the mechanistic role of arterial baroreflex dysfunction on sympathetic activation during mental stress in PTSD, and the therapeutic role of device-guided slow breathing on sympathetic regulation during stress in PTSD
2. NIH/NCATS Blumberg (Program PI) 08/01/2020-07/30/22. KL2TR002381. Title: Georgia Clinical and Translational Science Alliance Institutional Career Development. Role: Principal Investigator. The purpose of my KL2 mentored institutional career development award is to obtain preliminary data on the vascular and neural consequences of post-traumatic stress disorder (PTSD) in pre-menopausal women in preparation for this K01 proposal
3. Postdoctoral Fellow, Renal Division, Department of Medicine 06/2017 - 07/2020, Emory University. Advisor: Jeanie Park, MD, MS. Completed a clinical trial in post-traumatic stress disorder (PTSD), demonstrated the efficacy of slow guided breathing in PTSD, investigated the impact of PTSD severity on inflammation and autonomic function. This work resulted in 5 publications, including one in Brain Behavior and Immunity, and was funded through an NIH T-32 fellowship
4. Graduate Research Assistant, Department of Kinesiology and Integrative Physiology, 2015-2016, Michigan Technological University, advisor: Jason Carter, PhD. Found that muscle sympathetic activity was reproducible in humans and investigated the role of heredity and race in autonomic responses to stress. This work resulted in 3 articles in American Journal of Physiology and was funded through a King-Chavez-Parks Initiative, Future Faculty Fellowship, State of Michigan, and a Portage Health Foundation Graduate Assistantship.

 

Publications

Peer-reviewed articles (partial list)

1. Fonkoue IT, Michopoulos V., Park J. Sex differences in post-traumatic stress disorder risk: autonomic control and inflammation. Clinical Autonomic Research. 2020 Oct;30(5):409-421. doi:10.1007/s10286-020-00729-7. Epub 2020 Oct 6.
2. Jeong JH, Fonkoue IT, Quyyumi AA, DaCosta DR, Park J. Nocturnal blood pressure is associated with sympathetic nerve activity in patients with chronic kidney disease. Physiological Reports. 2020 Oct;8(20): e14602. doi: 10.14814/phy2.14602.
3. Fonkoue IT. Prolonged exposure therapy: Hypothalamic corticotropin-releasing hormone neurons might have a say in its success. Journal of Physiology. 2020 Sep 21. doi: 10.1113/JP280488. Online ahead of print.
4. Fonkoue IT, Hu Y, Jones T, Vemulapalli M, Sprick JD, Rothbaum B, Park J. Eight Weeks of Device Guided Slow Breathing Decreases Sympathetic Nervous Reactivity to Stress in Post-Traumatic Stress Disorder. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2020 Oct 1;319(4):R466-R475. doi: 10.1152/ajpregu.00079.2020. Epub 2020 Aug 26.
5. Fonkoue IT, Marvar PJ, Norrholm SD, Li Y, Kankam ML, Jones TN, Vemulapalli M, Rothbaum BO, Bremner JD, Le NA, Park J. Symptom severity impacts sympathetic dysregulation and inflammation in post-traumatic stress disorder (PTSD). Brain Behavior and Immunity. 2020 Jan; 83:260-269.
6. Sprick JD, Morison DL, Stein CM, Li Y, Paranjape SY, Fonkoue IT, DaCosta DR, Park J. Vascular Alpha-1 Adrenergic Sensitivity is Enhanced in Chronic Kidney Disease. Am J Physiol Regul Integr Comp Physiol. 2019 Sep 1;317(3): R485-R490.
7. Carter JR, Fonkoue IT, Greenlund IM, Schwartz CE, Mokhlesi B, Smoot CA. Sympathetic Neural Responsiveness to Sleep Deprivation in Older Adults: Sex Differences. Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H315-H322. Ida Fonkoue
8. Ye K, Fonkoue IT, Li Y, DaCosta D, Shah A, Park J. Altered Autonomic Reactivity During Lower Body Negative Pressure in End-Stage Renal Disease. The American Journal of the Medical Sciences. 2019 Jul; 358(1):11-18. doi: 10.1016/j.amjms.2019.04.003.
9. Sprick JD, Morison DL, Fonkoue IT, Li Y, DaCosta D, Rapista D, Choi H, Park J. Metabolic Acidosis Augments Exercise Pressor Responses in Chronic Kidney Disease. Am J Physiol Regul Integr Comp Physiol. 2019 Aug 1;317(2):R312-R318.
10. Fonkoue IT, Le NA, Kankam ML, DaCosta DR, Jones TN, Marvar PJ, Park J. Sympathoexcitation and Impaired Arterial Baroreflex Sensitivity are Linked to Vascular Inflammation in Elevated Resting Blood Pressure. Physiological Reports. 2019 Apr;7(7): e14057. doi: 10.14814/phy2.14057.

Invited Talks/Seminars

1. Graduate Program Seminar, Rehabilitation Science, University of Minnesota 12/2020, Minneapolis, MN. Title: Post-Traumatic Stress Disorder through the lens of the Autonomic Nervous System
2. Research and Evaluation in Health Sciences, Spellman College 09/2020 Atlanta, GA (Virtual). Title: Writing and Publishing a Research Study
3. Renal Division TSWU Seminar, Emory University School of Medicine 09/2018 Atlanta, GA. Title: Baroreflex Sensitivity and Autonomic Reactivity to Stress in Humans
4. Renal Division TSWU Seminar, Emory University School of Medicine 10/2016 Atlanta, GA. Title: Sympathetic Neural Reactivity to Mental Stress in Humans: Reliability, Heredity and Race
5. Human Factor Forum, Applied and Cognitive Sciences 02/2015 Michigan Technological University, Houghton, MI. Title: Neural Cardiovascular Responses to Alcohol in Humans: Race differences
6. Kinesiology and Integrative Physiology Seminar, 09/2015 Michigan Technological University, Houghton, MI. Title: Blood Pressure Dipping and Sympathetic Neural Reactivity: Race Differences
7. DET 400 class, Air Force ROTC 11/2012 Michigan Technological University, Houghton, MI. Title: The African Continent and the cultural differences with the US, humanitarian and medical support in war-affected regions of the Continent
8. World AIDS Day, Center for Diversity and Inclusion 12/2010 Michigan Technological University, Houghton, MI. Title: The socio-economic impact of HIV/AIDS in Sub-Saharan Africa

National/International Conference Presentations, Panels

1. Kidney Week 10/2020, Title: Basic Research Forum for Emerging Kidney Scientists: Work-Life Continuum Round Table

Oral Presentations (partial list)

1. Virtual Experimental Biology 05/2020 Title: Eight Weeks of Device Guided Slow Breathing Decreases Sympathetic Nervous Reactivity to Stress in Post-Traumatic Stress Disorder
2. 30th International Symposium on the Autonomic Nervous System 11/2019 Wyndham Grand Clearwater Beach, Clearwater, FL. Title: Sympathetic and Cardiovascular Responses to Acute Mental Stress in
3. Post-traumatic Stress Disorder: Sex Differences
4. Experimental Biology, San Diego, CA 04/2018 Title: Prehypertension Augments Autonomic Imbalance in Post-traumatic Stress Disorder
5. Spring Clinical meetings, National Kidney Foundation, Austin, TX 04/2018, Title: Impaired Arterial Baroreflex Sensitivity in Prehypertension
6. Southern Society for Clinical Investigation, New Orleans, LA 02/2018 Title: Impaired Arterial Baroreflex Sensitivity in Prehypertension.
7. International Sleep and Breathing Symposium, Madison, WI 07/2017 Title: Sympathetic neural activity in chronic insomnia
8. Experimental Biology, Chicago, IL 04/2017 Title: Black adults display reduced sympathetic reactivity to mental stress compared to non-Hispanic white adults.”
9. Pecha Kucha style presentation (20 slides, 20 seconds per slide) 08/2016 Keweenaw Medical Conference, Copper Harbor, MI. “Sympathetic Neural Control of Cardiovascular Function in humans”,
10. Experimental Biology, Boston, MA 03/2015 Title: Acute oral ingestion of alcohol modulates muscle sympathetic neural activity differently in Caucasians and African Americans.

Poster Presentations (partial list)

1. “Symptom Severity Impacts Inflammation and Sympathetic Over-activity in Post-traumatic Stress Disorder (PTSD).” Experimental Biology, Orlando, 04/2019
2. “Long-Term Effects of Device-Guided Slow Breathing on Autonomic Control at Rest and During Stress in Post-Traumatic Stress Disorder.” Experimental Biology, Orlando, FL, 04/2019
3. “Impaired Arterial Baroreflex Sensitivity in Prehypertension.” Experimental Biology, San Diego, CA, 04/2018
4. “Prehypertension Augments Autonomic Imbalance in Post-traumatic Stress Disorder Experimental Biology, San Diego, CA, 04/2018
5. “Black adults display reduced sympathetic reactivity to mental stress compared to non-Hispanic white adults.” Experimental Biology, Chicago, IL, 04/2017
6. “Total Sleep Deprivation and Sympathetic Neural Control in Older Adults.” 15th International Sleep and Breathing Symposium, Madison, WI, 07/2017
7. “Acute Effects of Device-Guided Slow Breathing on Sympathetic Nerve Activity and Baroreflex Sensitivity in Prehypertensive Veterans with Post-traumatic Stress Disorder.” 10th annual DOM Research Day, Emory University, 10/2017
8. “Acute alcohol consumption blunts the muscle sympathetic nerve activity response to mental stress in humans” Experimental Biology, San Diego, CA, 04/2016
9. “Acute alcohol consumption blunts the muscle sympathetic nerve activity response to mental stress in humans” Michigan Physiological Society, Detroit, MI, 05/2016
10. “Black adults display reduced sympathetic reactivity to mental stress compared to non-Hispanic white adults” Keweenaw Medical Conference, Copper Harbor, MI, 08/2016.

Published Abstracts (partial list)

1. Fonkoue IT, Jones TN, Vemulapalli M, Kankam ML, Park J. Long-Term Effects of Device-Guided Slow Breathing on Autonomic Control of Blood Pressure at Rest and During Stress in Post-Traumatic Stress Disorder. The FASEB Journal 33: 745.7, 2019
2. Fonkoue IT, Jones TN, DaCosta D, Kankam ML, Park J. Symptom Severity Impacts Inflammation and Sympathetic Over-activity in Post-Traumatic Stress Disorder (PTSD). The FASEB Journal 33: 859.7, 2019
3. Vemulapalli M, Fonkoue IT, Jones TN, Kankam ML, Park J. Sympathetic and Cardiovascular Response to Device Guided Slow Breathing Acutely Depends on Post-Traumatic Stress Disorder (PTSD) Severity. The FASEB Journal 33: 562.10, 2019
4. Cunningham H, Greenlund IM, Fonkoue IT, Smoot CA, Mokhlesi B, Carter JR. Total sleep deprivation and pain perception during cold noxious stimuli in older adults. The FASEB Journal 42: A91, 2019
5. Fonkoue IT, Kankam ML, Park J. Impaired arterial baroreflex sensitivity in prehypertension. Journal of Investigative Medicine 66(2) :501. http://dx.doi.org/10.1136/jim-2017-000697.501, 2018.
6. Fonkoue IT, Greenlund IM, Schwartz CE, Smoot CA, Mokhlesi B, Carter JR. Sleep Deprivation and Sympathetic Neural Control in Older Adults. The FASEB Journal 32: 730.5, 2018
7. Fonkoue IT, Schwartz CE, Gervais BM, and Carter JR. Black adults display reduced sympathetic reactivity to mental stress compared to non-Hispanic white adults. The FASEB Journal 31: 720.4, 2017.
8. Carter JR, Grimaldi D, Fonkoue IT, Medalie L, Mokhlesi B, and Van Cauter E. Sympathetic neural control in chronic insomnia. The FASEB Journal 31: 1086.6, 2017.
9. Wakeham TR, Fonkoue IT, Durocher JJ, Cooke WH, and Carter JR. Reliability of heart rate variability as an assessment of cardiac sympathetic activity in humans. The FASEB Journal 31: 1071.6, 2017.
10. Carter JR, Grimaldi D, Fonkoue IT, Medalie L, Whitmore H, Msallek S, Mokhlesi B, Van Cauter E. Sympathetic Neural and Cardiovascular control in chronic insomnia. SLEEP 39:B0506, 2016.

Bio

Areas of interest

Skeletal muscle physiology, exercise physiology, orthopaedic trauma, regenerative rehabilitation

Degrees

2015 Mayo Clinic, Rochester, MN; Postdoctoral Fellowship

2011 University of Minnesota, Minneapolis, MN; PhD Rehabilitation Science

2006 Canisius College, Buffalo, NY; MS Health and Human Performance

2004 Winona State University, Winona, MN; BS Exercise Science - Athletic Training

Positions and Academic Appointments

2015 - 2018, Adjunct Assistant Professor of Physiology, Mayo Clinic

2015 - 2018, Research Physiologist in Extremity Trauma and Regenerative Medicine, US Army Institute of Surgical Research

2018 - 2022, Assistant Professor of Kinesiology, University of Minnesota

2020 - 2022, McKnight Land-Grant Professor, University of Minnesota

2021 - Present, Faculty Center for Clinical Movement Science, University of Minnesota

2022 - Present,  Graduate Faculty Rehabilitation Science, University of Minnesota

2022 - Present, Associate Professor of Kinesiology, University of Minnesota

2022 - Present, Henry L. Taylor-Arthur S. Leon Professorship in Exercise Science and Health Enhancement

Professional Memberships and Activities

2004 - Present, American College of Sports Medicine

2011 - Present, American Physiological Society - Member of eBook Committee

2018 - Present, Orthopaedic Research Society - Co-Chair Women's Leadership Forum

2019 - Present, Tissue Engineering & Regenerative Medicine Society - Chair Musculoskeletal TWIG

Associate Editor, Connective Tissue Research

 

Research Summary

Research

Skeletal Muscle Plasticity and Regeneration Laboratory

Current research interests and long-term scientific goals of the laboratory revolve around the plasticity and regeneration of skeletal muscle, in efforts to mitigate the devastating functional limitations of limb salvage and traumatic muscle injuries. The laboratory examines the musculoskeletal and neuromuscular systems in efforts to understand and develop effective strategies to address the deleterious effects of complex traumatic muscle injuries, namely volumetric muscle loss.

Selected publications

1. Complete list of peer-reviewed articles

Teaching Summary

Teaching

Exercise Physiology (KIN 4385)

Applied Exercise Physiology (KIN 5122)

Seminar: Exercise Physiology (KIN 8122)

MS & PhD Advising Statement

Bio

Dr. Hansen directs the Minneapolis Adaptive Design & Engineering (MADE) Program at the Minneapolis VA Health Care System. The MADE Program develops and distributes adaptive technologies and interventions to help Veterans maximize their function and participation in meaningful activities throughout their life.

Research Summary

Research Summary/Interests

Design and Evaluation of Rehabilitation Technologies, Human Biomechanics, Rehabilitation Engineering, Prosthetics and Orthotics, Wheelchair Design and Evaluation

Research Funding Grants

1. Improving Footwear Options for Women and Men Veterans with Amputations – Department of Veterans Affairs, RR&D (PI: Hansen)
2. Improving Energy Return and Residual-Limb Climate in Prostheses for High-Functioning Amputees – Department of Defense, CDMRP (PI: Hansen)
3. Mobile Manual Standing Wheelchair – Department of Veterans Affairs, RR&D (PIs: Goldish and Hansen)
4. Upper Body Dynamic Positioning System for Persons with SCI – Minnesota Office of Higher Education (PIs: Hansen and Goldish)
5. Development of a Foot-Ankle Prosthesis to Improve Physical Therapy Outcomes – Department of Veterans Affairs, RR&D (PIs: Koehler-McNicholas and Hansen)
6. Development of a Personal Use Seating Pressure Measurement System – Department of Defense, CDMRP (PI: Morrow)
7. Self-management to improve functioning following limb loss – Department of Veterans Affairs, RR&D (PIs: Turner and Czerniecki)
8. Muscle Powered Exoskeleton for Standing and Walking by People with Spinal Cord Injury – Minnesota Office of Higher Education (PI: Durfee)
9. A Prosthetic Foot Emulator to Optimize Prescription of Prosthetic Feet in Veterans and Service Members with Leg Amputations System – Department of Defense, CDMRP (PI: Morgenroth)
10. Active Cooling Socket for Improving Residual Limb Skin Comfort and Skin Care – Department of Defense, CDMRP (PI: Hirschman)
11. Sensor System for Self-Management of Prosthetic Socket Fit loss – Department of Veterans Affairs, RR&D (PI: Ferguson)
12. Medical 3D Printing, System and Process for 3D Printing Prosthetic Components – Defense Logistics Agency (PI: Hand)
13. Women’s-Specific Footwear with Prosthetic Feet – Department of Defense, CDMRP (PI: Russell-Esposito)
14. Camera System Development for Pressure Injury Screening in Veterans with SCI – Department of Veterans Affairs, RR&D (PI: Olney)
15. New IV Clamp to Prevent Medication Errors – Department of Veterans Affairs, Innovation Spark Funding (PI: Goldish)
16. Development of an Arm Cycle Ergometer for Supine Use – Minnesota Office of Higher Education (PI: Goldish)
17. Socket Fit Sensing and Management System – Department of Defense RESTORE (PI: McDonald)
18. A Prosthetic Foot Test-Drive Strategy for Improving Stability and Falls-Related Outcomes in Veterans with Leg Amputations – Department of Defense, CDMRP (PI: Morgenroth)
19. Fall-Related Health Outcomes in Lower Limb Prosthesis Users: A Pragmatic Clinical Trial to Assess Effectiveness of Microprocessor-Controlled Prosthetic Knees – Department of Defense, CDMRP (PI: Hafner)
20. Pediatric Mobile Manual Standing Wheelchair for Children with Disabilities – University of Minnesota Office of Discovery and Translation, The Pediatric Device Innovation Consortium (PI: Hansen)

 

Patents

1. Hansen AH, Goldish GD, Nickel E. Collapsible manual wheelchair system for improved propulsion and transfers. United States Patent 9,795,522. Issued on October 24, 2017.
2. Goldish GD, Hansen A, Nickel E, Ferguson JE. System for screening skin condition for tissue damage. United States Patent 9,788,792. Issued on October 17, 2017.
3. Caldwell RJ, Hansen AH, Wood SM, Chen W, Radcliffe RA, Yngve KA, Kuhar BE, Nelson AJ, Nickel E. Vacuum Pump Systems for Prosthetic Limbs and Methods of Using the Same. United States Patent 9,757,255. Issued on September 12, 2017.
4. Hansen AH, Nickel EA. Ankle-Foot Prosthesis for Automatic Adaptation to Sloped Walking Surfaces. United States Patent 9,549,827. Issued on January 24, 2017.
5. Goldish, G., Hansen, A., Nickel, E. System for Screening the Skin Condition of the Plantar Surface of the Feet. United States Patent 9,301,688. Issued on April 5, 2016.
6. Starker, F., Schneider, U., Hansen, A., Childress, D., Pauli, J., Pauli, C. Artificial Ankle, Artificial Foot and Artificial Leg. United States Patent 9,204,979. Issued on December 8, 2015.
7. Goldish, G., Hansen, A., Nickel, E. Mobile Manual Standing Wheelchair. United States Patent 9,101,520. Issued on August 11, 2015.
8. Caldwell, R., Hansen, A., Wood, S., Chen, W., Radcliffe, R., Yngve, K., Kuhar, B., Nelson, A.J., Nickel, E. Vacuum Pump Systems for Prosthetic Limbs and Methods of Using the Same. United States Patent 9,066,822. Issued on June 30, 2015.
9. Goldish, G., Hansen, A. Mobile Manual Standing Wheelchair. United States Patent 9,044,369. Issued on June 2, 2015.
10. Hansen, A., Goldish, G. Manual Wheelchair System for Improved Propulsion and Transfers. United States Patent 8,905,421. Issued on December 9, 2014.
11. Hansen, A., Childress, D. Bi-modal Ankle-Foot Device. United States Patent 8,764,850. Issued on July 1, 2014.
12. Hansen, A., Nickel, E. Further Improvements to Ankle-Foot Prosthesis and Orthosis Capable of Automatic Adaptation to Sloped Walking Surfaces. United States Patent 8,696,764. Issued on April 15, 2014.
13. Hansen, A., Gard, S., Childress, D., Ruhe, B., Williams, R. Equilibrium-Point Prosthetic and Orthotic Ankle-Foot Devices. United States Patent 8,597,369. Issued on December 3, 2013.
14. Hansen, A., Sensinger, J. Passive Ankle-foot Prosthesis and Orthosis Capable of Automatic Adaptation to Sloped Walking Surfaces and Method of Use. United States Patent 8,480,760. Issued on July 9, 2013.
15. Hansen AH, Goldish GD. Manual wheelchair system for improved propulsion and transfers. United States Patent 9,445,958. Issued on September 20, 2016.
16. Goldish, G., Hansen, A., Nickel, E. System for Screening the Skin Condition of the Plantar Surface of the Feet. United States Patent 9,301,688. Issued on April 5, 2016.
17. Starker, F., Schneider, U., Hansen, A., Childress, D., Pauli, J., Pauli, C. Artificial Ankle, Artificial Foot and Artificial Leg. United States Patent 9,204,979. Issued on December 8, 2015.
18. Goldish, G., Hansen, A., Nickel, E. Mobile Manual Standing Wheelchair. United States Patent 9,101,520. Issued on August 11, 2015.
19. Caldwell, R., Hansen, A., Wood, S., Chen, W., Radcliffe, R., Yngve, K., Kuhar, B., Nelson, A.J., Nickel, E. Vacuum Pump Systems for Prosthetic Limbs and Methods of Using the Same. United States Patent 9,066,822. Issued on June 30, 2015.
20. Goldish, G., Hansen, A. Mobile Manual Standing Wheelchair. United States Patent 9,044,369. Issued on June 2, 2015.
21. Hansen, A., Goldish, G. Manual Wheelchair System for Improved Propulsion and Transfers. United States Patent 8,905,421. Issued on December 9, 2014.
22. Hansen, A., Childress, D. Bi-modal Ankle-Foot Device. United States Patent 8,764,850. Issued on July 1, 2014.
23. Hansen, A., Nickel, E. Further Improvements to Ankle-Foot Prosthesis and Orthosis Capable of Automatic Adaptation to Sloped Walking Surfaces. United States Patent 8,696,764. Issued on April 15, 2014.
24. Hansen, A., Gard, S., Childress, D., Ruhe, B., Williams, R. Equilibrium-Point Prosthetic and Orthotic Ankle-Foot Devices. United States Patent 8,597,369. Issued on December 3, 2013.
25. Hansen, A., Sensinger, J. Passive Ankle-foot Prosthesis and Orthosis Capable of Automatic Adaptation to Sloped Walking Surfaces and Method of Use. United States Patent 8,480,760. Issued on July 9, 2013.

 

Publications

1. Owen E, Fatone S, Hansen A. (In press) Effect of Walking in Footwear with Varying Heel Sole Differentials on Shank and Foot Segment Kinematics. Prosthetics Orthotics International, doi: 10.1177/0309364617728119.
2. Nickel E, Hansen A, Pearlman J, Goldish G. (In press) A Drive System to add Standing Mobility to a Manual Standing Wheelchair. Assistive Technology, doi: 10.1080/10400435.2016.1165757.
3. Olney C, Leestma J, Hansen A, Ferguson J, Murphy Kruse M, Goldish G (2017) Skin Self-Screening Camera for Veterans with Spinal Cord Injury. Proceedings of the 2017 Design of Medical Devices Conference. DMD2017-3330.
4. Fairhurst SR, Koehler-McNicholas SR, Slater BCS, Nickel EA, Koester KA, Voss GO, Hansen AH, Ferguson JE (2017) Improving Automatic Control of an Ankle-Foot Prosthesis using Machine Learning Algorithms. Proceedings of the 2017 Design of Medical Devices Conference. DMD2017-3464.
5. Koehler-McNicholas SR, Nickel EA, Medvec J, Barrons K, Mion S, Hansen AH (2017) The influence of a hydraulic prosthetic ankle on residual limb loading during sloped walking. PLoS One, doi: 10.1371/journal.pone.0173423, Published on March 9, 2017.
6. El-Khatib M, Ferguson J, Koehler-McNicholas S, Koester K, Hansen A (2016) Establishing the Feasibility of a Sensor-Based Sock Management System. Journal of Medical Devices. Vol. 10, No. 3, 030906-030906-2. doi:10.1114/1.4033740.
7. Fairhurst S, Nickel E, Morin S, Goldish G, Hansen A (2016) Design of an Ergonomic Wheelchair Drive System for Improved Shoulder Biomechanics. Journal of Medical Devices. Vol. 10, No. 3, 030952-030952-2. doi:10.1115/1.4033766.
8. Koehler-McNicholas SR, Nickel E, Schultz CJ, Hansen AH (2016) Rocker Shoes for Natural Immobilization of the Ankle during Single-Limb Support. Journal of Medical Devices. Vol. 10, No. 3, 030954-030954-2. doi:10.1115/1.4033767.
9. Fairhurst SR, Lin X, Nickel EA, Hansen AH, Ferguson JE (2015) Sensor Based Control of a Bimodal Ankle–Foot Prosthesis with a Smart Phone Interface. Journal of Medical Devices. Vol. 9, No. 3, 030907.
10. Fairhurst SR, Simone AB, Ferguson JE, Hansen AH (2015) Portable Wireless Visuotemporal Cue Device for Gait Therapy. Journal of Medical Devices. Vol. 9, No. 3, 030909.
11. Ferguson JE, Wittig BL, Payette M, Goldish GD, Hansen AH (2014) Pilot study of a strap-based custom wheelchair seating system in persons with spinal cord injury. Journal of Rehabilitation Research and Development, Vol. 51, No. 8, 1255-1264.
12. Nickel E, Sensinger J, Hansen A (2014) Passive Prosthetic Ankle-Foot Mechanism for Automatic Adaptation to Sloped Surfaces. Journal of Rehabilitation Research and Development, Vol. 51, No. 5, 803-814.
13. Koehler SR, Dhaher YY, Hansen AH (2014) Cross-validation of a portable, six-degree-of-freedom load cell for use in lower-limb prosthetics research. Journal of Biomechanics, Vol. 47, No. 6, 1542-1547.
14. Meier M, Tucker K, Hansen A (2014) Development of Inexpensive Prosthetic Feet for High Heel Shoes using a Simple Shoe Insole Model. Journal of Rehabilitation Research and Development, Vol. 51, No. 3, 439-450.
15. Hansen A, Bedore B, Nickel E, Hanowski K, Tangen S, Goldish G. (2014) Elastic Head Support for Persons with Amyotrophic Lateral Sclerosis (ALS). Journal of Rehabilitation Research and Development, Vol. 51, No. 2, 297-304.
16. Hansen A, Nickel E, Medvec J, Brielmaier S, Pike A, Weber M (2014) Effects of a Flat Prosthetic Foot Rocker Section on Balance and Mobility. Journal of Rehabilitation Research and Development, Vol. 51, No. 1, 137-148.
17. Komolafe O, Wood S, Caldwell R, Hansen A., Fatone S. (2013) Methods for Characterization of Mechanical and Electrical Prosthetic Vacuum Pumps. Journal of Rehabilitation Research and Development, Vol. 50, No. 8, 1069-1078.
18. Hansen AH, Nickel E. (2013) Development of a Bi-Modal Ankle-Foot Prosthesis for Walking and Standing/Swaying. ASME Journal of Medical Devices, Volume 7, No. 3, 035001.
19. Nickel E, Hansen A, Goldish G, Fairhurst F, Morin S (2013) Upper Limb Cycle Ergometer for Supine Exercise. ASME Journal of Medical Devices, Volume 7, No. 2, 020910.
20. Meier MR, Hansen AH, Gard SA, McFadyen AK. (2012) Obstacle Course: Users’ Maneuverability and Movement Efficiency when using the Otto Bock C-Leg and 3R60, and the CaTech SNS Prosthetic Knee Joints. Journal of Rehabilitation Research and Development, Vol. 49, No. 4, 583-596.
21. Boutwell E, Stine R, Hansen A, Tucker K, Gard S. (2012) Effect of Prosthetic Gel Liner Thickness on Gait and Pressure Distribution within the Transtibial Socket. Journal of Rehabilitation Research and Development, Vol. 49, No. 2, 227-240.
22. Nickel EA, Hansen AH, Gard SA. (2012) Prosthetic Ankle-Foot System that Adapts to Sloped Surfaces. ASME Journal of Medical Devices, Vol. 6, No. 1, 011006.
23. Sinitski EH, Hansen AH, Wilken JM. (2012) Biomechanics of the Ankle-Foot System during Stair Ambulation: Implications for Design of Advanced Ankle-Foot Prostheses. Journal of Biomechanics, Vol. 45, 588-594.
24. Gard SA, Su PF, Lipschutz RD, Hansen AH. (2011) The Effect of Prosthetic Ankle Units on Roll-Over Shape Characteristics During Walking in Persons with Bilateral Transtibial Amputations. Journal of Rehabilitation Research and Development, Vol. 48, No. 9, 1037-1048.
25. Hansen AH, Wang CC. (2011) Effect of Rocker Shoe Radius on Oxygen Consumption Rate in Young Able-bodied Persons. Journal of Biomechanics, Vol. 44, 1021-1024.
26. Dillon M, Fatone S, Hansen AH. (2011) The Effect of Prosthetic Design on the Center of Pressure Excursion in Partial Foot Prostheses. Journal of Rehabilitation Research and Development, Vol. 48, No. 2, 161-178.
27. Klodd E, Hansen AH, Fatone S, Edwards ML. (2010) Effects of Prosthetic Foot Forefoot Flexibility on Gait of Unilateral Transtibial Prosthesis Users. Journal of Rehabilitation Research and Development, Vol. 47, No. 9, 899-910.
28. Hansen AH, Childress DS. (2010) Investigations of Roll-over Shape: Implications for Design, Alignment, and Evaluation of Ankle-Foot Prostheses and Orthoses. Disability and Rehabilitation, Vol. 32, No. 26, 2201-2209.
29. Klodd E, Hansen AH, Fatone S, Edwards ML. (2010) Effects of Prosthetic Foot Forefoot Flexibility on Oxygen Cost and Subjective Preference Rankings of Unilateral Transtibial Prosthesis Users. Journal of Rehabilitation Research and Development, Vol. 47, No. 6, 543-552.
30. Wang CC, Hansen AH. (2010) Response of Able-bodied Persons to Changes in Shoe Rocker Radius during Walking: Changes in Ankle Kinematics to Maintain a Consistent Roll-Over Shape. Journal of Biomechanics, Vol. 43, 2288-2293.
31. Hansen AH, Wang CC. (2010) Effective Rocker Shapes Used by Able-Bodied Persons for Walking and Fore-aft Swaying: Implications for Design of Ankle-Foot Prostheses. Gait and Posture, Vol. 32, 181-184.
32. Hansen AH, Meier MR. (2010) Roll-over Shapes of the Ankle-Foot and Knee-Ankle-Foot Systems of Able-Bodied Children. Clinical Biomechanics, Vol. 25, 248-255.
33. Hansen AH, Miff SC, Childress DS, Gard SA, Meier MR. (2010) Net External Energy of the Biologic and Prosthetic Ankle during Gait Initiation. Gait and Posture, Vol. 31, 13-17.
34. Fatone S, Sorci E, Hansen AH. (2009) Effects of Clinically Prescribed Ankle Foot Orthoses on Ankle-Foot Roll-over Shapes: A Case Series. Journal of Prosthetics and Orthotics, Vol. 21, No. 4, 196-203.
35. Williams RJ, Hansen AH, Gard SA. (2009) Prosthetic Ankle-Foot Mechanism Capable of Automatic Adaptation to the Walking Surface. Journal of Biomechanical Engineering, Vol., 131, No. 3, 035002.
36. Srinivasan S, Westervelt ER, Hansen AH. (2009) A Low-Dimensional Sagittal Plane Forward-Dynamic Model for Asymmetric Gait and its Application to Study the Gait of Transtibial Prosthesis Users. Journal of Biomechanical Engineering, Vol. 131, No. 3, 031003.
37. Hansen AH, Childress DS. (2009) Effects of Shoe Heel Height on the Roll-over Shapes of Prosthetic Ankle-Foot Systems: Implications for Heel-Height Adjustable Components. Journal of Prosthetics and Orthotics, Vol. 21, No. 1, 48-54.
38. Hansen AH. (2008) Effects of Alignment on the Roll-over Shapes of Prosthetic Feet. Prosthetics and Orthotics International, Vol. 32, No. 4, 390-402.
39. Dillon M, Hansen AH, Fatone S. (2008) Influence of Marker Models on Ankle Kinematics in Persons with Partial Foot Amputation: An Investigation Using a Mechanical Model. Journal of Rehabilitation Research and Development, Vol. 45, No. 4, 567-576.
40. Miff SC, Hansen AH, Childress DS, Gard SA, Meier MR. (2008) Roll-over Shapes of the Able-Bodied Knee-Ankle-Foot System during Gait Initiation, Steady-State Walking, and Gait Termination. Gait and Posture, Vol. 27, 316-322.
41. Fatone S. and Hansen AH. (2007) Effect of an Ankle Foot Orthosis on Roll-over Shape in Adults with Hemiplegia. Journal of Rehabilitation Research& Development, Vol. 44, No. 1, 11-20.
42. Fatone S. and Hansen AH. (2007) A Model to Predict the Effect of Ankle Joint Misalignment on Calf Band Movement in Ankle-Foot Orthoses. Prosthetics and Orthotics International, Vol. 31, No. 1, 76-87.
43. Hansen, A., Meier, M., Sessoms, P., Childress, D. (2006) The Effects of Prosthetic Foot Roll-over Shape Arc Length on the Gait of Trans-tibial Prosthesis Users. Prosthetics and Orthotics International, Vol. 30, No. 3, 286-299.
44. Miff, S., Childress, D., Gard, S., Meier, M., Hansen, A. (2005) Temporal Symmetries During Gait Initiation and Termination in Non-Disabled Ambulators and in People with Unilateral Transtibial Limb Loss. Journal of Rehabilitation Research and Development, Vol. 42, No. 2, 175-182.
45. Hansen, A., Childress, D. (2005) Effects of Adding Weight to the Torso on Roll-over Characteristics of Walking. Journal of Rehabilitation Research and Development, Vol. 42, No. 3, 381-390.
46. Meier, M., Sam, M., Hansen, A., Childress, D. (2004) The Shape&Roll Prosthetic Foot (Part II): Field Testing in El Salvador. Medicine Conflict and Survival, Vol. 20, No. 4, 307-325.
47. Sam, M., Childress, D., Hansen, A., Meier, M., Lambla, S., Grahn, E., Rolock, J. (2004) The Shape&Roll Prosthetic Foot (Part I): Design and Development of Appropriate Technology for Low-Income Countries. Medicine Conflict and Survival, Vol. 20, No. 4, 294-306.
48. Sam, M., Hansen, A., Childress, D. (2004) Characterization of Prosthetic Feet Used in Low-Income Countries. Prosthetics and Orthotics International, Vol. 28, 132-140.
49. Hansen, A., Childress, D. (2004) Effects of Shoe Heel Height on Biologic Roll-over Characteristics During Walking. Journal of Rehabilitation Research and Development, Vol. 41, No. 4, 547-554.
50. Hansen, A., Sam, M., Childress, D. (2004) The Effective Foot Length Ratio (EFLR) A Potential Tool for Characterization and Evaluation of Prosthetic Feet. Journal of Prosthetics and Orthotics, Vol. 16, No. 2, 41-45.
51. Hansen, A., Childress, D., Knox, E. (2004) Roll-over Shapes of Human Locomotor Systems: Effects of Walking Speed. Clinical Biomechanics, Vol. 19, No. 4, 407-414.
52. Hansen, A., Childress, D., Miff, S., Gard, S., Mesplay, K. (2004) The Human Ankle During Walking: Implications for Design of Biomimetic Ankle Prostheses and Orthoses. Journal of Biomechanics, Vol. 37, No. 10, 1467-1474.
53. Hansen, A., Childress, D., Miff, S. (2004) Roll-over Characteristics of Human Walking on Inclined Surfaces. Human Movement Science, Vol. 23, No. 6, 807-821.
54. Hansen, A.H., Meier, M.R., Sam, M., Childress, D.S., Edwards, M.L. (2003) Alignment of Trans-tibial Prostheses Based on Roll-over Shape. Prosthetics and Orthotics International, Vol. 27, No. 2, 89-99.
55. Hansen, A., Childress, D., Meier, M. (2002) A Simple Method for Determination of Gait Events. Journal of Biomechanics, Vol. 35, No. 1, 135-138.
56. Hansen, A.H., Childress, D.S., Knox, E.H. (2000) Prosthetic Foot Roll-over Shapes with Implications for Alignment of Trans-tibial Prostheses. Prosthetics and Orthotics International, Vol. 24, No. 3, 205-215.
57. 1.Dillon M, Hansen AH, Fatone S. (2008) Influence of Marker Models on Ankle Kinematics in Persons with Partial Foot Amputation: An Investigation Using a Mechanical Model. Journal of Rehabilitation Research and Development, Vol. 45, No. 4, 567-576.
58. Miff SC, <strong>Hansen AH, </strong>Childress DS, Gard SA, Meier MR. (2008) Roll-over Shapes of the Able-Bodied Knee-Ankle-Foot System during Gait Initiation, Steady-State Walking, and Gait Termination. Gait and Posture, Vol. 27, 316-322.
59. Fatone S. and <strong>Hansen AH. </strong>(2007) Effect of an Ankle Foot Orthosis on Roll-over Shape in Adults with Hemiplegia. Journal of Rehabilitation Research & Development, Vol. 44, No. 1, 11-20.
60. Fatone S. and <strong>Hansen AH</strong>. (2007) A Model to Predict the Effect of Ankle Joint Misalignment on Calf Band Movement in Ankle-Foot Orthoses. Prosthetics and Orthotics International, Vol. 31, No. 1, 76-87.
61. Hansen, A., Meier, M., Sessoms, P., Childress, D. (2006) The Effects of Prosthetic Foot Roll-over Shape Arc Length on the Gait of Trans-tibial Prosthesis Users. Prosthetics and Orthotics International, Vol. 30, No. 3, 286-299.
62. Miff, S., Childress, D., Gard, S., Meier, M., Hansen, A. (2005) Temporal Symmetries During Gait Initiation and Termination in Non-Disabled Ambulators and in People with Unilateral Transtibial Limb Loss. Journal of Rehabilitation Research and Development, Vol. 42, No. 2, 175-182.
63. Hansen, A., Childress, D. (2005) Effects of Adding Weight to the Torso on Roll-over Characteristics of Walking. Journal of Rehabilitation Research and Development, Vol. 42, No. 3, 381-390.
64. Meier, M., Sam, M., Hansen, A., Childress, D. (2004) The Shape&Roll Prosthetic Foot (Part II): Field Testing in El Salvador. Medicine Conflict and Survival, Vol. 20, No. 4, 307-325.
65. Sam, M., Childress, D., Hansen, A., Meier, M., Lambla, S., Grahn, E., Rolock, J. (2004) The Shape&Roll Prosthetic Foot (Part I): Design and Development of Appropriate Technology for Low-Income Countries. Medicine Conflict and Survival, Vol. 20, No. 4, 294-306.
66. Sam, M., Hansen, A., Childress, D. (2004) Characterization of Prosthetic Feet Used in Low-Income Countries. Prosthetics and Orthotics International, Vol. 28, 132-140.1.
67. Hansen, A., Childress, D. (2004) Effects of Shoe Heel Height on Biologic Roll-over Characteristics During Walking. Journal of Rehabilitation Research and Development, Vol. 41, No. 4, 547-554.
68. Hansen, A., Sam, M., Childress, D. (2004) The Effective Foot Length Ratio (EFLR) A Potential Tool for Characterization and Evaluation of Prosthetic Feet. Journal of Prosthetics and Orthotics, Vol. 16, No. 2, 41-45.
69. Hansen, A., Childress, D., Knox, E. (2004) Roll-over Shapes of Human Locomotor Systems: Effects of Walking Speed. Clinical Biomechanics, Vol. 19, No. 4, 407-414.
70. Hansen, A., Childress, D., Miff, S., Gard, S., Mesplay, K. (2004) The Human Ankle During Walking: Implications for Design of Biomimetic Ankle Prostheses and Orthoses. Journal of Biomechanics, Vol. 37, No. 10, 1467-1474.
71. Hansen, A., Childress, D., Miff, S. (2004) Roll-over Characteristics of Human Walking on Inclined Surfaces. Human Movement Science, Vol. 23, No. 6, 807-821.
72. Hansen, A.H., Meier, M.R., Sam, M., Childress, D.S., Edwards, M.L. (2003) Alignment of Trans-tibial Prostheses Based on Roll-over Shape. Prosthetics and Orthotics International, Vol. 27, No. 2, 89-99.
73. Hansen, A., Childress, D., Meier, M. (2002) A Simple Method for Determination of Gait Events. Journal of Biomechanics, Vol. 35, No. 1, 135-138.
74. Hansen, A.H., Childress, D.S., Knox, E.H. (2000) Prosthetic Foot Roll-over Shapes with Implications for Alignment of Trans-tibial Prostheses. Prosthetics and Orthotics International, Vol. 24, No. 3, 205-215.

Bio

Areas of interest

Neurorehabilitation, motor control and development, stroke, robotics, neuroimaging

Degrees

2020 Post-doctoral Fellowship, Clinical Neurosciences, University of Calgary, Calgary, AB

2016 PhD, Biomedical Engineering, Northwestern University, Evanston, IL

2013 DPT, Physical Therapy, Northwestern University, Chicago, IL

2008 BS, Biomedical Engineering, University of Rochester, Rochester, NY

 

My overall research goal is to maximize recovery following a neurologic injury such as stroke. A key challenge in neurorehabilitation is a poor understanding of the specific impairments an individual may have, which makes it difficult to target therapies. I use robotics to measure specific motor and sensory impairments, and then link these impairments with neuroimaging findings. I am specifically interested in bilateral coordination in both adults who have had a stroke as well as children with hemiparetic cerebral palsy due to a stroke early in development. 

One of my areas of research will focus on developing robotic assessments of bilateral coordination. Bilateral coordination encompasses a wide range of tasks, from picking up a box with both hands to stabilizing a jar with one hand while opening it with the other. Robotic assessments can allow us to pinpoint the specific areas of bilateral coordination that are impaired in individuals with stroke and cerebral palsy, and then relate these impairments with neuroimaging findings. This will lead to more targeted interventions to improve rehabilitation outcomes.

A second area of focus is in how bilateral arm use typically develops, and how it is impacted by an early lesion. Accelerometers can be worn on the wrists to quantify how much a child moves their arms in daily life. We can then develop interventions to promote the use of the weaker arm in children with early lesions. Encouraging early use of the affected arm can drive positive neuroplastic changes to improve outcomes in children with hemiparetic cerebral palsy. 

Research Summary

Selected publications

1. Hawe RL, Kuczynski AM, Kirton A, Dukelow SP. “Impairments in rapid motor decisions and actions in children with perinatal stroke.” Journal of NeuroEngineering and Rehabilitation. 2020; 17(94). 

2. Bonkhoff AK, Hope T, Bzdok D, Guggisberg AG, Hawe RL, Dukelow SP, Rehme AK, Fink GR, Grefkes C, Bowman H. “Bringing Proportional Recovery into Proportion: Bayesian Hierarchical Modelling of Post-Stroke Motor Performance.” Brain. 143(7): 2189:2206.

3. Hawe RL, Kuczynski AM, Kirton A, Dukelow SP. “Assessment of Bilateral Motor Skills and Visuospatial Attention in Children with Perinatal Stroke using a Robotic Object Hitting Task.” Journal of NeuroEngineering and Rehabilitation. 2020; 17(18).

4. Findlater SE, Hawe RL, Mazerolle EM, Al Sultan AS, Cassidy JM, Scott SH, Pike GB, Dukelow SP. “Comparing CST lesion metrics as biomarkers for recovery of motor and proprioceptive impairments after stroke.” Neurorehabilitation and Neural Repair. 2019; 33(10):848-861.

5. Hawe RL, Scott SH, Dukelow SP. “Taking Proportional Out of Stroke Recovery.” Stroke. 2019; 50(1): 204-211.

6. Findlater SE, Hawe RL, Semrau JA, Kenzie JM, Yu AY, Scott SH, Dukelow SP. “Lesion locations associated with persistent proporioceptive impairment in the upper limbs after stroke.” Neuroscience: Clinical. 2018; 20:955-971.

7. Hawe RL, Findlater SE, Kenzie JM, Hill MD, Scott SH, Dukelow SP.  “Differential Impact of Acute Lesions Versus White Matter Hyperintensities on Stroke Recovery.” Journal of American Heart Association. 2018; 7(18).

8. Hawe RL, Dewald JP. “Development of a Method to Quantify Inter-Limb Coupling in Individuals with Hemiparetic Stroke.” Conference Proceedings of 2015 IEEE Engineering in Medicine and Biology Society. 2015; 3476-3479.

Selected presentations

1. "Using Robotics to Assess and Treat the Upper Limb in Children with Hemiparetic Cerebral Palsy" (August 2020). Neurorobotics Consortium, University of Minnesota, Minneapolis, MN, USA

2. “Proportional Recovery: Maxim or Myth" (October 2019). American Society for Neurorehabilitation Annual Meeting, Chicago, IL, USA

Bio

Dr. Jayasinghe is a tenure-track assistant professor in the Divisions of Physical Therapy & Rehabilitation Science. She received her BS in Biomedical Engineering from Georgia Institute of Technology. She then attended the University of Southern California where she received both her MS and PhD in Biomedical Engineering. Dr. Jayasinghe completed postdoctoral training at Pennsylvania State University’s College of Medicine prior to joining the U of M. Dr. Jayasinghe uses her engineering foundation to study clinically relevant questions related to upper limb movement. She is specifically interested in exploring the role of cognition in sensorimotor control in chronic stroke survivors.

Research Summary

Dr. Jayasinghe’s research interests are in motor neuroscience and neurorehabilitation, specifically in examining mechanisms of upper limb motor control to develop non-invasive and personalized tools for stroke rehabilitation. Currently, she is focused on understanding the role of lateralized motor and cognitive processes during movement, and how they influence functional outcomes in chronic stroke survivors with hemiparesis.

Research Funding Grants

1. Medical School/UMF Assistant Professor Award, University of Minnesota: Aug. 2022-July 2023
2. National Institute of Child Health and Human Development (R01 HD059783) 2019-2022. Title: Predicting ipsilesional motor deficits in stroke with dynamic dominance model. Role: Postdoctoral Scholar (MPI: Sainburg, Winstein). 

Research Interests

1. Motor control
2. Motor learning
3. Neurorehabilitation

Invited talks

1. University of Minnesota – Twin Cities - April 2022 Design of Medical Devices conference, “Neurorehabilitation Robotics” session “Examining hemisphere-specific movement deficits to develop personalized neurorehabilitation strategies”
2.  Marquette University & Medical College of Wisconsin - February 2021 Department of Biomedical Engineering “Motor lateralization and its role in stroke rehabilitation”
3. Marquette University - April 2021 Neuromotor control laboratory “NeuroGroup” series “Pursuing an academic career in motor control and motor rehabilitation”
4. Michigan State University - October 2017 Department of Kinesiology “Non-invasive sensory techniques for solving motor learning problems in rehabilitation”

Teaching Summary

Courses

• Neurorehabilitation I (PT 6286)
• Research Problems in Physical Therapy (PT 8193)

Bio

Awards & Recognition

• University of Delaware Graduate and Professional Education 2019 Summer Doctoral Fellowship Award
• Federation of State Boards of Physical Therapy (FSBPT) Academy of Advanced Item Writers, inducted 2019
• Phi Kappa Phi National Honor Society, inducted 2018
• University of Delaware Graduate and Professional Education 2018 Professional Development Travel Award
• Center for Biomedical Engineering Research Symposium Best Poster Award, 2017
• University of Puget Sound Trustee Scholarship winner (highest award) 2001-2005

 

Professional Associations

• American Physical Therapy Association
• European Society of Sports Traumatology, Knee Surgery, and Arthroscopy

Research Summary

Research Summary/Interests

My research focuses on lower extremity injuries: prevention, rehabilitation, and return to sport. My current research projects include a longitudinal survey of high school coaches, injury prevention programs, and team performance as well as work with the University of Minnesota athletic teams. I also have interdisciplinary collaborations involving wearable technologies and orthopedic assessment mannequin simulators.

Research Funding Grants

Grant Title: Soft wearable systems to prevent and rehabilitate musculoskeletal injuries. PI: Lucy Dunne. Granting Agency: CISCO SYSTEMS, INC.

Grant Title: Simulation and Education Tool for Physical Examinations of Orthopedic Pathologies. PI: John Condon. Granting Agency: NIH SBIR/INNOVATIVE DESIGN LABS INC.

Publications

• Johnson JL, Capin JJ, Arundale AJH, Zarzycki R, Smith AH, Snyder-Mackler L. Perturbation Training and Second ACL Injury Prevention in Female Athletes: 2-year Injury Rates in the ACL- SPORTS Randomized Control Trial. In Review at JOSPT.
• Johnson JL, Irrgang J, Risberg MA, Snyder-Mackler L. Can We Stop Asking So Many Questions? Evaluating Responsiveness in Selected Patient Reports Outcome Measures: A Delaware-Oslo Cohort Study. In Review at AJSM.
• Pederson, M. Johnson JL, Grindem H, Magnusson K, Snyder-Mackler L, Risberg, MA. Prognostic factors for knee function and physical activity two to ten years after anterior cruciate ligament injury or reconstruction - a systematic review. In review at JOSPT.
• Capin JJ, Failla M, Smith AH, Zarzycki R, Dix C, Johnson JL, Risberg MA, Huston LJ, Spindler KP, Snyder-Mackler L. Superior 2-Year Functional Outcomes Among Young Female Athletes After ACL Reconstruction in Just 10 Post-Operative Return-to-Sport Training Sessions. Orthop J Sports Med. 2019 Aug; 7(8).

Peer Reviewed Oral Presentations

• "Creating A Crosswalk For Knee Outcomes After ACLR From The KOOS(5) To The IKDC-SKF" 2021 International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine.
• “Higher rates of return to sport and competitive level when a specialized intervention is post-ACLR compared to pre-ACLR” 2021 European Society of Sports Traumatology, Knee surgery, and Arthroscopy (ESSKA)
• “Perturbation Training and Second ACL Injury Prevention: An ACL-Sports Study” 2020 APTA CSM, Denver, Colorado.
• “Can We Stop Asking So Many Questions? Evaluating Responsiveness in Selected Patient Reported Outcome Measures: A Delaware-Oslo Cohort Study” 2019 International Society of Arthroscopy, Knee Surgery, and Orthopaedic Sports Medicine (ISAKOS), Cancun, Mexico
• “Second injuries after ACL reconstruction: hop performance versus non-modifiable factors” 2019 APTA CSM, Washington DC

Teaching Summary

• DPT: Musculoskeletal Rehabilitation; Clinical Integration
• MS/PhD: Critical Analysis of Scientific Literature

Clinical Summary

Board Certifications

• Board Certified Orthopaedic Clinical Specialist, American Physical Therapy Association, 2011, recertified through 2031
• APTA-Credentialed Clinical Instructor since 2014

Bio

Peter B. Kang, MD, FAAN, FAAP is a pediatric neuromuscular neurologist and physician-scientist whose laboratory studies the genetics of muscular dystrophy and mechanisms of rare muscle diseases, with the goal of discovering new therapeutic targets for these diseases. He also studies DNA repair disorders including Cockayne syndrome and xeroderma pigmentosum.  He has published extensively on these subjects, has co-edited a textbook of pediatric electromyography, and has been awarded multiple grants from the NIH and the Muscular Dystrophy Association to support his investigations. With support from the CDC, he led the successful initiation of the first site in Florida for the MD STARnet consortium and continues to work on this project. He is an associate editor of Muscle & Nerve and serves on the editorial board of Neurology. National presentations include lectures on pediatric neuromuscular topics at the annual meetings of the American Academy of Neurology, American Academy of Pediatrics, American Association of Neuromuscular and Electrodiagnostic Medicine, the Child Neurology Society, and the Muscular Dystrophy Association. His former trainees hold faculty positions in the United States, Canada, South Korea, and Japan.  He is President-Elect of the Child Neurology Society.

Previously, Dr. Kang was Professor of Pediatrics, Chief of the Division of Pediatric Neurology, and Director of the Child Neurology Residency Program at the University of Florida College of Medicine. Earlier in his career, he was Director of the Electromyography Laboratory at Boston Children's Hospital and Associate Professor of Neurology at Harvard Medical School.

In clinic, Dr. Kang sees children with confirmed or suspected neuromuscular disorders such as muscular dystrophy, congenital myopathy, neuropathies, brachial plexus injuries, spinal muscular atrophy, and myasthenia gravis, as well as children with DNA repair disorders such as Cockayne syndrome and xeroderma pigmentosum. He will see adult patients with these conditions upon request.

Bio

Awards & Recognition

• National Institutes of Health Loan Repayment Program (LRP), competitive Renewal, 2019
• Faculty Success Program, National Center for Faculty Development, 2018
• National Institutes of Health Loan Repayment Program (LRP), 2017
• NIKE, Inc. Loren G. Myhre Environmental and Exercise Physiology Postdoctoral Research Award, EEP Section of the American Physiology Society, 2015
• Recognition Award for Beginning Investigators (Exercise and Environmental Physiology, EEP) section of the American Physiological Society, 2014
• Promotion of Doctoral Studies (PODS II) Scholarship from the Foundation of Physical Therapy, Marquette University, 2010
• Canadian Institutes of Health Research (CIHR) Research Award, McMaster, 2008
• Clinical Excellence Award, Marquette University, 2006

Professional Associations

• American Heart Association
• American Physical Therapy Association
• American Autonomic Society   
• American College of Sports Medicine, Member
• American Physiology Society, Member
  • Exercise and Environmental Physiology Section Member
  • Cardiovascular Section Member

Research Summary

The Cardiovascular Research and Rehabilitation Laboratory (CRRL) has a primary interest to investigate 1) factors that contribute to the greater cardiovascular risk in women after menopause and 2) exercise intolerance in those with cardiovascular and pulmonary disorders. In addition, we aim to develop novel treatment strategies to improve cardiorespiratory regulation and decrease cardiovascular disease.

The CRRL uses a multi-system approach to understand blood pressure regulation as the maintenance of blood pressure at rest and during exercise involves a highly redundant and sophisticated integration of multiple systems with the goal of maintaining homeostasis. Our laboratory uses several techniques to quantify autonomic function and limitations to exercise in healthy and clinical populations, such as those with cardiovascular diseases and muscular dystrophy. Techniques in our lab to quantify autonomic function are muscle sympathetic nerve activity (MSNA), which is the gold standard for measuring sympathetic activity, electrocardiography, heart rate variability, baroreflex function and venous occlusion plethysmography to measure limb blood flow. Our laboratory is also interested in limitations to exercise, including cardiopulmonary and skeletal muscle factors in healthy and clinical populations. We conduct maximal/peak oxygen consumption (VO_2max/peak)tests as well as fatigability tests isolated to single muscle groups. We aim to understand the contributing factors of autonomic dysregulation to cardiovascular disease and identify optimal treatment strategies to reduce cardiovascular risk and mortality in adults.

Current projects

• Mechanisms of increased cardiovascular disease risk in women who enter menopause premature or early
• Influence of menopausal symptoms, including hot flashes and sleep disturbance, to autonomic blood pressure regulation.
• Mechanisms of exercise intolerance in clinical populations including muscular dystrophy and heart failure
• The contribution of locomotor muscle afferents (group III and IV) to central drive and cardiorespiratory responses during exercise in both healthy adults and those with heart failure
• Use of neuromodulation to improve blood pressure in clinical populations.

 

Research Funding Grants

Institute of Engineering Medicine Working Grant University of Minnesota 
Working group to establish Autonomic Neuromodulation.
Role: Co-PI (Osborn-PI) 
2/2019-12/2020

Grant-In-Aid, University of Minnesota 
Autonomic blood pressure regulation in older premature and early menopause 
The goal of this GIA is to determine autonomic regulation of blood pressure in older women who entered menopause premature or early.
Role: PI
1/2020-6/2021

1 K01 AG064038-01A1, National Institute of Health
Autonomic blood pressure regulation in older premature and early menopause 
The goal of this Career Development grant to study autonomic blood pressure regulation in premature and early post-menopausal women.
Role: PI
5/2020-4/2025

Women’s Health Research Program, University of Minnesota (Keller-Ross-PI)
Sympathetic activity and baroreflex function in postmenopausal black females
The goal of this study is to investigate the differences in blood pressure regulation in typical age and premature/early menopause in black females.
Role: PI
10/2020-10/2021

 

Publications

2021

• Vera, K, McConville, Kyba, M, Keller-Ross, ML. Resting Metabolic Rate in Adults with Facioscapulohumeral Muscular Dystrophy. Appl Physiol, Nutr, Metab (2021). Mar 18. doi: 10.1139/apnm-2020-1119. PMID: 33735584.
• Anderson, E, Kelly, T, Sharp, A, Keller-Ross, ML, Brunsvold, ME. (2021) Active Rehabilitation in a patient during and after venovenous extracorporeal membrane oxygenation with a diagnosis of COVID-19, a case report. J Acute Care Phys Ther (In Press).
• Keller-Ross, ML, Chantigian, DP, Nemanich, S, Gillick, BT. (2021) Cardiovascular effects of transcranial direct current stimulation and bimanual training in children with cerebral palsy. Pediatric Physical Therapy Journal. Jan 1;33(1):11-16. DOI: 10.1097/PEP.0000000000000762.

2020

• Smith, JR, Joyner, MJ, Curry, TB, Borlaug, BA, Keller-Ross, ML, Van Iterson, EH, Olson, TP. In press. Locomotor Muscle Group III/IV Afferents Constrain Stroke Volume and Contribute to Exercise Intolerance in Human Heart Failure. J Physiol.
• Keller-Ross, ML, Chantigian, DP, Nemanich, S, Gillick, BT. In press. Cardiovascular effects of transcranial direct current stimulation and bimanual training in children with cerebral palsy. Pediatric Physical Therapy Journal. 
• Vera, K, McConville, Kyba, M, Keller-Ross, ML. (2020) Sarcopenic obesity in Facioscapulohumeral Muscular Dystrophy. Frontiers in Physiology. doi.org/10.3389/fphys.2020.01008. 
• Keller-Ross, ML, Cunningham, HA, Carter, JR. (2020) Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans. Am J Physiol Regul Integr Comp Physiol. doi: 10.1152/ajpregu.00045.2020 
• Lalande, S. Cross, TT, Keller-Ross, ML, Morris, N, Johnson, BD, Taylor, BJ (2020) Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System. Exercise and Sport Sciences Reviews. Jan;48(1):11-19.doi: 10.1249/JES.0000000000000208

 

2019

• Keller-Ross ML, Larson, M, Johnson, BD. Skeletal Muscle Fatigability in Heart Failure (2019). Frontiers in Physiology. Feb 21;10:129. doi:10.3389/fphys.2019.00129.
• Keller-Ross ML, Chantigian DP, Rich TL, Chen M, Chen CY, Gillick BT. Stability of the cardiovascular response during single-pulse TMS in perinatal stroke. (2019) Brain Stimul. pii: S1935-861X(18)30376-0. doi: 10.1016/j.brs.2018.11.010. 

2018

• Keller-Ross ML, Chantigian DP, Rich TL, Chen M, Chen CY, Gillick BT. Stability of the cardiovascular response during single-pulse TMS in perinatal stroke. Brain Stimul. (2018) Nov 20. pii: S1935-861X(18)30376-0. doi: 10.1016/j.brs.2018.11.010. 
• Keller-Ross, ML, Sarkinen, AL, Chantigian, DP, Cross, TJ, Johnson, BD, Olson, TP. Interaction of Chemoreflex and Ergoreflex during Dynamic Exercise in Healthy Adults. (2018). Translational Sports Med. doi.org/10.1002/tsm2.60. 
• Keller-Ross, ML, Chantigian, Dl, Evanoff, N, Bantle, Anne, Dengel, Donald, Chow, Lisa (2018). VE/VCO2 slope in Lean and Overweight Women and Its Relationship to Lean Leg Mass. Int J Cardiol Heart & Vasculature.

2017

• Ann Van de Winckel, Yu-Ting Tseng, Daniel Chantigian, Kaitlyn Lorant, Zinat Zarandi, Jeffrey Buchanan, Thomas A. Zeffiro, Mia Larson, Becky Olson-Kellogg, Jürgen Konczak, Manda L. Keller-Ross (2017). Age-Related Decline of Wrist Position Sense and its Relationship to Specific Physical Training. Front Hum Neuroscie.;11:570. 
• Wheatley, Courtney M., Baker, Sarah E, Taylor, Bryan J, Keller-Ross, Manda L. Chase, Steven C, Carlson, Alex R., Wentz, Robert J. Snyder, Eric M, Johnson, Bruce D. Influence of Inhaled Amiloride on Lung Fluid Clearance in Response to Normobaric Hypoxia in Healthy Individuals. (2017) High Altit Med & Biol.; 18:4: 343-354.

2016

• Keller-Ross, ML, Cowl, A, Cross, TJ, Johnson, BD, Olson, TP. (2016). Ventilation Increases with Lower Extremity Venous Occlusion in Young Adults. Med Sci Sports Exerc, 48 (3): 377-383.

2015

• Keller-Ross, ML, Johnson.BD, Carter, R, Joyner, MJJ, Eisenach, J, Curry, T, Olson, TP. (2015). Improved Ventilatory Efficiency with Locomotor Muscle Afferent Inhibition is Strongly Associated with Leg Composition in Heart Failure. Int J Cardiol, 202: 159-166.
• Cross TJ, Keller-Ross ML, Issa A, Wentz R. Taylor B, Johnson B. (2015). The impact of averaging window length on the desaturation indexes obtained via overnight pulse oximetry at high altitude. Sleep, 38(8): 1331-1334.

2014

• Keller-Ross ML, Joyner, MJ, Johnson, BD, Olson, TP.(2014) Influence of the metaboreflex on arterial blood pressure in heart failure patients. Am Heart J, 167(4):521-8.
• Keller-Ross ML, Pruse, J, Yoon T, Schlinder-Delap B, Harkins, A & Hunter SK. (2014) Stress- Induced increase in muscle fatigability of young men and women is predicted by strength but not voluntary activation. J Appl Physiol, 116(7):767-768.
• Keller-Ross ML, Schlinder-Delap B, Doyel, R, Larson, G & Hunter SK. (2014) Muscle fatigability is greater in veterans with posttraumatic stress disorder. Med Sci Sports Exerc, 46(7):1302-13.

2011

• Yoon T, Schlinder-Delap B, Keller ML & Hunter SK (2011b). Supraspinal fatigue impedes recovery from a low-intensity sustained contraction in old adults. J Appl Physiol 112, 849- 858.
• Keller ML, Pruse, J, Yoon T, Schlinder-Delap B, Harkins, A & Hunter SK (2011). Supraspinal Fatigue in men and women during a low force fatiguing contraction. Med Sci Sports Exerc.43, 1873-1883.
• Pereira H, Keller ML (2011). Understanding the mechanisms of neuromuscular fatigue with paired- pulse stimulation. J Physiol 589 (Pt 14), 3533-3544.

2010

• Hoeger Bement M, Weyer A, Keller, ML, Harkins AL, Hunter SK (2010) Anxiety and stress can predict pain perception following a cognitive stress. Physiology & Behavior 101: 87-92.

2009

• Yoon T, Keller ML, Delap BS , Harkins A, Lepers R, & Hunter SK (2009). Sex differences in response to cognitive stress during a fatiguing contraction. J Appl Physiol: respiratory, environmental and exercise physiology 107: 1486-1496.
• Hoeger-Bement M, Rasiarmos R, DiCapo R, Lewis A, Keller ML, Harkins A, Hunter S (2009). The Role of the Menstrual Cycle Phase In Pain Perception Before and After an Isometric Fatiguing Contraction. Eur J Appl Physiol 106: 105-112. (PMID:19189119).

Teaching Summary

Physiology

Bio

Awards & Recognition

• Women's Health Scholar (2017-2019)
• Dorothy Briggs Memorial Scientific Inquiry Award, American Physical Therapy Association (2016)
• Roza Steer Breast Cancer Research Award, University of Minnesota (2013)
• Doctoral Dissertation Fellowship, University of Minnesota (2011-2012)
• Fairview Courageous Leadership Scholarship, Fairview Health Care System (2007-2008)

 

Professional Associations

• National Lymphedema Network International Conference - Scientific Planning Committee
• University of Minnesota - Masonic Cancer Center Faculty
• International Society of Lymphology
• American Lymphedema Foundation
• Lymphology Association of North America
• National Lymphology Network
• American Physical Therapy Association
• Lymphology Association of North America (certified lymphedema therapist)

Professional and Scientific Activities

• Scientific Committee Member, National Lymphedema Network, 11th International Conference, 2013-present
• Manuscript Reviewer,

Research Summary

Dr. Koehler's area of interest includes cancer survivorship and lymphatic disorders. Her specific focus is on axillary web syndrome, lymphedema, and outcome measures following breast cancer treatment. Her research encompasses rehabilitation and exercise to improve the function and physical health in cancer survivors. In January 2015, Dr. Koehler obtained a research appointment within the Masonic Cancer Center. Through her research, her goal is to address the physical impairments following cancer treatment and enhance cancer rehabilitation.

Current Studies

• Axillary web syndrome ongoing medical evaluation
• Quality of life in breast cancer survivors who participate in dragon boat racing
• Measurement of local tissue water following breast cancer surgery
• Physical Rehabilitation Evaluation and Optimal Physical Therapy

Publications

• Koehler, LA, Mayrovitz HN. Trunk Lymphedema Following Breast Cancer Surgery. Physical Therapy Journal, accepted 2/2020.
• Chrischilles E, Riley D, Letuchy E, Koehler L, Neuner J, Gryzlak B, Segal N, McDowell B, Smith B, Sugg S, Armer J, Lizarraga I. Upper extremity disability and quality of life after breast cancer treatment in the Greater Plains Collaborative clinical data research network. Breast Cancer Res Treat. 2019 Jun;175(3):675-689. doi: 10.1007/s10549-019-05184-1. (Epub 2019 Mar 9.)
• Koehler, LA, Haddad T, Hunter D, Tuttle T. Axillary Web Syndrome following Breast Cancer Surgery: Symptoms, Complications, and Management Strategies. Breast Cancer-Targets and Therapy, Vol. 11 (Dec. 2018), 13-19. https://doi.org/10.2147/BCTT.S146635
• Koehler, LA, Mayrovitz HN. Spatial and Temporal Variability of Upper Extremity Edema Measures Following Breast Cancer Surgery. Lymphatic Research and Biology, 2019 Jun;17(3):308-315 doi: 10.1089/lrb.2018.0022. (Epub 2018 Nov 14.)
• Koehler L.A. (Interview). (2018, June 26, 2018) Axillary Web Syndrome After Breast Cancer Surgery: An Interview with Dr. Linda Koehler [Audio podcast]. Retrieved from https://academic.oup.com/ptj/pages/podcasts
• Koehler, LA, Hunter DW, Blaes AH, Haddad TC. Function, Shoulder Motion, Pain, and Lymphedema in Breast Cancer With and Without Axillary Web Syndrome: An 18-Month Follow-Up, Physical Therapy, Volume 98, Issue 6, 1 June 2018, Pages 518–527. https://doi.org/10.1093/ptj/pzy010
• Thompson Buum,H, Koehler L, Tuttle T. Venturing Out on a Limb: Axillary Web Syndrome, The American Journal of Medicine, Vol. 130, No.5, (May 2017), 209-210.
• Koehler LA, Blaes AH, Haddad TC, Hunter DW, Hirsch AT, Ludewig PM: Movement, function, pain, and post-op edema in axillary web syndrome. Physical Therapy, Vol. 95, No. 10, (October 2015), 1345-1353. doi: 10.2522/ptj.20140377.
• Koehler, LA, DW Hunter, TC Haddad, AH Blaes, AT Hirsch, PM Ludewig: Characterizing Axillary Web Syndrome: Ultrasonographic efficacy. Lymphology, Vol. 47, No. 4, (Dec 2014), 153-155.
• Koehler LA. Axillary Web Syndrome. In: Zuther, JE. Lymphedema Management, The Comprehensive Guide for Patients and Practitioners. 3^rd ed. New York, NY: Thieme Medical Scientific Publishers; 2013:64-67.
• Koehler LA. Klippel-Trenaunay Syndrome/Parkes Weber Syndrome. In: Zuther, JE. Lymphedema Management, The Comprehensive Guide for Patients and Practitioners. 3^rd ed. New York, NY: Thieme Medical Scientific Publishers; 2013:209-210.
• Koehler LA. Axillary Web Syndrome (ie.cording).Available at: http://www.lymphedemablog.com/2011/04/28/axillary-web-syndrome/. April 28, 2011.
• Koehler LA. Axillary web syndrome and lymphedema, a new perspective. Lymph Link 18(3):9-10; 2006

Teaching Summary

Teaching Areas

• Research
• Integument
• Lymphedema
• Cancer Rehabilitation
• Human Development
• Orientation to Physical Therapy

Clinical Summary

Board Certifications

Clinical Experience - Physical Therapist

• 2009-present: Fairview Lakes Medical Center, Casual Physical Therapist, Wyoming, MN
• 2002-2009: Fairview Lakes Medical Center, Physical Therapist; Clinical Specialist, Chisago City, MN
• 1995-2002: Sister Kenney Sports and Physical Therapy, Unity Hospital, Fridley, MN

Research Summary

My research combines biomechanical solutions with rehabilitation principles to solve fundamental problems in public health. I have a diverse background in the fields of ergonomics, biomedical, computer, and mechanical engineering, physical therapy, and public health. I have completed many ergonomic assessments of large-scale industrial factories including: automotive, appliance, and chemical plants and have trained incoming graduate students on how to properly conduct ergonomic assessments in the field. Additionally, I have led multiple research projects with physicians as well as government and private industrial research institutions as a Co-Investigator on several University and NIH-funded grants.

Bio

Expertise

Skeletal muscle biology in aging, health and disease

Professional Associations

• Fellow, American College of Sports Medicine
• Member, American Physiological Society
• Member, Institute on the Biology of Aging and Metabolism (iBAM), UMN
• Member, Paul and Sheila Wellstone Muscular Dystrophy Center, UMN

Research Summary

Dr. Lowe's laboratory investigates cellular and molecular mechanisms underlying skeletal muscle deterioration that occur with age, injury, and disease. We are particularly interested in how the loss of estradiol causes muscle weakness and impaired regeneration of injured muscles. Our studies point toward the deterioration of myosin function and satellite cells as two of the culprits. We are highly collaborative in muscular dystrophy research having published with eight other UMN muscle biologists. Our studies often have a flavor of exercise science and preventative medicine as well as rehabilitation. Trainee research experiences are enriched by the collaborative nature of our work that intersects muscle research from fields of biochemistry, physiology, biophysics, engineering, molecular and stem cell biology, pathology, endocrinology, immunology, and bone biology.

Research Funding Grants

• NIH, T32 AS007612-21 (MPI with Ervasti and Thomas)
  Minnesota Muscle Training Program
  05/01/2022-04/30/2027
• NIH, T32 AG029767-14 (MPI with Arriaga and Niedernhofer)
  Functional proteomics of aging training grant
  05/01/2019-04/30/2023
• NIH, R01 AG031743-12
  Interaction of Estrogen, Age and Activity on Musculoskeletal Strength in Females
  02/01/2009 - 01/31/2024
• NIH, R01 AG062899-2 (MPI with Michael Kyba)
  Dissecting Effects of Estrogen Deficiency on Satellite Cells on Muscle Regeneration in Females and Males
  10/01/2019 - 09/30/2024

Publications

2023:

Le G, Baumann CW, Warren GL, and Lowe DA (2023). In vivo potentiation of muscle torque is enhanced in female mice through estradiol-estrogen receptor signaling. J Appl Physiol (1985) 134(3):722-730. PMID: 36735234. PMC10027088.

2022:

Peyton MP, Tzu-Yi Y, Higgins L, Markowski TW, Vue C, Parker LL, Lowe DA (2022). Global phosphoproteomic profiling of skeletal muscle in ovarian-hormone deficient mice. Physiol Genomics 54(11):417-432. PMID 36062884. PMC9639773.

Norton A, Thieu K, Baumann CW, Lowe DA, Mansky KC (2022). Estrogen regulation of myokines that enhance osteoclast differentiation and activity. Scientific Reports 12:15900. PMID 36151243. PMC9508086.

Larson AA, Shams AS, McMillin SL, Sullivan BP, Vue C, Roloff ZA, Batchelor E, Kyba M, Lowe DA (2022). Estradiol deficiency reduces the satellite cell pool by impairing cell cycle progression. Am J Physiol Cell Physiol 322:C1123-C1137. PMID 35442828. PMC9169829.

Baumann CW, Ingalls CP, Lowe DA (2022). Mechanisms of weakness in mdx muscle following in vivo eccentric contractions. J Muscle Res 43(2):63-72. PMID 35445349.

Lin Y, Nhieu J, Liu P, Le G, Lee DJ, Wei C, Lin Y, Oh S, Lowe DA, Wei L (2022). CRABP1-CaMKII-Agrn regulates the maintenance of neuromuscular junction in spinal motor neuron. Cell Death Differ 29:1744-1756. PMID 35217789. PMC9433400.

McMillin SL, Minchew EC, Lowe DA, Spangenburg EE (2022). Skeletal muscle wasting: the estrogen side of sexual dimorphism. Am J Physiol Cell Physiol 322:C24-C37. PMID 34788147. PMC8721895.

Sidky SR, Ingalls CP, Lowe DA, Baumann CW (2022). Membrane proteins increase with the repeated bout effect. Med Sci Sports Exerc 54(1):57-66. PMID 34334717. PMC8678180.

2021:

Baumann CW, Lindsay A, Sidky SR, Ervasti JM, Warren GL, Lowe DA (2021). Contraction-Induced Loss of plasmalemmal electrophysiological function is dependent on the dystrophin glycoprotein complex. Front Physiol 12:757121. PMID 34764884. PMC8576390

Arpke RW, Shams AS, Collins BC, Larson AA, Lu N, Lowe DA, Kyba M (2021). Preservation of satellite cell number and regenerative potential with age reveals locomotory muscle bias. Skeletal Muscle 11:22. PMID 34481522. PMC8418011.

Trost JP, Chen M, Stark MM, Hodges JS, Richter S, Lindsay A, Warren GL, Lowe DA, Kimberley TJ (2021). Voluntary and magnetically evoked muscle contraction protocol in males with Duchenne muscular dystrophy: Safety, feasibility, reliability, and validity. Muscle Nerve 64:190-198. PMID 33974714.

Vang P, Baumann CW, Barok R, Larson AA, Dougherty BJ, Lowe DA (2021). Impact of estrogen deficiency on diaphragm and leg muscle contractile function in female mdx mice. PLoS ONE 16(3):e0249472. PMID 33788896. PMC8011782.

Lindsay A, Holm J, Razzoli M, Bartolomucci A, Ervasti JM, Lowe DA (2021). Some dystrophy phenotypes of dystrophin-deficient mdx mice are exacerbated by mild, repetitive daily stress. FASEB J 35(4):e21489. PMID 33734502.

Lindsay A, Kemp B, Larson AA, Baumann CW, McCourt PM, Holm J, Karachunski P, Lowe DA, Ervasti JM (2021). Tetrahydrobiopterin synthesis and metabolism is impaired in dystrophin-deficient mdx mice and humans. Acta Physiol (Oxf) 231(4):e13627. PMID 33580591.

Karvinen S, Juppi HK, Le G, Cabelka CA, Mader TL, Lowe DA, Laakkonen EK (2021). Estradiol deficiency and skeletal muscle apoptosis: Possible contribution of microRNAs. Exp Gero 147:111267. PMID 33548486.

Teaching Summary

Grant Writing: RSC 8206

Bio

Professional Associations

• American Physical Therapy Association 
  • Orthopaedics
  • Research Sections 
• American Society of Biomechanics
• International Society of Biomechanics International Shoulder Group

Research Summary

Dr. Ludewig's objective is to investigate biomechanical factors contributing to musculoskeletal dysfunction, in order to refine current clinical diagnosis and treatment approaches and develop novel scientifically founded rehabilitation interventions. The current research plan includes development and testing the effectiveness of biomechanically based rehabilitation strategies for improving shoulder function and reducing pain and disability in persons with pathologies related to abnormal movement patterns. Currently, in-vivo 3D motion and muscle activity data is collected from healthy and symptomatic subjects and integrated with state of the art shoulder models derived from imaging data. Dr. Ludewig's past and ongoing work is identifying mechanics of the full shoulder complex, identifying kinematic mechanisms of shoulder and foot dysfunction, quantifying effects of motion deviations on mechanical impingement risk to the rotator cuff tendons, and assessing the effectiveness of rehabilitation interventions including exercise programs. 

Research Funding Grants

Current Funded Research:

Improving Shoulder Health through an Ergonomic Wheelchair
Maslowski Charitable Trust

Publications

Selected Publications:

• Ludewig PM, Cook TM: Alterations in shoulder kinematics and associated muscle activity in people with symptoms of shoulder impingement. Phys Ther; 80(3):276-291; 2000.
• Ludewig PM, Cook TM: Translations of the humerus in persons with shoulder impingement symptoms. J Orthop Sports Phys Ther; 32:248-259; 2002.
• Ludewig PM, Borstad JD: Effects of a home exercise program on shoulder pain and functional status in construction workers. Occ Environ Med; 60:841-849; 2003.
• Ludewig PM, Hoff MS, Osowski EA, Meschke SA, Rundquist PJ: Relative balance of serratus anterior and upper trapezius muscle activity during push-up exercises. Am J Sports Med; 32:484-493; 2004.
• Ludewig PM, Behrens SA, Meyer SM, Spoden SM, Wilson LA: Three-dimensional clavicular motion during arm elevation: reliability and descriptive data. J Orthop Sports Phys Ther; 34:140-149; 2004.
• Rundquist PJ, Ludewig PM: Patterns of motion loss in subjects with idiopathic loss of shoulder range of motion. Clin Biomech; 19:810-818; 2004.
• Borstad JD, Ludewig PM: The effect of long versus short pectoralis minor resting length on scapular kinematics in healthy individuals. J Orthop Sports Phys Ther; 35:227-238; 2005.
• Borich MR, Bright JM, Lorello DJ, Cieminski CJ, Buisman T, Ludewig PM: Scapular angular positioning at end range internal rotation in cases of glehohumeral internal rotation deficit. J Orthop Sports Phys Ther; 36(12):926-934; 2006.
• Ogston JB, Ludewig PM. Differences in three-dimensional shoulder kinematics between persons with multidirectional instability and asymptomatic controls. Am J Sports Med; 35:1361-70; 2007.
• Meyer KE, Saether EE, Soiney EK, Shebeck MS, Paddock KL, Ludewig PM. Three-dimensional scapular kinematics during the throwing motion. J Applied Biomech24(1):24-34; 2008.
• Teece RM, Lunden JB, Lloyd AS, Kaiser AP, Cieminski CJ, Ludewig PM. Three-dimensional acromioclavicular joint motions during elevation of the arm. J Orthop Sports Phys Ther. 38(4):181-190; 2008.
• Ludewig PM, Phadke VP, Braman JP, Hassett DJ, Cieminski CJ, LaPrade RF. Motion of the shoulder complex motion during multiplanar humeral elevation. J Bone Joint Surg Am. 91:378-389; 2009.
• Borstad JD, Buetow B, Deppe E, Kyllonen J, Liekhus M, Cieminski CJ, Ludewig PM. A longitudinal analysis of the effects of a preventive exercise programme on the factors that predict shoulder pain in construction apprentices. Ergonomics. 52(2):232-244; 2009.
• Braman JP, Engel SC, LaPrade RF, Ludewig PM. In-vivo assessment of scapulohumeral rhythm during unconstrained overhead reaching in asymptomatic subjects. J Shoulder Elbow Surg. 18(6):960-967; 2009.
• Ludewig PM, Reynolds JF. The association of scapular kiematics and glenohumeral joint pathologies. J Orthop Sports Phys Ther; 39(2):90-104; 2009. 
• Phadke V, Camargo PR, Ludewig PM. Scapular and rotator cuff function during arm elevation: A review of normal function and alterations with shoulder impingement. Rev Bras Fisioter; São Carlos; 13(1):1-9; 2009.
• Lunden JB, Braman JP, LaPrade RF, Ludewig PM. Shoulder kinematics during the wall push-up plus exercise. J Shoulder Elbow Surg 19(2):216-223; 2010.
• Ludewig PM, Hassett DR, LaPrade RF, Camargo PR, Braman JP. Comparison of scapular local coordinate systems. Clin Biomech. 25(5):415-421; 2010.
• Braman JP, Thomas BM, LaPrade RF, Phadke V, Ludewig PM. Three-dimensional in vivo kinematics of an osteoarthritic shoulder before and after total shoulder arthroplasty. Knee Surg Sports Trauma Arthro. 18(12):1774-8; 2010.
• Ludewig PM, Braman JP. Shoulder impingement: Biomechanical considerations in rehabilitation. Manual Ther 16(1):33-9; 2011.
• Nawoczenski DA, Riek LM, Greco L, Staiti K, Luldewig PM. Effect of shoulder pain on shoulder kinematics during weight bearing tasks in persons with spinal cord injury. Arch Phys Med Rehabil. 93(8):1421-30; 2012.

Teaching Summary

• Clinical Biomechanics
• Advanced Biomechanics
• Research

Research Summary

Dr. McGee is a musculoskeletal rehabilitation translational scientist whose clinically-relevant research objective is to improve the health and participation of persons with upper limb musculoskeletal disorders. In addition, as an educator of entry-level and post-professional occupational therapy learners, Dr. McGee’s scholarship of teaching and learning objective is to test the impact of didactic training on learner self-efficacy. His active and past research fall in the following domains: 

• Characterizing and validating factors that predict responsiveness to a restorative intervention for persons with hand osteoarthritis 
• Developing and validating procedures for assessing hand strength, thumb mobility, and thumb CMC OA related disability 
• Studying rehabilitation intervention effectiveness for persons with forearm fragility fractures 
• Advancing measurement of the upper limb strength and force requirements during select daily activities 
• Studying entry-level student acute care ‘knowledge and skills’ self-efficacy 

List of Published Work in NCBI MyBibliography and ORCID.
 

More information on Dr. McGee's scholarship can be found at http://www.researchgate.net/profile/Corey_Mcgee.

Bio

Kimberley Monden, PhD, is an Assistant Professor in the Department of Rehabilitation Medicine at the University of Minnesota. Dr. Monden is a Licensed Psychologist with clinical experience in health and rehabilitation psychology. Her research focuses on psychosocial adaptation to injury. Dr. Monden studies resilience and appraisals of injustice, with a specific interest in improving quality of life and long- term psychosocial outcomes after spinal cord injury. Dr. Monden has research funding from the National Institute on Disability, Independent Living and Rehabilitation Research, the Department of Defense, and the Craig H. Neilsen Foundation. Dr. Monden earned her Doctoral degree in Counseling Psychology at the University of Kansas in 2009. She completed her pre-doctoral internship in Clinical Psychology at the University of Kansas Medical Center in Kansas City, KS, and Post-Doctoral Fellowship in Health Psychology and Integrated Primary Care at the University of Wisconsin Hospital and Clinics and Access Community Health Centers in Madison, Wisconsin.

Awards & Recognition

• Rosenthal Early Career Research Award, APA Division 22 (Rehabilitation Psychology), 2019
• Harold Yuker Award for Research Excellence, APA Division 22 (Rehabilitation Psychology), 2018
• American Psychological Association, Psi Chi National Convention Research Award, 2003

 

Professional Associations

• Academy of Spinal Cord Injury Professionals (ASCIP)
• American Congress of Rehabilitation Medicine (ACRM)
• American Psychological Association (APA)
• American Spinal Injury Association (ASIA)
• APA, Division 22 (Rehabilitation Psychology)
• APA, Division 38 (Health Psychology)
• International Spinal Cord Society (ISCoS)
• National Register of Health Service Providers 

Research Summary

Dr. Monden's research focuses on psychosocial adaptation to injury. She studies resilience and appraisals of injustice, with a specific interest in improving quality of life and long-term psychosocial outcomes after spinal cord injury.

Research Funding Grants

1. Minnesota Regional Spinal Cord Injury Model System, Principal Investigator: Leslie Morse. Kimberley Monden and Ann Van de Winckel, co-investigators. Sponsor: U.S. Department of Health & Human Services ACL. Timing: September 1, 2021 - August 31, 2026
2. The Impact of Injustice Appraisals on Pyschosocial Outcomes Following Spinal Cord Injury: A Longitudinal Study. Role: PI. Sponsor: U.S. Department of Defense. Timing: July 1, 2021 - June 30, 2024
3. Assistive Technology & Functional Outcomes Following Spinal Cord Injury. Role: PI. Sponsor: U.S. Department of Defense. Timing: June 10, 2021 - September 29, 2022
4. Reinventing Yourself after SCI: A Multi-site Randomized Controlled Trial of an Intervention to Improve Outcomes After Spinal Cord Injury. Role: PI.
   Sponsor: Craig Hospital, Englewood, CO. Timing: March 1, 2020 - September 20, 2022
5. Adaptation and Dissemination of the Spinal Cord Injury Physical Activity Guidelines. Role: PI. Sponsor: Paralyzed Veterans of America. Timing: June 1, 2021 - May 31, 2022
6. RACR: Promoting Resilience, Adjustment, and Community Reintegration After SCI. Role: PI. Sponsor: Craig Hospital, Englewood, CO. Timing: May 31, 2020 - May 30, 2022
7. Validation of the Use of the Injustice Experience Questionnaire in the Spinal Cord Injury Population. Role: PI. Sponsor: Craig Hospital, Englewood, CO. Timing: March 1, 2020 - December 31, 2021

Publications

I. Peer-Reviewed Publications (* indicates student author)

1. Starosta, A., Sayko Adams, R., Marwitz, J., Monden, K. R., Dams-O'Connor, K., & Hoffman, J. (2021). Scoping review of opioid use after traumatic brain injury. Journal of Head Trauma Rehabilitation, 36(5), 310-327. PMID: 34489382 PMCID: PMC8428300 doi: 10.1097/HTR.0000000000000721
2. Novack, T., Zhang, Y., Kennedy, R., Watanabe, T. K., Monden, K. R., Dreer, L. E., Bombardier, C., Brunner, R., Goldin, Y., Marwitz, J., & Niemeier, J. (2021). Return to driving following moderate-to-severe traumatic brain injury: A Traumatic Brain Injury Model System study. Archives of Physical Medicine and Rehabilitation, 102(8), 1568-1575. PMID: 33705772 doi: 10.1016/j.apmr.2021.02.006 
3. Mahoney, E. J., Silva, M. A., Reljic, T., Dams-O'Connor, K., Hammond, F. M., Monden, K. R., Chung, J. S., Dillahunt-Aspillaga, C., & Nakase-Richardson, R. (2021). Rehabilitation needs at five-years post-TBI: a VA TBI Model Systems study. Journal of Head Trauma Rehabilitation, 36(3), 175-185. PMID: 33201036 doi: 10.1097/HTR.0000000000000629
4. Monden, K. R., Philippus, A., MacIntyre, B., Welch, A., Sevigny, M., Draganich, C., Agtarap, S., & Morse, L. R. (2021). The impact of stigma on psychosocial outcomes following spinal cord injury: a cross-sectional analysis for stigma-mediated relationships. Rehabilitation Psychology, 66(2), 202-212. PMID: 33382334 doi: DOI: 10.1037/rep0000371
5. Silva, M. A., VandenBussche Jantz, A. B., Klocksieben, F., Monden, K. R., Rabinowitz, A. R., Cotner, B. A., Dillahunt-Aspillaga, C., & Nakase-Richardson, R. (2021). Unmet rehabilitation needs indirectly influence life satisfaction 5 years after traumatic brain injury: A Veterans Affairs TBI Model Systems study. Archives of Physical Medicine & Rehabilitation, 102(1), 58-67. PMID: 32949552 doi: 10.1016/j.apmr.2020.08.012
6. Draganich, C., Berliner, J., Sevigny, M., W, N., Philippus, A., Payne, L., Gerber, D., & Monden, K. R. (in press, accepted August 2021). The impact of a structured rehabilitation program for uninsured individuals. Rehabilitation Psychology.
7. Monden, K. R., Andrews, E., Pilarski, C., Hearn, J., & Morse, L. R. (in press, accepted June 2021). COVID-19 and the spinal cord injury community: concerns about medication rationing and social isolation. Rehabilitation Psychology.
8. Nakase-Richardson, R., Schwartz, D., Ketchum, J., Drasher-Phillips, L., Dahdah, M., Monden, K.R., Bell, K., Hoffman, J., Whyte, J., Bogner, J., Calero, K., Magalang, U. Comparison of diagnostic sleep studies in hospitalized neurorehabilitation patients with moderate to severe traumatic brain injury. doi:10.1016/j.chest.2020.03.083. Chest. Epub 2020 May 6. PMID: 32387522
9. Zeitzer, J.M., Hon, F., Whyte, J., Monden, K.R., Bogner, J., Dahdah, M., Wittine, L., Bell, K.R., Nakase-Richardson, R. Coherence between sleep detection by actigraphy and polysomnography in a multi-center, in-patient cohort of individuals with traumatic brain injury. Arch Phys Med Rehabil. doi:10.1002/pmrj.12353. Epub 2020 Mar 3. PMID: 32125095 
10. Makley, M., Gerber, D., Newman, J., *Philippus, A., Monden, K.R., Biggs, J., Spier, E., Tarwater, P., Weintraub, A. Optimized Sleep after Brain Injury (OSABI): a pilot study of a sleep hygiene intervention for individuals with moderate to severe brain injury. Neurorehabilitation and Neural Repair. Neurorehabil Neural Repair. 2020 Feb;34(2):111-121. doi: 10.1177/1545968319895478. Epub 2019 Dec 30. PMID: 31884895
11. Monden, K.R., *Philippus, A., Draganich, C., MacIntyre, B., Charlifue, S. A qualitative exploration of perceived injustice among individuals living with spinal cord injury. Rehabil Psychol. 2020 Feb;65(1):54-62. doi:10.1037/rep0000301. Epub 2019 Dec 12. PMID: 31829642
12. Nakase-Richardson, R., Schwartz, D.J., Drasher-Phillips, L., Ketchum, J.M., Calero, K., Dahdah, M.N., Monden, K.R., Bell, K., Magalang, U., Hoffman, J., Whyte, J., Bogner, J., Zeitzer, J. Comparative effectiveness of sleep apnea screening instruments during inpatient rehabilitation following moderate to severe TBI. Arch Phys Med Rehabil. 2020 Feb;101(2):283-296. doi:10.1016/j.apmr.2019.09.019. Epub 2019 Nov 6. PMID: 31705855
13. Monden, K.R., Sevigny, M., Ketchum, J.K., Charlifue, S., Severe, E., Tefertiller, C., Berliner, J., Coker, J., Taylor, H.B., Kolakowsky-Hayner, S.A., Morse, L.R. Associations between insurance provider and assistive technology use for computer and electronic devices one year after tetraplegia: findings from the Spinal Cord Injury Model Systems National Database. Arch Phys Med Rehabil. 2019 Dec;100(12):2260-2266. doi:10.1016/j.apmr.2019.06.013. Epub 2019 Jul 24. PMID: 31351077
14. Monden, K.R., *Philippus, A., Boals, A., *Draganich, C., Morse, L.R., Ketchum, J.M., Trost, Z. Unique predictors of perceived injustice and depression after spinal cord injury: evidence for distinct psychological constructs. Spinal Cord. 2019 Dec;57(12):1031-1039. doi: 10.1038/s41393-019-0318-9. Epub 2019 Jun 24. PMID: 31235873
15. *Draganich, C., Gerber, D., Monden, K.R., Newman, J., Weintraub, A., Biggs Arnold, J., *Philippus, A., Makley, M. Disrupted sleep and agitation following traumatic brain injury. Brain Inj. 2019 Jun 24. doi: 10.1080/02633052.2019.1631484. [Epub ahead of print]. PMID: 31215813
16. Makley, M.J., Monden, K.R., *Philippus, A., Tarwater, P., Newman, J., Biggs, J., Spier, E., Weintraub, A. Objective measures of sleep and wakefulness in patients with moderate to severe brain injury on an inpatient rehabilitation unit. Pearls and pitfalls of actigraph monitoring. Neurorehabilitation. 2018;43(3):277-285. doi:10.3233/NRE-182537. PMID: 30373965
17. *Bayer, J., Moulton, C., Monden, K.R., Goldstein, R.M., McKenna, G.J., Testa, G., Ruiz, R.M., Anthony, T.L., Onaca, N., Klintmalm, G.B., Kim, P.T.W. (2018). The role of multiorgan procurement for abdominal transplant in general surgery resident education. Am J Surg. 2018 Aug;216(2):331-336. doi: 10.1016/j.amjsurg.2017.08.015. Epub 2017 Aug 25. PMID: 28859922
18. *Linsk, A.M., Monden, K.R., Sankaranarayanan, G., Ahn, W., Jones, D.B., De, S., Schwaitzberg, S.D., Cao, C.G.L. Validation of the VBLaST pattern cutting task: A learning curve study. Surg Endosc. 2018 Apr;32(4):1990-2002. doi: 10.1007/s00464-017-5895-0. Epub 2017 Oct 19. PMID: 29052071; PMCID: PMC5845471
19. Boals, A., Trost, Z., Bernsten, D., *Nowlin, L., *Wheelis, T., Monden, K.R. Event centrality as a unique predictor of posttraumatic stress symptoms and perceived disability among individuals following spinal cord injury. Spinal Cord. 2017 Nov;55(11):1023-1027. doi: 10.1038/sc.2017.57. Epub 2017 May 30. PMID: 28555662
20. Trost, Z., Scott, W., Buelow, M., *Nowlin, L., Turan, B., Boals, A., Monden, K.R. The association between injustice perception and psychological outcomes in an inpatient spinal cord injury sample: the mediating effects of anger. Spinal Cord. 2017 Oct;55(10):898-905. doi. 10.1038/sc.2017.39. Epub 2017 May 30. PMID: 28555664
21. Hamilton, R., Driver, S.J., Noorani, S., Callender, L., Bennet, M., Monden, K.R. Utilization and access to healthcare services among community dwelling people living with spinal cord injury. J Spinal Cord Med. 2017 May;40(3):321-29. doi: 10.1080/10790268.2016.1184828. Epub 2016 May 25. PMID: 27221396; PMCID: PMC5472020
22. Salisbury, D.B., Parsons, T.D., Monden, K.R., Trost, Z., Driver, S.J. Brain-computer interface for individuals after spinal cord injury. Rehabil Pscyhol. 2016 Nov;61(4):435-41. doi: 10.1037/reo0000099. Epub 2016 Sep 29. PMID: 27684465
23. Driver, S.J., Warren, A.M., *Agtarap, S., *Reynolds, M., Hamilton, R., Trost, Z., Monden, K.R. Identifying predictors of resilience at inpatient and 3-months post spinal cord injury. J Spinal Cord Med. 2016;39(1):77-84. doi:10.1179/2045772314Y.0000000270. Epub 2014 Oct 9. PMID: 25297474; PubMed Central PMCID:PMC4725795
24. Trost, Z., Monden, K.R., Buelow, M., Boals, A., Scott, W. Perceived injustice predicts intention to litigate: findings from a spinal cord injury sample. Psychological Injury & Law. 2016 March;9(1):31-40. doi: 10.1007/s12207-015-9245-z
25. Monden, K.R., Trost, Z., Scott, W., Bogart, K.R., Driver, S.J. The unfairness of it all: exploring the role of injustice appraisals in rehabilitation outcomes. Rehabil Psychol. 2016 Feb;61(1):44-53. doi: 10.1037/rep0000075. Review. PMID: 26881306
26. Monden, K.R., Gentry, L., Cox, T.R. (2016). Delivering bad news to patients. Proc (Bayl Univ Med Cent). 2016 Jan;29(1):101-2. doi: 10.1080/08998280.2016.11929380. PMID: 25297474; PMCID: PMC4677873
27. Fromm, N., Salisbury, D.B., Driver, S.J., Dahdah, M., Monden, K.R. Functional recovery from neuroinvasive west nile virus: a tale of two courses. Rehabil Psychol. 2015 Nov;60(4):383-90. doi: 10.1037/rep0000058. Epub 2015 Oct 5. PMID: 26436993
28. Monden, K.R., Trost, Z., Catalano, D., *Garner, A., *Symcox, J., Driver, S., Hamilton, R.G., Warren, A.M. Resilience following spinal cord injury: a phenomenological view. Spinal Cord. 2014 Mar;52(3):197-201. doi: 10.1038/sc.2013.159. Epub 2014 Jan 14. PMID: 24418959
29. Serrano, N., Molander, R., Monden, K.R., Grosshans, A., Krahn, D. Exemplars in the use of technology for management of depression in primary care. WMJ. 2012 Jun;111(3):112-8. PMID: 22870556
30. Serrano, N., Monden, K.R. The effect of behavioral health consultation on the care of depression by primary care clinicians. WMJ. 2011 Jun;110(3):113-8. PMID: 21748995
31. Mollenkopf, D., Elliott, M., Monden, K.R. Effects of a professional development model on preschool teachers' literacy practices in Early Reading First classrooms. Journal of Research Methodology. 2008;32:273-294.

II. Non-Peer Reviewed Publications

1. Trost, Z., Sturgeon, J.A., Azuero, C., Monden, K.R. Injustice and disability. In D.S. Dunn (Ed.), Disability: Social Psychological Perspectives. 2019. New York, NY: Oxford University Press.
2. Monden, K.R., Gerber, D., Newman, J., Philippus, A., Biggs J., Schneider, H., Spier, E., Weintraub, A., Makley, M. Sleep hygiene: A novel, nonpharmacological approach to treating sleep-wake cycle disturbance after Page 10 of 19 moderate to severe brain injury on an inpatient rehabilitation unit. Brain Injury Professional. 2017;14(4):20-21.
3. Monden, K.R. How to deliver bad news with empathy [Web log post]. 2016 Mar 28. Available from http://scrubbing.in/how-to-deliver-bad-news-with-e...
4. Key-Roberts, M.J., Monden, K.R. Teaching positive psychology from a graduate students’ perspective. 2007 Fall. Naming and Nurturing.

III. Chapters in Books

1. Monden, K.R. Saving. In S.J. Lopez (Ed.), Encyclopedia of Positive Psychology, Volume 2. 2009. Malden, MA: Wiley-Blackwell.

Teaching Summary

Courses

Graduate Course: The Human Experience: A Dialogue between Philosophy and Positive Psychology

Undergraduate Course: Introduction to Positive Psychology

Graduate Course: Understanding Research in Education

Graduate Course: Lab: Introduction to Statistical Analysis (SPSS)

Graduate Course: Counseling Skills for Teachers

Bio

Dr. Leslie Morse obtained her Doctor of Osteopathic Medicine degree from the University of New England College of Osteopathic Medicine followed by her residency in Physical Medicine and Rehabilitation at Boston Medical Center. She is board certified by the American Board of Physical Medicine and Rehabilitation. Dr. Morse continues to work on local and national level to promote the field of rehabilitation medicine. 

Expertise

Therapeutic outcome analysis, stem cell therapy for spinal cord injury, osteoclast biology, gait training and analysis

 

Awards & Recognition

• 2020 American Paraplegia Society Excellence Award, Academy of Spinal Cord Injury Professionals (ASCIP)
• 2021 Rebecca “Becky” J. Adcock, PhD Award for Excellence in Mentoring, Academy of Spinal Cord Injury Professionals (ASCIP)

 

Professional Associations

• Member, Research Committee Member, Association of Academic Physiatrists
• International Society for Clinical Densitometry

Research Summary

Research Summary/Interests

Dr. Morse's research interests include the impact of mechanical unloading on bone metabolism and the development of novel stem cell therapies for motor recovery after SCI. 

Research Funding Grants

• Department of Defense
  SCI170159
  Role: Co-investigator
  2018 - 2022
  Assistive Technology and Functional Outcomes following Spinal Cord Injury (Monden PI) 
  The aims of this study are to: (1) examine perceived barriers to or facilitators of assistive technology (AT) access and utilization and the impact on functional and psychosocial outcomes after tetraplegia, (2) assess for variations in use of AT across insurance providers and socioeconomic status in Veterans and civilians with tetraplegia, (3) assess the relationship between AT use and productivity (employment/school), and (4) assess the relationship between AT and psychosocial outcomes.
• NIDILRR, Department of Health and Human Services
  90SI5015-01-00
  Role: Co-Project Director
  2016 - 2022
  Rocky Mountain Regional Spinal Injury System 
  The goals of this project are to (1) harness our existing multidisciplinary system of rehabilitation care designed specifically to meet the needs of individuals with SCI to extend the Model Systems knowledge base, (2) contribute to improving long term SCI outcomes through participation in site-specific and collaborative clinical trials and research projects, (3) contribute to the SCI model systems national database through longitudinal assessment of long term SCI outcomes, (4) Contribute to improved long term SCI outcomes by conducting a research project designed to reduce sublesional neuropathic pain following SCI.
• NIDILRR, Department of Health and Human Services
  H133A150065 (Nash PI)
  Role: Co-investigator
  2016 - 2021
  Lifestyle intervention targeting enhanced health and function for persons with chronic SCI in caregiver/care-receiver relationships: effects of caregiver co-treatment
  The goals of this project are to: 1) determine the efficacy of a lifestyle intervention to improve health and function of individuals with SCI.
• Department of Defense
  W81XWH-14-SCIRP-CTA
  Role: PI
  2015 - 2022
  Effects of Ekso-assisted gait training on Bone Health and Quality of Life: A Randomized Clinical Trial
  The goals of this project are to 1) determine whether exoskeleton-assisted gait training increases bone strength in the paralyzed lower extremity and 2) determine whether exoskeleton-assisted gait training improves quality of life after SCI. Secondarily, to determine whether gait training improves the following related outcomes and mediators of quality of life: mood, pain, and cortical activity of related emotional networks in the brain.
• NIH/NIAMS
  R01 AR064793-01A1 (Battaglino PI)
  Role: Co-investigator
  2015 - 2022
  Regulation of gastric and osteoclast acidification by Snx10
  The specific aims to be addressed in this project are: 1) Determine the cellular mechanisms by which Snx10 regulates osteoclast function. 2) Determine the role of osteoclastic expression of Snx10 on bone homeostasis in vivo. 3) Determine the whole of gastric expression of Snx10 on bone homeostasis in vivo.

Clinical Summary

Board Certifications

Physical Medicine and Rehabilitation (ABPMR)

Bio

Education

Post-Doctoral Training
NeuroMuscular Research Center
Boston University

Ph.D. Medical Sciences
Karolinska Institutet, Stockholm, Sweden

National Team Coach Program (Volleyball) & PE Teacher
GIH - The Swedish School of Sport and Health Sciences Engineering

Coursework in Engineering - Technical Physics and Electrotechnology
Linköping University

Biography

Lars Oddsson is an experienced biomedical scientist, an inventor, a visionary leader and an entrepreneur. He is Chief Technology Officer and Co-Founder of RxFunction, a start-up based on Oddsson’s IP commercializing walkasins®, a wearable sensory prosthetic for balance. RxFunction was semifinalist twice and finalist in the 2013 MN-Cup. Dr. Oddsson teaches in the M.S. in Medical Device Innovation program at the Technological Leadership Institute at the University of Minnesota, where he also holds a position as adjunct professor in the Department of Physical Medicine and Rehabilitation. He is a visiting professor at the Recanati School of Health Professions at Ben-Gurion University in Israel. Previously, Dr. Oddsson initiated and led the Injury Analysis and Prevention Lab at Boston University’s Neuromuscular Research Center, where he was a faculty research professor. In Boston, he held temporary adjunct appointments at Harvard Medical School and at MIT. Previously, Oddsson was the founding director of research at the Courage Kenny Research Center at Allina Health. He is co-investigator and consultant to NASA’s Johnson Space Center on projects related to the development of sensorimotor countermeasures to long-term spaceflight.

Dr. Oddsson has a broad background in physiology, engineering, rehabilitation sciences and technology development. He has served as a principal investigator and authored numerous papers on various biomedical, neuromotor control and rehabilitation studies. His board services include LifeScience Alley (now Medical Alley), Alley Institute, Swedish-American Chamber of Commerce and the University of MN Senate Governance Disabilities Issues Committee. He received engineering training at Linköping University, his doctorate in Medical Sciences at the Karolinska Institute, both in Sweden, post-doctoral training in biomedical engineering at Boston University and a mini-MBA in medtech management at the University of St. Thomas.

Alternate Job Roles

• President & Co-Founder - Rx Function Inc.

• Adjunct Professor - Department of Physical Medicine and Rehabilitation, Program in Rehabilitation Science

• Medical School - University of Minnesota

• Visiting Professor- Recanati School for Community Health Professions, Ben-Gurion University of the Negev, Israel

Programs
M.S. in Medical Device Innovation

Expertise

• Innovation incubation
• Grant writing/development
• Neuromotor control
• Rehabilitation science
• Exercise physiology
• Biomechanics
• Wearable technology development
• Medical devices

Consulting
NASA - Johnson Space Center, National Space Biomedical Research Institute (NSBRI), Massachusetts Eye & Ear Infirmary

Research Summary

Honors and Awards

Coach of the year award - Swedish Volleyball Association

Honorary Award - International Track and Field Coaches Association, Olympics in Atlanta

“Preis der Dr. Heinz und Helene Adam-Stiftung” as Co-Author of paper “Sensory-motor control of the lower back: Implications for rehabilitation”

Award by The Vestibular Disorders Association “for outstanding contributions toward improving the lives of people with Vestibular Disorders

Senior Member of IEEE

Teaching Summary

Currently Teaching Courses

Clinical Foundations of Medical Device Innovation (MDI 5004)

Research Summary

I am a nurse scientist with the Minneapolis Adaptive Design & Engineering (MADE) Program at the Minneapolis VA. My research focus is prevention of pressure injury, primarily focused on Veterans with spinal cord injury (SCI). I also support work with Veterans who have lower limb amputations. I work collaboratively with the multidisciplinary MADE team to conduct research to include leading the qualitative inquiry process during the iterative design and development of the research projects. My collaborations include working with scientists and clinicians from University of Minnesota, Mayo clinic, University of Washington, and numerous VA Health Care facilities across the nation. I have a deep commitment to assist those with barriers to participation in the activities they desire to partake!

Bio

The Pacak laboratory investigates mechanisms that lead to mitochondrial dysfunction in a variety of disease settings using differentiated patient-derived induced pluripotent stem cells (iPSCs), mouse models, and adeno-associated virus (AAV) mediated gene delivery systems.

Research Summary

The Pacak laboratory is focused on identifying common mechanisms of disease related to mitochondrial function that can be augmented through gene therapies. The lab uses differentiated iPSCs and a variety of in vivo models to pursue these investigations.

Research Summary

Research Summary/Interests

Dr. Snow’s research focuses on the biology of muscle and nerve in the limb weakness of stroke, as well as on clinically applicable aspects of biological aging.

Publications

Selected Publications:

• Snow LM (2020). Normal aging: Cell death/apoptosis. PM&amp;R Knowledge NOW-Online resource database for PM&amp;R physicians. https://now.aapmr.org/cell-death-apoptosis/
• Snow LM (2020). Age-associated changes and biology of aging. PM&R Knowledge NOW- Online resource database for PM&R physicians. https://now.aapmr.org/age-associated-changes-and-biology-of-aging/
• Snow LM (2020). Neurological consequences of aging. PM&amp;R Knowledge NOW-Online resource database for PM&R physicians. https://now.aapmr.org/neurological-consequences-of...aging/
• Snow L, Low W., Thompson L (2019). Distinct patterns of fiber type adaptation in rat hindlimb muscles 4 weeks after hemorrhagic stroke. Am J Phys Med Rehabil 98:266–274.
• Snow LM, Low WC, Thompson LV (2012). Skeletal muscle plasticity after hemorrhagic stroke in rats: Influence of spontaneous physical activity. Am J Phys Med Rehabil 91(11): 965-976
• Sanchez OA, Walseth TF, Snow LM, Serfass RC, Thompson LV. (2009) Skeletal muscle sorbitol levels in diabetic rats with and without insulin therapy and endurance exercise training. Exp Diabetes Res EPub 2009 Nov 23. PMID: 20016800.
• Snow LM, Thompson LV. (2009) Influence on insulin and muscle fiber type in n-epsilon-(carboxymethyl)-lysine accumulation in soleus muscle of rats with streptozotocin-inducin diabetes mellitus. Pathobiology 76(5): 227-234. PMID: 19816082.
• Snow LM, Fugere NA, Thompson LV. (2007) Advanced glycation end-product accumulation and associated protein modification in type II skeletal muscle with aging. J Gerontol, Part A, Biol Sci Med, 62(11): 1204-10. PMID: 18000139.
• Snow LM, Lynner CB, Nielsen EM, Neu HS, Thompson LV. (2006) Advanced glycation end product in diabetic rat skeletal muscle in vivo. Pathobiology 73: 244-251. PMID 17314495.
• Snow LM, Sanchez OA, McLoon LM, Serfass RC, Thompson LV. (2005) Effect of endurance exercise on myosin heavy chain isoform expression in diabetic rats with peripheral neuropathy. Am J Phys Med Rehabil 84(10): 770-779.
• Snow LM, Sanchez OA, McLoon LK, Serfass RC, Thompson LV. (2005) Myosin heavy chain isoform immunolabelling in diabetic rats with peripheral neuropathy. Acta Histochemica 107(3):221-229.
• Snow LM, McLoon, LK, Thompson LV. (2005) Adult and developmental myosin heavy chain isoforms in soleus of aging Fischer Brown Norway Rat. Anat Rec A Discov Mol Cell Evol Biol 286(1): 866-73.
• Sanchez OA, Snow LM, Lowe DA, Serfass RC, Thompson LV. (2005) Effects of endurance exercise- training on single fiber contractile properties of insulin-treated streptozotocin-induced diabetic rats. J Appl Physiol, 99: 472-478.
• Thompson LV, Snow LM. (2006). Muscle structure and function. Orthopaedic Physical Therapy Secrets, Placzek JD and Boyce DA, eds., Hanley and Belfus, Philadelphia PA.
• Lowe, DA, Warren, GL, Snow, LM, Thompson, LV, Thomas, DD. (2004) Muscle activity and aging affect myosin structural distribution and force generation in rat fibers. J Appl Physiol 96: 498-506.
• Snow, L. (2001) Aging with a disability: Is it safe to exercise? Orthopedic Physical Therapy Clinics of North America 10(2): 251-263.
• Snow, L. (2001) Exercise in the treatment of eating disorders. In: JE Mitchell (Ed.), The outpatient treatment of eating disorders. Minneapolis: University of Minnesota Press.
• Wieting, JM, Snow, LA, Garon, BC, Hannibal, RR. (1999) Cricopharyngeal achalasia associated with dermatomyositis: A conservative nonsurgical approach to treatment. J Rheum Med Rehab 10(1): 40-44.
• Kirner, KE, Luedtke, D., Snow, L. (1992) The Shoulder; Prevention: There’s No Better Treatment.Swimming Technique May-July, 41-45.

Teaching Summary

Teaching Areas

• Dr. Snow teaches Physiology
• Pathophysiology
• Neuroscience and Research within the Physical Therapy curriculum.

She also has educational focus in the biology of aging.

Bio

Professional Associations

• American College of Sports Medicine
• American Physical Therapy Association
  • Education Section Member
  • Orthopaedic Section Member
  • Sports Physical Therapy Section Member
• International Society of Biomechanics

Research Summary

Research Summary/Interests

Development of movement based diagnostic classifications and criteria that reliably and validly identify shoulder movement dysfunction. Biomechanical investigations of new and existing movement examination techniques and technology to assist clinicians in improving diagnosis and treatment of shoulder injuries.

Research Funding Grants

Grants/Awards: 

2017

• Keynote Speaker, University of Minnesota, Division of Physical Therapy, Doctoral of Physical Therapy Class of 2017 Commencement Ceremony

2016

• New Investigator Award, Orthopaedic Section, American Physical Therapy Association. $15,000. PI: “Clinical Diagnosis and Functional Implications of Shoulder Multidirectional Instability”

2015

• University of Minnesota Research Evaluation and NIH Commercialization HUB (MN-Reach Grant) $150,000. Co-PI: “3D Shoulder Motion Measurement Device: The MnMotion System™” Ludewig PM, Staker JL
• University of Minnesota MSA/COGS Graduate Student Teaching Award

2014-2015

• MnDrive Graduate Scholar Assistantship
  MnDrive Robotics, Sensors, and Advanced Manufacturing Initiative College of Science and Engineering/State of Minnesota

2014

• University of Minnesota Graduate and Professional Student Assembly Scholarly Travel Grant

2013-2014

• Florence P Kendall Post-Professional Doctoral Scholarship
  Foundation for Physical Therapy

Patents

• The MnMotion System: 3D Smartphone Measurement Device

Publications

Refereed:

• Ludewig PM, Kamonseki DH, Staker JL, Lawrence RL, Camargo PR, Braman JP. Changing Our Diagnostic Paradigm: Movement System Diagnostic Classification. International journal of sports physical therapy. 2017;12(6):884.
• Staker JL, Lelwica AE, Ludewig PM, Braman JP. “Three-dimensional kinematics of shoulder laxity examination and the relationship to clinical interpretation.” International Biomechanics. 2017 December 15; 4(2):77-85. doi: 10.1080/09593985.2017.1370753.
• Lawrence RL, Schlangen DM, Schneider KA, Schoenecker J, Senger AL, Starr WC, Staker JL, Ellermann JM, Braman JP, Ludewig PM. “Effect of glenohumeral elevation on subacromial supraspinatus compression risk during simulated reaching.” J. Orthop. Res. 2017 Oct;35(10):2329-2337. doi: 10.1002/jor.23515.
• Lawrence RL, Braman JP, Staker JL, LaPrade RF, Ludewig PM “Comparison of 3-dimensional shoulder complex kinematics in individuals with and without shoulder pain – Part II: Glenohumeral joint.” J Orthop Sports Phys Ther. 2014; 44(9):646-655.

Non-Refereed:

• Editorial Response: Ludewig PM, Braman JP, Lawrence RL, Staker JL. “Expanding the discussion on movement versus pathoanatomic diagnosis.” J Orthop Sports Phys Ther 2013;43(9):675.

Teaching Summary

Teaching Areas

• Biomechanics
• Musculoskeletal Rehabilitation
• Examination
• Advanced Kinematics

 

Clinical Summary

Board Certifications

• Board Certified Sports Clinical Specialist, American Physical Therapy Association, 2008-2028
• Board Certified Orthopaedic Clinical Specialist, American Physical Therapy Association, 2011-2021
• Emergency Medical Responder, American Red Cross, 2014-2020
• APTA-Credentialed Clinical Instructor, 2008

Research Summary

Research Summary/Interests

Dr. Ann Van de Winckel, PhD, MSPT, PT is Assistant Professor at the Medical School of the University of Minnesota in the Department of Rehabilitation Medicine (Division of Physical Therapy, and Division of Rehabilitation Science). She is also the Director of the Brain Body Mind Lab. 

The main research focus of her lab is to investigate the brain mechanisms of body awareness in physical therapy (cognitive multisensory rehabilitation or CMR) as well as mind and body approaches (such as Qigong) to improve health and daily life function in people with chronic neurological conditions and/or chronic pain. Her lab made a crucial discovery that focus on body awareness using CMR led to restoration of the disrupted parietal operculum network in adults with chronic stroke, in parallel with long-lasting improved upper limb sensorimotor function. Her studies of CMR on reducing neuropathic pain and improving sensorimotor function in other neurological conditions such as adults with spinal cord injury have led to long-lasting significant neuropathic pain reduction and improved sensation and movement. Those sensorimotor improvements were paired with significant improvements in brain function. Since mind and body approaches have been shown to improve body awareness and reduce pain, she also investigated the effect of Qigong on body awareness-related brain functions in adults with chronic low back pain and adults with neurological conditions such as adults with spinal cord injury with and without neuropathic pain with significant lasting reduction in chronic pain. Her long-term goals are to investigate the interactions between body awareness, physical impairments, and psychological factors such as mindset (brain-body-mind interactions) to facilitate development and implementation of new rehabilitation strategies that attend to these factors to provide pain relief and increased health and functional recovery in adults with chronic neurological conditions and/or chronic pain.

Research Funding Grants

Remotely delivered Cognitive Multisensory Rehabilitation for Sensory and Motor Recovery after Spinal Cord Injury

• Funding: Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program 2022
• Timeline: 10/1/2022-9/31/2024
• Role: Principal Investigator

A Clinical Trial of Cognitive Multisensory Rehabilitation for Sensory and Motor Recovery in Adults with Spinal Cord Injury

• Funding: Paralyzed Veterans of America
• Timeline: 1/1/2022-12/31/2023
• Role: Principal Investigator

Minnesota Regional Spinal Cord Injury Model System

• Funding: NIDILRR Department of Health and Human Services
• Timeline: 9/1/2021-8/31/2025
• Role: Co-Investigator

Identifying brain mechanisms of cognitive multisensory rehabilitation for neuropathic pain relief in adults with spinal cord injury

• Funding: Academic Investment Research Program (AIRP)
• Timeline: 9/1/2020-8/31/2022
• Role: Co-Investigator

Knowledge Translation to Promote Patient-Centered Care through Use of Standardized Assessments

• Funding: National Institute on Disability, Independent Living, and Rehabilitation Research
• Timeline: 10/1/2020-9/30/2025
• Role: Advisory Committee

A Randomized Pilot Study Assessing Vagus Nerve Stimulation (VNS) During Rehabilitation for Improved Upper Limb Motor Function after Stroke (MicroTransponder's Vivistim System)

• Funding: Microtransponder Inc. (Study MT-St-02 Stroke)
• Timeline: 12/1/2014-3/31/2022
• Role: Principal Investigator (8/18/2017-3/31/2022); Co-PI (7/7/2017-8/17/2017)

Feasibility of identifying brain mechanisms of Qigong and behavioral outcomes after Qigong practice in people with chronic low back pain

• Funding: 2019 Clinical Translational Research Services (CTRS) Pilot Funding Program
• Timeline: 9/1/19 - 2/28/2022
• Role: Principal Investigator

View More

Publications

2023

• Van de Winckel A, Carpentier ST, Deng W, Zhang L, Philippus A, Monden KR, Battaglino R, Morse LR. Using remotely delivered Spring Forest Qigong™ to reduce neuropathic pain in adults with spinal cord injury: A non-randomized controlled trial. medRxiv [Preprint]. 2023 Feb 15:2023.02.11.23285793. doi: 10.1101/2023.02.11.23285793. PMID: 36824929; PMCID: PMC9949188 
• Van de Winckel A, Zhang L, Hendrickson T, Lim KO, Mueller BA, Philippus A, Monden KR, Oh J, Huang Q, Ruen J, Konczak J, Evans R, Bronfort G. Identifying body awareness-related brain network changes after Spring Forest Qigong™ practice or P.Volve low-intensity exercise in adults with chronic low back pain: a feasibility Phase I Randomized Clinical Trial. medRxiv [Preprint]. 2023 Feb 14:2023.02.11.23285808. doi: 10.1101/2023.02.11.23285808. PMID: 36824785; PMCID: PMC9949220.
• Van de Winckel A, Carpentier ST, Deng W, Bottale S, Zhang L, Hendrickson T, Linnman C, Lim KO, Mueller BA, Philippus A, Monden KR, Wudlick R, Battaglino R, Morse LR. Identifying Body Awareness-Related Brain Network Changes after Cognitive Multisensory Rehabilitation for Neuropathic Pain Relief in Adults with Spinal Cord Injury: Delayed Treatment arm Phase I Randomized Controlled Trial. medRxiv [Preprint]. 2023 Feb 10:2023.02.09.23285713. doi: 10.1101/2023.02.09.23285713. PMID: 36798345; PMCID: PMC9934787.
• Deng W, Carpentier S, Blackwood J, Van de Winckel A. Rasch validation of the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) in community-dwelling adults. BMC Psychol. 2023 Feb 17;11(1):48. doi: 10.1186/s40359-023-01058-w. PMID: 36803574; PMCID: PMC9936469.
• Deng W, Carpentier S, Van de Winckel A. Physical body experiences questionnaire simplified for active aging (PBE-QAG): Rasch validation. PLoS One. 2023 Feb 10;18(2):e0280198. doi: 10.1371/journal.pone.0280198. PMID: 36763606; PMCID: PMC9916545.
• Blackwood J, Carpentier S, Deng W, Van de Winckel A. Preliminary Rasch analysis of the Multidimensional Assessment of Interoceptive Awareness in adults with stroke. PLoS One. 2023. In press. 

• Francisco GE, Engineer ND, Dawson J, Kimberley TJ, Cramer SC, Prudente CN, Pierce D, Tarver WB, Hinds RHA, Van de Winckel A, Yozbatiran N. Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Stroke: 2- and 3-Year Follow-up From the Pilot Study. Arch Phys Med Rehabil. 2023 Mar 30:S0003-9993(23)00147-8. doi: 10.1016/j.apmr.2023.02.012. PMID: 37001842.

2022

•  Hartman J, Sharp A, Van de Winckel A, Tetreault K, & Pechak C. (2022). Exploring the Characteristics of Doctor of Physical Therapy Students Intending to Work in Medically Underserved Areas. Journal of Health Care for the Poor and Underserved 33(3), 1368-1382. doi:10.1353/hpu.2022.0118.
• Mallinson T, Kozlowski AJ, Johnston MV, Weaver J, Terhorst L, Grampurohit N, Juengst S, Ehrlich-Jones L, Heinemann AW, Melvin J, Sood P, Van de Winckel A. Rasch Reporting Guideline for Rehabilitation Research (RULER): the RULER Statement. Arch Phys Med Rehabil. 2022 Jul;103(7):1477-1486. doi: 10.1016/j.apmr.2022.03.013. Epub 2022 Apr 12. PMID: 35421395.
• Van de Winckel A, Kozlowski AJ, Johnston MV, Weaver J, Grampurohit N, Terhorst L, Juengst S, Ehrlich-Jones L, Heinemann AW, Melvin J, Sood P, Mallinson T. Reporting Guideline for RULER: Rasch Reporting Guideline for Rehabilitation Research: Explanation and Elaboration. Arch Phys Med Rehabil. 2022 Jul;103(7):1487-1498. doi: 10.1016/j.apmr.2022.03.019. Epub 2022 Apr 15. PMID: 35436496.
• Van de Winckel A, Carpentier S, Deng W, Bottale S, Hendrickson T, Zhang L, Wudlick R, Linnman C, Battaglino R, Morse L. Identifying body awareness-related brain network changes after cognitive multisensory rehabilitation for reduced neuropathic pain in adults with spinal cord injury: Protocol of the pilot clinical trial. TSCIR. 2022.

2021

• Kim S, Van de Winckel A, Thompson KL, Heyn P. Book Chapter 78 Complementary and Integrative Medicine in Brain Injury Medicine, Principles and Practice, Third Edition, editors: Nathan D. Zasler MD; Douglas I. Katz MD; Ross D. Zafonte DO
• Van de Winckel A, Nawshin T, Byron C. Exploratory Study for Using the mobile Hudl App with Telehealth: A Randomized Controlled Trial Shows Positive Impact on Home Exercise Program Adherence in People with Chronic Diseases and in Financial Distress. JMIR Formative Research 2021;5(3):e22659. doi: 10.2196/22659
• Sharp A, Schmidt A, Casto C, Van de Winckel A. Lapses in Professional Behavior Identified by Students of Physical Therapy. JAH. 2021. J Allied Health 2021;50(2):e53-e57.

2020

• Van de Winckel A, De Patre D, Rigoni M, Fiecas M, Hendrickson TJ, Larson M, Jagadeesan BD, Mueller BA, Elvendahl W, Streib C, Ikramuddin F, Lim KO. Exploratory study of how Cognitive Multisensory Rehabilitation restores parietal operculum connectivity and improves upper limb movements in chronic stroke. Sci Rep. 2020 Nov 20;10(1):20278. DOI: 10.1038/s41598-020-77272-y. PMID: 33219267
• Larson M, Chantigian DP, Asirvatham-Jeyaraj N, Van de Winckel A, Keller-Ross ML. Slow-Paced Breathing and Autonomic Function in People Post-stroke. Front Physiol. 2020 Oct 30;11:573325. doi: 10.3389/fphys.2020.573325. eCollection 2020. PMID: 33192570
• Dawson J, Engineer ND, Prudente CN, Pierce D, Francisco G, Yozbatiran N, Tarver B, Casavant R, Kline D, Cramer SC, Van de Winckel A, Kimberley TJ. Vagus Nerve Stimulation Paired with Upper Limb Rehabilitation after Stroke: One-year Follow-up. Neurorehab Neural Repair. 2020 Jul;34(7):609-615. DOI: 10.1177/1545968320924361.

2019

• Van de Winckel A, Gauthier L. A revised Motor Activity Log following Rasch validation (Rasch-based MAL-18) and consensus methods in chronic stroke and multiple sclerosis. Neurorehabil Neural Repair 2019, 33(10):787–791
• Grampurohit N, Van de Winckel A, Ehrlich-Jones L. Measurement Characteristics and Clinical Utility of the ABILHAND-KIDS for children with neuromuscular conditions. Arch Phys Med Rehabil. 2019, 100(9):1795–1796
• Van de Winckel A, Ottiger B, Bohlhalter S, Nyffeler T, Vanbellingen T. Comprehensive ADL outcome measurement after stroke: Rasch validation of the Lucerne ICF-based Multidisciplinary Observation Scale (LIMOS). Arch Phys Med Rehabil. 2019, 100(12):2314-2323.

2018

• Van de Winckel A, Carey JR, Bisson TA, Hauschildt E, Streib C, Durfee W. Safety and Feasibility of Transcranial Direct Current Stimulation via Telerehabilitation in People with Stroke. Arch Phys Med Rehabil. 2018, 99(10):e74
• Van de Winckel A, Carey JR, Bisson TA, Hauschildt EC, Durfee WK. Home-Based Transcranial Direct Current Stimulation plus Tracking Training Therapy in People with Stroke: An Open-Label Feasibility Study. J NeuroEng Rehab. 2018, 15:83. https://doi.org/10.1186/s12984-018-0427-2
• Van de Winckel A, Ehrlich-Jones L. Measurement Characteristics and Clinical Utility of the Motor Evaluation Scale for Upper Extremity in Stroke Patients. Arch Phys Med Rehabil. 2018, 99(12):2657-2658. https://doi.org/10.1016/j.apmr.2018.08.176
• Van de Winckel A, Jarrar M, Grampurohit N, Ehrlich-Jones L. Measurement Characteristics and Clinical Utility of the ABILHAND Among People With Rheumatoid Arthritis. Arch Phys Med Rehabil. 2018, 99(8):1693–1694. https://doi.org/10.1016/j.apmr.2018.04.006.

2017

• Frost KL, Chen M, Cassidy JM, Snow L, Hodges JS, Van de Winckel A, Kimberley TJK, Carey JR. Paired Associative Stimulation to Suppress Contralesional Corticospinal Excitability in Three People with Stroke Using N-of-1 Crossover Design. J Neurol Transl Neurosci. 2017, 5(2): 1084
• Van de Winckel A, Tseng YT, Chantigian D, Lorant K, Zarandi Z, Buchannan J, Zeffiro TA, Larson M, Olson-Kellogg B, Konczak J, Keller-Ross M. Age-Related Decline of Wrist Position Sense and its Relationship to Specific Physical Training. Frontiers Hum Neurosci. 2017, 11:570. doi: 10.3389/fnhum.2017.00570
• Van de Winckel A, Tseng Y.T., Chantigian D,Lorant K, Zarandi Z, Buchanan J, Konczak J, Zeffiro T, Olson-Kellogg B, Larson M, Keller-Ross M. Mapping Age-Related Changes in Wrist Proprioception. Arch Phys Med Rehabil. 2017, 98(10):e80-e81
• De Patre D, Van de Winckel A*, Panté F, Rizzello C, Zernitz M, Mansour M, Zordan L, Zeffiro T, O’Connor EE, Bisson T, Lupi A, Perfetti C. A case report of visual and motor recovery after 8 months of "cognitive therapeutic exercises" in cortical blindness. JNPT. 2017, 41(3):164-172. doi: 10.1097/NPT.0000000000000189. *shared first author.

2016

• De Patre D, Van de Winckel A. Strategies for Scientific Research in Neurocognitive Rehabilitation Riabilitazione Neurocognitiva. 2016, (3):216-229
• Krewer K, Van de Winckel A, Elangovan N, Aman JE, Konczak J. Commentary on: "Assessing proprioception: A critical review of methods" by Han et al. (2015). JSHS. 2016, 5(1):91-92.

2013

• Van de Winckel A, Verheyden G, Wenderoth N, Peeters R, Sunaert S, Van Hecke W, Perfetti C, De Cock P, Desloovere K, Eyssen M, Feys H. Does somatosensory discrimination activate different brain areas in children with unilateral cerebral palsy compared to typically developing children? An fMRI study. Res Dev Dis. 2013, 34(5):1710-1720. doi: 10.1016/j.ridd.2013.02.017
• Van de Winckel A, Klingels K, Bruyninckx F, Wenderoth N, Peeters R, Sunaert S, Van Hecke W, De Cock P, Eyssen M, De Weerdt W, Feys H. How does brain activation differ in children with unilateral cerebral palsy compared to typically developing children during active and passive movements, and tactile stimulation? An fMRI study. Res Dev Dis. 2013, 34(1):183–197. doi: 10.1016/j.ridd.2012.07.030.

2012

• Van de Winckel A, Wenderoth N, Feys H, Sunaert S, Peeters R, Thijs V, Swinnen S, Perfetti C, De Weerdt W. Frontoparietal involvement in passively guided shape and length discrimination: A comparison between subcortical stroke patients and healthy controls. Exp Brain Res. 2012, 220(2):179-189. doi: 10.1007/s00221-012-3128-2
• Klingels K, Feys H, De Wit L, Jaspers E, Van de Winckel A, Verbeke G, De Cock P, Molenaers G. Arm and hand function in children with unilateral cerebral palsy: A one-year follow-up study. Eur J Paediatr Neurol. 2012, 16(3):257-265. doi: 10.1016/j.ejpn.2011.08.001
• Verhoeven J, Rommel N, Prodi E, Leemans A, Zink I, Vandewalle E, Noens I, Wagemans J, Steyaert J, Boets B, Van de Winckel A, Decock P, Sunaert S. Is there a common neuro-anatomical substrate of language deficit between Autism Spectrum Disorder and Specific Language Impairment? Cereb Cortex. 2012, 22(10):2263-2271. doi: 10.1093/cercor/bhr292.

2011

• Vanbellingen T, Kersten B, Van de Winckel A, Bellion M, Baronti F, Müri R, Bohlhalter S. A new bedside test of gestures in stroke: The apraxia screen of TULIA (AST). J Neurol Neurosurg Psychiatry. 2011, 82(4):389-392. doi: 10.1136/jnnp.2010.213371.

2010

• Klingels K, Jaspers E, Van de Winckel A, Huysmans A, Feys H. A systematic review of arm activity measures for children with hemiplegic cerebral palsy. Clin Rehabil. 2010, 24(10):887-900. doi: 10.1177/0269215510367994
• Vanbellingen T, Kersten B, Van Hemelrijk B, Van de Winckel A, Bertschi M, Müri R, De Weerdt W, Bohlhalter S. Comprehensive assessment of gesture production: a new test of upper limb apraxia (TULIA). Eur J Neurol. 2010, 17(1):59-66. doi: 10.1111/j.1468-1331.2009.02741.x.

2007

• Van de Winckel A, Feys H, Lincoln N, De Weerdt W. Assessment of arm function in stroke patients: Rivermead Motor Assessment arm section revised with Rasch analysis. Clin Rehabil. 2007, 21(5):471-479.
• Verheyden G, Nieuwboer A, Van de Winckel A, De Weerdt W. Clinical tools to measure trunk performance after stroke: a systematic review of the literature. Clin Rehabil. 2007, 21(5):387-394.

2006

• Van de Winckel A, Feys H, van der Knaap S, Messerli R, Baronti F, Lehmann R, Van Hemelrijk B, Pante F, Perfetti C, De Weerdt W. Can quality of movement be measured? Rasch analysis and inter-rater reliability of the Motor Evaluation Scale for Upper Extremity in Stroke Patients (MESUPES). Clin Rehabil. 2006, 20(10):871-884
• Van de Winckel A. Commentary on "Physiotherapy assessment of knee proprioception following stroke" by Piriyaprasarth et al (2006). IJTR. 2006, 13(10):456.

2005

• Van de Winckel A, Sunaert S, Wenderoth N, Peeters R, Van Hecke P, Feys H, Horemans E, Marchal G, Swinnen S, Perfetti C, De Weerdt W. Passive Somatosensory Discrimination Tasks in Healthy Volunteers: differential networks involved in familiar versus unfamiliar shape and length discrimination. NeuroImage. 2005, 26(2):441-453.

2004

• Van de Winckel A, Feys H, De Weerdt W, Dom R. Cognitive and behavioral effects of music-based exercises in patients with dementia. Clin Rehabil. 2004, 18(3):253-260.

2001

• De Weerdt W, Nuyens G, Feys H, Van Gronsveld P, Van de Winckel A, Nieuwboer A, Osaer J, Kiekens C. Group Physiotherapy improves time use by patients with stroke in rehabilitation. Aust J Physiother. 2001, 47(1):53-61.

2000

• De Weerdt W, Selz B, Nuyens G, Staes F, Swinnen D, Van de Winckel A, Nieuwboer A, Lysens R, Feys H. Time use of stroke patients in an intensive rehabilitation unit: A comparison between a Belgian and a Swiss setting. Disabil Rehabil. 2000, 22(4):181-186
• Feys H, De Weerdt W, Nuyens G, Selz B, Van de Winckel A, Kiekens C. Predicting motor recovery of the upper limb following stroke rehabilitation: value of a clinical examination. Physiother Res Int. 2000, 5(1):1-18.

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Teaching Summary

Courses

• CPMS 5101 Clinical Physiology and Movement Science (guest lecture)
• PT 6287 Neurorehabilitation (guest lecture)
• PT 6293 Essentials of Rehabilitation Research
• PT 8132 Research Seminar I
• PT 8193 Research Problems
• RSC 5106 Introduction to Rehabilitation Science
• RSC 8130 Current literature in Rehabilitation Science
• RSC 5294 Independent study in Rehabilitation Science
• RSC 8192 Research Design in Rehabilitation Science

Clinical Summary

Board Certifications

• Certified for AHA assessment for children with cerebral palsy (rater n° 579), 2009-present
• US Licensure Physical Therapy - Minnesota (license n° 9611), 2014-present
• Certification of Cranio-sacral Therapist Belgian Cranio-Sacral & Meditation Society, Belgium, 2005-present
• Certification Adult Practitioner Level 2 in "Cognitive Therapeutic Exercises" (aka "Cognitive Multisensory Rehabilitation") 2001-present

Awards & Recognition

• Service Commendation American Congress of Rehabilitation Medicine for Task Force Co-Chair Measurement Interdisciplinary Special Interest Group Rasch Reporting Guidelines. 2021
• Elite Reviewer for 2019 for the Archives of Physical Medicine and Rehabilitation in Grantsmanship for Rehabilitation Research (TIGRR) Fellowship, 2019-2020 (Sponsored by NIH/NICHD)
• APTA Early Career Award, 2016
• Training in Grantsmanship for Rehabilitation Research (TIGRR) Fellowship, 2014

Professional Associations

• American Physical Therapy Association (APTA)
  • Research
  • Neurology
• American Heart Association (AHA)
• American Congress of Rehabilitation Medicine
  • Task Force: Movement, Stroke-Interdisciplinary Special Interest Group (ISIG), Measurement Networking Group, Terminology, Complimentary Integrative Rehab Med
  • Section Member: Measurements, Geriatric Rehab, Neuroplasticity, Complementary Integrative Rehab Med, Stroke ISIG