Gillick Pediatric Neuromodulation Lab

Gillick Lab

Empowering Children for Life

In response to the COVID-19 pandemic, the Gillick lab has launched two new remote studies:

On May 5, 2020 the Gillick lab launched a study titled, “Impact of disrupted access to rehabilitation and support services on families of children with disabilities during COVID-19”. The majority of children with childhood-onset disabilities affecting physical and cognitive function need early and continuous therapies to address their needs and optimize outcomes. Disruption in therapeutic services will likely impact outcomes and recovery at a critical time in development. We hypothesize that the impact of COVID-19 will show greater influence on health and quality of life for families of children with disabilities over time than families with typically developing children. Additionally, we hypothesize that access to rehabilitation and support services will be reduced, potentially impacting both the child’s development during this critical time period of growth and create a feeling of isolation, depression and a family’s desire to break the ‘social distancing’ imperative. Participants complete an online survey that includes questions regarding the impact of COVID-19 on access to therapy services and mental health.

In addition, on May 29, 2020 the Gillick Lab launched a study titled, “Assessing the feasibility of at-home neurorehabilitation: Applications for children with cerebral palsy and limited mobility during the COVID-19 Mandate”. The COVID-19 stay at home mandate has changed the landscape of rehabilitation, and will likely require an increased capacity to deliver effective remote rehabilitation. Our lab and others have shown that neuromodulation may be an effective strategy to enhance the effects of standard rehabilitation interventions. This study is an initial step in the assessment of feasibility to perform remote neuromodulation (tDCS-transcranial direct current stimulation) in children with cerebral palsy. 

The Gillick Pediatric Neuromodulation Laboratory focuses on cortical plasticity and recovery from neurologic insult across the lifespan. The Laboratory research encompasses the use of different forms of non-invasive brain stimulation (transcranial magnetic stimulation and transcranial direct current stimulation), in combination with behavioral training, for improved motor function after brain injury.

  • Current Studies
  • Support for Research
  • Publications
  • News
  • Current Studies

    Research Study in Babies with Stroke or Bleeding in the Brain

    "How does a baby's brain develop after an early injury?"

    Past Studies

  • Support for Research

    Funding

    National Institutes of Health NICHD 1R21HD097575-01A1 (Gillick: PI)
    ‘Perinatal Brain Injury: Identifying Cortical Excitability and Circuitry through Multi-Modal Assessment’
    August 2019-July 2021

    Shepherd Trust/Jensen Family (Gillick: PI)
    January 2020- January 2021

    Previous Funding

     

    Associated Facilities

    Center for Magnetic Resonance Research
    2021 Sixth Street SE
    Minneapolis, MN 55455
    612-626-2001

    Center for Neurobehavioral Development
    717 Delaware Street SE, Ste. 333
    Minneapolis, MN 55414
    612-624-5600

    Clinical & Translational Science Institute
    717 Delaware St SE, 2nd floor
    Minneapolis, MN 55414
    612-625-2874

    Non-invasive Neuromodulation Laboratory (NNL)
    717 Delaware Street SE
    Minneapolis, MN 55414

  • Publications

    Recent Publications

    Nawshin T*, Behan M, Nemanich S*, Kowalski J*, Sutter E*, Francis S*, Dubinsky J, Freese R, Rudser K, Gillick B. ‘A Crossed-Disciplinary Evaluation of Parental Perceptions Surrounding Pediatric Non-Invasive Brain Stimulation Research.’, International Journal of Pharmaceutical and Healthcare marketing, in press.

    Keller-Ross M, Chantigian DP, Nemanich S*, Gillick BT. ‘The Influence of Combined Transcranial Direct Current Stimulation and Bimanual Training on Blood Pressure and Heart Rate in Children with Cerebral Palsy Due to Perinatal Stroke.’Pediatric Physical Therapy, in press.

    Marom Bikson, Colleen A Hanlon , Adam J Woods, Bernadette T Gillick , Leigh Charvet, Claus Lamm, Graziella Madeo, Adrienn Holczer , Jorge Almeida, Andrea Antal, Mohammad Reza Ay, Chris Baeken, Daniel M Blumberger, Salvatore Campanella, Joan A Camprodon, Lasse Christiansen, Colleen Loo, Jennifer T Crinion, Paul Fitzgerald, Luigi Gallimberti, Peyman Ghobadi-Azbari, Iman Ghodratitoostani, Roland H Grabner, Gesa Hartwigsen, Akimasa Hirata, Adam Kirton, Helena Knotkova, Evgeny Krupitsky, Paola Marangolo, Ester M Nakamura-Palacios, Weronika Potok, Samir K Praharaj, Christian C Ruff, Gottfried Schlaug, Hartwig R Siebner, Charlotte J Stagg, Axel Thielscher, Nicole Wenderoth, Ti-Fei Yuan, Xiaochu Zhang, Hamed Ekhtiari. Guidelines for TMS/tES clinical services and research through the COVID-19 pandemic [published online ahead of print, 2020 May 12]. Brain Stimul. 2020;13(4):1124‐1149.

    Francis SM*, Beard KL, Tseng A, Chen M, Gillick BT, Jacob S, Conelea CA. Transcranial direct current stimulation for compulsivity in adolescent fraternal twins with neurodevelopmental disorders [published online ahead of print, 2020 May 12]. Brain Stimul. 2020;13(4):1153‐1155.

    Wynn Legon, Sarah Adams, Priya Bansal, Parantap Patel, Hobbs Landon, Ai Leo, Jerel Mueller, Gregg Meekins, Bernadette Gillick. "A retrospective qualitative report of symptoms and safety from transcranial focused ultrasound for neuromodulation in humans". Scientific Reports, Scientific Reports, 2020 March 27:10(1):5573.

    Jesse L. Kowalski *, Marie Hickey, Raghavendra Rao, Michael Georgieff, Mo Chen, Bernadette T. GillickSafety of Single-Pulse TMS in Two Infants with Patent Ductus Arteriosus Implanted Devices.’ Brain Stimulation, 2020 Mar 14:13(3): 861-862. 
    Rich TL*, Nemanich S* (Co-First Authors), Chen CY*, Sutter EN*, Feyma T, Krach LE, Gillick BT.  ‘Ipsilateral corticospinal tract excitability contributes to the severity of mirror movements in unilateral cerebral palsy: A case series’.  Clinical EEG and Neuroscience, 2020 May; 51(3):185-190.

    Heidi Grohn, Bernadette T Gillick (co-first authors), Ivan Tkac, Petr Bednarik, Daniele Mascali, Dinesh Kumar Deelchand, Shalom Michaeli, Gregg D Meekins, Michael J Leffler-McCabe, Colum Doan MacKinnon, Lynn E Eberly, Silvia Mangia, ‘Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: a Pilot MRI/MRS Study at 7 T Journal.’ Frontiers in Neuroscience:Brain Imaging Methods. 2019 Nov 27;13:1260.

    Kowalski J* Nemanich S*, Nawshin T*, Chen M, Peyton C, Zorn E, Hickey M, Rao R, Georgieff M, Rudser K, Gillick BT. ‘Motor Evoked Potentials as Potential Biomarkers of Early Atypical Corticospinal Tract Development in Infants with Perinatal Stroke’. J Clin Med. 2019 Aug 13;8(8).

    Nemanich ST*, Mueller B, Gillick BT. ‘Neurite orientation dispersion and density imaging (NODDI) quantifies corticospinal tract microstructural organization in children with unilateral cerebral palsy’ Human Brain Mapping, 2019 Jul 2.

    Nemanich ST*, Rich TL*, Chen CY*, Menk JS, Rudser KD, Chen M, Meekins G, Gillick BT. “Safety and Feasibility of Transcranial Magnetic Stimulation as an Exploratory Assessment of Corticospinal Connectivity in Infants After Perinatal Brain Injury: an Observational Study” Physical Therapy, 2019 Jun 1:99(6):689-700.

    Nemanich ST*, Rich TL*, Chen CY*, Menk J, Rudser K, Chen M, Meekins G, Gillick BT. Influence of Combined Transcranial Direct Current Stimulation and Motor Training on Corticospinal Excitability in Children With Unilateral Cerebral Palsy. Front Hum Neurosci, 2019 Apr 24; 13:137.

    Nemanich ST*, Gordon A, Friel K, Gillick BT. ‘Bimanual skill learning after transcranial direct current stimulation in children with unilateral cerebral palsy: a brief report.’ Developmental Neurorehabilitation, 2019 Apr 3:1-5.  

    Rich TL*, Gillick BT. ‘Electrode Placement in Transcranial Direct Current Stimulation- How reliable is the determination of C3/C4?’ Brain Sciences, 2019 Mar 22; 9(3).

    Keller-Ross, ML, Chantigian DP, Chen M, Rich TL*, Chen CY*, Gillick BT.  “Stability of the Cardiovascular Response during Single-Pulse TMS in Pediatric Stroke.” Brain Stimulation, 2018, Brain Stimulation. 2019 Mar - Apr; 12(2):371-373. 

  • News

    * Congratulations to Ellen Sutter, PT, DPT, who was recently awarded a Promotion of Doctoral Studies I Scholarship from the Foundation for Physical Therapy. The Foundation for Physical Therapy Research funds research and develops researchers to optimize movement and health.

    * The Foundation for Physical Therapy interviews Dr. Gillick regarding her lab’s research. Dr. Gillick also offers thoughts for those beginning their research careers. Read the article here.

    * Ellen Sutter graduated from the DPT program and has completed all requirements to be a licensed physical therapist and will be continuing on with her PhD in the Gillick Lab. Congratulations, Ellen!

    * Samuel Nemanich, PhD, has completed his postdoctoral fellowship in the Gillick Lab. He has started a new position as Assistant Professor, Department of Occupational Therapy at Marquette University. Congratulations, Sam! 

    Ellen Sutter, DPT, PhD student, was awarded "Honorable Mention: NYC Neuromodulation 2020 Emerging Scientists" and Dr. Bernadette Gillick was awarded "NYC Neuromodulation 2020 outstanding presentation" at the NYC Neuromodulation 2020 Online Conference in April. This free conference connected professionals in the field to the community on all forms of neuromodulation and related imaging techniques. Congrats to Dr. Gillick and Ellen!  

    * The Gillick lab and their work was featured in the University of Minnesota's recent medical bulletin highlighting the kind of work the University's new Masonic Institute for the Developing Brain will perform to keep kids’ brains at their best.


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Watch Gillick Lab Videos

Learn more about Bernadette Gillick's research, lab and why she does what she does by watching the featured videos.

Family Resources

Calgary Pediatric Stroke Program provides children with cerebrovascular disease and their families with state-of-the-art diagnosis, treatment, and support while providing the opportunity to participate in leading clinical research initiatives.

Cerebral Palsy Research Registry is a multi-institutional collaborative effort whose primary mission is to improve our understanding of cerebral palsy.

Children's Hemiplegia and Stroke Association exists to help children who have survived an early brain injury that results in hemiplegia or hemiparesis (weakness on one side of the body.

ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. ClinicalTrials.gov is a service of the U.S. National Institutes of Health.

International Alliance for Pediatric Stroke offers the needed resources, support, inspiration, knowledge and information that will empower you to better understand pediatric stroke.

Research Match is a free and secure registry developed by major academic institutions across the country who want to involve you in helping today's research studies make a real difference for everyone's health in the future.

Contact

Phone: 612-597-2163
Fax: 612-625-4274
Email: gillick@umn.edu

Lab Location

306 Children's Rehabilitation Center
426 Church Street SE
Minneapolis, MN 55455

Mailing Address

Gillick Pediatric Neuromodulation Laboratory
University of Minnesota
420 Delaware Street SE
MMC 388
Minneapolis, MN 55455