The Capacchione Lab

JOHN CAPACCHIONE, MD

Dr. Capaccione

Dr. Capacchione is an anesthesiologist who completed his residency at National Naval Medical Center in Bethesda, Maryland. For the past 15 years, he has been interested in malignant hyperthermia (MH) diagnostic testing and research. MH is a potentially lethal pharmacogenetic disorder of skeletal muscle calcium regulation triggered by commonly used drugs during the delivery of general anesthesia. In July 2016, Dr. Capacchione began working at the University of Minnesota Medical School, home of one of the top three MH testing centers in the nation, to continue his research in MH and other related disorders, such as heat stroke and exertional rhabdomyolysis.

Areas of Research Focus

MH-related research has piqued Dr. Capacchione's curiosity in pharmacogenomics, especially as it relates to anesthesiology. Anesthesiologists deliver more pharmaceuticals acutely than conceivably all other medical professionals. However, the delivery of these medications is performed with very little regard to the genetic profiles of the patients. Despite the great variability that exists in response to the medications delivered for general anesthesia, the concept of Precision or Individualized Medicine for anesthesia delivery is virtually non-existent.

"It is my desire over the remainder of my career to develop the concept of Precision Anesthesia, as I believe this to be a very fruitful yet untapped area for discovery," said Dr. Capacchione.

At the University of Minnesota Medical School, Dr. Capacchione and his multi-disciplinary teams have assembled to advance the first ever Precision Anesthesia initiative. They utilize Extreme Phenotype Sampling Models to explore the genetic contributions to three common and critical perioperative problems:

  1. Increased narcotic requirements for pain control

  2. Unpredictable postoperative cognitive dysfunction (POCD)

  3. Refractory postoperative nausea and vomiting (PONV)

  • Research Publications
  • Previous Research
  • Research Publications

    Peer-Reviewed Publications

    -Capacchione, J. (2019). What More Can We Learn from Jordan McNair? Current sports medicine reports, 18(5), 161-162. PMID: 31082887 doi: 10.1249/JSR.0000000000000596

    -Larach, M. G., Klumpner, T. T., Brandom, B. W., Vaughn, M. T., Belani, K. G., Herlich, A.,Kim, T. W., Limoncelli, J., Riazi, S., Sivak, E. L., Capacchione, J., Mashman, D., Kheterpal, S., Kooij, F., Wilczak, J., Soto, R., Berris, J., Price, Z., Lins, S., Coles, P., Harris, J. M.,Cummings, 3rd, K. C., Berman, M. F., Nanamori, M., Adelman, B. T., Wedeven, C., LaGorio, J., McCormick, P. J., Tom, S., Aziz, M. F., Coffman, T., Ellis, 2nd, T. A., Molina, S., Peterson, W., Mackey, S. C., van Klei, W. A., Ginde, A. A., Biggs, D. A., Neuman, M. D., Craft, R. M., Pace, N. L., Paganelli, W. C., Durieux, M. E., Nair, B. J., Wanderer, J. P., Miller, S. A., Helsten, D. L., Turnbull, Z. A., & Schonberger, R. B. (2019). Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. Anesthesiology, 130(1), 41-54. PMID: 30550426 doi: 10.1097/ALN.0000000000002490

    -Sambuughin, N., Ren, M., Capacchione, J. F., Mungunsukh, O., Chuang, K., Horkayne-Szakaly, I., O'Connor, F. G., & Deuster, P. A. (2018). Multifactorial Origin of Exertional Rhabdomyolysis, Recurrent Hematuria, and Episodic Pain in a Service Member with Sickle Cell Trait. Case reports in genetics, 2018, 6898546.PMID: 30533233 doi: 10.1155/2018/6898546

    -Sambuughin, N., Mungunsukh, O., Ren, M., Capacchione, J. F., Horkayne-Szakaly, I., Chuang, K., Muldoon, S. M., Smith, J. K., O'Connor, F. G., & Deuster, P. A. (2018). Pathogenic and rare deleterious variants in multiple genes suggest oligogenic inheritance in recurrent exertional rhabdomyolysis. Molecular genetics and metabolism reports, 16, 76-81. PMID: 30094188 doi: 10.1016/j.ymgmr.2018.07.007

    -Rotruck, S., Suszan, L., Vigersky, R., Rotruck, J., Brown, C., Capacchione, J., & Todd, L. (2018). Should continuous subcutaneous insulin infusion (CSII) pumps be used during the perioperative period? Development of a clinical decision algorithm. AANA Journal, 86(3), 194-200. https://api.elsevier.com/content/abstract/scopus_id/85052639065

  • Previous Research

    Dr. Capaccione's contribution to science has been in identifying other phenotypes that share common pathophysiology with the MH phenotype and genotypes. Exploring these phenotype-genotype relationships has expanded his interests into Precision Medicine, especially as it relates to perioperative healthcare.