Minnesota Nathan Shock Center on Genome Integrity and Aging (MN NSC) aims to advance the mechanistic understanding of aging by focusing on genome integrity, a primary hallmark of aging.
The UMN NSC provides investigators access to cutting-edge cores for quantifying oxidative DNA damage, characterizing DNA damage response and repair capacity, and utilizing murine models and human cell lines with impaired genome maintenance. Through these resources, the UMN NSC supports the development and testing of interventions targeting genome instability and its downstream effects on other aging pathways.
Quantification and characterization of DNA damage and epigenetic alterations.
Evaluates DNA damage response (DDR) and DNA repair capacity at the cellular level.
Access to an extensive library of mouse models, human cell lines, mouse tissues and primary cells.
Advances the next generation of geroscientists through financial, educational and mentoring support.
Oversees the success of the UMN NSC across all platforms and organizes the annual NSC symposium.