Research

OneHealth is a collaborative multi-sector approach that recognizes the interconnectedness of human, animal, and environmental health. 

UMIID researcher activities include:

• Surveillance of humans and other animals for infectious agents
• Microbial surveillance and testing
• Surveillance of H5NI Avian Influenza Virus, Powassan Virus, and other insect-transmitted viruses, mTB, antibiotic-resistant microbes, including fungi
• Wastewater dashboard for SARS-CoV-2/COVID and other viral agents

UMIID researcher activities include:

• Building a broad species/virus infection atlas of mammalian susceptibility to RNA viruses and defining zoonotic potential for human infection.
• Isolating and characterizing new virus, bacteria, and fungi strains of human concern.
• Developing and evaluating infection models.
• Defining virus and microbe genetic diversity in linkage with disease.
• Conducting high-throughput multiomic analysis of virus/microbe infection.
• UMIID is actively involved with the CREID program to investigate and respond to emerging infectious diseases with our partners at multiple sites throughout the world. 

UMIID researcher activities include:

• Conducting studies to define mechanisms of antibiotic, antimicrobial, and antiviral resistance of bacteria, fungi, and viruses in human and animal diseases.
• Defining the genetics of drug resistance across microbes and viruses.
• Identifying novel small molecules and nucleic acid compounds for antimicrobial and antiviral applications to treat disease. 

UMIID researcher activities include:

• Defining pathogen recognition receptors of virus/bacteria/fungi infection.
• Defining the innate immune response to virus, bacteria, and fungi infections.
• Defining and developing innate immune therapeutic targets for the treatment of virus, bacteria, and fungal infections.
• Building and testing novel vaccines against virus infection.
• Conducting high-throughput surveillance of immune response parameters against virus and microbial infection.
• Defining and developing T-cell targeted therapeutics for immune enhancement, immune control, and suppression of infectious diseases.
• Establish relevant models of immune response to virus and microbial infection. 

• Developing new immune adjuvants for antiviral and antimicrobial immunity. 

UMIID researcher activities include:

• Defining the cross-talk of inflammation and immunity in pathogenesis and HIV infection control.
• Identifying and testing HIV cure strategies.
• Defining the MTB host interactions of infection control and disease.
• Revealing the metabolic features supporting and controlling MTB infection.
• Developing and testing novel vaccines for protection against MTB infection and disease.