Research
We aim to develop and evaluate innovative, effective acute trauma care technologies and training through collaborative efforts with industry, military, and academic partners.
Through this work, we can decrease the mortality and disability for all Minnesotans and members of the armed forces sustaining traumatic injuries. By conducting rigorous trauma care research in collaboration with our local business and military leaders, we have an opportunity to improve point of injury and resuscitative care that will decrease the mortality and disability for all Minnesotans and members of the armed forces sustaining traumatic injuries. We will accomplish this through:
Development and evaluation of innovative, effective acute trauma care, from point of injury through early post-injury care in austere, low resource, rural, and emergency care settings.
Development of technology and knowledge products deployable by both first responders and hospital-based health care workers that are applicable to military and non-military situations.
Focus Areas
Rural Trauma Care |
Wound Management |
Infection Prevention |
Prolonged Casualty Care |
Point of Injury |
Prehospital Care |
Resuscitation |
Volunteer Opportunities
This space will be used to promote Center and Center member volunteer opportunities.
Center members: Please email Amanda Hayward (haywa028@umn.edu) with any volunteer opportunities that you would like us to promote.
Center Leadership and Center Member Publications
- Clinical Outcomes
- Emergency Medicine
- Metabolomics
- Prehospital Care
- Prolonged Casualty Care
- Resuscitation
- Rural Trauma Care
- Randell Z, Martin B, Hendrickson N, Brodke D, Spiker R, Lawrence B, Spina N. Hypoalbuminemia as a Predictor of Mortality, Disability, and Readmission in Patients Undergoing Spine Surgery: A Retrospective Analysis. Spine (Phila Pa 1976). 2023 Sep 15;48(18):1300-1307. doi: 10.1097/BRS.0000000000004607. Epub 2023 Feb 20. PMID: 36809373.
- Braaten JA, Dillon BS, Wothe JK, Olson CP, Lusczek ER, Sather KJ, Beilman GJ, Brunsvold ME. Extracorporeal Membrane Oxygenation Patient Outcomes Following Restrictive Blood Transfusion Protocol. Crit Care Explor. 2023 Dec 14;5(12):e1020. doi: 10.1097/CCE.0000000000001020. PMID: 38107536; PMCID: PMC10723844.
- Joseph B, Saljuqi AT, Amos JD, Teichman A, Whitmill ML, Anand T, Hosseinpour H, Burruss SK, Dunn JA, Najafi K, Godat LN, Enniss TM, Shoultz TH, Egodage T, Bongiovanni T, Hazelton JP, Colling KP, Costantini TW, Stein DM, Schroeppel TJ, Nahmias J; AAST Frailty MIT Study Group. Prospective validation and application of the Trauma-Specific Frailty Index: Results of an American Association for the Surgery of Trauma multi-institutional observational trial. J Trauma Acute Care Surg. 2023 Jan 1;94(1):36-44. doi: 10.1097/TA.0000000000003817. Epub 2022 Oct 17. PMID: 36279368.
- Driver BE, Prekker ME, Wagner E, Cole JB, Puskarich MA, Stang J, DeVries P, Maruggi E, Miner JR. Recall of Awareness During Paralysis Among ED Patients Undergoing Tracheal Intubation. Chest. 2023 Feb;163(2):313-323. doi: 10.1016/j.chest.2022.08.2232. Epub 2022 Sep 8. PMID: 36089069.
- Kraus CK, Nguyen HB, Jacobsen RC, Ledeboer NA, May LS, O'Neal HR Jr, Puskarich MA, Rice TW, Self WH, Rothman RE. Rapid identification of sepsis in the emergency department. J Am Coll Emerg Physicians Open. 2023 Jun 3;4(3):e12984. doi: 10.1002/emp2.12984. PMID: 37284425; PMCID: PMC10239543.
- Knack SKS, Prekker ME, Moore JC, Klein LR, Atkins AH, Miner JR, Driver BE. The Effect of Ketamine Versus Etomidate for Rapid Sequence Intubation on Maximum Sequential Organ Failure Assessment Score: A Randomized Clinical Trial. J Emerg Med. 2023 Nov;65(5):e371-e382. doi: 10.1016/j.jemermed.2023.06.009. Epub 2023 Jun 20. PMID: 37741737.
- Jennaro TS, Puskarich MA, Evans CR, Karnovsky A, Flott TL, McLellan LA, Jones AE, Stringer KA. Sustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated With Mortality and Protein Markers of the Host Response. Crit Care Explor. 2023 Mar 27;5(4):e0881. doi: 10.1097/CCE.0000000000000881. PMID: 36998529; PMCID: PMC10047616.
- Jennaro TS, Puskarich MA, Flott TL, McLellan LA, Jones AE, Pai MP, Stringer KA. Kidney function as a key driver of the pharmacokinetic response to high-dose L-carnitine in septic shock. Pharmacotherapy. 2023 Dec;43(12):1240-1250. doi: 10.1002/phar.2882. Epub 2023 Oct 11. PMID: 37775945; PMCID: PMC10841498.
- Johnson RM, Larson NJ, Brown CT, Iyegha UP, Blondeau B, Dries DJ, Rogers FB. American Trauma Care: A System of Systems. Air Med J. 2023 Sep-Oct;42(5):318-327. doi: 10.1016/j.amj.2023.07.002. Epub 2023 Jul 27. PMID: 37716800.
- Morris, N., Craig, C., Schwieters, K., Drahos, B., Mabry, M., Floersch, E., Kessler, W. (2023). Limited training in undergarment and clothing removal techniques to expose wounds in combat care. In: Jay Kalra (eds) Emerging Technologies in Healthcare and Medicine. AHFE (2023) International Conference. AHFE Open Access, vol 116. AHFE International, USA. http://doi.org/10.54941/ahfe1004367
- Craig CM, Schwieters KR, Drahos BA, Morris NL. A Pilot Study on the Role of Experience and Patient Gender on MARCH Treatment Sequence. Mil Med. 2023 Jul 22;188(7-8):e2041-e2048. doi: 10.1093/milmed/usac383. PMID: 36515148.
- Fazal, T. M. Ukraine’s Military Medicine Is a Critical Advantage. Foreign Policy https://foreignpolicy.com/2022/10/31/ukraine-military-medicine-russia-war/ (2024).
- Bergman ZR, Kiberenge RK, Mohammed A, Bianco RW, Beilman GJ, Brophy CM, Hocking KM, Alvis BD, Wise ES. Central Venous Waveform Analysis and Cardiac Output in a Porcine Model of Endotoxemic Hypotension and Resuscitation. J Am Coll Surg. 2023 Feb 1;236(2):294-304. doi: 10.1097/XCS.0000000000000474. Epub 2022 Nov 4. PMID: 36648257.
- Bergman ZR, Kiberenge RK, Bianco R, Beilman G, Brophy CM, Hocking KM, Alvis BD, Wise ES. The Effect of Fluid Pre-loading on Vital Signs and Hemodynamic Parameters in a Porcine Model of Lipopolysaccharide-Induced Endotoxemia. Cureus. 2023 Aug 7;15(8):e43103. doi: 10.7759/cureus.43103. PMID: 37692606; PMCID: PMC10483090.
- Colling K, Hoff J, Harry M, Scott M. ED to ED transfer does not prolong emergency department stays in a rural trauma system. Injury. 2023 Jan;54(1):243-248. doi: 10.1016/j.injury.2022.08.059. Epub 2022 Aug 27. PMID: 36100509.
- Suresh MR, Nassani N, Servin-Abad LA, Walz DB, Davis PR, Boelter CW, Goettl TG, Beilman GJ, Freeman ML, Olson APJ, Bazerbachi F. Implementation of a same-day, round-trip interventional endoscopy service for rural and critical access hospital patients. J Hosp Med. 2024 May 2. doi: 10.1002/jhm.13333. Epub ahead of print. PMID: 38698607.
Current Literature
Suggested Readings
- Liu NT, Holcomb JB, Wade CE, Salinas J. Inefficacy of standard vital signs for predicting mortality and the need for prehospital life-saving interventions in blunt trauma patients transported via helicopter: A repeated call for new measures. J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S98-S103. doi: 10.1097/TA.0000000000001482. PMID: 28452878.
- Liu NT, Holcomb JB, Wade CE, Batchinsky AI, Cancio LC, Darrah MI, Salinas J. Development and validation of a machine learning algorithm and hybrid system to predict the need for life-saving interventions in trauma patients. Med Biol Eng Comput. 2014 Feb;52(2):193-203. doi: 10.1007/s11517-013-1130-x. Epub 2013 Nov 22. PMID: 24263362.
- Lusczek, Elizabeth R. PhD; Muratore, Sydne L. MD; Dubick, Michael A. PhD; Beilman, Greg J. MD. Assessment of key plasma metabolites in combat casualties. Journal of Trauma and Acute Care Surgery: February 2017 - Volume 82 - Issue 2 - p 309-316. doi: 10.1097/TA.0000000000001277
- James M Bardes, Daniel J Grabo, Aimee LaRiccia, M. Chance Spalding, Zachary D Warriner, Andrew C Bernard, Melissa B Linskey Dougherty, Scott B Armen, Aaron Hudnall, Conley Stout, Alison Wilson. A multicenter evaluation on the impact of non-therapeutic transfer in rural trauma. Injury, 2022, ISSN 0020-1383, https://doi.org/10.1016/j.injury.2022.07.045.
- Brendan G. Carr, Ariel J. Bowman, Catherine S. Wolff, Michael T. Mullen, Daniel N. Holena, Charles C. Branas, Douglas J. Wiebe. Disparities in access to trauma care in the United States: A population-based analysis. Injury, Volume 48, Issue 2, 2017, Pages 332-338, ISSN 0020-1383. https://doi.org/10.1016/j.injury.2017.01.008.
- Newgard, Craig D., et al. Evaluation of rural vs urban trauma patients served by 9-1-1 emergency medical services. JAMA Surgery 152.1 (2017): 11-18.
- Jarman, Molly P., et al. Associations of distance to trauma care, community income, and neighborhood median age with rates of injury mortality. JAMA Surgery 153.6 (2018): 535-543.
- van Rein, Eveline AJ, et al. Development and validation of a prediction model for prehospital triage of trauma patients. JAMA Surgery 154.5 (2019): 421-429.
- Wandling, Michael W., et al. Association of prehospital mode of transport with mortality in penetrating trauma: a trauma system–level assessment of private vehicle transportation vs ground emergency medical services. JAMA Surgery 153.2 (2018): 107-113.
- Hashmi ZG, Kaji AH, Nathens AB. Practical Guide to Surgical Data Sets: National Trauma Data Bank (NTDB). JAMA Surgery. 2018;153(9):852–853. doi:10.1001/jamasurg.2018.0483
- Haider, Adil H., et al. Developing best practices to study trauma outcomes in large databases: an evidence-based approach to determine the best mortality risk adjustment model. Journal of trauma and acute care surgery 76.4 (2014): 1061-1069.
- Larson, L, Harry, M, Kosmata, P, Colling, K . Is it a matter of time? The effect of transfer time on femur fracture outcomes.Trauma Surg Acute Care Open 2021 Jun 17;6(1):e000701. doi: 10.1136/tsaco-2021-000701. eCollection 2021.
- JAMA's October issue: Caring for the Critically Ill Patient
TCRTC Scholar and Pilot Award Recipients
2024:
- Sarah Knack, MD: "The Effects of Sedation and Analgesia on Cerebral Physiology in Severe TBI (ESCape-TBI)"
2023:
- Eric Wise, MD: “Defining the physiologic properties of the peripheral venous system in surgical sepsis”
- Kristin Colling, MD: “Pre-Hospital Care in a Rural Trauma Systems’ Effects on Outcomes in Traumatic Brain Injury.”
- Elizabeth Lusczek, PhD: “Toward Continuous Point-of-Care Monitoring of Succinate in Trauma Patients”
2024:
- Aaron Robinson, MD: "Optimal Prehospital Airway Management with Patients with Major Trauma"
2023:
- Sarah Knack, MD: "Sedation and Analgesia in Patients with Severe Traumatic Brain Injury and Risk of Shock"