Research
Our center works to improve acute trauma care by partnering with industry, military, and academia.
We aim to improve health outcomes and save the lives of Minnesotans and members of the armed forces facing traumatic injuries. We do this through:
- Development of acute trauma care catered to low-resource, rural, and emergency settings.
- Expansion in emergency medical devices and techniques, applicable to military and civilian settings.
Translational Research
Our Center is focused on translational and basic research related to improve outcomes for trauma care. General topic areas include:
- Treatment of Volumetric Shock
- Sepsis Identification and Treatment
- Injury-related Inflammation
Outcomes Research
Deaths resulting from motor vehicle crashes, traumatic occupational injuries, drowning and unintentional firearm injuries increase with increased rurality, with children and elderly patients at especially high risk of death. Our outcomes pillar uses state and nationwide data to test hypotheses and anecdotes of differences in trauma care by region. We have several partnerships that we collaborate with for this work, including Center for Learning Health System Sciences (CLHSS); providers throughout the state from critical access hospitals, ambulance services, and Level 1 and 2 trauma centers; state government; and research societies.
Job Openings and Volunteer Opportunities
TCRTC does not have any job or volunteer opportunities at this time.
Center Members: If you have a job opening that you would like to post on our website, please email Amanda Hayward ([email protected])
Center Leadership and Center Member Publications
- Clinical Outcomes
- Emergency Medicine
- Metabolomics
- Prehospital Care
- Prolonged Casualty Care
- Resuscitation
- Rural Trauma Care
- Randell Z, Martin B, Hendrickson N, Brodke D, Spiker R, Lawrence B, Spina N. Hypoalbuminemia as a Predictor of Mortality, Disability, and Readmission in Patients Undergoing Spine Surgery: A Retrospective Analysis. Spine (Phila Pa 1976). 2023 Sep 15;48(18):1300-1307. doi: 10.1097/BRS.0000000000004607. Epub 2023 Feb 20. PMID: 36809373.
- Braaten JA, Dillon BS, Wothe JK, Olson CP, Lusczek ER, Sather KJ, Beilman GJ, Brunsvold ME. Extracorporeal Membrane Oxygenation Patient Outcomes Following Restrictive Blood Transfusion Protocol. Crit Care Explor. 2023 Dec 14;5(12):e1020. doi: 10.1097/CCE.0000000000001020. PMID: 38107536; PMCID: PMC10723844.
- Joseph B, Saljuqi AT, Amos JD, Teichman A, Whitmill ML, Anand T, Hosseinpour H, Burruss SK, Dunn JA, Najafi K, Godat LN, Enniss TM, Shoultz TH, Egodage T, Bongiovanni T, Hazelton JP, Colling KP, Costantini TW, Stein DM, Schroeppel TJ, Nahmias J; AAST Frailty MIT Study Group. Prospective validation and application of the Trauma-Specific Frailty Index: Results of an American Association for the Surgery of Trauma multi-institutional observational trial. J Trauma Acute Care Surg. 2023 Jan 1;94(1):36-44. doi: 10.1097/TA.0000000000003817. Epub 2022 Oct 17. PMID: 36279368.
- Knack SKS, Robinson AE, Beilman GJ, Bhardwaj A, Puskarich MA. The Association of Lowest Prehospital Blood Pressure with Mortality in Severe Traumatic Brain Injury from a Nationwide Emergency Medical Services Database. Prehosp Emerg Care. 2025 Jan 13:1-10. doi: 10.1080/10903127.2024.2433153. Epub ahead of print. PMID: 39621944.
- Pandey SR, Knack SKS, Driver BE, Prekker ME, Scott N, Ringstrom SJ, Maruggi E, Kaus O, Tordsen W, Puskarich MA. Factors and outcomes associated with under- and overdiagnosis of sepsis in the first hour of emergency department care. Acad Emerg Med. 2024 Dec 27. doi: 10.1111/acem.15074. Epub ahead of print. PMID: 39726389.
- Knack SK, Robinson AE, Beilman GJ, Bhardwaj A, Puskarich MA. The Association of Lowest Prehospital Blood Pressure with Mortality in Severe Traumatic Brain Injury from a Nationwide Emergency Medical Services Database. Prehosp Emerg Care. 2024 Dec 2:1-28. doi: 10.1080/10903127.2024.2433153. Epub ahead of print. PMID: 39621944.
- Driver BE, Prekker ME, Wagner E, Cole JB, Puskarich MA, Stang J, DeVries P, Maruggi E, Miner JR. Recall of Awareness During Paralysis Among ED Patients Undergoing Tracheal Intubation. Chest. 2023 Feb;163(2):313-323. doi: 10.1016/j.chest.2022.08.2232. Epub 2022 Sep 8. PMID: 36089069.
- Kraus CK, Nguyen HB, Jacobsen RC, Ledeboer NA, May LS, O'Neal HR Jr, Puskarich MA, Rice TW, Self WH, Rothman RE. Rapid identification of sepsis in the emergency department. J Am Coll Emerg Physicians Open. 2023 Jun 3;4(3):e12984. doi: 10.1002/emp2.12984. PMID: 37284425; PMCID: PMC10239543.
- Knack SKS, Prekker ME, Moore JC, Klein LR, Atkins AH, Miner JR, Driver BE. The Effect of Ketamine Versus Etomidate for Rapid Sequence Intubation on Maximum Sequential Organ Failure Assessment Score: A Randomized Clinical Trial. J Emerg Med. 2023 Nov;65(5):e371-e382. doi: 10.1016/j.jemermed.2023.06.009. Epub 2023 Jun 20. PMID: 37741737.
- Jennaro TS, Puskarich MA, Evans CR, Karnovsky A, Flott TL, McLellan LA, Jones AE, Stringer KA. Sustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated With Mortality and Protein Markers of the Host Response. Crit Care Explor. 2023 Mar 27;5(4):e0881. doi: 10.1097/CCE.0000000000000881. PMID: 36998529; PMCID: PMC10047616.
- Jennaro TS, Puskarich MA, Flott TL, McLellan LA, Jones AE, Pai MP, Stringer KA. Kidney function as a key driver of the pharmacokinetic response to high-dose L-carnitine in septic shock. Pharmacotherapy. 2023 Dec;43(12):1240-1250. doi: 10.1002/phar.2882. Epub 2023 Oct 11. PMID: 37775945; PMCID: PMC10841498.
- Johnson RM, Larson NJ, Brown CT, Iyegha UP, Blondeau B, Dries DJ, Rogers FB. American Trauma Care: A System of Systems. Air Med J. 2023 Sep-Oct;42(5):318-327. doi: 10.1016/j.amj.2023.07.002. Epub 2023 Jul 27. PMID: 37716800.
- Morris, N., Craig, C., Schwieters, K., Drahos, B., Mabry, M., Floersch, E., Kessler, W. (2023). Limited training in undergarment and clothing removal techniques to expose wounds in combat care. In: Jay Kalra (eds) Emerging Technologies in Healthcare and Medicine. AHFE (2023) International Conference. AHFE Open Access, vol 116. AHFE International, USA.
- Craig CM, Schwieters KR, Drahos BA, Morris NL. A Pilot Study on the Role of Experience and Patient Gender on MARCH Treatment Sequence. Mil Med. 2023 Jul 22;188(7-8):e2041-e2048. doi: 10.1093/milmed/usac383. PMID: 36515148.
- Fazal, T. M. Ukraine’s Military Medicine Is a Critical Advantage. Foreign Policy (2024).
- Bergman ZR, Kiberenge RK, Bianco RW, Beilman GJ, Brophy CM, Hocking KM, Alvis BD, Wise ES. Norepinephrine Infusion and the Central Venous Waveform in a Porcine Model of Endotoxemic Hypotension with Resuscitation: A Large Animal Study. J Invest Surg. 2025 Dec;38(1):2445603. doi: 10.1080/08941939.2024.2445603. Epub 2025 Jan 6. PMID: 39761972.
- Bergman ZR, Kiberenge RK, Mohammed A, Bianco RW, Beilman GJ, Brophy CM, Hocking KM, Alvis BD, Wise ES. Central Venous Waveform Analysis and Cardiac Output in a Porcine Model of Endotoxemic Hypotension and Resuscitation. J Am Coll Surg. 2023 Feb 1;236(2):294-304. doi: 10.1097/XCS.0000000000000474. Epub 2022 Nov 4. PMID: 36648257.
- Bergman ZR, Kiberenge RK, Bianco R, Beilman G, Brophy CM, Hocking KM, Alvis BD, Wise ES. The Effect of Fluid Pre-loading on Vital Signs and Hemodynamic Parameters in a Porcine Model of Lipopolysaccharide-Induced Endotoxemia. Cureus. 2023 Aug 7;15(8):e43103. doi: 10.7759/cureus.43103. PMID: 37692606; PMCID: PMC10483090.
- Kaufman EJ, Prentice C, Williams D, Song J, Haddad DN, Brown JB, Chen X, Colling K, Chatterjee P. Geography of the Underserved: The Contribution of Rural Non-trauma Hospitals to Trauma Care. Ann Surg. 2025 Apr 1;281(4):533-539. doi: 10.1097/SLA.0000000000006540. Epub 2024 Sep 18. PMID: 39291384.
- Harrison J, Bhardwaj A, Houck O, Sather K, Sekiya A, Knack S, Saarunya Clarke G, Puskarich MA, Tignanelli C, Rogers L, Marmor S, Beilman G. Emergency medical services level of training is associated with mortality in trauma patients: A combined prehospital and in hospital database analysis. J Trauma Acute Care Surg. 2025 Jan 9. doi: 10.1097/TA.0000000000004540. Epub ahead of print. PMID: 39786151.
- Colling K, Hoff J, Harry M, Scott M. ED to ED transfer does not prolong emergency department stays in a rural trauma system. Injury. 2023 Jan;54(1):243-248. doi: 10.1016/j.injury.2022.08.059. Epub 2022 Aug 27. PMID: 36100509.
- Suresh MR, Nassani N, Servin-Abad LA, Walz DB, Davis PR, Boelter CW, Goettl TG, Beilman GJ, Freeman ML, Olson APJ, Bazerbachi F. Implementation of a same-day, round-trip interventional endoscopy service for rural and critical access hospital patients. J Hosp Med. 2024 May 2. doi: 10.1002/jhm.13333. Epub ahead of print. PMID: 38698607.
TCRTC Scholar and Pilot Award Recipients
2025:
- Brian Myer, MD: "Irrigating vs Traditional Negative Pressure Wound Therapy: A Pilot Randomized Controlled Trial for Necrotizing Soft Tissue Infections (NPWTi-NSTI trial)"
2024:
- Sarah Knack, MD: "The Effects of Sedation and Analgesia on Cerebral Physiology in Severe TBI (ESCape-TBI)"
2023:
- Eric Wise, MD: “Defining the physiologic properties of the peripheral venous system in surgical sepsis”
- Kristin Colling, MD: “Pre-Hospital Care in a Rural Trauma Systems’ Effects on Outcomes in Traumatic Brain Injury.”
- Elizabeth Lusczek, PhD: “Toward Continuous Point-of-Care Monitoring of Succinate in Trauma Patients”
2025:
- Elissa Butler, MD: "Epidemiology of Injured Children in Rural vs Urban Minnesota:
- Temor Dourandish, MBBS: "Optimizing Thresholds to Identify Shock Using Non-invasive Blood Pressure Monitoring in the Setting of Prehospital Transport for Trauma"
- Adam Shaaeli: "Modern Resuscitation: Transforming Ground-Based Emergency Medical Services in Minnesota with Blood Transfusions"
2024:
- Aaron Robinson, MD: "Optimal Prehospital Airway Management with Patients with Major Trauma"
2023:
- Sarah Knack, MD: "Sedation and Analgesia in Patients with Severe Traumatic Brain Injury and Risk of Shock"