Zera KA, Bradshaw K, Hahn O, Foltz A, Zhu L, Brahms S, Peterson T, Wyss-Coray T, Aghaeepour N, Buckwalter MS. Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration by reducing neuroinflammation and promoting vascular integrity. bioRxiv 2025.06.25.661593; doi: doi.org/10.1101/2025.06.25.661593
Zera KA*, Brezzo G*, Straus D, Goertz JE, Loppi S, Dames C, Berchtold D, Crumpacker R, Becktel D, Bradley A, Allan SM, Morro M, Meisel A, Doyle K, Anrather J, McColl B†, Buckwalter MS†. Assessing post-stroke cognition in preclinical models: Lessons and recommendations from a multi-center study. bioRxiv 2025.05.21.655267; doi: doi.org/10.1101/2025.05.21.655267
*,†These authors contributed equally to this work.
Wilson EN, Wang C, Swarowski MS, McReynolds MR, Wang Q, Zera KA, Chaney A, Ramos Benitez JA, Gauba E, Minhas PS, Blacher E, Iweka CA, Le Guen Y, Panchal M, Cropper H, Jain P, Liu Q, Mehta SS, Zuckerman AJ, Xin M, Umans J, Huang J, Durairaj AS, Serrano GE, Beach TG, Greicius MD, James ML, Buckwalter MS, Rabinowitz JD, Andreasson KI. TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer’s disease models. Nature Neuroscience, In press.
Zera KA*, Bidoki NH*, Nassar H*, Drag LL, Mlynash MM, Osborn E, Musabbir M, Kim DEK, Mendez MP, Lansberg MG, Aghaeepour N†, Buckwalter MS†. Machine learning models of plasma proteomic data predict mood in chronic stroke and tie it to aberrant peripheral immune responses. Brain, Behavior and Immunity. 2023. doi.org/10.1016/j.bbi.2023.08.002
*,†These authors contributed equally to this work.
Zera KA, Buckwalter MS. T cells direct microglial repair of white matter after stroke. 2021 July; DOI:doi.org/10.1016/j.tins.2021.07.005
Barnes SE, Zera KA, Ivison GT, Buckwalter MS, Engleman EG. Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability. J Neuroinflammation. 2021 Sep 12;18(1):199.
Zera KA, Buckwalter MS. The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development. Neurotherapeutics. 2020 Apr;17(2):414-435.
Yousef H, Czupalla CJ, Lee D, Chen MB, Burke AN, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno LN, Yang AC, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter MS, Quake SR, Butcher EC, Wyss-Coray T. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nature Medicine, 2019 Jun; 25(6):988-1000.
Zera K, Zastre J. Stabilization of the hypoxia-inducible transcription factor-1 alpha (HIF-1a) in thiamine deficiency is mediated by pyruvate accumulation. Tox and App Pharm. 2018; 355:180-188
Zera K, Zastre J. Thiamine deficiency activates hypoxia inducible factor-1alpha to facilitate pro- apoptotic responses in mouse primary astrocytes. PLoS One. 2017; 12(10): e0186707.
Zera K, Sweet R, Zastre J. Role of HIF-1alpha in the hypoxia inducible expression of the thiamine transporter, SLC19A3. Gene. 2016; 595(2): 212-20.
