Immunohistochemistry staining for proteins in the natriuretic peptide pathway imaged using a confocal microscope. Left image from cochlea; center and right from heart.
Our lab investigates the role of natriuretic peptides in hearing, and in hypertension.
Natriuretic peptides function as both local and systemic hormones, and they are involved in the regulation of fluid balance in many regions of the body. We are currently funded to investigate the changes in natriuretic peptide expression and function that occur in the heart during the earliest stages of hypertension. We also have a long-standing interest in determining the function of natiruretic peptides in the cochlea.
- Research Techniques
- Confocal imaging
- Auditory brainstem response recording
- Blood pressure recordings
- Biochemistry and molecular biology techniques (protein assays, qRT-PCR, etc.)
- Transgenic mouse models
- Fitzakerley, J.L. and Trachte, G.J. (2018) Genetics of guanylyl cyclase pathways in the cochlea and their influence on hearing. Physiol. Genomics 50(9): 780-806 PMID: 29958079 DOI 10.1152/physiolgenomics.00056.2018
- Trachte, G.J. and Fitzakerley, J.L. (2014) Chapter 11. Natriuretic peptides modulate inner ear function. In Natriuretic peptides: Physiology, molecular biology and clinical implications. Pandey, K.N. (ed.) Nova Science Publishers.
- Fitzakerley, J.L., Michlin, M.L., Paton, J. and Dubinsky, J.M. (2013) Neuroscientists’ classroom visits positively impact student attitudes. PloS One 8(12). PMID: 24358325 PMCID: PMC3865289 DOI:10.1371/journal.pone.0084035