Matthew Slattery, PhD
Sarah E. Lacher, PhD
Dr. Lacher is an Assistant Professor in the Department of Biomedical Sciences at the University of Minnesota Medical School. Her research focuses on characterizing cell-type specific patterns of gene regulation following exposure to various inducers of oxidative stress. Dr. Lacher received her BS in Biology with an emphasis in Secondary Education from University of Northern Colorado (2006). She then taught Secondary Science in Colorado before attending graduate school. Dr. Lacher earned a PhD in Toxicology from the University of Montana (2013), and was a Postdoctoral Associate at the University of Minnesota Medical School (2013–2018). Dr. Lacher is a member of the Society of Toxicology, and is a Founding Executive Board Member of the newly established Special Interest Group, Out Toxicologists and Allies (OTA). She is also a member of Women in Toxicology (WIT), Hispanic Organization of Toxicologists (HOT) and the Northland Regional Chapter of the Society of Toxicology.
Salil Saurav Pathak, PhD
Salil is a Postdoctoral Associate in the Department of Biomedical Sciences at the University of Minnesota Medical School. In his research, Salil is trying to understand how acute/chronic stress alters gene expression in mouse cerebellum and leads to disease. He integrates gene expression data with electrophysiology and mouse behavior to understand the stress response. Salil received his Masters in Molecular Biology and Biotechnology from Tezpur University, India. He received his PhD from Centre for Cellular and Molecular Biology, India for his work on the role of histone demethylases in stress induced depression.
Jennifer Krznarich, MS
Jennifer Krznarich is a PhD candidate at the University of Minnesota Medical School. Her research project is focused on understanding how multiple stress responses regulate a specific glutamate-cystine transporter in the brain and the resulting functional impacts. Jennifer received her B.S. in Biology from McKendree University. After graduation, she worked as a Production Chemist for Sigma Aldrich in St. Louis and later worked as an Academic Advisor for Upward Bound Math and Science. In 2017, she earned her M.S. from the University of Minnesota, studying melatonin’s role within the circadian system of developing zebrafish. Jennifer is also passionate about diversity, equity, and inclusion in STEM with a focus on equity through an intersectional lens. She has served as Northwoods Women in Science Vice President and President, and is a member of the Genetics Society of America.
Tessa Schumann is a current undergraduate student at the University of Minnesota Duluth. She is pursuing a Biology major, along with minors in Spanish studies and psychology. She serves as the founder and president of the Pre-Genetic Counseling Club at UMD and works at the Duluth YMCA teaching swimming lessons and coaching the swim team. In her spare time, she enjoys reading historical fiction, listening to music, and visiting local coffee shops!
*Lab Members names are bolded*
Transcriptional reprogramming by oxidative stress occurs within a predefined chromatin accessibility landscape. Levings DC, Lacher SE, Palacios-Moreno J, Slattery M, Free Radical Biology and Medicine 171, 319-331, 2021.
CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators. Johnson DM, Wells MB, Fox R, Lee JS, Loganathan R, Levings D, Bastien A, Slattery M, Andrew DJ, Traffic, 2020.
The Drosophila MLR COMPASS complex is essential for programming cis-regulatory information and maintaining epigenetic memory during development. Zraly CB, Zakkar A, Perez JH, Ng J, White KP, Slattery M, Dingwall AK, Nucleic acids research 48 (7), 3476-3495, 2020.
Genomic Resources for Dissecting the Role of Non-Protein Coding Variation in Gene Environment Interactions. Levings DC, Shaw KE, Lacher SE, Toxicology. 441, 2020.
Cis-regulatory architecture of a short-range EGFR organizing center in the Drosophila melanogaster leg. Newcomb S, Voutev R, Jory A, Delker RK, Slattery M, Mann RS. PLoS genetics 14 (8), e1007568, 2020.
A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations. Levings DC, Wang X, Kohlhase D, Bell DA, Slattery M. Redox biology 19, 235-249, 2018.
Identification of a Functional Antioxidant Response Element at the HIF1A Locus. Lacher SE, Levings DC, Freeman S, Slattery M, Redox Biology, 19: 401-411, 2018.
A role for monomethylation of histone H3-K27 in gene activity in Drosophila. Wang L, Joshi P, Miller EL, Higgins LA, Slattery M, Simon JA, Genetics 208 (3), 1023-1036, 2018.
A Hypermorphic Stress-responsive cis-regulatory Element is Associated with Increased MS4A6A Expression and Alzheimer’s disease. Lacher SE, Wang X, Bell DA, Pique-Regi R, Luca F, Slattery M, Redox Biology, 14: 686-693, 2018.
Gene Regulatory Effects of Disease Associated Variation in the NRF2 Network. Lacher SE, Slattery M, Current Opinion in Toxicology, 1: 71-79, 2016.
Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression. Loganathan R, Lee JS, Wells MB, Grevengoed E, Slattery M, Andrew DJ, Developmental biology 409 (1), 234-250, 2016.
A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders. Wang X, Campbell MR, Lacher SE, Cho H, Wan M, Crowl C, Chorley BN, Bond GL, Kleeberger SR, Slattery M, Bell D, Cell Reports; 15: 4, 830-842, 2016.
Beyond Antioxidant Genes in the Ancient Nrf2 Regulatory Network. Lacher SE. Lee JS, Wang X, Campbell M, Bell D, Slattery M, Free Radical Biology and Medicine; 88: B, 452-465, 2015.
DNA-binding sequence specificity of DUX4. Zhang Y, Lee JK, Toso EA, Lee JS, Choi SH, Slattery M, Aihara H, Kyba M, Skeletal muscle 6 (1), 1-11, 2015.
Absence of a simple code: how transcription factors read the genome. Slattery M, Zhou T, Yang L, Machado ACD, Gordân R, Rohs R, Trends in biochemical sciences 39 (9), 381-399, 2014.
Fall 2022, Dan Levings begins position as Computational Biologist II at Adaptive Biotechnologies
Summer 2022, Dr. Lacher - "Using Functional Genomics to Dissect Wildfire Smoke-Induced Pulmonary Disease, " awarded from the American Lung Association
Fall 2020, Madison Brendon begins Pharmacy program at the University of Wisconsin
Spring 2020, Dr. Lacher - “In Situ Dissection of NRF2-mediated HIF1A Expression Under Physiological O2 Tensions,” awarded from the Academic Investment Research Program (AIRP) of the UMN Medical School.
Spring 2020, Dr. Slattery Awarded “Effects of social isolation embedded in the cerebellum of mouse models for autism spectrum disorder”, awarded from the Academic Investment Research Program (AIRP) of the UMN Medical School.
Fall 2019- Spring 2020, Out Toxicologists and Allies, new special interest group of Society of Toxicology is established by Dr. Lacher (currently elected as Secretary-Treasurer)
Fall 2019, Sam Freeman begins PhD program at the University of Delaware
Juan Palacios Moreno, Entre Hermanos, Seattle's Latino LGBT Organization
Madison Brendon, Pharmacy Student, University of Wisconsin Madison
Samuel Freeman, PhD Student, University of Delaware
Derek Kohlhase, M.D., Boise, ID
J. Peter Glowacki, M.D., Saint Paul, MN
Keaton Joppru, M.D., La Crosse, WI
Joslynn Lee, Assistant Professor, Fort Lewis College, Colorado
Kirsten E. Shaw, M.D., Minneapolis, MN
Courtney Ryan, Sales Consultant at DePuy Synthes Companies, Duluth, MN
Jordan Treder, UMN Medical Student
Mariana Furio Franco Bernardes, PhD, Brazil
Brittney Berning, Operational Support Technician, FBI
Daniel C. Levings, PhD, Computational Biologist II at Adaptive Biotechnologies, MN
Current Lab Members
Department of Biomedical Sciences
University of Minnesota Medical School
1035 University Drive, SMed 264
Duluth, MN 55812
Phone: (218) 726-7223