Lorene Lanier, PhD

Associate Professor, Department of Neuroscience

Lorene Lanier

Contact Info


Office Phone 612-626-2399

Lab Address:
4-166 MCB


Research Summary/Interests

Developmental plasticity

We are interested in understanding the molecular basis of developmental plasticity. Current research is focused on medium spiny neurons (MSNs), the major type of neuron in the striatum. The striatum plays an important role in regulation of movement, motivation and reward and altered or abnormal activity of MSNs is associated with neurological diseases such as Huntington's (HD) and Parkinson's (PD) and is thought to be a major determinant of addiction. These changes in MSN activity have been correlated with changes in dendritic arborization and the number, distribution and morphology of dendritic spines. Current research in the lab uses a recently developed in vitro system are to 1) determine how neurotransmitter signaling affects MSN development and morphology, 2) analyze neurotransmitter receptor trafficking during dendritic spine development and 3) characterize the relationship between MSN development and network excitability. To achieve these goals, we use a combination of multi-electrode array (MEA) recordings and immunofluorescence microscopy to investigate the relationship between morphometric development and network activity of MSNs. Because it is easily amenable to molecular manipulation and microscopic visualization, future studies may use this in vitro model system to investigate the cellular and molecular mechanisms that regulate MSN development and function, determine the consequences of disease associated gene mutations and screen for drugs that regulate MSN synaptic properties.


Bastian, TW, von Hohenberg, WC, Georgieff, MK & Lanier, LM 2019, 'Chronic energy depletion due to iron deficiency impairs dendritic mitochondrial motility during hippocampal neuron development' Journal of Neuroscience, vol. 39, no. 5, pp. 802-813. https://doi.org/10.1523/JNEUROSCI.1504-18.2018

Bastian, TW, Duck, KA, Michalopoulos, GC, Chen, MJ, Liu, ZJ, Connor, JR, Lanier, LM, Sola-Visner, MC & Georgieff, MK 2017, 'Eltrombopag, a thrombopoietin mimetic, crosses the blood–brain barrier and impairs iron-dependent hippocampal neuron dendrite development' Journal of Thrombosis and Haemostasis, vol. 15, no. 3, pp. 565-574. https://doi.org/10.1111/jth.13602

Bastian, TW, von Hohenberg, WC, Mickelson, DJ, Lanier, LM & Georgieff, MK 2016, 'Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite Complexity' Developmental Neuroscience, vol. 38, no. 4, pp. 264-276. https://doi.org/10.1159/000448514

Penrod, RD, Campagna, J, Panneck, T, Preese, L & Lanier, LM 2015, 'The presence of cortical neurons in striatal-cortical co-cultures alters the effects of dopamine and BDNF on medium spiny neuron dendritic development' Frontiers in Cellular Neuroscience, vol. 9, no. July, 269, pp. 1-14. https://doi.org/10.3389/fncel.2015.00269

Spillane, M, Ketschek, A, Jones, SL, Korobova, F, Marsick, B, Lanier, LM, Svitkina, T & Gallo, G 2011, 'The actin nucleating Arp2/3 complex contributes to the formation of axonal filopodia and branches through the regulation of actin patch precursors to filopodia' Developmental Neurobiology, vol. 71, no. 9, pp. 747-758. https://doi.org/10.1002/dneu.20907

Penrod, RD, Kourrich, S, Kearney, E, Thomas, MJ & Lanier, LM 2011, 'An embryonic culture system for the investigation of striatal medium spiny neuron dendritic spine development and plasticity' Journal of Neuroscience Methods, vol. 200, no. 1, pp. 1-13. https://doi.org/10.1016/j.jneumeth.2011.05.029

Hoover, BR, Reed, MN, Su, J, Penrod, RD, Kotilinek, LA, Grant, MK, Pitstick, R, Carlson, GA, Lanier, LM, Yuan, LL, Ashe, KH & Liao, D 2010, 'Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration' Neuron, vol. 68, no. 6, pp. 1067-1081. https://doi.org/10.1016/j.neuron.2010.11.030

Fernandes, A, Falcão, AS, Abranches, E, Bekman, E, Henrique, D, Lanier, LM & Brites, D 2009, 'Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis' Developmental Neurobiology, vol. 69, no. 9, pp. 568-582. https://doi.org/10.1002/dneu.20727

Popko, J, Fernandes, A, Brites, D & Lanier, LM 2009, 'Automated analysis of neuronj tracing data' Cytometry Part A, vol. 75, no. 4, pp. 371-376. https://doi.org/10.1002/cyto.a.20660

Xu, X, Harder, J, Flynn, DC & Lanier, LM 2009, 'AFAP120 regulates actin organization during neuronal differentiation' Differentiation, vol. 77, no. 1, pp. 38-47. https://doi.org/10.1016/j.diff.2008.09.006



NCSI 3101: Introduction to Neuroscience I (Fall semester)