Areas of Focus

The focus of the Belani Lab is measuring cyanide toxicity, its treatment, and the role of sulfanegen, a new antidote. The team is currently working on an autoinjector for sulfanegen field use to treat cyanide toxicity following exposure, such as in bioterrorism or other potential exposures.

Lab Director

Kumar Belani, MBBS

Dr. Belani is an anesthesiologist who completed his residency and earned a master’s degree at the University of Minnesota Medical School. He completed a fellowship at Children’s Hospital of Philadelphia in pediatric anesthesiology and critical care and then returned to Minnesota to establish the Medical School’s division of pediatric anesthesia and the pediatric intensive care unit at the University of Minnesota Masonic Children’s Hospital. He frequently attends conferences held around the word in search of ways to ever deepen his understanding of the science of pain relief. Currently, his focussed is on researching cyanide toxicity.

Research Publications

Succinylcholine Use and Dantrolene Availability: Reply. Larach MG, Klumpner TT, Brandom BW, Vaughn MT, Belani KG, Herlich A, Kim TW, Limoncelli J, Riazi S, Sivak EL, Capacchione J, Mashman D. Anesthesiology. 2019 Oct;131(4):935-936. doi: 10.1097/ALN.0000000000002950. No abstract available. PMID: 31469670

Malignant Hyperthermia-Susceptible Adult Patient and Ambulatory Surgery Center: Society for Ambulatory Anesthesia and Ambulatory Surgical Care Committee of the American Society of Anesthesiologists Position Statement. Urman RD, Rajan N, Belani K, Gayer S, Joshi GP. Anesth Analg. 2019 Aug;129(2):347-349. doi: 10.1213/ANE.0000000000004257. PMID: 31166228

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. Larach MG, Klumpner TT, Brandom BW, Vaughn MT, Belani KG, Herlich A, Kim TW, Limoncelli J, Riazi S, Sivak EL, Capacchione J, Mashman D, Kheterpal S, Kooij F, Wilczak J, Soto R, Berris J, Price Z, Lins S, Coles P, Harris JM, Cummings KC 3rd, Berman MF, Nanamori M, Adelman BT, Wedeven C, LaGorio J, McCormick PJ, Tom S, Aziz MF, Coffman T, Ellis TA 2nd, Molina S, Peterson W, Mackey SC, van Klei WA, Ginde AA, Biggs DA, Neuman MD, Craft RM, Pace NL, Paganelli WC, Durieux ME, Nair BJ, Wanderer JP, Miller SA, Helsten DL, Turnbull ZA, Schonberger RB; Multicenter Perioperative Outcomes Group. Anesthesiology. 2019 Jan;130(1):41-54. doi: 10.1097/ALN.0000000000002490. PMID: 30550426

Previous Research

• Hemorrhagic Shock in the Canine Model
• Thermoregulation (Malignant Hyperthermia) research
• Anesthesia and Patient Safety (Effects of laparoscopy in a porcine model)
• Anesthetic and Drug Toxicity 
• Non-invasive Continuous BP measurement

Lab Assets & Equipment

• Large and small animal table
• Anesthesia Gas Machine 
• Hemodynamic Monitors
• Pulse oximetry monitor
• ETCO2 monitor
• NIRS monitor
• Bedside ultrasound
• Autoinfusion pumps
• Isoflurane vaporizer