The Stone Lab

stone lab

Laura Stone, PhD

stone labDr. Laura Stone received her PhD in Neuroscience at the University of Minnesota, completed post-doctoral training at the Oregon Health and Sciences University and was on the Faculty at McGill University from 2007-2020. Dr. Stone returned to the University of Minnesota to join the Department of Anesthesiology in June 2020. She is an inventor on 7 patents, has co-authored over 70 manuscripts.

Areas of Research Focus

Current research projects utilize both pre-clinical models and patient populations to investigate the mechanisms underlying low back and musculoskeletal pain, the optimization of pharmacological and non-pharmacological treatments and the epigenetic regulation of chronic pain.

  • Research Publications
  • Research Awards & Recognitions
  • Funding
  • Research Publications

    2022

    Bolt J, Patel F, Stone L, Pandian D, Manuel MM, Gaines N. Impact of COVID-19 on Pediatric Mental and Behavioral Health Visits to the Emergency Department. Pediatr Emerg Care. 2022 Aug 1;38(8):409-415. doi: 10.1097/PEC.0000000000002794. Epub 2022 Jun 27. PMID: 35766893; PMCID: PMC9351515.

    Millecamps, Magali; Sotocinal, Susana G.; Austin, Jean-Sebastien; Stone, Laura S.; Mogil, Jeffrey S. Sex-specific effects of neuropathic pain on long-term pain behavior and mortality in mice. PAIN: July 29, 2022, doi: 10.1097/j.pain.0000000000002742

    Angarita-Fonseca, Adriana PhD; Pagé, M. Gabrielle PhD; Meloto, Carolina B. DDS, PhD; Gentile, Erika Lauren BA; Léonard, Guillaume PT, PhD; Massé-Alarie, Hugo PT, PhD; Tufa, Iulia BSc; Roy, Jean-Sébastien PT, PhD; Stone, Laura S. PhD; Choinière, Manon PhD; Fortin, Maryse PhD CAT(C); Roy, Mathieu PhD; Sean, Monica MSc; Tétreault, Pascal PhD; Rainville, Pierre PhD; Deslauriers, Simon PT, PhD; Lacasse, Anaïs PhD, on behalf of the Quebec Back Pain Consortium. The Canadian version of the NIH minimum dataset for chronic low back pain research: reference values from the Quebec Low Back Pain Study. PAIN: June 02, 2022, doi: 10.1097/j.pain.0000000000002703

    Seunghwan Lee, Yuya Kawarai, Jean Ouellet, Lisbet Haglund, Moshe Szyf, Laura S. Stone, DNA Methylation in Degenerating Human Intervertebral Discs, The Journal of Pain, Volume 23, Issue 5, Supplement, 2022, Pages 38-39, ISSN 1526-5900, https://doi.org/10.1016/j.jpain.2022.03.148.

    Massé-Alarie H, Angarita-Fonseca A, Lacasse A, Pagé MG, Tétreault P, Fortin M, Léonard G, Stone LS, Roy JS. Low back pain definitions: effect on patient inclusion and clinical profiles. Pain Rep. 2022 Mar 22;7(2):e997. doi: 10.1097/PR9.0000000000000997. PMID: 35356510; PMCID: PMC8942771.

    Lee, S.H. Jang, M. Suzuki-Narita, S. Gregoire, M. Millecamps, L.S. Stone, Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice, Osteoarthritis and Cartilage, Volume 30, Issue 1, 2022, Pages 110-123, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2021.06.014.

    2021

    Grégoire, S., Cheishvili, D., Salmon-Divon, M., Dymov, S., Topham, L., Calderon, V., Shir, Y., Szyf, M., & Stone, L. S. (2021). Epigenetic signature of chronic low back pain in human T cells. Pain Reports, 6(4), e960. PMID: 34746619 PMCID: PMC8568391 doi: 10.1097/PR9.0000000000000960

    Kawarai, Y., Jang, S. H., Lee, S., Millecamps, M., Kang, H., Gregoire, S., Suzuki-Narita, M., Ohtori, S., & Stone, L. S. (2021). Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model. The spine journal: official journal of the North American Spine Society, 21(11), 1938-1949. PMID: 34116218 doi: 10.1016/j.spinee.2021.06.002

    Lee, S., Jang, S. H., Suzuki-Narita, M., Gregoire, S., Millecamps, M., & Stone, L. S. (2021). Voluntary running attenuates behavioural signs of low back pain: dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice. Osteoarthritis and Cartilage. PMID: 34534663 doi: 10.1016/j.joca.2021.06.014

    Millecamps, M., Lee, S., Foster, D. Z., & Stone, L. S. (2021). Disc degeneration spreads: long-term behavioural, histologic and radiologic consequences of a single-level disc injury in active and sedentary mice. European Spine Journal: Official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. PMID: 34216236 doi: 10.1007/s00586-021-06893-2

    Kawarai, Y., Jang, S. H., Lee, S., Millecamps, M., Kang, H., Gregoire, S., Suzuki-Narita, M., Ohtori, S., & Stone, L. S. (2021). Exercise attenuates low back pain and alters epigenetic regulation in intervertebral discs in a mouse model. The Spine Journal: Official journal of the North American Spine Society. PMID: 34116218 doi: 10.1016/j.spinee.2021.06.002

    James, G., Millecamps, M., Stone, L. S., & Hodges, P. W. (2021). Multifidus Muscle Fibre Type Distribution is Changed in Mouse Models of Chronic Intervertebral Disc Degeneration, but is not Attenuated by Whole Body Physical Activity. Spine. PMID: 33973565 doi: 10.1097/BRS.0000000000004105

    Kerr, G. J., To, B., White, I., Millecamps, M., Beier, F., Grol, M. W., Stone, L. S., & Séguin, C. A. (2021). Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice. Arthritis Research & Therapy, 23(1), 93. PMID: 33752736 PMCID: PMC7983381 doi: 10.1186/s13075-021-02463-5

    Buck, E., Lee, S., Stone, L. S., & Cerruti, M. (2021). Protein Adsorption on Surfaces Functionalized with COOH Groups Promotes Anti-inflammatory Macrophage Responses. ACS Applied Materials & Interfaces, 13(6), 7021-7036. PMID: 33539069 doi: 10.1021/acsami.0c16509

    Whittal, M. C., Molladavoodi, S., Zwambag, D. P., Millecamps, M., Stone, L. S., & Gregory, D. E. (2021). Mechanical Consequence of Induced Intervertebral Disc Degeneration in the SPARC-Null Mouse. Journal of Biomechanical Engineering, 143(2). PMID: 32734296 doi: 10.1115/1.4047995

    2020

    Lucas Topham, Stephanie Gregoire, HyungMo Kang, Mali Salmon-Divon, Elad Lax, Magali Millecamps, Moshe Szyf, Laura S Stone; “The transition from acute to chronic pain: dynamic epigenetic reprogramming of the mouse prefrontal cortex up to one year following nerve injury” Pain, in press.

    Magali Millecamps, Xiang Q Shi, Marjo H Piltonen, Stefania Echeverry, Luda Diatchenko, Ji Zhang, Laura S Stone; The geriatric pain experience in mice: intact cutaneous thresholds but altered behavioural responses to tonic and chronic pain. Neurobiology of Aging, May;89:1-11. https://www.ncbi.nlm.nih.gov/pubmed/32008855

    M Gabrielle Page, Anais Lacasse, Nicholas Beaudet, Manon Choiniere, Simon Deslauriers, Luda Diatchenko, Laurent Dupruis, Stephanie Gregoire, Richard Hovey, Erwan Leclair, Guillaume Leonard, Carolina B Meloto, Francesca Montagna, Alexandre Parent, Pierre Rainville, Jean-Sébastien Roy, Mathieu Roy, Mark Ware, Timothy Wideman, Laura S Stone; The Quebec Low Back Pain Study: A protocol for an innovative two-tier provincial cohort. Pain Reports, 5(1):e799; https://www.ncbi.nlm.nih.gov/pubmed/32072095

    Seunghwan Lee, Magali Millecamps, Daniel Z. Foster, Laura S. Stone; Long-Term Histological Analysis of Innervation & Macrophage Infiltration in a Mouse Model of Intervertebral Disc Injury-Induced Low Back Pain. Journal of Orthopedic Research, Jun;38(6):1238-1247.  https://www.ncbi.nlm.nih.gov/pubmed/31814143

    Beaulieu-Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, Davidova A, Stanton C, Khan U, Dietz C, Faure E, Fatima T, MacPherson A, Mouchbahani-Constance S, Bisson DG, Haglund L., Ouellet JA, Stone LS, Samson J, Smith MJ, Ask K, Ribeiro-da-Silva A, Blunck R, Poole K, Bourinet E, Sharif-Naeini RTACAN Is an Ion Channel Involved in Sensing Mechanical Pain” Cell, 2020 Mar 5;180(5):956-967.e17. https://www.ncbi.nlm.nih.gov/pubmed/32084332

    Junxuan Ma, Despina Stefanoska, Laura S. Stone, Corrinus C. van Donkelaar, Xuenong Zou, Sibylle Grad, Mauro Alini, Marianna Peroglio; Hypoxic Stress Enhances Extension and Branching of Sensory Neuronal Outgrowth”.Journal of Orthopedic Research – Spine, in press.

    H. Al-Waeli, B. Nicolau, L. S. Stone, L. Abu Nada, Q. Gao, MN. Abdallah, E. Abdulkader, M. Suzuki, A. Mansour, A. Al Subaie & F. Tamimi; “Chronotherapy of Non-Steroidal Anti-Inflammatory Drugs May Enhance Postoperative Recovery” Scientific Reports 10:468 (2020). https://www.ncbi.nlm.nih.gov/pubmed/31949183

    2019

    Stéphanie Grégoire,Seon Ho Jang, Moshe Szyf, Laura S Stone; Prenatal maternal stress is associated with increased sensitivity to neuropathic pain and sex-specific changes in supraspinal mRNA expression of epigenetic- and stress-related genes in adulthood. Behavioural Brain Research, 380:112396. https://www.ncbi.nlm.nih.gov/pubmed/31786273

    Emerson Krock, Magali Millecamps, Kathleen M. Anderson, Akanksha Srivastava, Troy E. Reihsen, Pawan Hari, Yue Ran Sun, Seon Ho Jang, George L. Wilcox, Kumar G. Belani, David S. Beebe, Jean Ouellet, Manuel R. Pinto, Lois J. Kehl, Lisbet Haglund, Laura S Stone; Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model. EBioMedicine, 43:487-500, May 2019. https://www.ncbi.nlm.nih.gov/pubmed/31047862

    Greg James, Magali Millecamps, Laura S. Stone, Paul W. Hodges; ISSLS Prize in Basic Science: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. European Spine Journal, 28(5):893-904, May 2019. https://www.ncbi.nlm.nih.gov/pubmed/30737621

    For a full list of publications, please see Dr. Stone’s google scholar page.

  • Research Awards & Recognitions

    2019: International Society for the Study of Lumbar Spine - Best Paper Award (Basic Science Category) – Awarded for the manuscript entitled: ISSLS Prize in Basic Science: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration. European Spine Journal, 28(5):893-904, May 2019. https://www.ncbi.nlm.nih.gov/pubmed/30737621.

    2014: International Society for the Study of Lumbar Spine - Best Paper Award (Basic Science Category) – Awarded for the manuscript entitled: “ISSLS Prize Winner: Increased Innervation and Sensory Nervous System Plasticity in a Mouse Model of Low Back Pain due to Intervertebral Disc Degeneration” by M. Miyagi, M. Millecamps, A.T. Danco, S. Ohtori, K. Takahashi and L.S. Stone; Spine 39:1345-1354.

    2011: Quebec Science Top 10 – Selected by Quebec Science Magazine as one of the top 10 scientific discoveries in the province for “Effective treatment of chronic low back pain reverses structural and functional brain changes” by D.A. Seminowicz, T.H. Wideman, L. Naso, Z. Hatami-Khoroushahi, S. Fallatah, M. Ware, P. Jarzem, M.C. Bushnell, Y. Shir, J.A. Ouellet, and L.S. Stone,Journal of Neuroscience, 31(20):7540-7550.

    2006: American Pain Society John C. Liebeskind Early Career Scholar Award - This award recognizes early career achievements that have or show exceptional promise of making an outstanding contribution to pain scholarship. One award per year.

    1999: John J. Bonica Post-Doctoral Training Fellowship - This training fellowship is awarded annually to one individual by the International Association for the Study of Pain. The 1999 fellowship represented the inaugural award.

    1999: Bacaner Research Award – This award is given annually at the University of Minnesota to recognize excellence in creative research by graduating students in the Medical Sciences.

    1998: Patrick J. Manning Research Award - This award is given annually at the University of Minnesota “In recognition of significant contributions to biomedical research and to the enhancement of the welfare of animals used in research”.

  • Funding

    2020-2025: CIHR (Canadian Institutes for Health Research) Project Grant – “Chronotherapy of Non-Steroidal Anti-Inflammatory Drugs could enhance bone fracture recovery” (Role = co-PI, Nominated Principle Applicant = Dr. Faleh Tamimi)

    2020-2025: US Department of Defense - Chronic Pain Management Research Program – “Understanding Acute to Chronic Back Pain Pathways and Testing New Solutions” (Role = co-I; PI = Dr. David Klyne; additional co-I’s Dr. Mary Barbe and Dr. Paul Hodges).

    2019-2021: NIH (National Institutes of Health; USA) (Subaward on 1R21NS113335) – “Targeting the VFG signaling system for new chronic pain treatments”. (Role = co-I, PI = Dr. Lucy Vulchanova).

    2016-2021: CIHR (Canadian Institutes for Health Research) Project Grant 362909 – “Epigenetic Mechanisms in Chronic Pain” (Role = Principle Investigator, Co-PI =Dr. Moshe Szyf, Co-Investigator = Dr. Magali Millecamps).

    2015-2020: CIHR (Canadian Institutes for Health Research) Operating Grant MOP-142291- “Low back pain: from mechanism to therapeutic intervention” (Role = Principle Investigator, Co-Investigators = Dr. Magali Millecamps, Dr. Lisbet A Haglund).