Javed Shaik

Assistant Professor, Medical School

Javed Shaik

Contact Info

Office Phone 612-626-3295

Office Address:
560G, Masonic Cancer Research Building

Mailing Address:
516 Delaware St SE, MMC 98
Minneapolis, MN 55455

Lab Address:
RM720 Masonic Cancer Research Building
425 E River PKWY
Minneapolis, MN 55455.

Assistant Professor, Medical School


M.S. and Ph.D., Immunology and Vaccine Development, Department of Animal Science, University of Connecticut. 2001-2006.

Doctor of Veterinary Medicine (D.V.M.), College of Veterinary Science, Acharya N. G. Ranga Agriculture University, Hyderabad, India. 1995-2000.

Summary

Dr. Shaik's research expertise is in Dermatology and Immunology with focus on biology and immunology of transforming growth factor beta1 (TGF-?) and its potential implications for therapy in autoimmunity, fibrosis and cancer.

Awards & Recognition

Dermatology Foundation Research Career Development Award, 2014-2017

Dermatology Foundation Research Grant, 2013-2014

American Skin Association Research Grant, 2013

Albert M. Kligman Travel Fellowship, Society for Investigative Dermatology, Raleigh, NC, 2012

Professional Associations

Member of Masonic Cancer Center Tumor Microenvironment Program, Ad hoc reviewer for Journal of Investigative Dermatology, Experimental Dermatology, Melanoma Research, Journal of Immunology

Research

Research Summary/Interests

Transforming growth factor beta1 (TGF?), a pleotropic cytokine, has dual role in cancer progression. It acts as a tumor-suppressor by promoting cytostasis and apoptosis during early stages while mediating invasion and metastasis during later stages of cancer progression. TGF? is secreted as part of a latent complex that has to be liberated to be biologically active, a process termed activation. A heterodimeric transmembrane integrin ?v?6 (comprising of integrins ?v (Itgav) and beta6 (Itgb6)) promotes TGF? signaling by activating latent TGF?. Itgb6 is highly expressed in advanced cancers that correlate with poor patient prognosis. Our goal is to elucidate pathways that regulate expression of Itgb6 on aggressive tumors that can be targeted therapeutically to block and reverse metastatic progression of advanced cancers.

Publications

Publications:

1.Javed Mohammed, Lalit K. Beura, Aleh Bobr, Brian Astry, Brian Chicoine, Sakeen W. Kashem, Nathan E. Welty, Botond Z. Igyarto, Sathi Wijeyesinghe, Emily A. Thompson, Catherine Matte, Laurent Bartholin, Alesia Kaplan, Dean Sheppard, Allina G. Bridges, Warren Shlomchik, David Masopust, Daniel H. Kaplan. “Stromal cells control epithelial residence of DC and memory T cells by regulated activation of TGF-?” Nature Immunology, 2016 April;7(4):414-421. Image from article is featured on Nature Immunology cover, April 2016.

2.Sakeen W. Kashem, Botond Z. Igyarto, Maryam Gerami-Nejad, Yosuke Kumamoto, Javed Mohammed, Elizabeth Jarrett, Rebecca A. Drummond, Sandra M. Zurawski, Gerard Zurawski, Judith Berman, Akiko Iwasaki, Gordon D. Brown, Daniel H. Kaplan. 2014. “Candida albicans morphology and DC subsets determines T helper differentiation”, Immunity, 2015 Feb;42(2):356-366.

3.Anand Ravindran, Javed Mohammed, Andrew Gunderson, Xiao Cui, Adam B. Glick. “Tumor Promoting Role of TGF?1 Signaling in Ultraviolet B Induced Skin Carcinogenesis is Associated with Cutaneous Inflammation and Lymph Node Migration of Dermal Dendritic Cells”, Carcinogenesis, 2014 Apr;35(4):959-66.

4.Andrew Gunderson, Javed Mohammed, Michael Podolsky, Frank Horvath, Cherie Anderson, Adam Glick.CD8+ T cells promote RAS-induced psoriasis-like skin inflammation through IFN?”, Journal of Investigative Dermatology, 2013 Apr;133(4):955-63.

5.Javed Mohammed, Andrew Gunderson, Lina Khong, Richard Koubek, Mark C. Udey, Adam Glick. “TGF?1 Overexpression in Keratinocytes Alters Skin Dendritic Cell Homeostasis and Enhances Contact Hypersensitivity”, Journal of Investigative Dermatology, 2013 Jan;133(1):135-43.

6.Javed Mohammed, Andrew Ryscavage, Rolando Perez-Lorenzo, Andrew Gunderson, Nicholas Blazanin, and Adam Glick.“TGF?1 Induced Inflammation in Premalignant Epidermal Squamous Lesions Requires IL-17”, Journal of Investigative Dermatology, 2010 Apr:130; 2295-2303.

7.Adam Glick, Rolando Perez-Lorenzo and Javed Mohammed. “Context Dependent Regulation of Cutaneous Immunological Responses by TGF-beta1 and its Role in Skin Carcinogenesis”, Carcinogenesis, 2008 29:9-14.

8.Javed Mohammed, Salvatore Frasca Jr., Katharine Cecchini, Debra Rood, Akinyi C. Nyaoke, Steven J. Geary, Lawrence K. Silbart.“Chemokine and Cytokine Gene Expression Profiles in Chickens Inoculated With Mycoplasma gallisepticum strains Rlowor GT5”, Vaccine, 2007 Dec:25; 8611-21.

9.Javed Mohammed, Salvatore Frasca Jr., Debra Rood, Katharine Cecchini, Martha Gladd, Steven J. Geary, Lawrence K. Silbart.“Correlates of Immune Protection in GT5 Vaccinated Chickens Challenged with Pathogenic Mycoplasma gallisepticum Rlow”, Infection and Immunity, 2005 Sept;73:5410-9.

10.Leka Papazisi, Lawrence K. Silbart, Salvatore Frasca Jr., Debra Rood, Xiaofen Liao, Martha Gladd, Javed Mohammed, Steven J. Geary. “A modified live Mycoplasma gallisepticum vaccine to protect chickens from respiratory disease”, Vaccine, 2002 Nov;20:3709-3719.

Selected Oral Presentations:

1.“Targeting latent TGF-?1 activation to modulate tumor progression and immunity.” Oncology Discovery, AbbVie, North Chicago, IL, May 2nd, 2016.

2.“Targeting latent TGF-?1 activation to modulate skin cancer progression.” Cutaneous Oncology Translational Working Group, University of Minnesota, Minneapolis, MN, April 14th, 2016.

3.“Regulating TGF-?1 activation by epidermal cells to modulate cutaneous biology and immunity.” Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, April 11th, 2016.

4.“TGF-?1 mediates crosstalk between epidermal and immune cells in skin.” Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, Feb 25th, 2016.

5.“Stromal cells control residence of immune cells through latent TGFb activation at barrier surfaces.” Seattle Genetics, Bothell, WA, November 24th, 2015.

6.“Spatial Expression of RGD-binding Integrins on Keratinocytes Control Homeostatic and UV-induced Langerhans Cell Migration by Activating Latent TGF?.” 2015 Society of Investigative Dermatology Annual Meeting, Atlanta, GA, May 6-9, 2015.

7.“Keratinocytes Controls Homeostatic and UV-induced Langerhans Cell Migration by Activating Latent TGF?1 activation.” 10th Annual Dermatology Research Day, University of Minnesota, Minneapolis, MN, March 25th 2015.

8.“Regulated activation of latent TGF? by keratinocytes controls homeostatic and UV-induced Langerhans Cell migration.” Keystone Symposia-Dendritic Cells and Macrophages United (C4), Montreal, QC, Canada, Mar 8-13, 2015.

9.“Keratinocytes Controls Homeostatic and UV-induced Langerhans Cell Migration by Regulating Latent TGF?1 activation” Supergroup, University of Minnesota, Minneapolis, MN, November 6th, 2014.

10.“Keratinocytes Control Langerhans Cell Migration by TGF?1 Activating Integrin ?6.” 13th International Workshop on Langerhans Cells, Amsterdam, Netherlands, Oct 10-13, 2013.

11.“Keratinocytes Control Langerhans Cell Homeostasis by TGF?1 Activating Integrin ?v?6.” Supergroup, University of Minnesota, Minneapolis, MN, July 31st, 2013.

12.“Keratinocytes Control Langerhans Cell Homeostasis by TGF?1 Activating Integrins.” Department of Dermatology Research Day, University of Minnesota, Minneapolis, MN, Feb 13th, 2013.

13.“Overexpression of TGF?1 in Murine Epidermis Alters Skin Dendritic Cell Homeostasis and Enhances Adaptive Immunity.” 72nd Society of Investigative Dermatology (SID) Annual Meeting, Raleigh, NC, May 9 – 12, 2012.

14.“TGF?1 Overexpression in Skin Alters Dendritic Cell Homeostasis and Promotes Inflammation and Contact Hypersensitivity.” University of Minnesota, Minneapolis, MN. February 24th, 2012.

15.“TGF?1 Modulates Skin Immunity by Altering Dendritic cell and T cell Homeostasis.” Virginia Tech, Blacksburg, VA. October 18th, 2011.

16.“Effects of TGF?1 Overexpression on Skin Dendritic Cells and Adaptive Immunity.” 3rd Annual Dermatology Research Conference, Penn State Hershey Dermatology, Hershey, PA, September 22nd, 2011.

17.“TGF?1 overexpression in skin promotes dendritic cell migration and adaptive immunity.” Pathobiology Combined Research Retreat, The lodge at Tussey Mountain, State College, PA. August 16th, 2011.

18.“TGF?1 Modulates Inflammatory and Adaptive Immune Response in Normal and Premalignant Skin.” Baylor Institute of Immunology Research, Dallas, TX. June 27th, 2011.

Teaching

Academic Interests and Focus

Research training of students and postdocs