Evaluation of the SCALED (SCaling AcceptabLE cDs) Approach 
for the Implementation of Interoperable CDS for 
Venous Thromboembolism Prevention – AHRQ R18


Problem & Need for the Study

There is a global emphasis and critical need to close the patient-centered outcomes research (PCOR) evidence to practice gap. The current climate of each healthcare system developing “home-grown” CDS for the exact same guidelines is not tenable. Building capabilities to rapidly translate PCOR to the bedside at scale and share interoperable CDS routinely with an updated knowledge base (living evidence synthesis) is necessary.

Innovation & Impact

The R18 project will adapt a currently deployed CDS system to also deliver a VTE prevention guideline for adult patients with traumatic brain injury (TBI). We believe this is an ideal PCOR use case given PCORI’s continued effort to combat VTE in trauma and our experience previously implementing this guideline. Our overall goal is to successfully scale, evaluate, and maintain an interoperable TBI CDS across our 4-institution collaborative network.

Read more about this project.

Key Personnel & Performance Sites

Primary Site - University of Minnesota

Headshot of Chris Tignanelli
Headshot of Genevieve Melton-Meaux
  • Principal Investigators: Christopher Tignanelli and Genevieve Melton-Meaux 
  • Co-Investigators: Mary Butler, Joseph Gaugler, Christie Martin, Nathan Shippee, Lianne Siegel, Sean Switzer, David Vock

University of California, Davis

  • Rachael Callcut (Co-Investigator)

Geisinger Health

  • Denise Torres (Co-Investigator)
  • David Vawdrey (Co-Investigator)

Johns Hopkins University

  • Elliott Haut (Co-Investigator)

Mayo Clinic Arizona

  • Surbhi Shah (Co-Investigator)

Regenstrief Institute/Indiana University

  • Peter Jenkins (Co-Investigator)
  • Thankam Thyvalikakath (Co-Investigator)

This AHRQ R18 grant is a three-year, nearly $3 million award.
Project dates: 08/05/2022-07/31/2025.