Prolonged exposure to drugs of abuse trigger persistent changes, or adaptations, throughout the brain’s “reward system,” which are believed to cause core features of addiction, such as craving and relapse. Growing evidence suggests that chronic drug exposure diminishes the function of the prefrontal cortex (PFC) – a component of the reward system – which is believed to cause cognitive and behavioral impairments that lead to the loss of inhibitory control over drug-seeking and drug-taking behaviors. Read full article HERE.