At the Center for Learning Health System Sciences (CLHSS), we bridge the gap between research and practice by fostering continuous learning in healthcare delivery. Founded in 2021, CLHSS is a partnership between the University of Minnesota Medical School and School of Public Health. Learn more about what we do.

Our Vision

Health systems where evidence and learning flow continuously — driving better outcomes, empowering care team professionals and patients, and transforming care for all.

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To foster fast, continuous learning within Minnesota’s healthcare systems where data from practice and existing evidence are used to inform care delivery and to generate new knowledge.

  • Build a distinguished research and education program for LHS sciences
  • Accelerate the application of science to transform and improve patient care and affect population health
  • Seamlessly integrate research, care delivery, and continuous improvement to create new knowledge and directly improve care

Graphic spelling out the acronym HEALTH: Humanity, Ethics, Accountability, Learning, Trust, and Harmony
  • Humanity – Lead with generosity, kindness, and compassion toward self and others.
  • Ethics – Uphold integrity, do no harm, and embrace policy and regulations as essential for responsible and rigorous scientific research and to protect patients and communities.
  • Accountability – Take ownership to meet deadlines and deliver service that exceeds expectations.
  • Learning – Engage in everyday and lifelong learning for continuous improvement, including  learning from and with patients and caregivers to improve research and healthcare delivery for all.
  • Trust – Nurture an inclusive environment that welcomes all, encourages open dialogue, builds trust, and prioritizes broad representation and engagement.
  • Harmony – Practice work-life balance and whole person health in support of both personal wellbeing and professional goals.

What is a Learning Health System?

Learning Health System (LHS) is a cycle between translational research and healthcare practice. Research findings are used to improve clinical practices which then generate data that can be used for more research. The National Academy of Medicine describes a Learning Health System as: “A system in which science, informatics, incentives, and culture are aligned for continuous improvement and innovation, with best practices seamlessly embedded in the care process, patients and families as active participants in all elements, and new knowledge is captured as an integral by-product of the care experience.” 

Learning Health Systems are critical to healthcare improvement and reducing the time it takes for research findings to make it into healthcare practice. Building a Learning Health System involves identifying a challenge in healthcare delivery, gathering evidence on the challenge, implementing a change, and evaluating that change by collecting data on its impact.

Join Us in Advancing Healthcare Through Integrating Research and Practice

At CLHSS, we are committed to transforming healthcare through translational research and continuous learning. Join us in advancing healthcare systems that deliver better outcomes for everyone.

Our 2024 Annual Report is now available!

Read the report

Minnesota is at the forefront of a new model for translating research to practice known as Learning Health Systems.

Working with CLHSS has been a phenomenal experience. Their support has not only accelerated my research, CLHSS has also provided insights and opportunities that has changed the trajectory of my research program. Best of all, the CLHSS family is a joy to work with day in and day out!

Nick Ingraham, Assistant Professor

I was so pleased with the CLHSS team as we prepared a UG3/UH3 submission and resubmission. The staff were very knowledgeable, professional and provided relevant and timely resources for planning and preparing the application. If funded, CLHSS will provide project management for a multisite project.

- Abbie Begnaud, Associate Professor of Medicine

When our project was accepted into one of CLHSS's programs, I audibly sighed. I thought, ''Here begins the tedious task of actually doing the work, which is somewhat difficult-- the leadership buy-in, convincing all concerned parties, the IT component, having to do 90% of the work.'' All issues I had dealt with prior initiatives at different institutes. The actual LHS experience has been a polar opposite and a complete breath of fresh air. The team is amazing, everyone is motivated, and most importantly, we have great leadership investment to actually implement change. Things have really been seamless and I cannot believe how everyone and everything has come together to make a complex project come to life. 100% recommend. I would any day take the support and resources of CLHSS-- over a $200k cash grant-- they are priceless.

Arjun Gupta, Assistant Professor of Medicine