
Evaluation of Interoperable CDS System
Adapting and Scaling Clinical Decision Support for Improved TBI Care
The SCALED (SCaling AcceptabLE cDs) approach is adapting a Clinical Decision Support system to deliver VTE prevention guidelines in patients with traumatic brain injury.
Scaling Interoperable Clinical Decision Support for Traumatic Brain Injury (TBI) Care
Problem and Need for the Study
There is a critical global need to bridge the gap between patient-centered outcomes research (PCOR) and clinical practice. Currently, many healthcare systems independently develop “home-grown” CDS systems to implement the same guidelines, which is inefficient and unsustainable.
To address this challenge, healthcare systems must build capabilities to rapidly translate PCOR evidence to the bedside at scale and share interoperable clinical decision support systems. These CDS systems must be equipped with a routinely updated knowledge base through living evidence synthesis to keep pace with evolving guidelines.
Innovation and Impact
The R18 project will adapt a currently deployed CDS system to deliver VTE prevention guidelines for adult patients with TBI. We believe this is an ideal PCOR use case given the Patient-Centered Outcomes Research Institute’s continued effort to combat VTE in trauma and our experience previously implementing this guideline. Our overall goal is to successfully scale, evaluate, and maintain an interoperable TBI CDS system across our 4-institution collaborative network.
Key Personnel


Performance Sites
University of Minnesota
- Multiple Principal Investigators: Christopher Tignanelli, Genevieve Melton-Meaux
- Research Scientists: Mary Butler, Joseph Gaugler, Christie Martin, Nathan Shippee, Lianne Siegel, Sean Switzer, David Vock
University of California, Davis
- Research Scientists: Rachael Callcut
Johns Hopkins University
- Research Scientists: Elliott Haut
Geisinger Health
- Research Scientists: Denise Torres, David Vawdrey
Mayo Clinic Arizona
- Research Scientists: Surbhi Shah
Regenstrief Institute/Indiana University
- Research Scientists: Peter Jenkins, Thankam Thyvalikakath
Grand Details
- This AHRQ R18 grant is a three-year, nearly $3 million award.
- Project dates: 5-August-2022 to 31-July-2025.