Christopher Tignanelli, MD, MS, MBA
Administrative Contact
(Non-Research) Keara Carpenter | carpe803@umn.edu
Research Scheduling Contact:
Keara Carpenter | carpe803@umn.edu
Address
MMC B247
420 Delaware St. SE
Minneapolis, MN, 55455
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Biography
I wholeheartedly enjoy caring for patients with critical illness and emergency surgical conditions. I aim to provide high-quality, evidence-based emergency surgical and critical care to those in need. I treat every patient like I would my own family member. Dr. Tignanelli is an Acute Care Surgeon at the University of Minnesota, providing trauma, emergency surgery, critical care, and ECMO care for critically ill patients. He is triple board-certified in General Surgery, Surgical Critical Care, and Clinical Informatics. His research lab, MNCCORE, includes over 30 researchers developing and deploying informatics-based tools to improve the delivery of healthcare within and beyond the University of Minnesota system. His research focuses on the development and validation of machine learning and AI-enabled decision support systems, as well as the implementation, user-centered design, and scaling of interoperable clinical decision support tools.
Dr. Tignanelli is a tenured Associate Professor of Surgery in the Division of Acute Care Surgery at the University of Minnesota. Within the University of Minnesota, Dr. Tignanelli is also the Associate Dean for Data Science, co-Director for UMN’s Program for Clinical Artificial Intelligence, and co-Director for UMN’s Quality Outcomes, Discovery and Evaluation Core, which oversees the UMN’s clinical data repository. He has published over 125 papers, and his research program focuses on the implementation of an evaluation of AI-enabled and non-AI-based clinical decision support systems into practice with the goal of improving the delivery of evidence-based care. His research program has received $29 million in direct funding from the Gates Foundation, NIH, AHRQ, and the Henry M Jackson Foundation for the Advancement of Military Medicine at the principal investigator or director level.
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Education
MS (Clinical Research), Other, University of Minnesota Twin Cities
MD, University of Medicine and Dentistry of New Jersey
BS with High Honors, Other, The College of William and Mary
MBA, Information Systems Specialization, University of Minnesota, Carlson School of Business - 2024
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Research
Quality Improvement Patient Safety Trauma Systems Research Surgical Outcomes
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Licensures & Certifications
Board Certified in Clinical Informatics - 2020,
Board Certified in Surgical Critical Care- 2019,
Pediatric Advanced Life Support (PALS),
Minnesota Medical Board License,
Licensure/Certification Number: #62128
Michigan Medical Board,
Board Certified in General Surgery Certificate,
Licensure/Certification Number: #062069
Fundamentals of Laparoscopic Surgery,
North Carolina Medical Board,
Advanced Cardiovascular Life Support,
Advanced Trauma Life Support,
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Awards, Honors and Recognitions
Healthcare Heroes: Health Entrepreneur, Minneapolis/St. Paul Magazine- 2021, 2021
Top Doctors: Rising Stars, Minneapolis/St. Paul Magazine - 2020, 2020
Academic Surgical Congress Grant Writing Workshop, "2019 Annual Meeting", Houston, TX - 2019, 2019
Best Paper Competition, Minnesota Surgical Society - 2019, 2019
Department of Surgery Research Day Award, University of Minnesota Twin Cities, 2018
2017 TQIP Annual Scientific Meeting Performance Improvement Abstract Award, 2017 TQIP Annual Scientific Meeting and Training, 2017
Excellence in Research Award, 2017 Surgical Critical Care Program Director Society (SCCPDS), 2017
Variability in Management of Blunt Liver Trauma and Contribution of Level of ACS-COT Verification Status on Mortality, Michigan State Committee on Trauma Resident Paper Competition, 2017
Best AAS Overall Manuscript Submission by an AAS Resident or Fellow, 2017 ASC National Meeting, 2017
Herbert J. Proctor Award for Excellence in Surgical Research, University of North Carolina, 2015
John William Pope Clinical Fellowship, University of North Carolina, 2014
American Pancreatic Association Young Investigator Travel Award, University of North Carolina, 2013
Runner-up, Best Oral Presentation, 38th Annual Lineberger Postdoc Faculty Research Day, 2013
National Cancer Education Summer Research Fellowship Program Award, UMDNJ - New Jersey Medical School, 2006
NIH-NCI: Cancer Education Grant, UMDNJ - New Jersey Medical School, 2006
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Presentations
Purcell, L., Tignanelli, C. J., Maine, R., Charles, A. G. "Racial and Sex Differences in End of Life Decision Making in Critically Ill Surgical Patients in the Intensive Care Unit", American College of Surgeons 2018 Clinical Congress, Boston, Massachusetts. October 01, 2018.
Tignanelli, C. J., Hemmila, M. R., Rogers, M., Raghavendran, K. "Independent Risk Factors for Acute Respiratory Distress Syndrome after Trauma", The American College of Surgeons (ACS) 2018 Annual Meeting, Boston, Massachusetts. October 01, 2018.
Oliphant, B. W., Tignanelli, C. J., Napolitano, L. M., Goulet, J. A., Hemmila, M. R. "ACS_COT Verification Level Affects Trauma Center Management of Pelvic Ring Injuries and Patient Mortality", American Association for the Surgery of Trauma (Plenary, AAST) 2018 Annual Meeting, San Diego, California. September 01, 2018.
Tignanelli, C. J., Adzemovic, T., Murray, T., Ottosen, J., Iyegha, P., Napolitano, L. M., Hemmila, M. R., Gipson, J. "Should They Stay or Should They Go? Who Benefits from Interfacility Transfer to a Higher Level Trauma Center Following Initial Presentation from a Lower Level Trauma Center", American Association for the Surgery of Trauma (Plenary, AAST) 2018 Annual Meeting, San Diego, California. September 01, 2018.
Tignanelli, C. J. "Geriatric Trauma Morbidity, Mortality, and Quality Improvement", 2018 University of Minnesota Health Geriatric Trauma Conference, Crowne Plaza West Hotel, Minneapolis, Minnesota. May 01, 2018.
Tignanelli, C. J. "Epidemiology and Evolving Public Health Impact Related to Pre-Injury Controlled Substance Use", University of Minnesota School of Public Health, Minneapolis, Minnesota. April 01, 2018.
Tignanelli, C. J., Sheetz, K. H., Park, P. K., Napolitano, L. M., Cooke, C., Cherry-Bukowiec, J. R. "Underutilization of ICU Nutrition Consultation is Associated with Increased Mortality", Society of Critical Care Medicine (SCCM) Annual Congress, San Antonio, Texas. February 01, 2018.
Tignanelli, C. J. "Variability in Management of Blunt Liver Trauma and Contribution of Level of ACS-COT Verification Status on Mortality", American College of Surgeons, Region 5 Trauma Competition, Madison, Wisconsin. November 01, 2017.
Gipson, J., R. R., Tignanelli, C. J., Thorson, M., West, M., Reicks, P. "Impact of Implementation of an Institutional Guideline for VTE Prophylaxis Process of Care in Patients with Severe Trauma Brain Injury (TBI)", 2017 TQIP Annual Scientific Meeting and Training, Chicago, Illinois. November 01, 2017.
Tignanelli, C. J. "National Outcomes in Lung Transplantation", University of Minnesota ECMO Symposium: Advancement Management of the Failing Lung of Heart, Commons Hotel, Minneapolis, Minnesota. October 01, 2017.
Tignanelli, C. J. "Variability in Management of Blunt Liver Trauma and Contribution of Level of ACS-COT Verification Status on Mortality", American Association for the Surgery of Trauma (Plenary, AAST) Annual Meeting, Baltimore, Maryland. September 01, 2017.
Tignanelli, C. J. "Compliance with ACS-COT Recommended Criteria for Full Trauma Team Activation and Association with Undertriage Deaths", American Association for the Surgery of Trauma (Plenary, AAST) Annual Meeting, Baltimore, Maryland. September 01, 2017.
Tignanelli, C. J. "Variability in Management of Blunt Liver Trauma and Contribution of Level of ACS-COT Verification Status on Mortality", American College of Surgeons/Committee Annual Meeting - Michigan Chapter, Boyne Falls, Michigan. May 01, 2017.
Tignanelli, C. J. "Compliance with ACS-COT Recommended Criteria for Full Trauma Team Activation and Association with Undertriage Deaths", MTQIP Publications Committee Update, Michigan Trauma Quality Improvement Meeting, Boyne Falls, Michigan. May 01, 2017.
Tignanelli, C. J. "Variability in Management of Blunt Liver Trauma and Contribution of Level of ACS-COT Verification Status on Mortality", MTQIP Publications Committee Update, Michigan Trauma Quality Improvement Meeting, Boyne Falls, Michigan. May 01, 2017.
Tignanelli, C. J. "A Performance Comparison of an Inexpensive, Homemade Central Line Simulator to Commercial Models (Presented by Dr. Brown, co-first author)", Academic Surgical Congress National Meeting, Las Vegas, Nevada. February 01, 2017.
Tignanelli, C. J. "Interdisciplinary Morbidity and Mortality Conference, A Method for System-Wide Improvement", Academic Surgical Congress National Meeting, Las Vegas, Nevada. February 01, 2017.
Tignanelli, C. J. "Adaptive Response of Pancreatic Cancer to Single Agent Kinase Inhibitor Therapies", Research Day: University of North Carolina, Chapel Hill, North Carolina. May 01, 2016.
Tignanelli, C. J. "Pasireotide for the Prevention of Pancreatic Fistula Formation", General Surgery Grand Rounds, University of North Carolina, Chapel Hill, North Carolina. March 01, 2016.
Tignanelli, C. J. "Enhanced Recovery After Surgery at UNC", Multidisciplinary FI Medicine/Surgery Conference, University of North Carolina, Chapel Hill, North Carolina. February 01, 2016.
Tignanelli, C. J. "Is There a Role for Tranexamic Acid (TXA) in Trauma?", General Surgery Grand Rounds, University of North Carolina, Chapel Hill, North Carolina. December 01, 2015.
Tignanelli, C. J. "Adaptive Response of Pancreatic Cancer to Single Agent Kinase Inhibitor Therapies", Society of Surgical Oncology Annual Cancer Symposium, Houston, Texas. March 01, 2015.
Tignanelli, C. J. "P13K and Pan-ErbB Inhibition Overcomes ErbB Cross-Talk in Pancreatic Ductal Adenocarcinoma", Academic Surgical Congress National Meeting, Las Vegas, Nevada. February 01, 2015.
Tignanelli, C. J. "Enhanced Recovery After Surgery", Multidisciplinary GI Medicine/Surgery Conference, University of North Carolina, Chapel Hill, North Carolina. November 01, 2014.
Tignanelli, C. J. "A Rational Approach for Combination Therapy Selection in Pancreatic Cancer", American College of Surgeons Annual Meeting, San Francisco, California. October 01, 2014.
Tignanelli, C. J. "Benzodiazepine Verses Nonbenzodiazepine-Based Sedation for Mechanically Ventilated, Critically Ill Adults", General Surgery Grand Rounds, University of North Carolina, Chapel Hill, North Carolina. October 01, 2014.
Tignanelli, C. J. "A Rational Approach for Combination Therapy Selection in Pancreatic Cancer", General Grand Rounds, University of North California, Chapel Hill, North Carolina. May 01, 2014.
Tignanelli, C. J. "Multiplexed Kinase Inhibitor Beads Identify Multiple Pathways of Resistance to P13K Inhibition Facilitating the Rational Selection of Novel Combination Therapies in Pancreatic Cancer", AACR Pancreatic Cancer: Innovations in Research and Treatment, New Orleans, Louisiana. May 01, 2014.
Tignanelli, C. J. "Resistance to P13K Inhibition in Pancreatic Cancer is Mediated through the ErbB Pathway", Translational Medicine Symposium, Chapel Hill, North Carolina. April 01, 2014.
Tignanelli, C. J. "Resistance to P13K Inhibition in Pancreatic Cancer is Mediated through the ErbB Pathway", Society of Surgical Oncology Annual Cancer Symposium, Pheonix, Arizona. March 01, 2014.
Tignanelli, C. J. "Method for High Sensitivity KRAS Mutation Detection Circulating Tumor Cells (CTCs)", Academic Surgical Congress, San Diego, California. February 01, 2014.
Tignanelli, C. J. "KRAS and P13K Mutation Frequencies in Patient Derived Xenograft (PDX) Models of Pancreatic and Metastatic Colorectal cancer (mCRC) are reflective of patient tumors and stable across passages", Southeastern Surgical Annual Scientific Meeting, Savannah, Georgia. February 01, 2014.
Tignanelli, C. J. "Circulating Tumor Cells (CTCs) as an Early Biomarker of Treatment Response in Pancreatic Ductal Adenocarcinoma (PDAC)", American Pancreatic Association Annual Meeting, Miami, Florida. November 01, 2013.
Tignanelli, C. J. "The P13K inhibitor BKM120 Inhibits Growth of Pancreatic Ductal Adenocarcinoma (PDAC) in Vitro and in Vivo", American College of Surgeons Annual Meeting, Washington, District of Columbia. October 01, 2013.
Tignanelli, C. J., Torphy, R. J., Moffitt, R., Soper, S. A., Yeh, J. J. "Circulating Tumor Cells as a Biomarker of Response to Treatment in Patient Derived Xenograft Mouse Models of Pancreatic Adenocarcinoma", Journal of the American College of Surgeons 2013. September 01, 2013.
Tignanelli, C. J., Herrera, S. G., Torphy, R. J., Yeh, J. J. "The PI3K Inhibitor BKM120 Inhibits Growth of Pancreatic Ductal Adenocarcinoma in Vitro and in Vivo", Journal of the American College of Surgeons 2013. September 01, 2013.
Tignanelli, C. J. "A Rational Approach for Combination Therapy Selection in Pancreatic Ductal Adenocarcinoma", 38th Annual Lineberger Postdoc-Faculty Research Day, Chapel Hill, North Carolina. September 01, 2013.
Tignanelli, C. J. "Circulating Tumor Cells as a Biomarker of Treatment Response in Pancreatic Ductal Adenocarcinoma", Center for Gastrointestinal Biology and Disease Annual Scientific Retreat, Chapel Hill, North Carolina. June 01, 2013.
Tignanelli, C. J. "BKM120, a Potential Therapy in Pancreatic Cancer", Annual Womack Society Meeting: University of North Carolina, Chapel Hill, North Carolina. May 01, 2013.
Tignanelli, C. J. "Isolation of Circulating Tumor Cells from Patient Derived Xenograft Mouse Models of Pancreatic Cancer", American Surgical Congress National Meeting, New Orleans, Louisiana. February 01, 2013.
Tignanelli, C. J. "Circulating Tumor Cells as Biomarkers of Response in Patient Derived Xenografts of Pancreatic Cancer", Center for Gastrointestinal Biology and Disease Research Competition, Chapel Hill, North Carolina. October 01, 2012.
Tignanelli, C. J. "Our Experience with Single Incision Laparoscopic Cholecystectomy", Annual Womack Society Meeting, University of North Carolina, Chapel Hill, North Carolina. June 01, 2010.
Tignanelli, C. J. "Isolation of Mutations in MRE11 Gene to Enhance the ATM Checkpoint Pathway", National Cancer Education Research Forum: Rutgers New Jersey Medical School, Newark, New Jersey. August 01, 2006.
Tignanelli, C. J. "The Effect of Residual Ca2+ on the Stochastic Gating of Ca2+ -Regulated Ca2+ Channel Models", Biophysical Society Annual Meeting, Baltimore, Maryland. February 01, 2004.
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Professional Memberships
Eastern Association for the Surgery of Trauma, Quality, Safety, and Outcomes Committee Member
Eastern Association for the Surgery of Trauma
American Medical Informatics Association, 2019 Informatics Summit-Manuscript Reviewer
Surgical Infection Society
Shock Society
Surgical Outcomes Club
Society of Critical Care Medicine
American College of Surgeons
Association for Academic Surgery
Ben Rush Surgical Society
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Clinical Summary
Trauma, Surgical Critical Care, ECMO, Emergency general surgery