MRI of Osteonecrosis of the Femoral Head Study Trial (MOST)

About the Study

The purpose of this research study is to investigate new magnetic resonance imaging (MRI) methods to better detect and monitor osteonecrosis of the femoral head (ONFH) before and after treatment. ONFH causes injury to the hip joint that can lead to osteoarthritis  and the eventual need for a hip replacement. Moreover, available treatments are not always effective at preventing the progression of ONFH.

This research may benefit others with ONFH by providing more effective medical imaging tools to detect ONFH earlier and inform treatment decisions to increase the chance of stopping or delaying the progression of ONFH and preventing hip osteoarthritis. 

Study Activities Include

Frequently Asked Questions

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Frequently Asked Questions

What is core decompression surgical treatment?

This is a surgical treatment on the hip to allow for increased blood flow and slow or stop bone and/or joint deterioration. It is commonly performed to treat osteonecrosis. Your surgeon will talk to you to see if this is something that can be used to treat your hip issues.

What is the purpose of the study?

Osteonecrosis of the femoral head (ONFH) is a serious hip disorder that can lead to femoral head collapse and hip osteoarthritis. It accounts for 10% of hip replacements in the United States. Early treatment of ONFH is important to stop irreversible damage that happens over time. A problem is that ONFH often goes undetected in its earliest stages and treatments are less effective in later stages. X-rays and traditional MRIs do not detect early stage ONFH. 

The study will use improved MRI imaging techniques to give surgeons better information in the early stages of ONFH about the disease progression so that they can do more precise surgical treatment. We will use these more sensitive MRI techniques before and after surgery to preserve the hip (core decompression) to monitor the disease and continue to develop ways to earlier detect and treat ONFH. 

What will I have to do?

  1. Two MRIs – 1 before surgery and one 6 months after surgery. Allow 90 minutes for each MRI and completion of questionnaires. 
  2. Phone calls – the study coordinator will call you 3, 12, 18, and 24 months after your surgery for a brief call to check in and ask you questions about your hip health.

How much does the study pay me?

Up to $200; $100 for each completed MRI visit. If you do not complete the full visit, you will be paid for the amount of the visit that was completed.

When and how do I get paid in this study?

When you enroll in the study, you will receive a pre-paid MasterCard debit card. After each MRI visit, the study coordinator will add your payment amount to that card. 

If I participate in the study, can I see my doctor sooner?

No, but we appreciate you considering the study anyway.

Do I have to have surgery with specific surgeons to participate in the study?

Not necessarily. While Dr. Edward Cheng, MD is the study surgeon who conducts the core decompression treatment that we are studying, you may be using a different surgeon for this treatment. Please contact us with the name of your surgeon, the surgical treatment you will have, and where you will be receiving the treatment so we can determine whether you will be eligible to participate in the study.

I am having trouble getting to the study web site using the QR code or link listed on the brochure. How can I get more information about the study?

Please call study coordinator Ife Onuoha at 612-626-7545 or email Thank you!

What if I have more questions?

Please call study coordinator Ife Onuoha at 612-626-7545 or email Thank you!

Study Contacts

Study Coordinator: Ife Onuoha
(612) 626-7545

Principal Investigators:
Edward Cheng, MD
Casey Johnson, PhD

Departments of Veterinary Clinical Sciences & Orthopedic Surgery