Fred S. Apple

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Credentials

PhD, DABCC

Bio

Dr. Apple received his doctorate degree from the University of Minnesota in 1979 and obtained a fellowship in Laboratory Medicine in 1982 from Washington University. He is board certified in Clinical Chemistry and Toxicology.  He serves as the principal investigator of the CLIA-accredited Cardiac Biomarkers Trials Laboratory of the Hennepin Healthcare Research Institute. In addition to his investigative research, Dr. Apple is a Professor at the University of Minnesota Department of Laboratory Medicine and Pathology. Dr. Apple also serves as an Associate Editor for the journal Clinical Chemistry and is a Fellow of the American College of Sports Medicine.

Research Summary

Publications

Sandoval Y, Smith SW, Apple FS. Present and future of high sensitivity cardiac troponin in clinical practice: a paradigm shift to high sensitivity assays. Amer J Med 2016;129:354-65.

Sandoval Y, Chapman AR, Mills NL, Than M, Pickering JW, Worster A, Kavsak PA, Apple FS. Sex-specific kinetics of high-sensitivity cardiac troponin I and T following symptom onset and early presentation in non-ST-segment elevation myocardial infarction. Clin Chem 2021;67:321-324.

Sandoval Y, Apple FS, Mahler SA, Body R, Collinson PO, Jaffe AS; International Federation of Clinical Chemistry and Laboratory Medicine Committee on the Clinical Application of Cardiac Biomarkers. High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain. Circulation. 2022 Aug 16;146(7):569-581. doi: 10.1161/CIRCULATIONAHA.122.059678

Apple FS, Smith SW, Greenslade JH, Sandoval Y, Parsonage W, Ranasinghe I, Gaikwad N, Schulz K, Stephensen L, Schmidt CW,  Okeson B,  Cullen L. Single high-sensitivity point of care whole blood cardiac troponin I measurement to rule out acute myocardial infarction at low risk. Circulation 2022;46: 1918-1929. 10.1161/CIRCULATIONAHA.122.061148.