Jesse Seegmiller, PhD

Assistant Professor, Department of Laboratory Medicine and Pathology

Jesse Seegmiller

Contact Info

Office Phone 612-625-6198

Clinical Chemistry Fellow, Department of Laboratory Medicine, University of Minnesota, 2014-2016

PhD, Analytical Chemistry, University of Wyoming, 2004

BS Chemistry, University of Minnesota Duluth, 2000


Dr. Seegmiller is a board certified clinical chemist in the Department's Division of Clinical Chemistry. He focuses his research activities on esoteric testing where he primarily employs mass spectrometry to analyze and develop methods for biological samples in the Advanced Research and Diagnostics Laboratory (ARDL).

Before his fellowship and faculty appointment Dr. Seegmiller worked in industry for a mass spectrometry company as a Product Applications Specialist in Clinical Applications. Prior to that he worked in the Department of Laboratory Medicine at Mayo Clinic.


Liquid chromatography tandem mass spectrometry (LC-MS/MS) and test development.

Awards & Recognition

Richard Marshall Education Award, American Association of Clinical Chemistry Midwest Section 2016

Kenneth F. Ernst Award: Best Fellow Abstract University of Minnesota Department of Laboratory Medicine and Pathology2016

Society for Young Clinical Laboratorians Travel Award, 2016

American Association of Clinical Chemistry MSACL 2016 Annual Meeting Trainee Travel Grant Award

The Association for Mass Spectrometry Applications to the Clinical Lab, 2016

Outstanding Achievement in Clinical Research Applications Support, AB SCIEX, 2012

Edward G. Weston Fellowship, The Electrochemical Society, Inc., 2004


Research Summary/Interests

Dr. Seegmiller is an analytical chemist in the Department's Division of Clinical Chemistry.  He focuses his research activities mainly on mass spec analysis of biological samples in the Advanced Research and Diagnostics Laboratory (ARDL).


Recent Publications:

Seegmiller JC, Kokaisel EL, Story SJ, Zaun CP, Peters JM, Thomas SN, and Karger AB. Method comparison of SARS-CoV-2 serology assays involving three commercially available platforms and a novel in-house developed enzyme-linked immunosorbent assay Clin Biochem. 2020;S0009-9120(20)30812-2. doi:10.1016/j.clinbiochem.2020.08.004.

Seegmiller JC, Eckfeldt JH, Lieske JC. Challenges in Measuring Glomerular Filtration Rate: A Clinical Laboratory Perspective. Adv Chronic Kidney Dis. 2018 Jan;25(1):84-92. doi: 10.1053/j.ackd.2017.10.006

Seegmiller JC, Miller WG, Bachmann LM. Moving Toward Standardization of Urine Albumin Measurements. EJIFCC. 2017 Dec 19;28(4):258-267. eCollection 2017 Dec.

Schwartz GJ, Wang H, Erway B, Nordin G, Seegmiller J, Lieske JX, Bäck S-E, Miller WG, Eckfeldt JH. Multicenter Laboratory Comparison of Iohexol Measurement. The Journal of Applied Laboratory Medicine Mar 2018, 2 (5) 711-724; DOI: 10.1373/jalm.2017.024240

Love SA, Seegmiller JC, Kloss J, Apple FS. Urine Creatinine Concentrations in Drug Monitoring Participants and Hospitalized Patients. J Anal Toxicol. 2016 Sep 1-4.

Larson TS, Seegmiller J, In Reply to 'Iohexol Versus Iothalamate for GFR Measurement'. Am J Kidney Dis. 2016 Jun;67(6):991-2.

Seegmiller JC, Burns BE, Schinstock CA, Lieske JC, Larson TS, Iothalamate Quantification by Discordance between Iothalamate and Iohexol Renal Clearances, Am J Kidney Dis. 2016; 67:49-55

Seegmiller JC, Burns BE, Lieske JC, Larson TS, Iothalamate Quantification by Tandem Mass Spectrometry for Measurement of Glomerular Filtration Rate, Clin Chem. 2010; 56: 568 - 574.

Korpi-Steiner NL, Netzel BC, Seegmiller JC, Hagan JB, Singh RJ, Liquid chromatography–tandem mass spectrometry analysis of urinary fluticasone propionate-17beta-carboxylic acid for monitoring compliance with inhaled-fluticasone propionate therapy, Steroids 2010; 75: 77 - 82.

Seegmiller JC, Sviridov D, Burns BE, Larson TS, Hortin GL, Lieske JC, Comparison of urinary albumin quantification via immunoturbidimetric, competitive immunoassay and protein cleavage liquid chromatography-tandem mass spectrometric methods, Clin Chem. 2009; 55: 1991 - 1994.

Seegmiller JC, Barnidge DR, Burns BE, Larson TS, Lieske JC, Kumar R, Quantification of Urinary Albumin Using Protein Cleavage and LC-MS/MS, Clin Chem. 2009 Clin. Chem. 2009; 55: 1100 - 1107.

Shaikh A, Seegmiller JC, Borland TM, Burns BE, Ladwig PM, Singh RJ, Kumar R, Larson TS, Lieske JC, Comparison between immunoturbidimetry, size-exclusion chromatography, and LC-MS to quantify urinary albumin, Clin Chem. 2008; 54: 1504-10.