Shijia Zhu
,
Credentials
PhD
Bio
Dr. Zhu earned MS and PhD degrees in computer science and technology, Harbin Institute of Technology, China. He was a postdoctoral fellow and then a senior scientist in the Department of Genetics and Genomic Sciences and Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York. Before joining LMP, Zhu was a faculty member in the Department of Internal Medicine at the University of Texas Southwestern Medical Center in Dallas.
Research Summary
A computational biologist, Zhu maintains the Genotype-imputed Gene Set Enrichment Analysis software tool (GIGSEA), a novel bioinformatics resource.
Publications
Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, Li L, Zeng Q, Lin YH, Hsieh MH, Gopal P, Wang T, Hoare M, Campbell P, Hoshida Y, Zhu H. Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Cell. 2023 Apr 27;186(9):1968-1984.e20. doi: 10.1016/j.cell.2023.03.014.
Zhu S, Qian T, Hoshida Y, Shen Y, Yu J, Hao K. GIGSEA: genotype imputed gene set enrichment analysis using GWAS summary level data. Bioinformatics. 2019 Jan 1;35(1):160-163. doi: 10.1093/bioinformatics/bty529.
S Zhu, N Kubota, S Wang, T Wang, G Xiao, Y Hoshida, STIE: Single-cell level deconvolution, convolution, and clustering in spatial transcriptomics by aligning spot level transcriptome to nuclear morphology. Nature Methods, under review.
R Pippa, S Santasusagna, S Zhu, WM Song, H Yoshikawa H, N Fujiwara, A Dominguez-Andres, M Carceles-Cordon, V Miguela, J Woo, Y Cendon-Florez, J Koh AP, J Carter, G Kumar, P Li , E Grabocka, AE Aplin, DP Petrylak, RB Den, WK Kelly, C Eischen, Y-M Hou, A Ertel, AI Lamond, MJ Schiewer, A Lujambio, KE Knudsen, Y Hoshida, V Rodriguez-Bravo, J Domingo-Domenech. The microphthalmia transcription factor (MITF) contributes to castration resistance via a targetable translation mechanism in lethal prostate cancer. Cell, under review.