The research mission of the Department of Integrative Biology and Physiology (IBP) is dedicated to an integrative systems biology approach to biomedical discovery.
We partner with colleagues across disciplines to investigate questions ranging from the gene/molecule to the whole animal, while striving for excellence in research and dissemination of new knowledge with local, national, and global impact.
Current IBP research is cross-cutting and state-of-the-art in the areas of cardiovascular/muscle, metabolism/obesity and hypertension.
Research projects in the Alejandro lab are aimed to understand the developmental origins of insulin-producing beta-cell dysfunction and to identify novel endogenous modulators of insulin secretion and plasticity for potential treatment.
The Bartolomucci Lab focuses on the molecular mechanisms of obesity and stress-induced pathologies. We use an integrative approach to animal patho-physiology that combines state-of-the-art in vivo models with cellular models and molecular techniques. We also emphasize the construct validity of animal models employed to treat specific human diseases.
The Metzger Lab seeks mechanistic insights into normal and diseased cardiac muscle function. The lab's overarching goal is to translate basic science discoveries into potential therapeutic strategies to combat inherited and acquired forms of heart disease. Lab projects embrace individuality, emphasize cooperation and collaboration, and encompass a standard of excellence in all that we do as individual researchers and as a laboratory. Its guiding principles are to treat others with respect and courtesy, to maintain the lab in a collegial, safe and professional environment, and to work each day to the fullest of our capabilities.
The O'Connell Lab focuses primarily on the G-protein coupled receptor (GPCR) signaling in heart failure.
Our research aims to understand the link between overactivity of the sympathetic nervous system and cardiovascular disease. Projects range from investigating the various signals the brain receives that chronically regulate sympathetic activity, to understanding how organ-specific sympathetic activity contributes to cardiovascular disease. Although most of our work focuses on the neurogenic basis of high blood pressure (hypertension), we have more recently begun to study the complex relationship between metabolic and cardiovascular diseases.
Our research investigates the integrative biology of metabolic disease with emphasis on the role of the immune system on obesity and its complications.
The research in the Ruan laboratory is centered on understanding how metabolic homeostasis is maintained at the physiological level and defining the pathological alterations in diseases, including obesity, diabetes, digestive disease, cardiovascular disease, and inflammation.
The Townsend Lab takes an integrative approach to problems relevant to cardiovascular disease and examines cardiac biology from the level of the isolated protein to the intact animal.