Research Support

The Department of Laboratory Medicine and Pathology has both strong basic and clinical research components. It has consistently been among the top medical school pathology departments in the United States in NIH Grant funding in recent years.  The major areas of research emphasis and support in the department include cancer biology, immunology, neuroscience, cardiovascular disease, diabetes, and genomics.

LMP Research Vice Chair Kristin Hogquist can assist faculty on a number of fronts:  Equipment or other research resources needs; research services: bioinformatics, statistics, commercial services, or local cores; local collaborations; funding opportunities and feedback on grants; trainees and trainee funding opportunities; and new faculty hires and set up.  Feel free to contact Kris (hogqu001@umn.edu). 

Investigational Histopathology Support

LMP has arrangement with BioNet to support faculty archival tissue-based research studies including cutting H&E stained sections, performing immunohistochemistry, tissue microarray construction, etc. The department will cover expenses for LMP faculty who are lead or senior investigators except for PIs who have grant support, startup funding or Innovation Initiative (for this work). 

Faculty can send requests on an ongoing basis for histopathology studies to BioNet manager, Cole Drifka (cdrifka@umn.edu). A faculty committee (Paari Murugan and Pawel Mroz) will review and approve these requests, work with BioNet staff, discuss details with faculty, and prioritize projects pending availability of department support in the fiscal year cycle.

The request should be in the form of a brief single page project document that includes:

  1. Principal and co-investigators
  2. Specific aims or hypothesis
  3. Study design
  4. Services required from BioNet (including number of cases, IHC, TMA etc.)
  5. Time frame for completion of project
  6. Expected deliverable (manuscript, conference presentation, grant application etc.)

Research Bioinformatics Support

LMP provides limited bioinformatics support for research, with the goal of growing the portfolio of genomics-related grants and publications. For those research projects (funded or unfunded, in planning stages or completed) that have a bioinformatics requirement, guidelines for requesting support are outlined below.

A one-page request should be prepared that outlines:

  1. the scientific problem and its relevance to human health,
  2. datasets that have been (or will be) generated,
  3. specific bioinformatics support needs,
  4. optimal time frame for support to be available (e.g. immediately, within a month, in 6 months, etc.), 5) a publication plan for the finalized datasets and/or
  5. a plan for leveraging finalized datasets to procure external funding.

Requests will be accepted and reviewed on an ongoing basis pending availability of department support.

Send requests via email to Jean Kurata (jkurata@umn.edu).

A committee composed of Drs. Orr, Hirsch, Dehm, and Thyagarajan will review these requests for bioinformatics support, work with supervisors at RIS to direct bioinformatics support effort to the most meritorious projects, and/or discuss with applicants strategies for adjusting project goals in cases where the full level of support requested may not be available. Work on a project may stop after one month even if it is not completed, which will give the PI/lab time to consider the results and complete additional follow up experiments before additional support may become available.

If you are not certain of your bioinformatics support needs, or require consultation services that are not available as standard RIS services, the bioinformaticians have limited open office hours available each week. Consultations can be scheduled during these open office hours by contacting Christine Henzler by email (chenzler@umn.edu).

Research Biostatistics Support

LMP has engaged the Biostatistical Design and Analysis Center (BDAC) to provide limited biostatistics support for research. For those research projects (funded or unfunded, in planning stages or completed) that have a biostatistics requirement, guidelines for requesting support are outlined below.

A one-page request should be prepared that briefly outlines:

  1. The scientific problem and its relevance to human health
  2. Datasets that have been (or will be) generated
  3. Specific biostatistics support needs
  4. Optimal time frame for support to be available (e.g. immediately, within a month, in 6 months, etc.)
  5. An estimated duration of support for the project if known
  6. A publication plan for the finalized datasets and/or a plan for leveraging finalized datasets to procure external funding

Requests will be accepted and reviewed on an ongoing basis pending availability of department support.

Send requests via email to Jean Kurata (jkurata@umn.edu).

A committee composed of Drs. Hogquist, Killeen, Pankratz and Thyagarajan will review these requests for biostatistics support and approve effort to the most meritorious projects and/or discuss with applicants strategies for adjusting project goals in cases where the biostatistics needs fall outside the expertise provided by the BDAC.

Once approved by the committee, projects should be requested thru the CTSI CTR portal.

1. Go to the CTR Portal, http://z.umn.edu/ctsirequest. You will be asked to log in with your x500 username and password.

2. Select "New Request" in the upper right.

3. Search for your project, or if it is a new project, you can select "No the project doesn't yet exist" and you will be prompted to enter the project title and the PI information. Then select "Proceed to the next step".

4. Choose "Yes I would" from the pop-up and then select the first button on the next page. It reads, 'Biostatistical and Data Management Support'. Proceed to the next step.

5. Answer the remaining questions as completely as you can and submit the form upon completion.

**There’s a question on the form that asks you to identify funding. You’ll want to select “Non Federal”, “Department Contract”, “Lab Medicine and Pathology”** 

Project requests are reviewed and assigned by the BDAC team every Monday afternoon. The assigned statistician will contact you directly to arrange a meeting to proceed with your request.

If you are not certain of your biostatistics support needs, consultations can be scheduled with a statistician by contacting Melissa Hansen (ctsi@umn.edu).