David Walk, MD, FAAN

My clinical and research interests include motor neuron disorders, Charcot-Marie-Tooth (CMT), and other neuropathies

• MDA Dr. Stephen Smith Champion of Hope Award, 2018
• Minneapolis-St. Paul Magazine Top Doctor, 2010, 2012-2020

2020 ALS Association Natural History Pilot Project Local Principal Investigator

2018-2020 ALS Association A Pilot Study of Lung Volume Recruitment Combined with Expiratory Muscle Strength Training in ALS Principal Investigator

2017-2020 Acceleron CMTA Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of ACE-083 in Patients with Charcot-Marie-Tooth Disease Types 1 and X Local Principal Investigator

2016-2020 NIH Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIAT Co-Investigator

2016-present Inherited Neuropathy Consortium Rare Disease Clinical Research Network Genetics of CMT - Modifiers of CMT1A, New Causes of CMT Local Principal Investigator

2016-present Inherited Neuropathy Consortium Rare Disease Clinical Research Network A Natural History Study of CMT1B, CMT2A, CMT4A and CMT4C Local Principal Investigator

1. Walk D, editor. Handbook of Neuromuscular Medicine. New York, Springer; 2018.
2. Turner MR, Barohn RJ, Corcia P, Fink JK, Harms MB, Kiernan MC, Ravits J, Silani V, Simmons Z, Statland J, van den Berg LH; Delegates of the 2nd International PLS Conference, Mitsumoto H. Primary lateral sclerosis: consensus diagnostic criteria. J Neurol Neurosurg Psychiatry 2020; in press.
3. Muley SA, Jacobsen B, Parry G, Usman U, Ortega E, Walk D, Allen J, Pasnoor M, Varon M, Dimachkie MM. Rituximab in refractory chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 2020; in press.
4. Wasan AD, Alter BJ, Edwards RR, Argoff CE, Sehgal N, Walk D, Moeller-Bertram T, Wallace MS, Backonja M. Test-retest and inter-examiner reliability of a novel bedside quantitative sensory testing battery in postherpetic neuralgia patients. J Pain 2019; in press.
5. Mitsumoto H, Chiuzan C, Gilmore M, Zhang Y, Simmons Z, et al. Primary lateral sclerosis (PLS) functional rating scale: PLS-specific clinimetric scale. Muscle Nerve 2020; in press.
6. Fridman V, Sillau S, Acsadi G, Bacon C, Bray K, et al. A longitudinal study of CMT1A using Rasch analysis based CMT neuropathy and examination scores. Neurology 2019; in press.
7. Walk D. Neurophysiologic techniques to investigate small fiber excitability. Muscle & Nerve 2019;60:345-346.
8. Barney C, Merbler A, Simone F, Walk D, Symons FJ. Investigating the feasibility of a modified quantitative sensory testing approach to profile sensory function and predict pain outcomes following intrathecal baclofen implant surgery in cerebral palsy. Pain Medicine, 2019; in press.
9. Cheong I, Deelchand D, Eberly L, Marjanska M, Manousakis G, Guliani G, Walk D, Oz G. Neurochemical correlates of functional decline in amyotrophic lateral sclerosis. J Neurol Neursurg Psychiatr; 2019;90:294-301.
10. Walk, D. Measures of cutaneous pain perception and nociceptor density: more than skin deep. Muscle & Nerve 58;2018;58:472-474.
11. Salter CG, Beijer D, Hardy H, Barwick K, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, Chioza B, Blakely RD, Chilton JK, De Bleecker J, Baets J, Baple EL, Walk D, Crosby AH. Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies. Neurology Genetics 2018;4:e222.
12. Panosyan FB, Laura M, Rossor AM, Pisciotta C, Piscosquito G, Burns J, and the Inherited Neuropathies Consortium. Cross-sectional analysis of a large cohort with X-linked Charcot-Marie-Tooth disease (CMTX1). Neurology 2017;89:927-935.
13. Cheong I, Marjanska M, Deechand D, Eberly L, Walk D, Oz G. Ultra-High Field Proton MR Spectroscopy in Early-Stage Amyotrophic Lateral Sclerosis. Neurochem Res, 2017;42:1833-1844.
14. Walk D. Using random forest methods to identify factors associated with diabetic neuropathy: a novel approach. Pain Med 2017;18:1-2.
15. Walk D, Poliak-Tunis M. Chronic pain management: An overview of taxonomy, conditions commonly encountered, and assessment. Med Clin 2016;100:1-16.
16. Macchi Z, Wang, Y, Moore D, Katz J; Saperstein D, Walk D, et al. Possible Mitochondrial Target Engagement in an Open Label Trial of Rasagiline for ALS. Amyotroph Lateral Scler Frontotemporal Degener 2015;16:345-352.