CUTTING-EDGE RESEARCH IN NEUROSURGERY
Because we deal with some of the most complicated and difficult neurosurgical diseases, we constantly face problems for which there are not definite answers. Our basic, translational and clinical research programs are focused on better understanding these problems, which can lead to effective treatments in the future.
Research in the Department of Neurosurgery encompasses a wide spectrum of projects including:
- Stem cell use in the treatment of neurological disorders such as ischemic brain injury, Parkinson's disease and spinal cord injury
- Gene therapies, including development of vector systems for treating lysosomal storage disorders of the brain such as MPS I (Hurler Syndrome) and MSP II (Hunter's Syndrome)
- Neuro-oncology projects, including a collaboration with the Department of Pediatrics and College of Veterinary Medicine to create vaccines to fight brain tumors in humans and their canine companions as well as multicenter trials for treatments of brain tumors using blood-brain barrier disruption
- Projects on neuro-protective compounds include the study of anti-apoptotic agents such as tauro-ursodeoxycholic acid (TUDCA) to prevent neuronal loss in conditions such as stroke, Alzheimer's disease and spinal cord injury
- Projects on neuro-transport include the study of water movement for hydrocephalus and debris/blood from trauma out of the intracranial cavity.
Because we deal with some of the most complicated and difficult neurosurgical diseases, we constantly face problems for which there are not definite answers. The neurosurgical research laboratories have developed a focus on stem-cell mediated recovery from various forms of nervous system injury.