Meyer Lab


The Meyer lab is investigating the interaction of heart rate and calcium cycling in heart failure with preserved ejection fraction (HFpEF). A main goal is the development of chronotherapy to improve symptoms and outcomes in HFpEF. In a bench-to-bedside approach we study disease models, human heart tissue samples and conduct clinical studies.

Markus Meyer faculty profile

Current Lab Projects
  • Heart rate effects on cardiac hemodynamics and the myocardium
  • Novel approaches and pharmacologic targets in HFpEF
  • Mechanisms and dosing of chronotherapy
  • Biosensor to monitor sarcoplasmic reticulum dependent relaxation
Selected Publications

Full list of publications at Experts@Minnesota.

  1. Meyer M, LeWinter MM, Zile MR. A Targeted Treatment Opportunity for HFpEF: Taking Advantage of Diastolic Tone. Circulation. 2021 Oct 19;144(16):1269-1271.
  2. Arnold M, Dostmann W, Martin J, Previs M, Palmer B, LeWinter MM, Meyer M. Serca2a-Phospholamban Interaction Monitored by an Interposed Circularly Permutated Green Fluorescent Protein. American Journal of Physiology 2021.
  3. Silverman DN, Rambod M, Lustgarten DL, Lobel R, LeWinter MM, Meyer M. Heart Rate-Induced Myocardial Calcium Retention and Left Ventricular Volume Loss in Patients with HFpEF. Accepted for publication JAHA 2020
  4. Nambiar L, Silverman D, Vanburen P, LeWinter M, Meyer M. Beta-Blocker Cessation in Stable Outpatients With Heart Failure With a Preserved Ejection Fraction. J Card Fail. 2019 Aug 31. pii: S1071-9164(19)30616-5.
  5. Silverman DN, Plante TB, Infeld M, Callas PW, Juraschek SP, Dougherty GB, M Meyer. Beta-blocker Use and Heart Failure Hospitalizations in Patients with Preserved Ejection Fractions: A Secondary Analysis of the TOPCAT trial. JAMA Netw Open. 2019 Dec 2;2(12):e1916598.
  6. Meyer M, LeWinter MM. Heart Rate and Heart Failure With Preserved Ejection Fraction: Time to Slow β-Blocker Use? Circ Heart Fail. 2019 Aug;12(8):e006213. 
  7. Wahlberg K, Arnold ME, Lustgarten D, Meyer M. Effects of a Higher Heart Rate on Quality of Life and Functional Capacity in Patients with Left Ventricular Diastolic Dysfunction. Am J Cardiol. 2019 Oct 1;124(7):1069-1075.
Contact Info


(612) 625-9538

(612) 301-8298

Office Address:
4-165 Cancer & Cardiovascular Research Building