Chen Lab

The Chen Clinical Research Lab is focused on patient-oriented research related to atrial fibrillation and atrial myopathy with particular emphasis on 3 themes:

(1) To identify novel risk factors for atrial fibrillation and atrial myopathy, and discover new strategies to prevent both conditions,

(2) To characterize the relationship of atrial fibrillation and atrial myopathy to cardiovascular and neurocognitive outcomes such as stroke and dementia, and to elucidate the underlying mechanisms,

(3) To discover novel strategies to prevent complications related to atrial fibrillation and atrial myopathy

Lin Yee Chen, MD, MS faculty bio

Current Projects

NIH RF1 NS135615 (2023-2028): Cognitive Impairment and Dementia, Vascular Brain Injury, and Atrial Myopathy: Implications for Prevention of Alzheimer's Disease-Related Dementias
NIH RF1 NS127266 (2022-2027), Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related Dementias
NIH R01 AG075883 (2022-2027), Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related Dementias
NIH R01 HL158022 (2022-2026), Glucose patterns and cardiac arrhythmias in older adults with diabetes
NIH K24 HL155813 (2021-2026): Mentoring and Research to Classify Atrial Cardiomyopathy
NIH R01 HL141288 (2018-2023): Left Atrial Abnormality and Atrial Fibrillation-Related Cerebral Infarcts and Cognitive Decline
NIH R01 HL126637 (2016-2023): Significance of Atrial Fibrillation and Atrial Fibrillation Burden Detected by Novel ECG Monitoring in Community-Dwelling Elderly

Selected Publications

Ji Y, Zhang MJ, Wang W, Norby FL, Eaton AA, Inciardi RM, Alonso A, Sedaghat S, Ganz P, Van't Hof J, Solomon SD, Chaves PHM, Heckbert SR, Shah AM, Chen LY. Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS. Circulation. 2024 Nov 21. doi: 10.1161/CIRCULATIONAHA.124.070278. Epub ahead of print. PMID: 39569504.

Yao Y, Zhang MJ, Wang W, Zhong Z, He R, Ji Y, Knutson KA, Norby FL, Alonso A, Soliman EZ, Tang W, Pankow JS, Pan W, Chen LY. Multimodal Data Integration to Predict Atrial Fibrillation. Eur Heart J Digit Health. 2024 Jan:ztae081. doi: 10.1093/ehjdh/ztae081.

Inciardi RM, Wang W, Alonso A, Soliman EZ, Selvaraj S, Gonçalves A, Zhang MJ, Chandra A, Prasad NG, Skali H, Shah AM, Solomon SD, Chen LY. Cardiac mechanics and the risk of atrial fibrillation in a community-based cohort of older adults. Eur Heart J Cardiovasc Imaging. 2024 Nov 27;25(12):1686-1694. doi: 10.1093/ehjci/jeae162. PMID: 38959330.

Wang W, Lutsey PL, Inciardi RM, Reyes JL, Mosley TH, Johansen MC, Gottesman RF, Alonso A, Jack CR Jr, Solomon SD, Shah AM, Wasserman BA, Chen LY. Association of left atrial function with vascular brain injury: The Atherosclerosis Risk in Communities study. Eur J Neurol. 2024 Nov 21:e16549. doi: 10.1111/ene.16549. Epub ahead of print. PMID: 39569699.

Sun D, Parikh RR, Wang W, Eaton A, Lutsey PL, Windham BG, Inciardi RM, Solomon SD, Ballantyne CM, Shah AM, Chen LY. Association of left atrial function with frailty: The Atherosclerosis Risk in Communities (ARIC) study. J Am Geriatr Soc. 2024 Sep 13. doi: 10.1111/jgs.19187. Epub ahead of print. PMID: 39268991.

Maheshwari A, Norby FL, Inciardi RM, Wang W, Zhang MJ, Soliman EZ, Alonso A, Johansen MC, Gottesman RF, Solomon SD, Shah AM, Chen LY. Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke : A Prospective Cohort Study. Ann Intern Med. 2023 Jan;176(1):39-48. doi: 10.7326/M22-1638. Epub 2022 Dec 20. PMID: 36534978.

Wang W, Zhang MJ, Inciardi RM, Norby FL, Johansen MC, Parikh R, Van't Hof JR, Alonso A, Soliman EZ, Mosley TH, Gottesman RF, Shah AM, Solomon SD, Chen LY. Association of Echocardiographic Measures of Left Atrial Function and Size With Incident Dementia. JAMA. 2022 Mar 22;327(12):1138-1148. doi: 10.1001/jama.2022.2518. PMID: 35315884; PMCID: PMC8941355.

Inciardi RM, Claggett B, Minamisawa M, Shin SH, Selvaraj S, Gonçalves A, Wang W, Kitzman D, Matsushita K, Prasad NG, Su J, Skali H, Shah AM, Chen LY, Solomon SD. Association of Left Atrial Structure and Function With Heart Failure in Older Adults. J Am Coll Cardiol. 2022 Apr 26;79(16):1549-1561. doi: 10.1016/j.jacc.2022.01.053. PMID: 35450571.

Chen LY, Ribeiro ALP, Platonov PG, Cygankiewicz I, Soliman EZ, Gorenek B, Ikeda T, Vassilikos VP, Steinberg JS, Varma N, Bayés-de-Luna A, Baranchuk A. P Wave Parameters and Indices: A Critical Appraisal of Clinical Utility, Challenges, and Future Research-A Consensus Document Endorsed by the International Society of Electrocardiology and the International Society for Holter and Noninvasive Electrocardiology. Circ Arrhythm Electrophysiol. 2022 Apr;15(4):e010435. doi: 10.1161/CIRCEP.121.010435. Epub 2022 Mar 25. PMID: 35333097; PMCID: PMC9070127.

Maheshwari A, Norby FL, Roetker NS, Soliman EZ, Koene RJ, Rooney MR, O'Neal WT, Shah AM, Claggett BL, Solomon SD, Alonso A, Gottesman RF, Heckbert SR, Chen LY. Refining Prediction of Atrial Fibrillation-Related Stroke Using the P2-CHA2DS2-VASc Score. Circulation. 2019 Jan 8;139(2):180-191. doi: 10.1161/CIRCULATIONAHA.118.035411. PMID: 30586710; PMCID: PMC6481672.

Chen LY, Chung MK, Allen LA, Ezekowitz M, Furie KL, McCabe P, Noseworthy PA, Perez MV, Turakhia MP; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council. Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association. Circulation. 2018 May 15;137(20):e623-e644. doi: 10.1161/CIR.0000000000000568. Epub 2018 Apr 16. PMID: 29661944; PMCID: PMC8463258

Current Members