Andrew W. Grande, MD

Associate Professor and Co-director, Earl Grande, Vel, V. Richard Zerling Stroke, Stem Cell and Neuroimaging Laboratory, Department of Neurosurgery

Andrew W. Grande

Contact Info

grande@umn.edu

Office Phone 612-624-6666

Office Address:
Department of Neurosurgery
MMC 96 Room D429
420 Delaware Street SE
Minneapolis, MN 55455

Mailing Address:
Neurosurgery Department
MMC 96 Mayo
8096A (Campus Delivery Code)
420 Delaware St SE
Minneapolis, MN 55455

Administrative Assistant Name
Deborah Fellows

Administrative Phone
612-624-6666

Administrative Email
fello062@umn.edu

Associate Professor and Co-director, Earl Grande, Vel, V. Richard Zerling Stroke, Stem Cell and Neuroimaging Laboratory, Department of Neurosurgery

Faculty, Graduate Program in Neuroscience

Faculty, Masters Program in Stem Cell Biology

Associate Director, Residency Program, Department of Neurosurgery


Neurosurgeon


MD, University of Minnesota

Residency in Neurosurgery, University of Cincinnati

Fellowship in Vascular/Endocascular Neurosurgery, University of Cincinnati

Fellowship in Neural Stem Cells and Neurogenesis, Ludwig-Maximilians University, Germany

BA, St. Olaf College

Emerging Physicians Leadership Program, University of Minnesota

Minneapolis, MN, 2014-2017

Summary

Andrew Grande, MD, is from the Twin Cities. He grew up in the Minneapolis lakes area and then later moved to St. Paul where he attended high school at St. Thomas Academy. He graduated from St. Olaf College (Northfield, MN) with a BA in chemistry and then attended the University of Minnesota Medical School. During college and medical school, Dr. Grande was active in research, working in the laboratories of Drs Esam El Fakahany, Virginia Seybold and Walter Low. These experiences later culminated in a burning curiosity in and passion for using stem cells to treat stroke.

Dr. Grande completed his neurosurgical training at the Mayfield Clinic and University of Cincinnati. During his training, he worked very closely with Dr. John Tew, learning the nuances of trigeminal neuralgia treatment, including both microvascular decompression and radiofrequency ablation. He then went on to complete a fellowship with Mario Zuccarello, Andrew Ringer and Todd Abruzzo at the University of Cincinnati in both endovascular and cerebrovascular neurosurgery. During this time, Dr. Grande was exposed to intracranial bypass surgery for treating moyamoya disease and to cutting-edge endovascular treatments such as the use of Onyx glue for treating cerebral aneurysms.

During his residency and then continuing into his fellowship, Dr. Grande was involved in stem cell research with Dr. Masato Nakafuku at Cincinnati Children’s Hospital. Professor Nakafuku was one of the world's first to demonstrate neurogenesis in the hippocampus following stroke and he remains internationally recognized for his work with adult neurogenesis. In Nakafuku’s laboratory, Grande’s research focused primarily on reprogramming cells within the cerebral cortex to form neurons following stroke.

In 2010, Grande was the recipient of the William P. Van Wagenen Fellowship from the American Association of Neurological Surgeons. As a Van Wagenen Fellow, he traveled to Munich, Germany, where he completed a post-doctoral fellowship in the laboratory of Dr. Magdalena Gotz at Ludwig-Maximilians-Universitat. There he focused his research on identifying afferent connections to new neurons generated in the rodent cortex following a cortical layer specific injury.

Following his post-doctoral fellowship, Dr. Grande spent one month as a visiting neurosurgeon with Dr. Juha Hernesniemi in Helsinki, Finland.

Dr. Grande joined the University of Minnesota Department of Neurosurgery in 2011. His clinical interests are in treating cerebral vascular diseases, using either open vascular or endovascular techniques. He has specific interests in treating complex aneurysms, moyamoya disease, and trigeminal neuralgia.

Dr. Grande also directs the Earl Grande, Vel, V. Richard Zerling Stroke, Stem Cell and Neuroimaging Laboratory at the University of Minnesota. His research is focused on translating stem cell therapies for stroke from the bench to the bedside. Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming reactive astrocytes to form neurons, and characterizing normal adult neural stem cells found in the brains of humans and other large animals.

“It has always been a dream of mine to be a neurosurgeon in Minnesota, in particular at the University of Minnesota. I was born and raised here, my entire family is here and there is nothing I enjoy more than interacting with Minnesota patients. When contemplating places to work, I only considered Minnesota; I just knew I could be a better neurosurgeon here. I think there is something comforting in having a neurosurgeon with whom you have some connection.”

Philosophy of Care:

My philosophy is to care for others as I would my mother, father, wife or child. I ask my patients to call me “Andy” because it's important to be on a first name basis with those who entrust their lives with me. While neurosurgery is a world of unpredictable fates, I am committed to each patient to do my absolute best all the time.

Awards & Recognition

  • Mpls.St.Paul Magazine Top Doctors: 2019, 2020
  • Mpls.St.Paul Magazine Top Doctors: Rising Stars 2017, 2018
  • Minnesota Monthly Top Doctors: 2018, 2019, 2020
  • Champions of Care Award Recipient, Fairview Foundation, 2012, 2016
  • William P. Van Wagenen Award, American Association of Neurosurgeons, 2010

Professional Associations

  • American Association of Neurological Surgeons
  • American Heart/American Stroke Association
  • Congress of Neurological Surgeons
  • Congress of State Neurosurgical Societies
  • European Society for Gene and Cell Therapy
  • Facial Pain Association
  • Frank H. Mayfield Society
  • International Society for Stem Cell Research
  • Minnesota State Neurological Society
  • Minnesota Stroke Association
  • Society of Neurointervention

Research

Research Summary/Interests

Research Interests
Dr. Grande co-directs the Earl Grande, Vel, V. Richard Zarling Stroke, Stem Cell and Neuroimaging Laboratory at the University of Minnesota. His research interest is focused translating stem cell therapies for stroke from the "bench to the bedside." Ongoing studies include exogenous cord blood stem cell transplantation for neuroprotection, reprogramming of reactive astrocytes to form neurons, and characterization of normal adult neural stem cells found in the brains of humans and other large animals.

Research Funding Grants

  1. Individual KL2, NIH, Repairing the brain after stroke — neuroregenerative therapy in a canine model of stroke, 4/1/2018-3/31/2021
  2. Multi-PI, NIH-NINDS, Stem Cells for Treating Acute Stroke, 04/01/2019-03/31/2022
  3. PI, Minnesota Office of Higher Education, Harnessing Exosomes as a Biomarker and Therapeutic Approach to Traumatic Brain Injury, 7/10/2018 – 6/30/2020
  4. PI, Minnesota Office of Higher Education, Therapeutic application of non-hematopoietic umbilical cord blood stem cells (nh-UCBSCs in traumatic brain injury: immune modulation with acute and long-term benefits, 08/10/2017-06/30/2020
  5. PI, Minnesota Office of Higher Education, Reprogramming astrocytes into neurons to provide therapeutic benefit in TBI, 7/13/2018-6/30/2020
  6. Co-PI. Minnesota Office of Higher Education, Improving Functional Outcomes Through Optimization of Surgical Subdural Hematoma Evacuation Technique, 7/1/2019-6/30/2021
  7. Co-PI, Minnesota Office of Higher Education, Characterizing the Neuro-inflammation Associated with Sequential TBI in a Rodent Model, 7/1/2019-6/30/2021
  8. Co-I, NIH-NIDDK, A Novel Stem-based Approach for Generating Non-Human Primate Livers in Pigs, 4/2/2018-3/31/2022
  9. Co-I, NIH, Stem Cell Therapy to Modulate Stroke-Induced Progressive Brain Inflammation, 7/1/20-6/30/25

Publications

Impact Analytics

h-Index h(fl)-Index Total Publications First/Last Author Publications Total Citations First/Last Author Citations
9 9 30 12 339

Publications

Peer-Reviewed Publications (10 most recent)

  1. Darrow DP, Spano A, Grande A. The Potential for Undue Patient Exposures during the Use of Telementoring Technology. Cureus 2020, 8 April. 12(4): e7594, doi 107759/cureus.7594.
  2. Boltza J, Modo MM, Mays RW, Taguchi A, Jolkkonen J, Savitz S, (STEPS 4 participants Bates D, Bath P, Carmichael ST, Cox Jr CS, Daadi MM, Tejedo ED, Grande AW, Gutiérrez Fernández María , Hematti P, Hess D, Huang DY, Kokaia Z, Kuroda S, Moniche FP, Muir K, Olson S, Rosado de Castro PH, Sinden J, Satani N, Shichinohe H, Steinberg GK, Walczak P, Wechsler L, West F, Vahidy F, Vawter DE, Yavagal DR, Yang B, Zrinzo L). Stem Cells as an Emerging Paradigm in Stroke 4.:Advancing and Accelerating Preclinical Research. Stroke. 2019 50:3299‐3306. PMID 31658004. Cited: NA; Impact factor: 6.032
  3. Sude A, Nixdorf DR, Grande AW. Human papillomavirus – positive oropharyngeal squamous cell carcinoma manifesting as glossopharyngeal neuralgia. Journal of the American Dental Association. 2019 150(12) 1059-1061. Cited: 0; Impact Factor 2.786
  4. Sorenson TJ, Mehta T, Grande AW. Which Aneurysm Ruptured? Journal of Clinical and Medical Images. 2019, Sept 15 2 (2). Cited: 0; Impact Factor 1.820
  5. Chrostek MR, Fellows EG, Guo WL, Swanson WJ, Crane AT, Cheeran MC, Low WC, Grande AW. Efficacy of Cell-Based Therapies for Traumatic Brain Injuries. Brain Sciences. 2019; Sep‐Oct; 28(9‐10): 1091‐1105. PMID 31426665. Cited: 0; Impact Factor: 3.477
  6. Crane AT, Aravalli RN, Asakura A, Grande AW, Krishna VD, Carlson DF, Cheeran MCJ, Danczyk G, Dutton JR, Hackett PB, Hu WS, Li L, Lu WC, Miller ZD, O’Brien TD, Panoskaltsis-Mortari A, Parr AM, Pearce C, Ruiz-Estevez M, Shiao M, Sipe CJ, Toman NG, Joseph J, Xie1 H, Steer CJ, Low WC. Interspecies Organogenesis for Human Transplantation. Cell Transplantation2019; Sep‐Oct; 28(9‐10): 1091‐1105. PMID 31426665. Cited: 0; Impact Factor: 3.477
  7. Blackburn, SL, Grande AW, Swisher CB, Hauck EF, Jagadeesan B, Provencio JJ. Prospective Trial of Cerebrospinal Fluid Filtration After Aneuyrsmal Subachnoic Hemorrhage via Lumber Catheter. Stroke. 2019, Sept, 2558‐2561. DOI: 10.1161/STROKEAHA.119.025399. Cited 1; Impact Factor 6.032
  8. Toman N, Grande A, Low W. Neural Repair in Stroke. Cell Transplantation. 2019, Jul 29: 963689719863784. PMID 31353939. Cited: 0; Impact Factor: 2.885. Role: Concept, design, manuscript preparation, editing, review.
  9. Mehta T, Patel S, Male S, Zhang A, Khan A, Narwal P, Grande A, Tummala R, Jagadeesan Bharathi. Readmission Trends Related to Unruptured Intracranial Aneurysm Treatment. Stroke. 2019; 50.10.1161/str.50.suppl_1.WP120. Cited: 0; Impact Factor: 6.032. Role: Manuscript preparation, editing, review.
  10. Blackburn, SL, Grande AW, Swisher CB, Hauck EF, Jagadeesan B, Provencio JJ. Prospective Trial of Cerebrospinal Fluid Filtration After Aneuyrsmal Subachnoic Hemorrhage via Lumber Catheter. Stroke. 2019, Sept, 2558-2561. DOI: 10.1161/STROKEAHA.119.025399. Cited 1; Impact Factor 6.032.

Non-Peer-Reviewed Publications

  1. Grande AW, Laarson AS, Steevens A. Continued Hope for Stem Cells and Ischemic Strokew: Review and Future Perspectives. Congress Quarterly. Congress of Neurological Surgeons. Spring 2020
  2. Grande A, Grewal S. Allergic to Nickel? Be Sure to Let Your Doctor Know! The Mayfield Brain & Spinal Column. 2014. Role: Guarantor of integrity of entire study, developed study concept, developed study design, conducted literature research, manuscript editing, manuscript review.
  3. Grande A. Making the Leap from Bench to Bedside: The Promise and Present State of Stem Cell Therapy in Treating Stroke. Minnesota Physician. 2013, 26(11). Role: Guarantor of integrity of entire study, developed study concept, developed study design, conducted literature research, manuscript preparation, manuscript editing, manuscript review.
  4. Grande A, Tummala R, Jagadeesan B (2012) Carotid Artery Disease - Heading to the OR to Reduce the Risk of Stroke. Minnesota Physician. 2012; 26(5). Roles: Guarantor of integrity of entire study, developed study concept, conducted literature research, manuscript preparation, manuscript editing, manuscript review.
  5. Tew J., Grande A. Percutaneous Stereotactic Radiofrequency Treatment of Trigeminal Neuralgia. 2008. COSMAN Procedure Technique Series. Role: Guarantor of integrity of entire study, conducted literature research, manuscript preparation, editing.

Chapters in Books

  1. Robertson J, Sorenson J, Grande A, Brown M. Visualization and Optics in Neurosurgery. In Youmans and Winn Neurological Surgery, 7/e, 2016.
  2. Ringer AJ, Grande AW, Grossman AW, Andaluz N, Abruzzo T and Zuccarello M. Diagnosis and Treatment of Post-Hemorrhagic Cerebral Vasospasm. In Youmans and Winn Neurological Surgery, 7/e, 2016.
  3. Stone LL, Low WC, Grande A. Stem Cell Therapies for Ischemic Stroke, In Laurent Lescaudron, Julien Rossignol, Gary L. Dunbar, eds. Stem Cells and Neurodegenerative Diseases, CRC Press (2013) Roles: Guarantor of integrity of entire study; manuscript editing; manuscript review
  4. Nakafuku M, Grande A. (2013) Neurogenesis in the Damaged Mammalian Brain, Chapter 29. In John Rubenstein and Pasko Rakic, eds. Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience. Elsevier/Academic Press. Roles: Conducted literature research; manuscript preparation; manuscript editing; manuscript review
  5. Morgan C, Grande A, Tew J. (2012) Percutaneous Stereotactic Rhizotomy in the Treatment of Intractable Facial Pain, Chapter 124. In Alfredo Quinones-Hinojosa ed. Schmidek & Sweet, Sixth Edition. Elsevier/Saunders Roles: Conducted literature research; manuscript preparation; manuscript editing; manuscript review
  6. Ringer A, Nichols C, Khan S, Grande A, Khan U, Pyne-Geithman G, Abruzzo T. (2011) Angioplasty and Stenting for Management of Intracranial Arterial Stenosis, Chapter 31. In Bernard Bendok, Andrew Naidech, and Hunt Batjer, eds. Hemorrhagic and Ischemic Stroke: Surgical, Interventional, Imaging, and Medical Approaches. Thieme Roles: Guarantor of integrity of entire study; manuscript preparation; manuscript editing; manuscript review
  7. Grande A., Morgan C., Tew J. (2011) Percutaneous Stereotactic Rhizotomy. In Peter Jennetta, eds, Trigeminal Neuralgia, Oxford University Press (New York) Roles: Guarantor of integrity of entire study; conducted literature research; manuscript preparation; manuscript editing
  8. Tew J., Grande A., (2008) Percutaneous Stereotactic Radiofrequency Treatment of Trigeminal Neuralgia. COSMAN Procedure Technique Series Roles: Guarantor of integrity of entire study; defined intellectual content; conducted literature research; manuscript preparation; manuscript editing
  9. Choutka O., Grande A., Kuntz IV C. (2006) Posterior Thoracic Instrumentation with Pedicle Screws, Hooks, Wires, and Rods. Neurosurgical Operative Atlas, Spine and Peripheral Nerve 2nd Edition Roles: Manuscript editing; manuscript review

Presentations

Invited Oral Presentations at International Professional Meetings, Conferences, etc.

  1. Facial Pain. University of Minnesota Facial Pain Center (Karolinska Institute (Sweden) / University of Minnesota Pain Research Meeting). 4 June 2019.
  2. Cellular reprogramming for stroke treatment. ASNTR (American Society for Neural Therapy and Repair), Clearwater Beach, Florida. 25 February 2019.
  3. Clinical Trials: Bench to Clinic. Saudi Association of Neurological Surgery Annual Meeting & 2nd Arab Pediatric Neurosurgery Annual Meeting Joint Conference. Riyadh, Saudi Arabia. 8 April 2017.
  4. Stem Cells Therapy in the Central Nervous System: Bench to Clinic. Saudi Association of Neurological Surgery Annual Meeting & 2nd Arab Pediatric Neurosurgery Annual Meeting Joint Conference. Riyadh, Saudi Arabia. 8 April 2017
  5. Training in Endovascular Neurosurgery: Dual Trained Neurosurgeons Panel Discussion, Neurovascon Conference, Bangalore, India, September 2014
  6. Treatment of Aneurysms - Moving Forward with a Toolbox Approach, Keynote Speaker, Neurosurgery Alor Star Summit, Penang, Malaysia, April 2012
  7. Trigeminal Neuralgia: Different Treatment, Neurosurgery Alor Star Summit, Penang, Malaysia, April 2012
  8. Evolving Treatments for Stroke - A New Renaissance, Keynote Speaker, Neurosurgery Alor Star Summit, Penang, Malaysia, April 2012
  9. Single Center Experience with Onyx HD500 for Intracranial Aneurysms: Is general anesthesia required?, Invited Speaker, Technical University, Department of Neurosurgery, München, Germany, 2011
  10. Microscopic and Endoscopic Approaches to the Skull Base Course, Laboratory Instructor, Laproscopic Training Center, Strasbourg, France 2011

Invited Oral Presentations at National Professional Meetings, Conferences, etc. (Most Recent)

  1. Complications and Avoidance in Bypass Surgery. University of Wisconsin Cerebrovascular Course, University of Wisconsin, Madison. 14 September 2019.
  2. Bypass Indications and Types of Revascularizations. University of Wisconsin Cerebrovascular Course, University of Wisconsin, Madison. 14 September 2019.
  3. Neurocritical Care. Integra Advanced Neuroanatomy Course. UM, 1 -2 May 2019
  4. Cellular Reprogramming. ASNTR 2019 Conference, Tampa, FL. 26 April 2019.
  5. Neuroanatomy. Integra Advanced Neuroanatomy Course. UM, 29-30 October 2018
  6. Neurocritical Care. Integra Advanced Neuroanatomy Course. UM, 29-30 October 2018
  7. Mechanical Embolectomy. AANS/NREF Endovascular and Vascular Techniques Course for Senior Residents, MERI Lab, Memphis TN. October 12, 2018.
  8. AVM Resection. AANS/NREF Endovascular and Vascular Techniques Course for Senior Residents, MERI Lab, Memphis TN. October 13, 2018.
    Developing a Business Plan. CNS Leadership in Healthcare Course 
  9. Webinar. Faculty, Webinar. 20 June 2018.
  10. Stem Cells Therapy for Stroke. 2018 AANS Annual Scientific Meeting. New Orleans LA. 2 May 2018.

Poster Abstract Presentations at Professional Meetings, Conferences, etc. (most recent)

  1. Radha S, Steevens A, Marron E, Crane A, Grande A, Low W. Cellular Reprogramming in Experimental Parkinson’s disease model. Neuroscience 2019. Society for Neuroscience, October 2019.
  2. Steevens A, Radha S, Marron E, Crane A, Parr A, Grande A, Low W. Characterizing Astrocytes as a cell source for transplantation and reprogramming to repair the brain. Neuroscience 2019. Society for Neuroscience, October 2019.
  3. Fellows EG, Crane AT, Toman NG, Steevens AR, Chrostek MR, Grande AW. Viral reprogramming of reactive astrocytes to neurons as a therapy for cerebral injury. Neuroscience 2019. Society for Neuroscience. October 2019.
  4. Shih ED, Barocas VH, Grande AW, Alford, PW. Extracellular Stiffness Influences Vascular Smooth Muscle Cell Mechanical Properties. 2019 Society of Engineering Sciences Conference. St Louis MO. 13 October 2019.
  5. Emmitt N, Krishna VD, Crane A, Grande A, Low W, Cheeran M. Profiling temporal changes in immune cell phenotypes in traumatic brain injury. Neurotrauma 2019 (National Neurotrauma Society), Pittsburgh PA. 29 June 2019.
  6. Crane A, Grande A. Gene therapy to reprogram astrocytes into neurons following cerebral injury. ISSCR 2019 Annual Meeting, Los Angeles CA. 26 June 2019.
  7. Mulford K , Lenglet C, Pisharad P, Moen S , Nixdorf DR, Jagadeesan BD, Grande AW, Van de Moort P-F. Toward identifying individual branches of the trigeminal nerve with dMRI-based tractography at 7 Tesla: methodological considerations. ISMRM (International Society for Magnetic Resonance in Medicine), Montreal. 11 May 2019.
  8. Crane AT, Fellows E, DesJardin B, Lim J, Dahlquist E, Grande AW. Viral reprogramming of reactive astrocytes into neurons as a regenerative therapy in stroke. European Society of Gene & Cell Therapy, Lausanne Switzerland. 17 October 2018.
  9. Fellows E, Crane AT, Grande AW. Evaluating the use of Adeno-Associated Virus as a Vehicle for Reprogramming Reactive Glial Cells After Stroke Into Neurons. UM Clinical and Translational Science Institute.
  10. Blackburn SL, Swisher CB, Hauck EF, Jagadeesan B, Grande AW. Cerebrospinal Fluid Filtration in Aneurysmal Subarachnoid Hemorrhage Patients: Results from the PILLAR Feasibility Trial. CNS Annual Meeting, October 8, 2018.

Clinical

Clinics

Clinics and Surgery Center;Neurosurgery Clinic

Board Certifications

American Board of Neurosurgeons, Diplomate

Clinical Interests

Cerebral aneurysms, arteriovenous malformations (AVMs); Carotid artery disease; Trigeminal neuralgia; Hemifacial spasm; Intracranial/extracranial stenosis; Moya Moya disease; Skull-base surgery; Stem cells and the treatment of stroke

Hospital Privileges

Fairview Health Systems Fairview University Medical Center Fairview Southdale Hospital Hennepin County Medical Center Park Nicollet Methodist Hospital Minneapolis VA Medical Center

Community Engagement

Minnesota Brain Injury Alliance 2011-present

  • Board Member, elected 2013-present
  • Advocacy Committee, appointed 2012-present

Minnesota Stroke Association 2011-present

  • Partnership Committee, appointed 2011-present
  • Conference Planning Committee, appointed 2011-present

Media

Video

Video

Why Andrew Grande Does What He Does

U of MN Health Sciences Expert Link

U of MN - Health Experts Page