Past Publications (2015-2023)

2023 Publications

Editorial: Immune mechanisms of inflammation in NASH.
Hirsova P, Revelo XS.
Front Endocrinol (Lausanne). 2022 Sep 21;13:1039238. doi: 10.3389/fendo.2022.1039238. eCollection 2022.
PMID: 36213275

Effectiveness and Safety of Colonic and Capsule Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.
Vaughn BP, Fischer M, Kelly CR, Allegretti JR, Graiziger C, Thomas J, McClure E, Kabage AJ, Khoruts A.
Clin Gastroenterol Hepatol. 2022 Sep 17:S1542-3565(22)00880-1. doi: 10.1016/j.cgh.2022.09.008. Online ahead of print.
PMID: 36126907

Non-criteria antiphospholipid antibodies and pediatric rheumatic disease: a case series.
Mahmud SA, Bullock DR, Correll CK, Hobday PM, Riskalla MM, Vehe RK, Binstadt BA.
Pediatr Rheumatol Online J. 2022 Aug 20;20(1):70. doi: 10.1186/s12969-022-00732-4.
PMID: 35987646

Functional virus-specific memory T cells survey glioblastoma. 
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC. 
Cancer Immunol Immunother. 2022 Aug;71(8):1863-1875. doi: 10.1007/s00262-021-03125-w. Epub 2022 Jan 10.
PMID: 35001153

Natural Killer Cell Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Against Plasmodium falciparum-Infected Red Blood Cells.
Dick JK, Hart GT.
Methods Mol Biol. 2022;2470:641-657. doi: 10.1007/978-1-0716-2189-9_48.
PMID: 35881380

Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion.
Breed ER, Vobořil M, Ashby KM, Martinez RJ, Qian L, Wang H, Salgado OC, O'Connor CH, Hogquist KA.
Nat Immunol. 2022 Jul;23(7):1042-1051. doi: 10.1038/s41590-022-01218-x. Epub 2022 May 30.
PMID: 35637352

Targeted sequencing of candidate gene regions for myelofibrosis in dogs.
Campbell AG, Seelig DM, Beckman JD, Minor KM, Heinrich DA, Friedenberg SG, Modiano JF, Furrow E.
J Vet Intern Med. 2022 Jul;36(4):1237-1247. doi: 10.1111/jvim.16476. Epub 2022 Jul 11.
PMID: 35815881

Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction.
Hong SW, Krueger PD, Osum KC, Dileepan T, Herman A, Mueller DL, Jenkins MK.
Nature. 2022 Jul;607(7920):762-768. doi: 10.1038/s41586-022-04916-6. Epub 2022 Jul 6.
PMID: 35794484

Retinoic acid signaling acts as a rheostat to balance Treg function.
Thangavelu G, Andrejeva G, Bolivar-Wagers S, Jin S, Zaiken MC, Loschi M, Aguilar EG, Furlan SN, Brown CC, Lee YC, Hyman CM, Feser CJ, Panoskaltsis-Mortari A, Hippen KL, MacDonald KP, Murphy WJ, Maillard I, Hill GR, Munn DH, Zeiser R, Kean LS, Rathmell JC, Chi H, Noelle RJ, Blazar BR.
Cell Mol Immunol. 2022 Jul;19(7):820-833. doi: 10.1038/s41423-022-00869-y. Epub 2022 May 17.
PMID: 35581350

Combining nilotinib and PD-L1 blockade reverses CD4+ T-cell dysfunction and prevents relapse in acute B-cell leukemia.
Tracy SI, Venkatesh H, Hekim C, Heltemes-Harris LM, Knutson TP, Bachanova V, Farrar MA.
Blood. 2022 Jul 28;140(4):335-348. doi: 10.1182/blood.2021015341.
PMID: 35275990

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.
Zhang Z, Salgado OC, Liu B, Moazzami Z, Hogquist KA, Farrar MA, Ruan HB.
Front Immunol. 2022 Jul 8;13:874863. doi: 10.3389/fimmu.2022.874863. eCollection 2022.
PMID: 35874700 

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.
Wanhainen KM, Peng C, Zhou MH, Macedo BG, O'Flanagan S, Yang T, Kelekar A, Burbach BJ, Borges da Silva H, Jameson SC.
Cancer Immunol Res. 2022 Jul 1;10(7):871-884. doi: 10.1158/2326-6066.CIR-21-0691.
PMID: 35588154

Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease.
Pape KA, Dileepan T, Matchett WE, Ellwood C, Stresemann S, Kabage AJ, Kozysa D, Evert C, Matson M, Lopez S, Krueger PD, Graiziger CT, Vaughn BP, Shmidt E, Rhein J, Schacker TW, Bold TD, Langlois RA, Khoruts A, Jenkins MK.
JCI Insight. 2022 Jun 22;7(12):e159618. doi: 10.1172/jci.insight.159618.
PMID: 35730567

Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer.
Wenzel AT, Champa D, Venkatesh H, Sun S, Tsai CY, Mesirov JP, Bui JD, Howell SB, Harismendy O.
NPJ Syst Biol Appl. 2022 Jun 17;8(1):20. doi: 10.1038/s41540-022-00230-z.
PMID: 35715421

CD47 Promotes Autoimmune Valvular Carditis by Impairing Macrophage Efferocytosis and Enhancing Cytokine Production.
Meier LA, Faragher JL, Osinski V, Auger JL, Voeller R, Marath A, Binstadt BA.
J Immunol. 2022 Jun 15;208(12):2643-2651. doi: 10.4049/jimmunol.2100903. Epub 2022 Jun 3.
PMID: 35867674

Unravelling the sex-specific diversity and functions of adrenal gland macrophages.
Dolfi B, Gallerand A, Firulyova MM, Xu Y, Merlin J, Dumont A, Castiglione A, Vaillant N, Quemener S, Gerke H, Stunault MI, Schrank PR, Kim SH, Zhu A, Ding J, Gilleron J, Magnone V, Barbry P, Dombrowicz D, Duranton C, Wakkach A, Blin-Wakkach C, Becher B, Pagnotta S, Argüello RJ, Rantakari P, Chakarov S, Ginhoux F, Zaitsev K, Kim KW, Yvan-Charvet L, Guinamard RR, Williams JW, Ivanov S.
Cell Rep. 2022 Jun 14;39(11):110949. doi: 10.1016/j.celrep.2022.110949.
PMID: 35705045

Macrophage Fate Mapping.
Xu Y, Schrank PR, Williams JW.
Curr Protoc. 2022 Jun;2(6):e456. doi: 10.1002/cpz1.456.
PMID: 35687806

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.
Teigen L, Mathai PP, Lopez S, Matson M, Elkin B, Kozysa D, Kabage AJ, Hamilton M, Vaughn BP, Sadowsky MJ, Khoruts A.
Clin Nutr. 2022 Jun;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Epub 2022 Apr 5.
PMID: 35500315

Embracing the heterogeneity of natural viruses in mouse studies.
Fiege JK, Langlois RA.
J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001758.PMID: 35737518

Parabiosis in Mice to Study Tissue Residency of Immune Cells.
Wang H, Gavil NV, Koewler N, Masopust D, Jameson SC.
Curr Protoc. 2022 May;2(5):e446. doi: 10.1002/cpz1.446.
PMID: 35612420

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine. 
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21
PMID: 35446142

Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats.
Baehr C, Robinson C, Kassick A, Jahan R, Gradinati V, Averick SE, Runyon SP, Pravetoni M.
ACS Omega. 2022 May 4;7(19):16584-16592. doi: 10.1021/acsomega.2c00820. eCollection 2022 May 17.
PMID: 35601290

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Mills LJ, Scott MC, Shah P, Cunanan AR, Deshpande A, Auch B, Curtin B, Beckman KB, Spector LG, Sarver AL, Subramanian S, Richmond TA, Modiano JF.
Bone. 2022 May;158:115716. doi: 10.1016/j.bone.2020.115716. Epub 2020 Oct 27.
PMID: 33127576

γδ Thymocyte Maturation and Emigration in Adult Mice. 
Joannou K, Golec DP, Wang H, Henao-Caviedes LM, May JF, Kelly RG, Chan R, Jameson SC, Baldwin TA.
J Immunol. 2022 May 1;208(9):2131-2140. doi: 10.4049/jimmunol.2100360. Epub 2022 Apr 8. 
PMID: 35396221

Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Chen J, Farrugia G, Redinbo MR, Grover M.
Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038/s41564-022-01103-1. Epub 2022 Apr 28.
PMID: 35484230

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine.
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21.
PMID: 35446142

Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.
Baehr CA, Wu MM, Pandit SG, Arias-Umana J, AuCoin D, Pravetoni M.
J Pharmacol Exp Ther. 2022 May;381(2):129-136. doi: 10.1124/jpet.121.001048. Epub 2022 Feb 13.
PMID: 35153198

A dominant function of LynB kinase in preventing autoimmunity. 
Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. 
Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. 
PMID: 35452291

Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.
Crouse B, Wu MM, Gradinati V, Kassick AJ, Song D, Jahan R, Averick S, Runyon S, Comer SD, Pravetoni M.
ACS Pharmacol Transl Sci. 2022 Apr 20;5(5):331-343. doi: 10.1021/acsptsci.1c00260. eCollection 2022 May 13.
PMID: 35592436

Brown adipose tissue involution associated with progressive restriction in progenitor competence.
Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB.
Cell Rep. 2022 Apr 12;39(2):110575. doi: 10.1016/j.celrep.2022.110575.
PMID: 35417710

The Conundrum of Lung Disease and Drug Hypersensitivity-like Reactions in Systemic Juvenile Idiopathic Arthritis.
Binstadt BA, Nigrovic PA.
Arthritis Rheumatol. 2022 Apr 12. doi: 10.1002/art.42137. Online ahead of print.
PMID: 35413159

Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. 
Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. 
Immunity. 2022 Apr 12;55(4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5.PMID: 35385697

Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer.
Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. 
JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. 
PMID: 35393950

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
Brian BF 4th, Sjaastad FV, Freedman TS.
Sci Rep. 2022 Apr 7;12(1):5875. doi: 10.1038/s41598-022-09589-9. 
PMID: 35393453

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.
Teigen L, Mathai PP, Lopez S, Matson M, Elkin B, Kozysa D, Kabage AJ, Hamilton M, Vaughn BP, Sadowsky MJ, Khoruts A.
Clin Nutr. 2022 Apr 5;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Online ahead of print.
PMID: 35500315

The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8+ T Cells. 
Vardam-Kaur T, van Dijk S, Peng C, Wanhainen KM, Jameson SC, Borges da Silva H.
J Immunol. 2022 Apr 1;208(7):1686-1699. doi: 10.4049/jimmunol.2100555. Epub 2022 Mar 9.
PMID: 35264459

Glucosamine facilitates cardiac ischemic recovery via recruiting Ly6Clow monocytes in a STAT1 and O-GlcNAcylation-dependent fashion.
Zhou W, Jiang X, Tang Q, Ding L, Xiao W, Li J, Wu Y, Ruan HB, Shen Z, Chen W.
Clin Transl Med. 2022 Mar;12(3):e762. doi: 10.1002/ctm2.762. 
PMID: 35343077

Toll-like Receptor 7 and 8 Imidazoquinoline-Based Agonist/Antagonist Pairs. 
Yang M, Larson PG, Brown L, Schultz JR, Kucaba TA, Griffith TS, Ferguson DM. 
Bioorg Med Chem Lett. 2022 Mar 1;59:128548. doi: 10.1016/j.bmcl.2022.128548. Epub 2022 Jan 18.
PMID: 35051578

Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells. 
Hullsiek R, Li Y, Snyder KM, Wang S, Di D, Borgatti A, Lee C, Moore PF, Zhu C, Fattori C, Modiano JF, Wu J, Walcheck B. 
Front Immunol. 2022 Feb 24;13:841859. doi: 10.3389/fimmu.2022.841859. eCollection 2022. 
PMID: 35281028

Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens. 
Hester AK, Semwal MK, Cepeda S, Xiao Y, Rueda M, Wimberly K, Venables T, Dileepan T, Kraig E, Griffith AV. 
Cell Rep. 2022 Feb 15;38(7):110363. doi: 10.1016/j.celrep.2022.110363. 
PMID: 35172147

Insufficiency of compound immune checkpoint blockade to overcome engineered T cell exhaustion in pancreatic cancer.
Stromnes IM, Hulbert A, Rollins MR, Basom RS, Delrow J, Bonson P, Burrack AL, Hingorani SR, Greenberg PD. 
J Immunother Cancer. 2022 Feb;10(2):e003525. doi: 10.1136/jitc-2021-003525.
PMID: 35210305

Characterization of influenza A virus induced transposons reveals a subgroup of transposons likely possessing the regulatory role as eRNAs. 
Shen SS, Nanda H, Aliferis C, Langlois RA. 
Sci Rep. 2022 Feb 9;12(1):2188. doi: 10.1038/s41598-022-06196-6. 
PMID: 35140280

Natural rodent model of viral transmission reveals biological features of virus population dynamics.
Fay EJ, Balla KM, Roach SN, Shepherd FK, Putri DS, Wiggen TD, Goldstein SA, Pierson MJ, Ferris MT, Thefaine CE, Tucker A, Salnikov M, Cortez V, Compton SR, Kotenko SV, Hunter RC, Masopust D, Elde NC, Langlois RA.
J Exp Med. 2022 Feb 7;219(2):e20211220. doi: 10.1084/jem.20211220. Epub 2021 Dec 27. 
PMID: 34958350

Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles. 
Tan HX, Juno JA, Esterbauer R, Kelly HG, Wragg KM, Konstandopoulos P, Alcantara S, Alvarado C, Jones R, Starkey G, Wang BZ, Yoshino O, Tiang T, Grayson ML, Opdam H, D'Costa R, Vago A; Austin Liver Transplant Perfusionist Group, Mackay LK, Gordon CL, Masopust D, Groom JR, Kent SJ, Wheatley AK. 
Sci Immunol. 2022 Jan 28;7(67):eabf5314. doi: 10.1126/sciimmunol.abf5314. Epub 2022 Jan 28.
PMID: 35089815

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells. 
Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC.
Immunity. 2022 Jan 11;55(1):98-114.e5. doi: 10.1016/j.immuni.2021.11.017. Epub 2021 Dec 20.
PMID: 34932944

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
Evrard M, Wynne-Jones E, Peng C, Kato Y, Christo SN, Fonseca R, Park SL, Burn TN, Osman M, Devi S, Chun J, Mueller SN, Kannourakis G, Berzins SP, Pellicci DG, Heath WR, Jameson SC, Mackay LK.
J Exp Med. 2022 Jan 3;219(1):e20210116. doi: 10.1084/jem.20210116. Epub 2021 Oct 22.
PMID: 34677611

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.
Ubah OC, Lake EW, Gunaratne GS, Gallant JP, Fernie M, Robertson AJ, Marchant JS, Bold TD, Langlois RA, Matchett WE, Thiede JM, Shi K, Yin L, Moeller NH, Banerjee S, Ferguson L, Kovaleva M, Porter AJ, Aihara H, LeBeau AM, Barelle CJ. 
Nat Commun. 2021 Dec 16;12(1):7325. doi: 10.1038/s41467-021-27611-y. 
PMID: 34916516

Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells.
Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC.
 Immunity. 2021 Dec 14:S1074-7613(21)00509-4. doi: 10.1016/j.immuni.2021.11.017. Online ahead of print. 
PMID: 34932944

Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis.
Revelo XS, Parthiban P, Chen C, Barrow F, Fredrickson G, Wang H, Yücel D, Herman A, van Berlo JH. 
Circ Res. 2021 Dec 3;129(12):1086-1101. doi: 10.1161/CIRCRESAHA.121.319737. Epub 2021 Oct 14.
PMID: 34645281

Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation.
Lee RD, Munro SA, Knutson TP, LaRue RS, Heltemes-Harris LM, Farrar MA.
Nat Commun. 2021 Nov 25;12(1):6843. doi: 10.1038/s41467-021-27232-5.
PMID: 34824268

Genetic ancestry effects on the response to viral infection are pervasive but cell type specific.
Randolph HE, Fiege JK, Thielen BK, Mickelson CK, Shiratori M, Barroso-Batista J, Langlois RA, Barreiro LB.
Science. 2021 Nov 26;374(6571):1127-1133. doi: 10.1126/science.abg0928. Epub 2021 Nov 25.
PMID: 34822289

Cancer Immunology and Immunotherapies: Mechanisms That Affect Antitumor Immune Response and Treatment Resistance.
Zhao X, Subramanian S.
Cancers (Basel). 2021 Nov 12;13(22):5655. doi: 10.3390/cancers13225655.
PMID: 34830808

Simultaneous Engagement of Tumor and Stroma Targeting Antibodies by Engineered NK-92 Cells Expressing CD64 Controls Prostate Cancer Growth.
Hintz HM, Snyder KM, Wu J, Hullsiek R, Dahlvang JD, Hart GT, Walcheck B, LeBeau AM. 
Cancer Immunol Res. 2021 Nov;9(11):1270-1282. doi: 10.1158/2326-6066.CIR-21-0178. Epub 2021 Aug 27.

STAT5 is activated in macrophages by breast cancer cell-derived factors and regulates macrophage function in the tumor microenvironment.
Jesser EA, Brady NJ, Huggins DN, Witschen PM, O'Connor CH, Schwertfeger KL.
Breast Cancer Res. 2021 Nov 7;23(1):104. doi: 10.1186/s13058-021-01481-0.
PMID: 34743736

Methanogen Abundance Thresholds Capable of Differentiating In Vitro Methane Production in Human Stool Samples.
Teigen L, Mathai PP, Matson M, Lopez S, Kozysa D, Kabage AJ, Hamilton MJ, Vaughn BP, Sadowsky MJ, Khoruts A.
Dig Dis Sci. 2021 Nov;66(11):3822-3830. doi: 10.1007/s10620-020-06721-5. Epub 2020 Nov 28. 
PMID: 33247793

Mice with diverse microbial exposure histories as a model for preclinical vaccine testing.
Fiege JK, Block KE, Pierson MJ, Nanda H, Shepherd FK, Mickelson CK, Stolley JM, Matchett WE, Wijeyesinghe S, Meyerholz DK, Vezys V, Shen SS, Hamilton SE, Masopust D, Langlois RA.
Cell Host Microbe. 2021 Oct 27:S1931-3128(21)00463-7. doi: 10.1016/j.chom.2021.10.001. Online ahead of print.
PMID: 34731647

Autoimmunity Increases Susceptibility to and Mortality from Sepsis.
Jensen IJ, Jensen SN, McGonagill PW, Griffith TS, Mangalam AK, Badovinac VP.
Immunohorizons. 2021 Oct 26;5(10):844-854. doi: 10.4049/immunohorizons.2100070.
PMID: 34702761

Emerging Roles of T Cells in the Pathogenesis of Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
Hirsova P, Bamidele AO, Wang H, Povero D, Revelo XS.
Front Endocrinol (Lausanne). 2021 Oct 28;12:760860. doi: 10.3389/fendo.2021.760860. eCollection 2021.
PMID: 34777255

Can FMT cause or prevent CRC? Maybe, but there is more to consider. 
Khoruts A. 
Gastroenterology. 2021 Oct;161(4):1103-1105. doi: 10.1053/j.gastro.2021.06.074. Epub 2021 Jul 2.
PMID: 34224741

Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset.
Huggins DN, LaRue RS, Wang Y, Knutson TP, Xu Y, Williams JW, Schwertfeger KL. 
Cancer Res. 2021 Oct 15;81(20):5284-5295. doi: 10.1158/0008-5472.CAN-21-0101. Epub 2021 Aug 13. 
PMID: 34389631

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells.
Jensen IJ, Li X, McGonagill PW, Shan Q, Fosdick MG, Tremblay MM, Houtman JC, Xue HH, Griffith TS, Peng W, Badovinac VP.
Elife. 2021 Oct 15;10:e70989. doi: 10.7554/eLife.70989. Online ahead of print.
PMID: 34652273

ACKR4 in Tumor Cells Regulates Dendritic Cell Migration to Tumor-Draining Lymph Nodes and T-Cell Priming.
Wangmo D, Premsrirut PK, Yuan C, Morris WS, Zhao X, Subramanian S.
Cancers (Basel). 2021 Oct 7;13(19):5021. doi: 10.3390/cancers13195021.
PMID: 34638505 

Phenotypic and Functional Diversity in Regulatory T Cells.
Sjaastad LE, Owen DL, Tracy SI, Farrar MA.
Front Cell Dev Biol. 2021 Sep 23;9:715901. doi: 10.3389/fcell.2021.715901. eCollection 2021.
PMID: 34631704

High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines. 
Pape KA, Dileepan T, Kabage AJ, Kozysa D, Batres R, Evert C, Matson M, Lopez S, Krueger PD, Graiziger C, Vaughn BP, Shmidt E, Rhein J, Schacker TW, Khoruts A, Jenkins MK. 
Cell Rep. 2021 Sep 25:109823. doi: 10.1016/j.celrep.2021.109823. Online ahead of print. 
PMID: 34610291

Regulation of myeloid-cell activation. 
Greene JT, Brian BF 4th, Senevirathne SE, Freedman TS. 
Curr Opin Immunol. 2021 Sep 30;73:34-42. doi: 10.1016/j.coi.2021.09.004. Online ahead of print. 
PMID: 34601225

Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia. 
Heltemes-Harris LM, Hubbard GK, LaRue RS, Munro SA, Yang R, Henzler CM, Starr TK, Sarver AL, Kornblau SM, Farrar MA. 
Oncogene. 2021 Sep 17. doi: 10.1038/s41388-021-02012-z. Online ahead of print. 
PMID: 34535769

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection. 
Geng Q, Tai W, Baxter VK, Shi J, Wan Y, Zhang X, Montgomery SA, Taft-Benz SA, Anderson EJ, Knight AC, Dinnon KH 3rd, Leist SR, Baric RS, Shang J, Hong SW, Drelich A, Tseng CK, Jenkins M, Heise M, Du L, Li F. 
PLoS Pathog. 2021 Sep 7;17(9):e1009897. doi: 10.1371/journal.ppat.1009897. Online ahead of print. 
PMID: 34492082

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning. 
Makielski KM, Donnelly AJ, Khammanivong A, Scott MC, Ortiz AR, Galvan DC, Tomiyasu H, Amaya C, Ward KA, Montoya A, Garbe JR, Mills LJ, Cutter GR, Fenger JM, Kisseberth WC, O'Brien TD, Weigel BJ, Spector LG, Bryan BA, Subramanian S, Modiano JF.
Lab Invest. 2021 Sep 6. doi: 10.1038/s41374-021-00655-w. Online ahead of print. 
PMID: 34489559

Brown adipose tissue monocytes support tissue expansion. 
Gallerand A, Stunault MI, Merlin J, Luehmann HP, Sultan DH, Firulyova MM, Magnone V, Khedher N, Jalil A, Dolfi B, Castiglione A, Dumont A, Ayrault M, Vaillant N, Gilleron J, Barbry P, Dombrowicz D, Mack M, Masson D, Bertero T, Becher B, Williams JW, Zaitsev K, Liu Y, Guinamard RR, Yvan-Charvet L, Ivanov S. 
Nat Commun. 2021 Sep 6;12(1):5255. doi: 10.1038/s41467-021-25616-1. 
PMID: 34489438

The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues. 
Kok L, Masopust D, Schumacher TN. 
Nat Rev Immunol. 2021 Sep 3:1-11. doi: 10.1038/s41577-021-00590-3. Online ahead of print. 
PMID: 34480118

Enhanced CD4+ and CD8+ T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses.
Alexander J. Dwyer, Jacob M. Ritz, Jason S. Mitchell, Tijana Martinov, Mohannad Alkhatib, Nubia Silva, Christopher G. Tucker, Brian T. Fife
Sci Rep. 2021 Aug 25;11(1):17142. doi: 10.1038/s41598-021-96327-2. 
PMID: 34433860

IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. 
Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. 
Cell Metab. 2021 Aug 26:S1550-4131(21)00367-3. doi: 10.1016/j.cmet.2021.08.004. Online ahead of print. 
PMID: 34473956

MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells. 
Dileepan T, Malhotra D, Kotov DI, Kolawole EM, Krueger PD, Evavold BD, Jenkins MK. 
Nat Biotechnol. 2021 Aug;39(8):943-948. doi: 10.1038/s41587-021-00893-9. Epub 2021 May 3. 
PMID: 33941928

Housing conditions and microbial environment do not affect the efficacy of vaccines for treatment of opioid use disorders in mice and rats. 
Crouse B, Zhang L, Robinson C, Ban Y, Vigliaturo JR, Roy S, Pravetoni M. 
Hum Vaccin Immunother. 2021 Aug 19:1-10. doi: 10.1080/21645515.2021.1954442. Online ahead of print. 
PMID: 34411500

Metabolic regulation of macrophage proliferation and function in atherosclerosis. 
Patterson MT, Williams JW. 
Curr Opin Lipidol. 2021 Jul 28. doi: 10.1097/MOL.0000000000000778. Online ahead of print. 
PMID: 34334628

Sepsis and multiple sclerosis: causative links and outcomes.    
Miljković Đ, Stanisavljević S, Jensen IJ, Griffith TS, Badovinac VP. 
Immunol Lett. 2021 Jul 25:S0165-2478(21)00117-6. doi: 10.1016/j.imlet.2021.07.008. Online ahead of print. 
PMID: 34320384

The Src-family kinase Lyn in immunoreceptor signaling. 
Brian Iv BF, Freedman TS.
Endocrinology. 2021 Jul 28:bqab152. doi: 10.1210/endocr/bqab152. Online ahead of print. 
PMID: 34320188

Contribution of Antibody-Mediated Effector Functions to the Mechanism of Efficacy of Vaccines for Opioid Use Disorders. 
Huseby Kelcher AM, Baehr CA, Hamid FA, Hart GT, Pravetoni M. 
J Immunol. 2021 Jul 19:ji2100204. doi: 10.4049/jimmunol.2100204. Online ahead of print.
PMID: 34281999

Inflating the role of stromal cells in CD8+ T cell memory. 
Block KE, Jameson SC. 
Nat Immunol. 2021 Jul 15. doi: 10.1038/s41590-021-00974-6. Online ahead of print. 
PMID: 34267376

A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19.
Puskarich MA, Cummins NW, Ingraham NE, Wacker DA, Reilkoff RA, Driver BE, Biros MH, Bellolio F, Chipman JG, Nelson AC, Beckman K, Langlois R, Bold T, Aliota MT, Schacker TW, Voelker HT, Murray TA, Koopmeiners JS, Tignanelli CJ.
EClinicalMedicine. 2021 Jun 17;37:100957. doi: 10.1016/j.eclinm.2021.100957. eCollection 2021 Jul. 
PMID: 34195577

Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults. 
Greenfield KG, Badovinac VP, Griffith TS, Knoop KA.
Immunohorizons. 2021 Jun 28;5(6):512-522. doi: 10.4049/immunohorizons.2000104. 
PMID: 34183380

Irreversible electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. 
Burbach BJ, O'Flanagan SD, Shao Q, Young KM, Slaughter JR, Rollins MR, Street TJL, Granger VE, Beura LK, Azarin SM, Ramadhyani S, Forsyth BR, Bischof JC, Shimizu Y. 
Nat Commun. 2021 Jun 23;12(1):3862. doi: 10.1038/s41467-021-24132-6. 
PMID: 34162858

Prolonged Reactive Oxygen Species Production following Septic Insult. 
Jensen IJ, McGonagill PW, Berton RR, Wagner BA, Silva EE, Buettner GR, Griffith TS, Badovinac VP.
Immunohorizons. 2021 Jun 18;5(6):477-488. doi: 10.4049/immunohorizons.2100027. 
PMID: 34145054

Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder. 
Raleigh MD, King SJ, Baruffaldi F, Saykao A, Hamid FA, Winston S, LeSage MG, Pentel PR, Pravetoni M. 
Neuropharmacology. 2021 Jun 11:108653. doi: 10.1016/j.neuropharm.2021.108653. Online ahead of print. 
PMID: 34126123

Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH. 
Fredrickson G, Barrow F, Dietsche K, Parthiban P, Khan S, Robert S, Demirchian M, Rhoades H, Wang H, Adeyi O, Revelo XS. 
Mol Metab. 2021 Jun 9:101270. doi: 10.1016/j.molmet.2021.101270. Online ahead of print. 
PMID: 34118476

Senolytics reduce coronavirus-related mortality in old mice.
Camell CD, Yousefzadeh MJ, Zhu Y, Langhi Prata LGP, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Machado Espindola-Netto J, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD.
Science. 2021 Jun 8:eabe4832. doi: 10.1126/science.abe4832. Online ahead of print.
PMID: 34103349

Intranasal nanoparticle vaccination elicits a persistent, polyfunctional CD4 T cell response in the murine lung-specific for a highly conserved influenza antigen that are sufficient to mediate protection from influenza virus challenge. 
Nelson SA, Dileepan T, Rasley A, Jenkins MK, Fischer NO, Sant AJ. 
J Virol. 2021 Jun 2:JVI0084121. doi: 10.1128/JVI.00841-21. Online ahead of print. 
PMID: 34076479

Structural modifications that increase gut restriction of bile acid derivatives. 
Nakhi A, Wong HL, Weldy M, Khoruts A, Sadowsky MJ, Dosa PI. 
RSC Med Chem. 2021 Feb 12;12(3):394-405. doi: 10.1039/d0md00425a. eCollection 2021 Mar 1. 
PMID: 34046622

Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge. 
Stone AE, Scheuermann SE, Haile CN, Cuny GD, Velasquez ML, Linhuber JP, Duddupudi AL, Vigliaturo JR, Pravetoni M, Kosten TA, Kosten TR, Norton EB. 
NPJ Vaccines. 2021 May 13;6(1):69. doi: 10.1038/s41541-021-00329-0. 
PMID: 33986280

An aged immune system drives senescence and ageing of solid organs. 
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. 
Nature. 2021 Jun;594(7861):100-105. doi: 10.1038/s41586-021-03547-7. Epub 2021 May 12.
PMID: 33981041

The Emerging Role of B Cells in the Pathogenesis of NAFLD. 
Barrow F, Khan S, Wang H, Revelo XS. 
Hepatology. 2021 May 7. doi: 10.1002/hep.31889. Online ahead of print.
PMID: 33961302

The Role of Programmed Death-1 in Type 1 Diabetes. 
Tucker CG, Dwyer AJ, Fife BT, Martinov T. 
Curr Diab Rep. 2021 May 6;21(6):20. doi: 10.1007/s11892-021-01384-6.
PMID: 33956235

Immunology Lessons from the SARS-CoV-2 Pandemic. 
Yokoyama WM, Hogquist KA, O'Shea JJ. 
Annu Rev Immunol. 2021 Apr 26;39:v-vii. doi: 10.1146/annurev-iy-39-030121-100001. Epub 2021 May 3. 
PMID: 33939926

CD8+ T cell self-tolerance permits responsiveness but limits tissue damage. 
Truckenbrod EN, Burrack KS, Knutson TP, Borges da Silva H, Block KE, O'Flanagan SD, Stagliano KR, Hurwitz AA, Fulton RB, Renkema KR, Jameson SC. 
Elife. 2021 Apr 30;10:e65615. doi: 10.7554/eLife.65615. Online ahead of print. 
PMID: 33929324

CD4+ Memory T-Cell Formation during Type 1 Immune Responses. 
Krueger PD, Osum KC, Jenkins MK. 
Cold Spring Harb Perspect Biol. 2021 Apr 26:a038141. doi: 10.1101/cshperspect.a038141. Online ahead of print.
PMID: 33903156

Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells. 
Georgiev H, Peng C, Huggins MA, Jameson SC, Hogquist KA. 
Nat Commun. 2021 Apr 16;12(1):2308. doi: 10.1038/s41467-021-22589-z. 
PMID: 33863906

Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells. 
Krueger PD, Goldberg MF, Hong SW, Osum KC, Langlois RA, Kotov DI, Dileepan T, Jenkins MK. 
Immunity. 2021 Mar 23:S1074-7613(21)00118-7. doi: 10.1016/j.immuni.2021.03.006. Online ahead of print. 
PMID: 33773107

Expansible residence decentralizes immune homeostasis. 
Wijeyesinghe S, Beura LK, Pierson MJ, Stolley JM, Adam OA, Ruscher R, Steinert EM, Rosato PC, Vezys V, Masopust D. 
Nature. 2021 Mar 17. doi: 10.1038/s41586-021-03351-3. Online ahead of print. 
PMID: 33731934

Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses. 
Joag V, Wijeyesinghe S, Stolley JM, Quarnstrom CF, Dileepan T, Soerens AG, Sangala JA, O'Flanagan SD, Gavil NV, Hong SW, Bhela S, Gangadhara S, Weyu E, Matchett WE, Thiede J, Krishna V, Cheeran MC, Bold TD, Amara R, Southern P, Hart GT, Schifanella L, Vezys V, Jenkins MK, Langlois RA, Masopust D.
 J Immunol. 2021 Mar 1;206(5):931-935. doi: 10.4049/jimmunol.2001400. Epub 2021 Jan 13. 
PMID: 33441437

P2Y11: The CD4 T cell mitochondrial shepherd. 
Borges da Silva H. 
J Leukoc Biol. 2021 Mar;109(3):477-479. doi: 10.1002/JLB.2CE0620-240R. Epub 2020 Sep 2. 
PMID: 32876961

Generating Mice with Diverse Microbial Experience. 
Pierson M, Merley A, Hamilton SE. 
Curr Protoc. 2021 Feb;1(2):e53. doi: 10.1002/cpz1.53. 
PMID: 33621444

Microbiota-Driven Activation of Intrahepatic B Cells Aggravates Nonalcoholic Steatohepatitis through Innate and Adaptive Signaling. 
Barrow F, Khan S, Fredrickson G, Wang H, Dietsche K, Parthiban P, Robert S, Kaiser T, Winer S, Herman A, Adeyi O, Mouzaki M, Khoruts A, Hogquist KA, Staley C, Winer DA, Revelo XS. 
Hepatology. 2021 Feb 20. doi: 10.1002/hep.31755. Online ahead of print. 
PMID: 33609303

A Picture is Worth A Thousand Words, but Only if it is a Good Picture. 
Solomon DH, Binstadt BA, Felson DT, Nigrovic PA. 
Arthritis Rheumatol. 2021 Feb 9. doi: 10.1002/art.41682. Online ahead of print. 
PMID: 33559356

Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC). 
Khanna V, Kim H, Zhang W, Larson P, Shah M, Griffith TS, Ferguson D, Panyam J. 
Sci Rep. 2021 Feb 8;11(1):3346. doi: 10.1038/s41598-021-83005-6.
PMID: 33558639

CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model. 
Burrack AL, Rollins MR, Spartz EJ, Mesojednik TD, Schmiechen ZC, Raynor JF, Wang IX, Kedl RM, Stromnes IM.
J Immunol. 2021 Feb 8:ji2000765. doi: 10.4049/jimmunol.2000765. Online ahead of print. 
PMID: 33558374

Initial determination of COVID-19 seroprevalence among outpatients and healthcare workers in Minnesota using a novel SARS-CoV-2 total antibody ELISA. 
Thomas SN, Altawallbeh G, Zaun C, Pape K, Peters JM, Titcombe PJ, Dileepan T, Rapp MJ, Bold TD, Schacker TW, Arbefeville S, Ferrieri P, Thyagarajan B, Jenkins MK, Karger AB. 
Clin Biochem. 2021 Feb 1:S0009-9120(21)00027-8. doi: 10.1016/j.clinbiochem.2021.01.010. Online ahead of print. 
PMID: 33539808

Modulating the quantity of HIV Env-specific CD4 T cell help promotes rare B cell responses in germinal centers.
Lee JH, Hu JK, Georgeson E, Nakao C, Groschel B, Dileepan T, Jenkins MK, Seumois G,Vijayanand P, Schief WR,Crotty S.
J Exp Med. 2021 Feb 1;218(2):e20201254. doi: 10.1084/jem.20201254.
PMID: 33355623

MHC Class I on murine hematopoietic APC selects Type A IEL precursors in the thymus. 
Lee ST, Georgiev H, Breed ER, Ruscher R, Hogquist KA.
Eur J Immunol. 2021 Jan 31. doi: 10.1002/eji.202048996. Online ahead of print. 
PMID: 33521937

NK Cell-Derived IL-10 Supports Host Survival during Sepsis. 
Jensen IJ, McGonagill PW, Butler NS, Harty JT, Griffith TS, Badovinac VP. 
J Immunol. 2021 Jan 29:ji2001131. doi: 10.4049/jimmunol.2001131. Online ahead of print. 
PMID: 33514512

Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma. 
Schmiechen ZC, Stromnes IM.
Front Immunol. 2021 Jan 28;11:613815. doi: 10.3389/fimmu.2020.613815. eCollection 2020. 
PMID: 33584701

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium. 
Fiege JK, Thiede JM, Nanda HA, Matchett WE, Moore PJ, Montanari NR, Thielen BK, Daniel J, Stanley E, Hunter RC, Menachery VD, Shen SS, Bold TD, Langlois RA.
PLoS Pathog. 2021 Jan 28;17(1):e1009292. doi: 10.1371/journal.ppat.1009292. Online ahead of print. 
PMID: 3350795

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with nonsevere disease. 
Gniadek TJ, Thiede JM, Matchett WE, Gress AR, Pape KA, Fiege JK, Jenkins MK, Menachery VD, Langlois RA, Bold TD.
Transfusion. 2021 Jan;61(1):17-23. doi: 10.1111/trf.16101. Epub 2020 Oct 2.
PMID: 32935872

Immune profiling reveals early disease trajectories associated with COVID-19 mortality: a sub-study from the ACTT-1 trial. 
Thiede JM, Gress AR, Libby SD, Ronayne CE, Matchett WE, Noren B, Billings JL, Menachery VD, Langlois RA, Kline S, Bold TD.
J Infect Dis. 2021 Jan 21:jiab035. doi: 10.1093/infdis/jiab035. Online ahead of print.
PMID: 33476387

Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology. 
Khoruts A, Staley C, Sadowsky MJ. 
Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):67-80. doi: 10.1038/s41575-020-0350-4. 
PMID: 32843743

T Cell Memory: Understanding COVID-19. 
Jarjour NN, Masopust D, Jameson SC.
Immunity. 2021 Jan 12;54(1):14-18. doi: 10.1016/j.immuni.2020.12.009. Epub 2020 Dec 19. 
PMID: 33406391

The Naming of Memory T-Cell Subsets.
Jameson SC.
Cold Spring Harb Perspect Biol. 2021 Jan 4;13(1):a037788. doi: 10.1101/cshperspect.a037788.
PMID: 33229439

Probiotics and the Microbiome: How can we help patients make sense of probiotics?
Britton RA, Hoffmann DE, Khoruts A.
Gastroenterology. 2020 Dec 8:S0016-5085(20)35525-6. doi: 10.1053/j.gastro.2020.11.047. 
PMID: 33307023

Monoclonal Antibodies Counteract Opioid-Induced Behavioral and Toxic Effects in Mice and Rats.
Baehr C, Kelcher AH, Khaimraj A, Reed DE, Pandit SG, AuCoin D, Averick S, Pravetoni M.
J Pharmacol Exp Ther. 2020 Dec;375(3):469-477. doi: 10.1124/jpet.120.000124. Epub 2020 Sep 26.
PMID: 32980813

Methanogen Abundance Thresholds Capable of Differentiating In Vitro Methane Production in Human Stool Samples.
Teigen L, Mathai PP, Matson M, Lopez S, Kozysa D, Kabage AJ, Hamilton MJ, Vaughn BP, Sadowsky MJ, Khoruts A.
Dig Dis Sci. 2020 Nov 28. doi: 10.1007/s10620-020-06721-5.  
PMID: 33247793

Therapeutic and Prophylactic Vaccines to Counteract Fentanyl Use Disorders and Toxicity.
Robinson C, Gradinati V, Hamid F, Baehr C, Crouse B, Averick S, Kovaliov M, Harris D, Runyon S, Baruffaldi F, LeSage M, Comer S, Pravetoni M.
J Med Chem. 2020 Nov 20. doi: 10.1021/acs.jmedchem.0c01042.  
PMID: 33215913

Sepsis impedes EAE disease development and diminishes autoantigen-specific naïve CD4 T cells.
Jensen IJ, Jensen SN, Sjaastad FV, Gibson-Corley KN, Dileepan T, Griffith TS, Mangalam AK, Badovinac VP.
Elife. 2020 Nov 16;9:e55800. doi: 10.7554/eLife.55800. 
PMID: 33191915

Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche.
Hirai T, Yang Y, Zenke Y, Li H, Chaudhri VK, De La Cruz Diaz JS, Zhou PY, Nguyen BA, Bartholin L, Workman CJ, Griggs DW, Vignali DAA, Singh H, Masopust D, Kaplan DH.
Immunity. 2020 Nov 11:S1074-7613(20)30463-5. doi: 10.1016/j.immuni.2020.10.022. 
PMID: 33212014

T cell economics: precursor cells predict inflation.
Huggins MA, Hamilton SE.
Nat Immunol. 2020 Oct 29. doi: 10.1038/s41590-020-00819-8. Online ahead of print.
PMID: 33122851

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Mills LJ, Scott MC, Shah P, Cunanan AR, Deshpande A, Auch B, Curtin B, Beckman KB, Spector LG, Sarver AL, Subramanian S, Richmond TA, Modiano JF.
Bone. 2020 Oct 27:115716. doi: 10.1016/j.bone.2020.115716.  
PMID: 33127576

Countermeasures for preventing and treating opioid overdose.
France CP, Ahern G, Averick S, Disney A, Enright HA, Esmaeli-Azad B, Federico A, Gerak LR, Husbands SM, Kolber B, Lau EY, Lao V, Maguire DR, Malfatti MA, Martinez G, Mayer BP, Pravetoni M, Sahibzada N, Skolnick P, Snyder EY, Tomycz N, Valdez CA, Zapf J.
Clin Pharmacol Ther. 2020 Oct 28. doi: 10.1002/cpt.2098. 
PMID: 33113208

T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis.
Napier RJ, Lee EJ, Davey MP, Vance EE, Furtado JM, Snow PE, Samson KA, Lashley SJ, Brown BR, Horai R, Mattapallil MJ, Xu B, Callegan MC, Uebelhoer LS, Lancioni CL, Vehe RK, Binstadt BA, Smith JR, Caspi RR, Rosenzweig HL.
Nat Commun. 2020 Oct 26;11(1):5406. doi: 10.1038/s41467-020-18961-0.
PMID: 33106495

Repeated dermal application of the common preservative methylisothiazolinone triggers local inflammation, T cell influx, and prolonged mast cell-dependent tactile sensitivity in mice.
Kline JM, Arriaga-Gomez E, Yangdon T, Boo B, Landry J, Saldías-Montivero M, Neamonitaki N, Mengistu H, Silverio S, Zacheis H, Pasha D, Martinov T, Fife BT, Chatterjea D.
PLoS One. 2020 Oct 26;15(10):e0241218. doi: 10.1371/journal.pone.0241218. eCollection 2020.
PMID: 33104726

Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.
Crouse B, Robinson C, Huseby Kelcher A, Laudenbach M, Abrahante JE, Pravetoni M.
NPJ Vaccines. 2020 Oct 21;5:99. doi: 10.1038/s41541-020-00247-7. eCollection 2020.
PMID: 33101712

Single Cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium
Jessica K. Fiege, Joshua M. Thiede, Hezkiel Nanda, William E Matchett, Patrick J. Moore, Noe Rico Montanari, Beth K Thielen, Jerry Daniel, Emma Stanley, Ryan C Hunter, Vineet D Menachery, Steven S. Shen, Tyler D. Bold, Ryan A. Langlois.
bioRxiv. 2020 Oct 19:2020.10.19.343954. doi: 10.1101/2020.10.19.343954. Preprint.
PMID: 33106802

Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.
Brouwers H, Jónasdóttir HS, Kuipers ME, Kwekkeboom JC, Auger JL, Gonzalez-Torres M, López-Vicario C, Clària J, Freysdottir J, Hardardottir I, Garrido-Mesa J, Norling LV, Perretti M, Huizinga TWJ, Kloppenburg M, Toes REM, Binstadt B, Giera M, Ioan-Facsinay A.
J Immunol. 2020 Oct 2:ji1801653. doi: 10.4049/jimmunol.1801653.  
PMID: 33008950

Cerebrospinal fluid bacillary load by Xpert MTB/RIF Ultra PCR Cycle Threshold value predicts two-week mortality in HIV-associated tuberculous meningitis.
Martyn EM, Bangdiwala AS, Kagimu E, Rutakingirwa MK, Kasibante J, Okirwoth M, Stead G, Wadda V, Pullen MF, Bold TD, Meya DB, Boulware DR, Bahr NC, Cresswell FV.
Clin Infect Dis. 2020 Sep 28:ciaa1444. doi: 10.1093/cid/ciaa1444.  
PMID: 32986792

Diverse Macrophage Populations Contribute to the Inflammatory Microenvironment in Premalignant Lesions During Localized Invasion.
Ibrahim AM, Moss MA, Gray Z, Rojo MD, Burke CM, Schwertfeger KL, Dos Santos CO, Machado HL.
Front Oncol. 2020 Sep 24;10:569985. doi: 10.3389/fonc.2020.569985. eCollection 2020.
PMID: 33072601

Hybrid Fc-fused interleukin-7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy.
Kim JH, Kim YM, Choi D, Jo SB, Park HW, Hong SW, Park S, Kim S, Moon S, You G, Kang YW, Park Y, Lee BH, Lee SW.
Clin Transl Immunology. 2020 Sep 4;9(9):e1168. doi: 10.1002/cti2.1168. eCollection 2020.
PMID: 32994996

Antigen-Specific CD4+ T Cells Exhibit Distinct Kinetic and Phenotypic Patterns During Primary and Secondary Responses to Infection.
Malhotra D, Burrack KS, Jenkins MK, Frosch AE.
Front Immunol. 2020 Sep 2;11:2125. doi: 10.3389/fimmu.2020.02125. eCollection 2020.
PMID: 32983171

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease.
Gniadek TJ, Thiede JM, Matchett WE, Gress AR, Pape KA, Fiege JK, Jenkins MK, Menachery VD, Langlois RA, Bold TD.
Transfusion. 2020 Sep 16. doi: 10.1111/trf.16101.  
PMID: 32935872

Immunopharmacology and Quantitative Analysis of Tyrosine Kinase Signaling.
Brian BF 4th, Guerrero CR, Freedman TS.
Curr Protoc Immunol. 2020 Sep;130(1):e104. doi: 10.1002/cpim.104.
PMID: 32931655

The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?
Peng C, Jameson SC.
Int Immunol. 2020 Sep 8;32(9):583-587. doi: 10.1093/intimm/dxaa045.
PMID: 32620009

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression.
Williams JW, Zaitsev K, Kim KW, Ivanov S, Saunders BT, Schrank PR, Kim K, Elvington A, Kim SH, Tucker CG, Wohltmann M, Fife BT, Epelman S, Artyomov MN, Lavine KJ, Zinselmeyer BH, Choi JH, Randolph GJ.
Nat Immunol. 2020 Sep 7. doi: 10.1038/s41590-020-0768-4.  
PMID: 32895539

Lessons of COVID-19: A roadmap for post-pandemic science.
Freedman TS, Headley MB, Serwas N, Ruhland M, Castellanos CA, Combes AJ, Krummel MF.
J Exp Med. 2020 Sep 7;217(9):e20201276. doi: 10.1084/jem.20201276.
PMID: 32735669

P2Y11: The CD4 T cell mitochondrial shepherd.
Borges da Silva H.
J Leukoc Biol. 2020 Sep 2. doi: 10.1002/JLB.2CE0620-240R.  
PMID: 32876961

Isolation of Cancer-Derived Exosomes Using a Variety of Magnetic Nanostructures: From Fe3O4 Nanoparticles to Ni Nanowires.
Nemati Z, Zamani Kouhpanji MR, Zhou F, Das R, Makielski K, Um J, Phan MH, Muela A, Fdez-Gubieda ML, Franklin RR, Stadler BJH, Modiano JF, Alonso J.
Nanomaterials (Basel). 2020 Aug 25;10(9):E1662. doi: 10.3390/nano10091662.
PMID: 32854239

Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology.
Khoruts A, Staley C, Sadowsky MJ.
Nat Rev Gastroenterol Hepatol. 2020 Aug 25. doi: 10.1038/s41575-020-0350-4.  
PMID: 32843743

ZipSeq: barcoding for real-time mapping of single cell transcriptomes.
Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF.
Nat Methods. 2020 Aug;17(8):833-843. doi: 10.1038/s41592-020-0880-2. Epub 2020 Jul 6.
PMID: 32632238

Cell type- and replication stage-specific influenza virus responses in vivo.
Fay EJ, Aron SL, Macchietto MG, Markman MW, Esser-Nobis K, Gale M Jr, Shen S, Langlois RA.
PLoS Pathog. 2020 Aug 13;16(8):e1008760. doi: 10.1371/journal.ppat.1008760.  
PMID: 32790753

Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.Polymicrobial Sepsis Impairs Antigen-Specific Memory CD4 T Cell-Mediated Immunity.
Sjaastad FV, Kucaba TA, Dileepan T, Swanson W, Dail C, Cabrera-Perez J, Murphy KA, Badovinac VP, Griffith TS.
Front Immunol. 2020 Aug 12;11:1786. doi: 10.3389/fimmu.2020.01786. eCollection 2020.
PMID: 32903436

Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells.
Zhao M, Ren K, Xiong X, Cheng M, Zhang Z, Huang Z, Han X, Yang X, Alejandro EU, Ruan HB.
Cell Rep. 2020 Aug 11;32(6):108013. doi: 10.1016/j.celrep.2020.108013.
PMID: 32783937

Novel protein pathways in development and progression of pulmonary sarcoidosis.
Bhargava M, Viken KJ, Barkes B, Griffin TJ, Gillespie M, Jagtap PD, Sajulga R, Peterson EJ, Dincer HE, Li L, Restrepo CI, O'Connor BP, Fingerlin TE, Perlman DM, Maier LA.
Sci Rep. 2020 Aug 6;10(1):13282. doi: 10.1038/s41598-020-69281-8.
PMID: 32764642

Intestinal CD8αα IELs derived from two distinct thymic precursors have staggered ontogeny.
Ruscher R, Lee ST, Salgado OC, Breed ER, Osum SH, Hogquist KA.
J Exp Med. 2020 Aug 3;217(8):e20192336. doi: 10.1084/jem.20192336
PMID: 32687575

Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection.
Stolley JM, Johnston TS, Soerens AG, Beura LK, Rosato PC, Joag V, Wijeyesinghe SP, Langlois RA, Osum KC, Mitchell JS, Masopust D.
J Exp Med. 2020 Aug 3;217(8):e20192197. doi: 10.1084/jem.20192197.
PMID: 32568362

Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity.
Tucker CG, Mitchell JS, Martinov T, Burbach BJ, Beura LK, Wilson JC, Dwyer AJ, Singh LM, Mescher MF, Fife BT.
J Immunol. 2020 Jul 31:ji2000007. doi: 10.4049/jimmunol.2000007.  
PMID: 32737148

Kinetically distinct processing pathways diversify the CD8+ T cell response to a single viral epitope.
Cosma GL, Lobby JL, Fay EJ, Siciliano NA, Langlois RA, Eisenlohr LC.
Proc Natl Acad Sci U S A. 2020 Jul 27:202004372. doi: 10.1073/pnas.2004372117.  
PMID: 32719124

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
Zernecke A, Winkels H, Cochain C, Williams JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA, Binder CJ, Cybulsky MI, Scipione CA, Hedrick CC, Galkina EV, Kyaw T, Ghosheh Y, Dinh HQ, Ley K.
Circ Res. 2020 Jul 17;127(3):402-426. doi: 10.1161/CIRCRESAHA.120.316903. Epub 2020 Jul 16.
PMID: 32673538

CD4 T Cell Responses and the Sepsis-Induced Immunoparalysis State.
Martin MD, Badovinac VP, Griffith TS.
Front Immunol. 2020 Jul 7;11:1364. doi: 10.3389/fimmu.2020.01364. eCollection 2020.
PMID: 32733454

Chemotherapy brings virtual memory T cells into reality for cancer therapy.
Schmiechen ZC, Burrack AL, Stromnes IM.
Cell Mol Immunol. 2020 Jul 3. doi: 10.1038/s41423-020-0496-6.  
PMID: 32620786

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β.
Borges da Silva H, Peng C, Wang H, Wanhainen KM, Ma C, Lopez S, Khoruts A, Zhang N, Jameson SC.
Immunity. 2020 Jul 2:S1074-7613(20)30265-X. doi: 10.1016/j.immuni.2020.06.010.  
PMID: 32640257

Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function.
Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ.
PLoS One. 2020 Jul 2;15(7):e0235518. doi: 10.1371/journal.pone.0235518. eCollection 2020.
PMID: 32614928

KLRG1+ Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
Renkema KR, Huggins MA, Borges da Silva H, Knutson TP, Henzler CM, Hamilton SE.
J Immunol. 2020 Jul 1:ji1901512. doi: 10.4049/jimmunol.1901512.  
PMID: 32611727

New Insights into the Immune System Using Dirty Mice.
Hamilton SE, Badovinac VP, Beura LK, Pierson M, Jameson SC, Masopust D, Griffith TS.
J Immunol. 2020 Jul 1;205(1):3-11. doi: 10.4049/jimmunol.2000171.
PMID: 32571979

Frequency of MicroRNA Response Elements Identifies Pathologically Relevant Signaling Pathways in Triple-Negative Breast Cancer.
Nair AA, Tang X, Thompson KJ, Vedell PT, Kalari KR, Subramanian S.
iScience. 2020 Jun 26;23(6):101249. doi: 10.1016/j.isci.2020.101249. Epub 2020 Jun 6.
PMID: 32629614

Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity.
Gradinati V, Baruffaldi F, Abbaraju S, Laudenbach M, Amin R, Gilger B, Velagaleti P, Pravetoni M.
Vaccine. 2020 Jun 19;38(30):4704-4712. doi: 10.1016/j.vaccine.2020.05.027. Epub 2020 May 19.
PMID: 32439214

Probiotics: Promise, Evidence, and Hope.
Khoruts A, Hoffmann DE, Britton RA.
Gastroenterology. 2020 Jun 9:S0016-5085(20)34728-4. doi: 10.1053/j.gastro.2020.05.058.  
PMID: 32531290

Comparative phenotypes of peripheral blood and spleen cells from cancer patients.
Cole KE, Ly QP, Hollingsworth MA, Cox JL, Stromnes IM, Padussis JC, Foster JM, Vargas LM, Talmadge JE.
Int Immunopharmacol. 2020 Jun 7;85:106655. doi: 10.1016/j.intimp.2020.106655. [Epub ahead of print]
PMID: 32521493

Instructing Memory in CD8+ Thymocytes.
Ashby KM, Hogquist KA.
Trends Immunol. 2020 Jun 6. pii: S1471-4906(20)30121-6. doi: 10.1016/j.it.2020.05.006. [Epub ahead of print]
PMID: 32518054

Different hierarchies of anti-modified protein autoantibody reactivities in rheumatoid arthritis.
Sahlström P, Hansson M, Steen J, Amara K, Titcombe PJ, Forsström B, Stålesen R, Israelsson L, Piccoli L, Lundberg K, Klareskog L, Mueller DL, Catrina AI, Skriner K, Malmström V, Grönwall C.
Arthritis Rheumatol. 2020 Jun 5. doi: 10.1002/art.41385.  
PMID: 32501655

TLR7/8 Agonist-Loaded Nanoparticles Augment NK Cell-Mediated Antibody-Based Cancer Immunotherapy.
Kim H, Khanna V, Kucaba TA, Zhang W, Sehgal D, Ferguson DM, Griffith TS, Panyam J
Mol Pharm. 2020 Jun 1;17(6):2109-2124. doi: 10.1021/acs.molpharmaceut.0c00271. Epub 2020 May 21.
PMID: 32383885

Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice.
Wang Y, Chaffee TS, LaRue RS, Huggins DN, Witschen PM, Ibrahim AM, Nelson AC, Machado HL, Schwertfeger KL.
Elife. 2020 Jun 1;9:e57438. doi: 10.7554/eLife.57438.
PMID: 32479261

T Cell Receptor Engineered Lymphocytes for Cancer Therapy.
Rollins MR, Spartz EJ, Stromnes IM.
Curr Protoc Immunol. 2020 Jun;129(1):e97. doi: 10.1002/cpim.97.
PMID: 32432843

Probiotics: promise, evidence, and hope.
Khoruts A, Hoffmann DE, Britton RA.
Gastroenterology. 2020 May 25. pii: S0016-5085(20)34728-4. doi: 10.1053/j.gastro.2020.05.058. [Epub ahead of print] No abstract available. 
PMID: 32531290

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.
Witschen PM, Chaffee TS, Brady NJ, Huggins DN, Knutson TP, LaRue RS, Munro SA, Tiegs L, McCarthy JB, Nelson AC, Schwertfeger KL.
Cancers (Basel). 2020 May 22;12(5):E1325. doi: 10.3390/cancers12051325.
PMID: 32455980

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging.
Khan S, Chan YT, Revelo XS, Winer DA.
Front Endocrinol (Lausanne). 2020 May 15;11:267. doi: 10.3389/fendo.2020.00267. eCollection 2020.
PMID: 32499756

Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity.
Gradinati V, Baruffaldi F, Abbaraju S, Laudenbach M, Amin R, Gilger B, Velagaleti P, Pravetoni M.
Vaccine. 2020 May 19:S0264-410X(20)30646-0. doi: 10.1016/j.vaccine.2020.05.027.  
PMID: 32439214

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.
Arunachalam PS, Charles TP, Joag V, Bollimpelli VS, Scott MKD, Wimmers F, Burton SL, Labranche CC, Petitdemange C, Gangadhara S, Styles TM, Quarnstrom CF, Walter KA, Ketas TJ, Legere T, Jagadeesh Reddy PB, Kasturi SP, Tsai A, Yeung BZ, Gupta S, Tomai M, Vasilakos J, Shaw GM, Kang CY, Moore JP, Subramaniam S, Khatri P, Montefiori D, Kozlowski PA, Derdeyn CA, Hunter E, Masopust D, Amara RR, Pulendran B.
Nat Med. 2020 May 11. doi: 10.1038/s41591-020-0858-8.  
PMID: 32393800

Acquired Resistance to Immune Checkpoint Blockade Therapies.
Zhao X, Wangmo D, Robertson M, Subramanian S.
Cancers (Basel). 2020 May 5;12(5):E1161. doi: 10.3390/cancers12051161.
PMID: 32380703

CD8+ T cells mediate ultraviolet A-induced immunomodulation in a model of extracorporeal photochemotherapy.
Hequet O, Nosbaum A, Guironnet-Paquet A, Blasco E, Nicolas-Virelizier E, Griffith TS, Rigal D, Cognasse F, Nicolas JF, Vocanson M.
Eur J Immunol. 2020 May;50(5):725-735. doi: 10.1002/eji.201948318. Epub 2020 Feb 10.
PMID: 32012249

Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance.
Dobson HE, Dias LDS, Kohn EM, Fites S, Wiesner DL, Dileepan T, Kujoth GC, Abraham A, Ostroff GR, Klein BS, Wüthrich M.
Mucosal Immunol. 2020 May;13(3):518-529. doi: 10.1038/s41385-019-0244-3. Epub 2020 Jan 3.
PMID: 31900406

Single Cell RNA Sequencing in Atherosclerosis Research.
Williams JW, Winkels H, Durant CP, Zaitsev K, Ghosheh Y, Ley K.
Circ Res. 2020 Apr 24;126(9):1112-1126. doi: 10.1161/CIRCRESAHA.119.315940. Epub 2020 Apr 23.
PMID: 32324494

NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells.
Hainberger D, Stolz V, Zhu C, Schuster M, Müller L, Hamminger P, Rica R, Waltenberger D, Alteneder M, Krausgruber T, Hladik A, Knapp S, Bock C, Trauner M, Farrar MA, Ellmeier W. 
Front Immunol. 2020 Apr 3;11:579. doi: 10.3389/fimmu.2020.00579. eCollection 2020.
PMID: 32318068

Is the opioid use disorder epidemic impacting our immunological health?
Pravetoni M.
Brain Behav Immun. 2020 Apr 10. pii: S0889-1591(20)30487-6. doi: 10.1016/j.bbi.2020.04.022. [Epub ahead of print] No abstract available. 
PMID: 32283290

Exploiting antibody biology for the treatment of cancer.
Khanna V, Panyam J, Griffith TS.
Immunotherapy. 2020 Mar 24. doi: 10.2217/imt-2019-0118. [Epub ahead of print]
PMID:  32208784

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade.
Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF.
Melanoma Res. 2020 Apr;30(2):147-158. doi: 10.1097/CMR.0000000000000629.
PMID:  31205227

Gut dysbiosis during antileukemia chemotherapy versus allogeneic hematopoietic cell transplantation.
Rashidi A, Kaiser T, Graiziger C, Holtan SG, Rehman TU, Weisdorf DJ, Dunny GM, Khoruts A, Staley C.
Cancer. 2020 Apr 1;126(7):1434-1447. doi: 10.1002/cncr.32641. Epub 2019 Dec 24.
PMID:  31873965

Developmental plasticity allows outside-in immune responses by resident memory T cells.
Fonseca R, Beura LK, Quarnstrom CF, Ghoneim HE, Fan Y, Zebley CC, Scott MC, Fares-Frederickson NJ, Wijeyesinghe S, Thompson EA, Borges da Silva H, Vezys V, Youngblood B, Masopust D, 
Nat Immunol. 2020 Apr;21(4):412-421. doi: 10.1038/s41590-020-0607-7. Epub 2020 Feb 17.
PMID:32066954

Neutrophils Recirculate through Lymph Nodes to Survey Tissues for Pathogens.
Bogoslowski A, Wijeyesinghe S, Lee WY, Chen CS, Alanani S, Jenne C, Steeber DA, Scheiermann C, Butcher EC, Masopust D, Kubes P.
J Immunol. 2020 Mar 23. pii: ji2000022. doi: 10.4049/jimmunol.2000022. [Epub ahead of print]
PMID:  32205425

Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma.
Borgatti A, Fieberg A, Winter AL, Stuebner K, Taras E, Todhunter D, Masyr A, Rendhal A, Vallera DA, Koopmeiners JS, Modiano JF.
Vet Comp Oncol. 2020 Mar 18. doi: 10.1111/vco.12590. [Epub ahead of print]
PMID:  32187827

Recent advances in iNKT cell development.
Hogquist K, Georgiev H.
F1000Res. 2020 Feb 20;9. pii: F1000 Faculty Rev-127. doi: 10.12688/f1000research.21378.1. eCollection 2020. Review.
PMID:  32148771

Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer.
Judge SJ, Yanagisawa M, Sturgill IR, Bateni SB, Gingrich AA, Foltz JA, Lee DA, Modiano JF, Monjazeb AM, Culp WTN, Rebhun RB, Murphy WJ, Kent MS, Canter RJ.
PLoS One. 2020 Feb 21;15(2):e0224775. doi: 10.1371/journal.pone.0224775. eCollection 2020
PMID:32084139

Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system.
Lefevre EM, Pisansky MT, Toddes C, Baruffaldi F, Pravetoni M, Tian L, Kono TJY, Rothwell PE.
Neuropsychopharmacology. 2020 Feb 20. doi: 10.1038/s41386-020-0643-x. [Epub ahead of print]
PMID:32079024

Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart.
Adamo L, Rocha-Resende C, Lin CY, Evans S, Williams J, Dun H, Li W, Mpoy C, Andhey PS, Rogers BE, Lavine K, Kreisel D, Artyomov M, Randolph GJ, Mann DL.
JCI Insight. 2020 Feb 13;5(3). pii: 134700. doi: 10.1172/jci.insight.134700.
PMID: 31945014

PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection.
Im SJ, Konieczny BT, Hudson WH, Masopust D, Ahmed R.
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4292-4299. doi: 10.1073/pnas.1917298117.
PMID: 32034098

Integrating resident memory into T cell differentiation models.
Rosato PC, Wijeyesinghe S, Stolley JM, Masopust D.
Curr Opin Immunol. 2020 Feb 1;63:35-42. doi: 10.1016/j.coi.2020.01.001. [Epub ahead of print] Review.
PMID: 32018169

Interactions between the gut microbiome and host gene regulation in cystic fibrosis.
Dayama G, Priya S, Niccum DE, Khoruts A, Blekhman R.
Genome Med. 2020 Jan 28;12(1):12. doi: 10.1186/s13073-020-0710-2.
PMID: 31992345

VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
ElTanbouly MA, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, Ceeraz S, Lines JL, Peng C, Carriere C, Huang X, Day M, Koehn B, Lee SW, Silva Morales M, Hogquist KA, Jameson SC, Mueller D, Rothstein J, Blazar BR, Cheng C, Noelle RJ.
Science. 2020 Jan 17;367(6475). pii: eaay0524. doi: 10.1126/science.aay0524.
PMID: 31949051

Vitamin D3-mediated resistance to a multiple sclerosis model disease depends on myeloid cell 1,25-dihydroxyvitamin D3 synthesis and correlates with increased CD4+ T cell CTLA-4 expression.
Spanier JA, Nashold FE, Nelson CD, Praska CE, Hayes CE.
J Neuroimmunol. 2020 Jan 15;338:577105. doi: 10.1016/j.jneuroim.2019.577105. Epub 2019 Nov 7.
PMID: 31731231

The Impact of Regulatory Policies on the Future of Fecal Microbiota Transplantation.
Khoruts A, Hoffmann DE, Palumbo FB.
J Law Med Ethics. 2019 Dec;47(4):482-504. doi: 10.1177/1073110519897726.
PMID: 31957587

Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats.
Fulenwider HD, Nennig SE, Hafeez H, Price ME, Baruffaldi F, Pravetoni M, Cheng K, Rice KC, Manvich DF, Schank JR.
Addict Biol. 2019 Dec 12:e12822. doi: 10.1111/adb.12822. [Epub ahead of print]
PMID: 31830773

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma.
Megquier K, Turner-Maier J, Swofford R, Kim JH, Sarver AL, Wang C, Sakthikumar S, Johnson J, Koltookian M, Lewellen M, Scott MC, Schulte AJ, Borst L, Tonomura N, Alfoldi J, Painter C, Thomas R, Karlsson EK, Breen M, Modiano JF, Elvers I, Lindblad-Toh K.
Mol Cancer Res. 2019 Dec;17(12):2410-2421. doi: 10.1158/1541-7786.MCR-19-0221. Epub 2019 Sep 30.
PMID: 31570656

Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment.
Langsten KL, Kim JH, Sarver AL, Dewhirst M, Modiano JF.
Front Oncol. 2019 Nov 7;9:1185. doi: 10.3389/fonc.2019.01185. eCollection 2019. Review.
PMID: 31788448

Can intestinal microbiota and circulating microbial products contribute to pulmonary arterial hypertension?
Thenappan T, Khoruts A, Chen Y, Weir EK.
Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1093-H1101. doi: 10.1152/ajpheart.00416.2019. Epub 2019 Sep 6.
PMID: 31490732

Microbiota transplant therapy and autism: lessons for the clinic.
Adams JB, Borody TJ, Kang DW, Khoruts A, Krajmalnik-Brown R, Sadowsky MJ.
Expert Rev Gastroenterol Hepatol. 2019 Oct 30. doi: 10.1080/17474124.2019.1687293. [Epub ahead of print]
PMID: 31665947

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy.
Gingrich AA, Modiano JF, Canter RJ.
J Clin Med. 2019 Oct 27;8(11). pii: E1802. doi: 10.3390/jcm8111802. Review.
PMID: 31717876 

Demystifying Cancer Immunotherapy for Lay Audiences
Ellis K, Pennell CA.
Front Immunol. 2019 Oct 18;10:2488. doi: 10.3389/fimmu.2019.02488. eCollection 2019.
PMID: 31681338

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.
Wong JB, Hewitt SL, Heltemes-Harris LM, Mandal M, Johnson K, Rajewsky K, Koralov SB, Clark MR, Farrar MA, Skok JA.
Nat Commun. 2019 Oct 18;10(1):4768. doi: 10.1038/s41467-019-12824-z.
PMID: 31628339

Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla.
Wang H, Breed ER, Lee YJ, Qian LJ, Jameson SC, Hogquist KA.
Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201910412. doi: 10.1073/pnas.1910412116. [Epub ahead of print]
PMID: 31611396

Regulatory T Cell Development in the Thymus.
Owen DL, Sjaastad LE, Farrar MA.
J Immunol. 2019 Oct 15;203(8):2031-2041. doi: 10.4049/jimmunol.1900662. Review.
PMID: 31591259

A wild microbiome improves mouse modeling of the human immune response.
Hamilton SE, Griffith TS.
Lab Anim (NY). 2019 Oct 7. doi: 10.1038/s41684-019-0421-8. [Epub ahead of print] No abstract available.
PMID: 31591550

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.
Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS.
Transplantation. 2019 Oct;103(10):2075-2089. doi: 10.1097/TP.0000000000002774.
PMID: 31343575

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations.
Pampusch MS, Haran KP, Hart GT, Rakasz EG, Rendahl AK, Berger EA, Connick E, Skinner PJ.
Mol Ther Methods Clin Dev. 2019 Sep 30;16:1-10. doi: 10.1016/j.omtm.2019.09.007. eCollection 2020 Mar 13. [Epub ahead of print]
PMID: 31673565 

Long-term surviving influenza infected cells evade CD8+ T cell mediated clearance.
Fiege JK, Stone IA, Dumm RE, Waring BM, Fife BT, Agudo J, Brown BD, Heaton NS, Langlois RA.
PLoS Pathog. 2019 Sep 26;15(9):e1008077. doi: 10.1371/journal.ppat.1008077. [Epub ahead of print]
PMID: 31557273

Contributions of natural killer cells to the immune response against Plasmodium.
Burrack KS, Hart GT, Hamilton SE.
Malar J. 2019 Sep 18;18(1):321. doi: 10.1186/s12936-019-2953-1. Review.
PMID: 31533835

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GvHD.
Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR.
Blood. 2019 Sep 18. pii: blood.2019001950. doi: 10.1182/blood.2019001950. [Epub ahead of print]
PMID: 31533918

Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens.
Nelson CE, Thompson EA, Quarnstrom CF, Fraser KA, Seelig DM, Bhela S, Burbach BJ, Masopust D, Vezys V.
Cell Rep. 2019 Sep 17;28(12):3092-3104.e5. doi: 10.1016/j.celrep.2019.08.038.
PMID: 31533033

Deubiquitinase Otub1 negatively regulates IL-15 signaling in CD8 T cells and NK cells.
Huggins MA, Hamilton SE.
Cell Mol Immunol. 2019 Sep 11. doi: 10.1038/s41423-019-0283-4. [Epub ahead of print] No abstract available.
PMID: 31511640

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation.
Clark SE, Burrack KS, Jameson SC, Hamilton SE, Lenz LL.
Front Immunol. 2019 Sep 4;10:2087. doi: 10.3389/fimmu.2019.02087. eCollection 2019.
PMID: 31552035

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Zhang Z, Huang Z, Ong B, Sahu C, Zeng H, Ruan HB.
Haematologica. 2019 Sep;104(9):1731-1743. doi: 10.3324/haematol.2018.205856. Epub 2019 Feb 21.
PMID: 30792196

A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation.
Tran TM, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, Jones M, Moebius J, Venepally P, Doumbo S, DeRiso EA, Li S, Vijayan K, Anzick SL, Hart GT, O'Connell EM, Doumbo OK, Kaushansky A, Alter G, Felgner PL, Lorenzi H, Kayentao K, Traore B, Kirkness EF, Crompton PD.
Immunity. 2019 Aug 23. pii: S1074-7613(19)30335-8. doi: 10.1016/j.immuni.2019.08.009. [Epub ahead of print]
PMID: 31492649

Poly(d,l-lactide-co-glycolide) Nanoparticles as Delivery Platforms for TLR7/8 Agonist-Based Cancer Vaccine.
Kim H, Griffith TS, Panyam J.
J Pharmacol Exp Ther. 2019 Sep;370(3):715-724. doi: 10.1124/jpet.118.254953. Epub 2019 Jan 4.
PMID: 30610006

Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors.
Hassler T, Urmann E, Teschner S, Federle C, Dileepan T, Schober K, Jenkins MK, Busch DH, Hinterberger M, Klein L.
Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18537-18543. doi: 10.1073/pnas.1907615116. Epub 2019 Aug 26.
PMID: 31451631

Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma.
Burrack AL, Spartz EJ, Raynor JF, Wang I, Olson M, Stromnes IM.
Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059.
PMID: 31433988

Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
Huggins MA, Sjaastad FV, Pierson M, Kucaba TA, Swanson W, Staley C, Weingarden AR, Jensen IJ, Danahy DB, Badovinac VP, Jameson SC, Vezys V, Masopust D, Khoruts A, Griffith TS, Hamilton SE.
Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028.
PMID: 31412243

Gut-associated IgA+ immune cells regulate obesity-related insulin resistance.
Luck H, Khan S, Kim JH, Copeland JK, Revelo XS, Tsai S, Chakraborty M, Cheng K, Tao Chan Y, Nøhr MK, Clemente-Casares X, Perry MC, Ghazarian M, Lei H, Lin YH, Coburn B, Okrainec A, Jackson T, Poutanen S, Gaisano H, Allard JP, Guttman DS, Conner ME, Winer S, Winer DA.
Nat Commun. 2019 Aug 13;10(1):3650. doi: 10.1038/s41467-019-11370-y.
PMID: 31409776

The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection.
Fiege JK, Stone IA, Fay EJ, Markman MW, Wijeyesinghe S, Macchietto MG, Shen S, Masopust D, Langlois RA.
J Immunol. 2019 Aug 15;203(4):936-945. doi: 10.4049/jimmunol.1900093. Epub 2019 Jun 24.
PMID: 31235552

The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location.
Walsh DA, Borges da Silva H, Beura LK, Peng C, Hamilton SE, Masopust D, Jameson SC.
J Immunol. 2019 Aug 15;203(4):946-955. doi: 10.4049/jimmunol.1900052. Epub 2019 Jun 26.
PMID: 31243092

Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes.
Martinov T, Swanson LA, Breed ER, Tucker CG, Dwyer AJ, Johnson JK, Mitchell JS, Sahli NL, Wilson JC, Singh LM, Hogquist KA, Spanier JA, Fife BT.
J Immunol. 2019 Aug 15;203(4):844-852. doi: 10.4049/jimmunol.1801535. Epub 2019 Jul 19.
PMID: 31324724

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.
Vacchio MS, Ciucci T, Gao Y, Watanabe M, Balmaceno-Criss M, McGinty MT, Huang A, Xiao Q, McConkey C, Zhao Y, Shetty J, Tran B, Pepper M, Vahedi G, Jenkins MK, McGavern DB, Bosselut R.
Immunity. 2019 Aug 13. pii: S1074-7613(19)30293-6. doi: 10.1016/j.immuni.2019.06.023. [Epub ahead of print]
PMID: 31422869

Self-Regulation of Memory CD8 T Cell Metabolism through Extracellular ATP Signaling.
Wanhainen KM, Jameson SC, da Silva HB.
Immunometabolism. 2019;1(1). pii: e190009. doi: 10.20900/immunometab20190009. Epub 2019 Jul 23.
PMID: 31428464

Engineered adoptive T-cell therapy prolongs survival in a preclinical model of advanced stage ovarian cancer.
Anderson KG, Voillet V, Bates B, Chiu EY, Burnett MG, Garcia NM, Oda SK, Morse CB, Stromnes IM, Drescher CW, Gottardo R, Greenberg PD.
Cancer Immunol Res. 2019 Jul 23. pii: canimm.0258.2019. doi: 10.1158/2326-6066.CIR-19-0258. [Epub ahead of print]
PMID: 31337659

Early childhood education is critical for Treg cells.
Salgado OC, Hogquist KA.
Nat Immunol. 2019 Jul 15. doi: 10.1038/s41590-019-0440-z. [Epub ahead of print] No abstract available.
PMID: 31308543

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.
Brian BF, Jolicoeur AS, Guerrero CR, Nunez MG, Sychev ZE, Hegre SA, Sætrom P, Habib N, Drake JM, Schwertfeger KL, Freedman TS.
Elife. 2019 Jul 8;8. pii: e46043. doi: 10.7554/eLife.46043. [Epub ahead of print]
PMID: 31282857

7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Substantial Increase in TGR5 Receptor Potency.
Nakhi A, McDermott CM, Stoltz KL, John K, Hawkinson JE, Ambrose EA, Khoruts A, Sadowsky MJ, Dosa PI.
J Med Chem. 2019 Jul 3. doi: 10.1021/acs.jmedchem.9b00770. [Epub ahead of print]
PMID: 31268316

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade.
Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF.
Melanoma Res. 2019 Jun 12. doi: 10.1097/CMR.0000000000000629. [Epub ahead of print]
PMID: 31205227

Fecal Microbiota Transplant: A Rose by Any Other Name.
Khoruts A, Brandt LJ.
Am J Gastroenterol. 2019 Jun 14. doi: 10.14309/ajg.0000000000000286. [Epub ahead of print] No abstract available.
PMID: 31205129

Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.
Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.
J Exp Med. 2019 Jun 3;216(6):1280-1290. doi: 10.1084/jem.20181681. Epub 2019 Apr 12.
PMID:30979790

BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors.
Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK.
J Exp Med. 2019 Jun 3;216(6):1450-1464. doi: 10.1084/jem.20182376. Epub 2019 May 3.
PMID: 31053612

Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4+ T Cells.
Kotov DI, Jenkins MK.
Curr Protoc Immunol. 2019 Jun;125(1):e75. doi: 10.1002/cpim.75. Epub 2019 Apr 29.
PMID: 31034767

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors.
Irey EA, Lassiter CM, Brady NJ, Chuntova P, Wang Y, Knutson TP, Henzler C, Chaffee TS, Vogel RI, Nelson AC, Farrar MA, Schwertfeger KL.
Proc Natl Acad Sci U S A. 2019 May 30. pii: 201816410. doi: 10.1073/pnas.1816410116. [Epub ahead of print]
PMID: 31147469

Cytomegalovirus evades TRAIL-mediated innate lymphoid cell 1 defenses.
Picarda G, Ghosh R, McDonald B, Verma S, Thiault N, El Morabiti R, Griffith TS, Benedict CA.
J Virol. 2019 May 29. pii: JVI.00617-19. doi: 10.1128/JVI.00617-19. [Epub ahead of print]
PMID: 31142671

Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL.
Ruscher R, Hogquist KA.
Curr Opin Immunol. 2019 May 27;58:83-88. doi: 10.1016/j.coi.2019.04.010. [Epub ahead of print] Review.
PMID: 31146182

Risk Factors for Development of Canine and Human Osteosarcoma: A Comparative Review.
Makielski KM, Mills LJ, Sarver AL, Henson MS, Spector LG, Naik S, Modiano JF.
Vet Sci. 2019 May 25;6(2). pii: E48. doi: 10.3390/vetsci6020048. Review.
PMID: 31130627 

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells.
Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH.
Immunity. 2019 May 21;50(5):1249-1261.e5. doi: 10.1016/j.immuni.2019.03.002. Epub 2019 Apr 2.
PMID: 30952606

Editorial: Fresh Ideas, Foundational Experiments: Immunology and Diabetes.
Spanier JA, Tse HM, Horwitz MS, Fife BT.
Front Endocrinol (Lausanne). 2019 May 16;10:315. doi: 10.3389/fendo.2019.00315. eCollection 2019. No abstract available.
PMID: 31156560

Differential Regulation of T Cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.
Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS.
Transplantation. 2019 May 7. doi: 10.1097/TP.0000000000002774. [Epub ahead of print]
PMID: 31343575

CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.
Beura LK, Fares-Frederickson NJ, Steinert EM, Scott MC, Thompson EA, Fraser KA, Schenkel JM, Vezys V, Masopust D.
J Exp Med. 2019 May 6;216(5):1214-1229. doi: 10.1084/jem.20181365. Epub 2019 Mar 28
PMID: 30923043

Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes.
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN.
Nat Metab. 2019 May;1(5):509-518. doi: 10.1038/s42255-019-0061-8. Epub 2019 May 6.
PMID: 31423480

Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation and Persistent Tactile Sensitivity in Mouse Model of Allergen-Provoked Localized Vulvodynia.
Boo B, Kamath R, Arriaga-Gomez E, Landry J, Emanuel E, Joo S, Saldías Montivero M, Martinov T, Fife BT, Chatterjea D.
Int J Mol Sci. 2019 May 1;20(9). pii: E2163. doi: 10.3390/ijms20092163.
PMID: 31052404

TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
Kotov DI, Mitchell JS, Pengo T, Ruedl C, Way SS, Langlois RA, Fife BT, Jenkins MK.
J Immunol. 2019 May 1;202(9):2535-2545. doi: 10.4049/jimmunol.1801609. Epub 2019 Mar 11.
PMID: 30858199

Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression.
Hornick EE, Dagvadorj J, Zacharias ZR, Miller AM, Langlois RA, Chen P, Legge KL, Bishop GA, Sutterwala FS, Cassel SL.
J Clin Invest. 2019 Apr 30;130. pii: 124937. doi: 10.1172/JCI124937.
PMID: 31038471

Tissue-Resident T Cells and Other Resident Leukocytes.
Masopust D, Soerens AG.
Annu Rev Immunol. 2019 Apr 26;37:521-546. doi: 10.1146/annurev-immunol-042617-053214. Epub 2019 Feb 6.
PMID: 30726153

Differential effects of depleting versus programming tumor-associated macrophages on engineered T cells in pancreatic ductal adenocarcinoma.
Stromnes IM, Burrack AL, Hulbert A, Bonson P, Black C, Brockenbrough JS, Raynor JF, Spartz EJ, Pierce RH, Greenberg PD, Hingorani SR.
Cancer Immunol Res. 2019 Apr 26. pii: canimm.0448.2018. doi: 10.1158/2326-6066.CIR-18-0448. [Epub ahead of print]
PMID: 31028033

Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet tolerance.
Martinov T, Fife BT.
Ann N Y Acad Sci. 2019 Apr 26. doi: 10.1111/nyas.14106. [Epub ahead of print] Review.
PMID: 31025378

Measuring Thymic Clonal Deletion at the Population Level.
Breed ER, Watanabe M, Hogquist KA.
J Immunol. 2019 Apr 22. pii: ji1900191. doi: 10.4049/jimmunol.1900191. [Epub ahead of print]
PMID: 31010850

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.
Diessner BJ, Marko TA, Scott RM, Eckert AL, Stuebner KM, Hohenhaus AE, Selting KA, Largaespada DA, Modiano JF, Spector LG.
Cancer Med. 2019 Apr 21. doi: 10.1002/cam4.2177. [Epub ahead of print]
PMID: 31006987

Dysbiosis patterns during re-induction/salvage versus induction chemotherapy for acute leukemia.
Rashidi A, Kaiser T, Shields-Cutler R, Graiziger C, Holtan SG, Rehman TU, Wasko J, Weisdorf DJ, Dunny G, Khoruts A, Staley C.
Sci Rep. 2019 Apr 15;9(1):6083. doi: 10.1038/s41598-019-42652-6.
PMID: 30988420

Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.
Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.
J Exp Med. 2019 Apr 12. pii: jem.20181681. doi: 10.1084/jem.20181681. [Epub ahead of print]
PMID: 30979790

ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets.
Borges da Silva H, Wang H, Qian LJ, Hogquist KA, Jameson SC.
J Immunol. 2019 Apr 1;202(7):2153-2163. doi: 10.4049/jimmunol.1801613. Epub 2019 Feb 18.
PMID: 30777922

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells.
Hirai T, Zenke Y, Yang Y, Bartholin L, Beura LK, Masopust D, Kaplan DH.
Immunity. 2019 Mar 23. pii: S1074-7613(19)30092-5. doi: 10.1016/j.immuni.2019.03.002. [Epub ahead of print]
PMID: 30952606

Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues.
Thompson EA, Mitchell JS, Beura LK, Torres DJ, Mrass P, Pierson MJ, Cannon JL, Masopust D, Fife BT, Vezys V.
Cell Rep. 2019 Mar 12;26(11):2859-2867.e4. doi: 10.1016/j.celrep.2019.02.034.
PMID: 30865878

Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis.
Zachs DP, Offutt SJ, Graham RS, Kim Y, Mueller J, Auger JL, Schuldt NJ, Kaiser CRW, Heiller AP, Dutta R, Guo H, Alford JK, Binstadt BA, Lim HH.
Nat Commun. 2019 Mar 12;10(1):951. doi: 10.1038/s41467-019-08721-0.
PMID: 30862842

Combination of Sunitinib and PD-L1 Blockade Enhances Anticancer Efficacy of TLR7/8 Agonist-Based Nanovaccine.
Kim H, Khanna V, Kucaba TA, Zhang W, Ferguson DM, Griffith TS, Panyam J.
Mol Pharm. 2019 Mar 4;16(3):1200-1210. doi: 10.1021/acs.molpharmaceut.8b01165. Epub 2019 Jan 25.
PMID: 30620878

Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
Petitdemange C, Kasturi SP, Kozlowski PA, Nabi R, Quarnstrom CF, Reddy PBJ, Derdeyn CA, Spicer LM, Patel P, Legere T, Kovalenkov YO, Labranche CC, Villinger F, Tomai M, Vasilakos J, Haynes B, Kang CY, Gibbs JS, Yewdell JW, Barouch D, Wrammert J, Montefiori D, Hunter E, Amara RR, Masopust D, Pulendran B.
JCI Insight. 2019 Feb 21;4(4). pii: 126047. doi: 10.1172/jci.insight.126047. eCollection 2019 Feb 21.
PMID: 30830870

Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function.
Dumm RE, Fiege JK, Waring BM, Kuo CT, Langlois RA, Heaton NS.
Nat Commun. 2019 Feb 15;10(1):779. doi: 10.1038/s41467-019-08617-z.
PMID: 30770807

Reprogramming responsiveness to checkpoint blockade in dysfunctional CD8 T cells.
Nelson CE, Mills LJ, McCurtain JL, Thompson EA, Seelig DM, Bhela S, Quarnstrom CF, Fife BT, Vezys V.
Proc Natl Acad Sci U S A.  2019 Feb 12;116(7):2640-2645. doi: 10.1073/pnas.1810326116. Epub 2019 Jan 24.
PMID: 30679280

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy.
Rosato PC, Wijeyesinghe S, Stolley JM, Nelson CE, Davis RL, Manlove LS, Pennell CA, Blazar BR, Chen CC, Geller MA, Vezys V, Masopust D.
Nat Commun. 2019 Feb 4;10(1):567. doi: 10.1038/s41467-019-08534-1.
PMID: 30718505

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Rahrmann EP, Wolf NK, Otto GM, Heltemes-Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.
Mol Cancer Res. 2019 Feb;17(2):567-582. doi: 10.1158/1541-7786.MCR-18-0582. Epub 2018 Oct 24.
PMID: 30355676

Dual TCR T Cells: Identity Crisis or Multitaskers?
Schuldt NJ, Binstadt BA.
J Immunol. 2019 Feb 1;202(3):637-644. doi: 10.4049/jimmunol.1800904. Review.
PMID: 30670579

A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats.
Raleigh MD, Baruffaldi F, Peterson SJ, Le Naour M, Harmon TM, Vigliaturo JR, Pentel PR, Pravetoni M.
J Pharmacol Exp Ther. 2019 Feb;368(2):282-291. doi: 10.1124/jpet.118.253674. Epub 2018 Nov 8.
PMID: 30409833

Thymic regulatory T cells arise via two distinct developmental programs.
Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA.
Nat Immunol. 2019 Feb;20(2):195-205. doi: 10.1038/s41590-018-0289-6. Epub 2019 Jan 14.
PMID: 30643267

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM.
Nat Med. 2019 Jan;25(1):141-151. doi: 10.1038/s41591-018-0221-5. Epub 2018 Nov 12.
PMID: 30420753

Engineering T cell response to cancer antigens by choice of focal therapeutic conditions.
Shao Q, O'Flanagan S, Lam T, Roy P, Pelaez F, Burbach BJ, Azarin SM, Shimizu Y, Bischof JC.
Int J Hyperthermia. 2019 Jan 24:1-9. doi: 10.1080/02656736.2018.1539253. [Epub ahead of print]
PMID: 30676126

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation.
Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB.
Nat Commun. 2019 Jan 21;10(1):354. doi: 10.1038/s41467-019-08300-3.
PMID: 30664665

Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets.
Kotov JA, Jenkins MK.
J Immunol. 2019 Jan 15;202(2):401-405. doi: 10.4049/jimmunol.1801349. Epub 2018 Dec 14.
PMID: 30552165

Autoantibodies in the Pathogenesis, Diagnosis, and Prognosis of Juvenile Idiopathic Arthritis.
Mahmud SA, Binstadt BA.
Front Immunol. 2019 Jan 14;9:3168. doi: 10.3389/fimmu.2018.03168. eCollection 2018. Review.
PMID: 30693002

Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders.
Robinson C, Baehr C, Schmiel SE, Accetturo C, Mueller DL, Pravetoni M.
Hum Vaccin Immunother. 2019 Jan 9. doi: 10.1080/21645515.2018.1558697. [Epub ahead of print]
PMID: 30625019

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.
Lloyd KA, Wigerblad G, Sahlström P, Garimella MG, Chemin K, Steen J, Titcombe PJ, Marklein B, Zhou D, Stålesen R, Ossipova E, Lundqvist C, Ekwall O, Rönnelid J, Mueller DL, Karlsson MCI, Kaplan MJ, Skriner K, Klareskog L, Wermeling F, Malmström V, Grönwall C.
Front Immunol. 2019 Jan 4;9:3033. doi: 10.3389/fimmu.2018.03033. eCollection 2018.
PMID: 30662440 

Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease.
Vaughn BP, Rank KM, Khoruts A.
Clin Gastroenterol Hepatol. 2019 Jan;17(2):353-361. doi: 10.1016/j.cgh.2018.07.026. Epub 2018 Jul 25. Review.
PMID: 30055267

Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies.
Kotov DI, Pengo T, Mitchell JS, Gastinger MJ, Jenkins MK.
J Immunol. 2019 Jan 1;202(1):300-308. doi: 10.4049/jimmunol.1801202. Epub 2018 Dec 3.
PMID: 30510065

Embracing microbial exposure in mouse research.
Huggins MA, Jameson SC, Hamilton SE.
J Leukoc Biol. 2019 Jan;105(1):73-79. doi: 10.1002/JLB.4RI0718-273R. Epub 2018 Sep 27. Review.
PMID: 30260516

Vaccines to treat opioid use disorders and to reduce opioid overdoses.
Baehr C, Pravetoni M.
Neuropsychopharmacology. 2019 Jan;44(1):217-218. doi: 10.1038/s41386-018-0197-3. No abstract available. 
PMID: 30405185

Breaking through to the Other Side: Microenvironment Contributions to DCIS Initiation and Progression.
Nelson AC, Machado HL, Schwertfeger KL.
J Mammary Gland Biol Neoplasia. 2018 Dec;23(4):207-221. doi: 10.1007/s10911-018-9409-z. Epub 2018 Aug 31. Review.
PMID:30168075

Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells.
Goldberg MF, Roeske EK, Ward LN, Pengo T, Dileepan T, Kotov DI, Jenkins MK.
Immunity. 2018 Dec 18;49(6):1090-1102.e7. doi: 10.1016/j.immuni.2018.10.009. Epub 2018 Dec 11.
PMID: 30552021

Adenosine 2a receptor signals block autoimmune arthritis by inhibiting pathogenic germinal center T follicular helper cells.
Schmiel SE, Kalekar LA, Zhang N, Blankespoor TW, Robinson LJ, Mueller DL.
Arthritis Rheumatol. 2018 Dec 5. doi: 10.1002/art.40796. [Epub ahead of print]
PMID: 30516351

Chrysalis: A New Method for High-Throughput Histo-Cytometry Analysis of Images and Movies.
Kotov DI, Pengo T, Mitchell JS, Gastinger MJ, Jenkins MK.
J Immunol. 2018 Dec 3. pii: ji1801202. doi: 10.4049/jimmunol.1801202. [Epub ahead of print]
PMID:30510065

Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.
Breed ER, Lee ST, Hogquist KA.
Semin Cell Dev Biol. 2018 Dec;84:2-10. doi: 10.1016/j.semcdb.2017.07.045. Epub 2017 Aug 9. Review.
PMID:28800929

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis.
Regan Anderson TM, Ma S, Perez Kerkvliet C, Peng Y, Helle TM, Krutilina RI, Raj GV, Cidlowski JA, Ostrander JH, Schwertfeger KL, Seagroves TN, Lange CA.
Mol Cancer Res. 2018 Nov;16(11):1761-1772. doi: 10.1158/1541-7786.MCR-18-0410. Epub 2018 Jul 10.
PMID:29991529

Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy.
Kim H, Sehgal D, Kucaba TA, Ferguson DM, Griffith TS, Panyam J.
Nanoscale. 2018 Nov 15;10(44):20851-20862. doi: 10.1039/c8nr07201a.
PMID: 30403212

US Immigration Westernizes the Human Gut Microbiome.
Vangay P, Johnson AJ, Ward TL, Al-Ghalith GA, Shields-Cutler RR, Hillmann BM, Lucas SK, Beura LK, Thompson EA, Till LM, Batres R, Paw B, Pergament SL, Saenyakul P, Xiong M, Kim AD, Kim G, Masopust D, Martens EC, Angkurawaranon C, McGready R, Kashyap PC, Culhane-Pera KA, Knights D.
Cell. 2018 Nov 1;175(4):962-972.e10. doi: 10.1016/j.cell.2018.10.029.
PMID: 30388453

Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses.
Sjaastad FV, Condotta SA, Kotov JA, Pape KA, Dail C, Danahy DB, Kucaba TA, Tygrett LT, Murphy KA, Cabrera-Perez J, Waldschmidt TJ, Badovinac VP, Griffith TS.
Front Immunol. 2018 Oct 31;9:2532. doi: 10.3389/fimmu.2018.02532. eCollection 2018.
PMID: 30429857

Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.
Jensen IJ, Winborn CS, Fosdick MG, Shao P, Tremblay MM, Shan Q, Tripathy SK, Snyder CM, Xue HH, Griffith TS, Houtman JC, Badovinac VP.
PLoS Pathog. 2018 Oct 31;14(10):e1007405. doi: 10.1371/journal.ppat.1007405. eCollection 2018 Oct.
PMID: 30379932

Targeting the microbiome: from probiotics to fecal microbiota transplantation.
Khoruts A.
Genome Med. 2018 Oct 30;10(1):80. doi: 10.1186/s13073-018-0592-8.
PMID: 30376869

Enrichment and Quantification of Epitope-specific CD4+ T Lymphocytes using Ferromagnetic Iron-gold and Nickel Nanowires.
Shore DE, Dileepan T, Modiano JF, Jenkins MK, Stadler BJH.
Sci Rep. 2018 Oct 24;8(1):15696. doi: 10.1038/s41598-018-33910-0.
PMID: 30356071

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Rahrmann EP, Wolf NK, Otto GM, Heltemes Harris L, Ramsey LB, Shu J, LaRue RS, Linden MA, Rathe SK, Starr TK, Farrar MA, Moriarity BS, Largaespada DA.
Mol Cancer Res. 2018 Oct 24. pii: molcanres.0582.2018. doi: 10.1158/1541-7786.MCR-18-0582. [Epub ahead of print]
PMID: 30355676

MicroRNA-Attenuated Virus Vaccines.
Fay EJ, Langlois RA.
Noncoding RNA. 2018 Oct 2;4(4). pii: E25. doi: 10.3390/ncrna4040025. Review.
PMID: 30279330

Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy.
Murphy KA, James BR, Sjaastad FV, Kucaba TA, Kim H, Brincks EL, Chua SC Jr, Wilber A, Griffith TS.
J Immunol. 2018 Oct 1;201(7):1837-1841. doi: 10.4049/jimmunol.1701738. Epub 2018 Aug 22.
PMID: 30135180

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.
McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, Kirchmeier AK, Osborn MJ, Hippen KL, Kelekar A, Serody JS, Turka LA, Munn DH, Chi H, Neubert TA, Dustin ML, Blazar BR.
J Clin Invest. 2018 Oct 1;128(10):4604-4621. doi: 10.1172/JCI95713. Epub 2018 Aug 14.
PMID: 30106752

Embracing microbial exposure in mouse research.
Huggins MA, Jameson SC, Hamilton SE.
J Leukoc Biol. 2018 Sep 27. doi: 10.1002/JLB.4RI0718-273R. [Epub ahead of print] Review.
PMID:30260516

1,25-Dihydroxyvitamin D3 increases the methionine cycle, CD4+ T cell DNA methylation and Helios+Foxp3+ T regulatory cells to reverse autoimmune neurodegenerative disease.
Moore JR, Hubler SL, Nelson CD, Nashold FE, Spanier JA, Hayes CE.
J Neuroimmunol. 2018 Nov 15;324:100-114. doi: 10.1016/j.jneuroim.2018.09.008. Epub 2018 Sep 21
PMID:30267995

Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo.
Sjaastad LE, Fay EJ, Fiege JK, Macchietto MG, Stone IA, Markman MW, Shen S, Langlois RA.
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9610-9615. doi: 10.1073/pnas.1807516115. Epub 2018 Sep 4.
PMID: 30181264

Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell Vaccines: To B or Not to B?
Beura LK, Jameson SC, Masopust D.
Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a028910. doi: 10.1101/cshperspect.a028910. Review.
PMID: 29254982

Human plasma cell derived monoclonal antibodies to post-translationally modified proteins recognize amino acid motifs rather than specific proteins.
Steen J, Forsström B, Sahlström P, Odowd V, Israelsson L, Krishnamurthy A, Badreh S, Mathsson Alm L, Compson J, Ramsköld D, Ndlovu W, Rapecki S, Hansson M, Titcombe PJ, Bang H, Mueller DL, Catrina AI, Grönwall C, Skriner K, Nilsson P, Lightwood D, Klareskog L, Malmström V.
Arthritis Rheumatol. 2018 Aug 27. doi: 10.1002/art.40699. [Epub ahead of print]
PMID: 30152202

CCR7 defines a precursor for murine iNKT cells in thymus and periphery.
Wang H, Hogquist KA.
Elife. 2018 Aug 13;7. pii: e34793. doi: 10.7554/eLife.34793.
PMID: 30102153

Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease.
Vaughn BP, Rank KM, Khoruts A.
Clin Gastroenterol Hepatol. 2018 Jul 25. pii: S1542-3565(18)30751-1. doi: 10.1016/j.cgh.2018.07.026. [Epub ahead of print] Review.
PMID:30055267

Eradication of Established Tumors by Chemically Self-Assembled Nanoring Labeled T Cells.
Petersburg JR, Shen J, Csizmar CM, Murphy KA, Spanier J, Gabrielse K, Griffith TS, Fife B, Wagner CR
ACS Nano. 2018 Jul 24;12(7):6563-6576. doi: 10.1021/acsnano.8b01308. Epub 2018 Jun 4.
PMID: 29792808

A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance.
Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA.
Arthritis Res Ther. 2018 Jul 27;20(1):154. doi: 10.1186/s13075-018-1661-5.
PMID:30053832

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS.
Nature. 2018 Jul 18. doi: 10.1038/s41586-018-0345-2. [Epub ahead of print]
PMID:30022164

Cutting Edge: Evidence for Nonvascular Route of Visceral Organ Immunosurveillance by T Cells.
Steinert EM, Thompson EA, Beura LK, Adam OA, Mitchell JS, Guo M, Breed ER, Sjaastad FV, Vezys V, Masopust D.
J Immunol. 2018 Jul 15;201(2):337-342. doi: 10.4049/jimmunol.1800279. Epub 2018 Jun 6.
PMID:29875151

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells.
Borges da Silva H, Beura LK, Wang H, Hanse EA, Gore R, Scott MC, Walsh DA, Block KE, Fonseca R, Yan Y, Hippen KL, Blazar BR, Masopust D, Kelekar A, Vulchanova L, Hogquist KA, Jameson SC.
Nature. 2018 Jul 4. doi: 10.1038/s41586-018-0282-0. [Epub ahead of print]
PMID: 29973721

SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma.
Sakthikumar S, Elvers I, Kim J, Arendt ML, Thomas R, Turner-Maier J, Swofford R, Johnson J, Schumacher SE, Alföldi J, Axelsson E, Couto CG, Kisseberth WC, Pettersson ME, Getz G, Meadows JRS, Modiano JF, Breen M, Kierczak M, Forsberg-Nilsson K, Marinescu VD, Lindblad-Toh K.
Cancer Res. 2018 Jul 1;78(13):3421-3431. doi: 10.1158/0008-5472.CAN-17-3558. Epub 2018 May 3.
PMID: 29724721

For T Cells, the Child Is Father of the Man.
Hogquist KA, Hamilton SE.
Cell. 2018 Jun 28;174(1):16-18. doi: 10.1016/j.cell.2018.06.015.
PMID: 29958105

How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.
Wang H, Hogquist KA.
Front Immunol. 2018 Jun 26;9:1450. doi: 10.3389/fimmu.2018.01450. eCollection 2018. Review.
PMID: 29997620

The virtuous self-tolerance of virtual memory T cells.
Truckenbrod EN, Jameson SC.
EMBO J. 2018 Jun 26. pii: e99883. doi: 10.15252/embj.201899883. [Epub ahead of print] No abstract available.
PMID:29946017

Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis.
Titcombe PJ, Wigerblade G, Sippl N, Zhang N, Shmagel AK, Sahlström P, Zhang Y, Barsness LO, Ghodke-Puranik Y, Baharpoor A, Hansson M, Israelsson L, Skriner K, Niewold TB, Klareskog L, Svensson CI, Amara K, Malmström V, Mueller DL.
Arthritis Rheumatol. 2018 Jun 21. doi: 10.1002/art.40590. [Epub ahead of print]
PMID:29927106

Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment.
Burns MB, Montassier E, Abrahante J, Priya S, Niccum DE, Khoruts A, Starr TK, Knights D, Blekhman R.
PLoS Genet. 2018 Jun 20;14(6):e1007376. doi: 10.1371/journal.pgen.1007376. [Epub ahead of print]
PMID:29924794 

Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM+ and Transient IgG+ Memory B Cells.
Pape KA, Maul RW, Dileepan T, Paustian AS, Gearhart PJ, Jenkins MK.
Immunity. 2018 Jun 19;48(6):1135-1143.e4. doi: 10.1016/j.immuni.2018.04.019. Epub 2018 Jun 5.
PMID:29884459

CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis.
Meier LA, Auger JL, Engelson BJ, Cowan HM, Breed ER, Gonzalez-Torres MI, Boyer JD, Verma M, Marath A, Binstadt BA.
Circulation. 2018 Jun 5;137(23):2478-2493. doi: 10.1161/CIRCULATIONAHA.117.033144. Epub 2018 Jan 31.
PMID:29386201

Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.
Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR.
Sci Immunol. 2018 Jun 1;3(24). pii: eaar4526. doi: 10.1126/sciimmunol.aar4526.
PMID:29858286

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Osum KC, Burrack AL, Martinov T, Sahli NL, Mitchell JS, Tucker CG, Pauken KE, Papas K, Appakalai B, Spanier JA, Fife BT.
Sci Rep. 2018 May 29;8(1):8295. doi: 10.1038/s41598-018-26471-9.
PMID:29844327

Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization.
Tan HX, Wheatley AK, Esterbauer R, Jegaskanda S, Glass JJ, Masopust D, De Rose R, Kent SJ.
Mucosal Immunol. 2018 May;11(3):994-1007. doi: 10.1038/mi.2017.89. Epub 2017 Oct 25.
PMID:29067995

Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy.
Kim H, Niu L, Larson P, Kucaba TA, Murphy KA, James BR, Ferguson DM, Griffith TS, Panyam J.
Biomaterials. 2018 May;164:38-53. doi: 10.1016/j.biomaterials.2018.02.034. Epub 2018 Feb 17.
PMID: 29482062

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis.
Owen DL, Mahmud SA, Vang KB, Kelly RM, Blazar BR, Smith KA, Farrar MA.
J Immunol. 2018 May 4. pii: ji1800097. doi: 10.4049/jimmunol.1800097. [Epub ahead of print]
PMID:29728511

Duration of high-dose aspirin therapy does not affect long-term coronary artery outcomes in Kawasaki disease.
Migally K, Braunlin EA, Zhang L, Binstadt BA.
Pediatr Res. 2018 May 2. doi: 10.1038/pr.2018.44. [Epub ahead of print]
PMID:29554081

Is fecal microbiota transplantation a temporary patch for treatment of Clostridium difficile infection or a new frontier of therapeutics?
Khoruts A.
Expert Rev Gastroenterol Hepatol. 2018 May;12(5):435-438. doi: 10.1080/17474124.2018.1465818. Epub 2018 Apr 20.No abstract available.
PMID:29667436

Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.
Raleigh MD, Laudenbach M, Baruffaldi F, Peterson SJ, Roslawski MJ, Birnbaum AK, Carroll FI, Runyon SP, Winston S, Pentel PR, Pravetoni M.
J Pharmacol Exp Ther. 2018 May;365(2):346-353. doi: 10.1124/jpet.117.247049. Epub 2018 Mar 13.
PMID:29535156

The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology.
Meier LA, Binstadt BA.
Front Immunol. 2018 Apr 27;9:911. doi: 10.3389/fimmu.2018.00911. eCollection 2018. Review.
PMID: 29755478

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.
Hülsdünker J, Ottmüller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, Follo M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser MJ, Fife BT, Blazar BR, Beilhack A, Hill GR, Häcker G, Zeiser R.
Blood. 2018 Apr 19;131(16):1858-1869. doi: 10.1182/blood-2017-10-812891. Epub 2018 Feb 20.
PMID:29463561

Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose.
Laudenbach M, Baruffaldi F, Robinson C, Carter P, Seelig D, Baehr C, Pravetoni M.
Sci Rep. 2018 Apr 3;8(1):5508. doi: 10.1038/s41598-018-23777-6.
PMID:29615715 

What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Reevaluating the Potential of Mouse Models for the Human Immune System.
Jameson SC, Masopust D.
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a029132. doi: 10.1101/cshperspect.a029132. Review.
PMID:28348039

Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.
Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K.
Circulation. 2018 Mar 27. pii: CIRCULATIONAHA.117.031420. doi: 10.1161/CIRCULATIONAHA.117.031420. [Epub ahead of print]
PMID:29588316

Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.
Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, Cichocki F, Miller JS, Hart GT, Johnson AJ, Jameson SC, Hamilton SE.
Immunity. 2018 Mar 20. pii: S1074-7613(18)30088-8. doi: 10.1016/j.immuni.2018.03.012. [Epub ahead of print]
PMID:29625893

Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers.
Kim JH, Frantz AM, Sarver AL, Gorden Klukas BH, Lewellen M, O'Brien TD, Dickerson EB, Modiano JF.
Vet Comp Oncol. 2018 Mar;16(1):E176-E184. doi: 10.1111/vco.12368. Epub 2017 Nov 20. Erratum in: Vet Comp Oncol. 2018 Sep;16(3):416.
PMID: 29152836

Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.
Kotov DI, Kotov JA, Goldberg MF, Jenkins MK.
J Immunol. 2018 Mar 15;200(6):2004-2012. doi: 10.4049/jimmunol.1700420. Epub 2018 Feb 7.
PMID:29436413

Inflammatory arthritis in pediatric patients with morphea.
Kashem SW, Correll CK, Vehe RK, Hobday PM, Binstadt BA, Maguiness SM.
J Am Acad Dermatol. 2018 Mar 10. pii: S0190-9622(18)30365-7. doi: 10.1016/j.jaad.2018.03.005. [Epub ahead of print]
PMID:29535035

Antibiotic-induced Disruption of Intestinal Microbiota Contributes to Failure of Vertical Sleeve Gastrectomy.
Jahansouz C, Staley C, Kizy S, Xu H, Hertzel AV, Coryell J, Singroy S, Hamilton M, DuRand M, Bernlohr DA, Sadowsky MJ, Khoruts A, Ikramuddin S.
Ann Surg. 2018 Mar 8. doi: 10.1097/SLA.0000000000002729. [Epub ahead of print]
PMID:29521742

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection.
Lloyd KA, Steen J, Amara K, Titcombe PJ, Israelsson L, Lundström SL, Zhou D, Zubarev RA, Reed E, Piccoli L, Gabay C, Lanzavecchia A, Baeten D, Lundberg K, Mueller DL, Klareskog L, Malmström V, Grönwall C.
Eur J Immunol. 2018 Mar 7. doi: 10.1002/eji.201747446. [Epub ahead of print]
PMID: 29512823

Intravenous Labeling and Analysis of the Content of Thymic Perivascular Spaces.
Ruscher R, Hogquist KA.
Bio Protoc. 2018 Mar 5;8(5). pii: e2757. doi: 10.21769/bioprotoc.2757.
PMID: 29644257

RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation.
Nair PM, Starkey MR, Haw TJ, Ruscher R, Liu G, Maradana MR, Thomas R, O'Sullivan BJ, Hansbro PM.
Am J Respir Cell Mol Biol. 2018 Mar;58(3):352-365. doi: 10.1165/rcmb.2017-0242OC.
PMID:28960101

A Howling Cause of Pancytopenia.
Casciato A, Lind C, Olson APJ, Binstadt BA, Davis AM.
J Hosp Med. 2018 Mar 1;13(3):205-209. doi: 10.12788/jhm.2855. Epub 2017 Oct 4. No abstract available.
PMID: 29069118

Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation.
Smillie CS, Sauk J, Gevers D, Friedman J, Sung J, Youngster I, Hohmann EL, Staley C, Khoruts A, Sadowsky MJ, Allegretti JR, Smith MB, Xavier RJ, Alm EJ.
Cell Host Microbe. 2018 Feb 14;23(2):229-240.e5. doi: 10.1016/j.chom.2018.01.003.
PMID:29447696

Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.
Foss JD, Fiege J, Shimizu Y, Collister JP, Mayerhofer T, Wood L, Osborn JW.
Physiol Rep. 2018 Feb;6(3). doi: 10.14814/phy2.13602.
PMID:29405658 

Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations.
Hadjiliadis D, Khoruts A, Zauber AG, Hempstead SE, Maisonneuve P, Lowenfels AB; Cystic Fibrosis Colorectal Cancer Screening Task Force.
Gastroenterology. 2018 Feb;154(3):736-745.e14. doi: 10.1053/j.gastro.2017.12.012. Epub 2017 Dec 29.
PMID:29289528

Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides.
Burrack AL, Malhotra D, Dileepan T, Osum KC, Swanson LA, Fife BT, Jenkins MK.
J Immunol. 2018 Jan 15;200(2):477-482. doi: 10.4049/jimmunol.1701434. Epub 2017 Dec 18.
PMID: 29255075

Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides.
Burrack AL, Malhotra D, Dileepan T, Osum KC, Swanson LA, Fife BT, Jenkins MK.
J Immunol. 2018 Jan 15;200(2):477-482. doi: 10.4049/jimmunol.1701434. Epub 2017 Dec 18.
PMID:29255075

Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.
Scott MC, Temiz NA, Sarver AE, LaRue RS, Rathe SK, Varshney J, Wolf NK, Moriarity BS, O'Brien TD, Spector LG, Largaespada DA, Modiano JF, Subramanian S, Sarver AL.
Cancer Res. 2018 Jan 15;78(2):326-337. doi: 10.1158/0008-5472.CAN-17-0576. Epub 2017 Oct 24.
PMID: 29066513

MicroRNA-Based Attenuation of Influenza Virus across Susceptible Hosts.
Waring BM, Sjaastad LE, Fiege JK, Fay EJ, Reyes I, Moriarity B, Langlois RA.
J Virol. 2018 Jan 2;92(2). pii: e01741-17. doi: 10.1128/JVI.01741-17. Print 2018 Jan 15.
PMID: 29093096

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.
Schmidt ME, Knudson CJ, Hartwig SM, Pewe LL, Meyerholz DK, Langlois RA, Harty JT, Varga SM.
PLoS Pathog. 2018 Jan 2;14(1):e1006810. doi: 10.1371/journal.ppat.1006810. eCollection 2018 Jan.
PMID: 29293660

Do Memory B Cells Form Secondary Germinal Centers? It Depends.
Pape KA, Jenkins MK.
Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1). pii: a029116. doi: 10.1101/cshperspect.a029116. Review.
PMID: 28320756

Functional Genomics of Host-Microbiome Interactions in Humans.
Luca F, Kupfer SS, Knights D, Khoruts A, Blekhman R.
Trends Genet. 2018 Jan;34(1):30-40. doi: 10.1016/j.tig.2017.10.001. Epub 2017 Oct 26. Review.
PMID: 29107345

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.
Canter RJ, Grossenbacher SK, Foltz JA, Sturgill IR, Park JS, Luna JI, Kent MS, Culp WTN, Chen M, Modiano JF, Monjazeb AM, Lee DA, Murphy WJ.
J Immunother Cancer. 2017 Dec 19;5(1):98. doi: 10.1186/s40425-017-0305-7.
PMID: 29254507

Cutting Edge: Allograft Rejection Is Associated with Weak T Cell Responses to Many Different Graft Leukocyte-Derived Peptides.
Burrack AL, Malhotra D, Dileepan T, Osum KC, Swanson LA, Fife BT, Jenkins MK.
J Immunol. 2017 Dec 18. pii: ji1701434. doi: 10.4049/jimmunol.1701434. [Epub ahead of print]
PMID: 29255075

Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell Vaccines: To B or Not to B?
Beura LK, Jameson SC, Masopust D.
Cold Spring Harb Perspect Biol. 2017 Dec 18. pii: a028910. doi: 10.1101/cshperspect.a028910. [Epub ahead of print]
PMID: 29254982

The current status of immunobased therapies for metastatic renal-cell carcinoma.
Sathianathen NJ, Krishna S, Anderson JK, Weight CJ, Gupta S, Konety BR, Griffith TS.
Immunotargets Ther. 2017 Dec 5;6:83-93. doi: 10.2147/ITT.S134850. eCollection 2017. Review.
PMID: 29255699

T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes.
Burrack AL, Martinov T, Fife BT.
Front Endocrinol (Lausanne). 2017 Dec 5;8:343. doi: 10.3389/fendo.2017.00343. eCollection 2017. Review.
PMID: 29259578

Increased Effector Memory Insulin-Specific CD4+T-cells Correlate with Insulin Autoantibodies in Recent-Onset Type 1 Diabetic Patients.
Spanier JA, Sahli NL, Wilson JC, Martinov T, Dileepan T, Burrack AL, Finger EB, Blazar BR, Michels AW, Moran A, Jenkins MK, Fife BT.
Diabetes. 2017 Dec;66(12):3051-3060. doi: 10.2337/db17-0666. Epub 2017 Aug 25
PMID: 28842400

Contemporary Applications of Fecal Microbiota Transplantation to Treat Intestinal Diseases in Humans.
Staley C, Khoruts A, Sadowsky MJ.
Arch Med Res. 2017 Nov 25. pii: S0188-4409(17)30235-7. doi: 10.1016/j.arcmed.2017.11.006. [Epub ahead of print] Review.
PMID:29183720

Functional Genomics of Host-Microbiome Interactions in Humans.
Luca F, Kupfer SS, Knights D, Khoruts A, Blekhman R.
Trends Genet. 2017 Oct 26. pii: S0168-9525(17)30182-8. doi: 10.1016/j.tig.2017.10.001. [Epub ahead of print] Review.
PMID: 29107345

Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization.
Tan HX, Wheatley AK, Esterbauer R, Jegaskanda S, Glass JJ, Masopust D, De Rose R, Kent SJ.
Mucosal Immunol. 2017 Oct 25. doi: 10.1038/mi.2017.89. [Epub ahead of print]
PMID: 29067995

Wait, Wait … OK Now Go In: iNKT Cells Resolve Liver Inflammation.
Wang H, Hogquist KA.
Immunity. 2017 Oct 17;47(4):609-610. doi: 10.1016/j.immuni.2017.10.002.
PMID: 29045892

Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.
Larson P, Kucaba TA, Xiong Z, Olin M, Griffith TS, Ferguson DM.
ACS Med Chem Lett. 2017 Oct 16;8(11):1148-1152. doi: 10.1021/acsmedchemlett.7b00256. eCollection 2017 Nov 9.
PMID: 29152046

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.
Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML.
Dev Cell. 2017 Oct 13. pii: S1534-5807(17)30782-7. doi: 10.1016/j.devcel.2017.09.023. [Epub ahead of print]
PMID: 29056552

Defining total-body AIDS-virus burden with implications for curative strategies.
Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, Callisto SP, Pearson H, Reimann T, Schuster J, Schoephoerster J, Southern P, Perkey K, Shang L, Wietgrefe SW, Fletcher CV, Lifson JD, Douek DC, McCune JM, Haase AT, Schacker TW.
Nat Med. 2017 Oct 2. doi: 10.1038/nm.4411. [Epub ahead of print]
PMID:28967921

Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions.
Aukes K, Forsman C, Brady NJ, Astleford K, Blixt N, Sachdev D, Jensen ED, Mansky KC, Schwertfeger KL.
PLoS One. 2017 Oct 2;12(10):e0185736. doi: 10.1371/journal.pone.0185736. eCollection 2017.
PMID:28968431

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
Danahy DB, Anthony SM, Jensen IJ, Hartwig SM, Shan Q, Xue HH, Harty JT, Griffith TS, Badovinac VP.
PLoS Pathog. 2017 Sep 14;13(9):e1006569. doi: 10.1371/journal.ppat.1006569. eCollection 2017 Sep.
PMID: 28910403

The synergy between ionizing radiation and immunotherapy in the treatment of prostate cancer.
Sathianathen NJ, Krishna S, Konety BR, Griffith TS.
Immunotherapy. 2017 Sep;9(12):1005-1018. doi: 10.2217/imt-2017-0051.
PMID: 28971750

TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.
Hirsova P, Weng P, Salim W, Bronk SF, Griffith TS, Ibrahim SH, Gores GJ.
Hepatol Commun. 2017 Sep;1(7):648-662. doi: 10.1002/hep4.1069. Epub 2017 Jul 20.
PMID: 29124251

Landscape review of current HIV 'kick and kill' cure research - some kicking, not enough killing.
Thorlund K, Horwitz MS, Fife BT, Lester R, Cameron DW.
BMC Infect Dis. 2017 Aug 29;17(1):595. doi: 10.1186/s12879-017-2683-3. Review.
PMID: 28851294

Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.
Breed ER, Lee ST, Hogquist KA.
Semin Cell Dev Biol. 2017 Aug 9. pii: S1084-9521(16)30452-9. doi: 10.1016/j.semcdb.2017.07.045. [Epub ahead of print] Review.
PMID: 28800929

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.
Brady NJ, Farrar MA, Schwertfeger KL.
Dev Biol. 2017 Aug 1;428(1):232-244. doi: 10.1016/j.ydbio.2017.06.007. Epub 2017 Jun 9
PMID: 28606561

Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning.
Staley C, Kaiser T, Beura LK, Hamilton MJ, Weingarden AR, Bobr A, Kang J, Masopust D, Sadowsky MJ, Khoruts A.
Microbiome. 2017 Aug 1;5(1):87. doi: 10.1186/s40168-017-0306-2.
PMID:28760163 

Corrigendum: Spontaneous partial loss of the OT-I transgene.
Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.
Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951b. No abstract available.
PMID:28722721

Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers.
Tien SH, Crabtree JN, Gray HL, Peterson EJ.
PLoS One. 2017 Jul 19;12(7):e0181338. doi: 10.1371/journal.pone.0181338. eCollection 2017.
PMID: 28723925 

Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.
Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA.
Immunity. 2017 Jul 18;47(1):107-117.e8. doi: 10.1016/j.immuni.2017.06.015. Epub 2017 Jul 11.
PMID: 28709804

Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology.
Masopust D, Sivula CP, Jameson SC.
J Immunol. 2017 Jul 15;199(2):383-388. doi: 10.4049/jimmunol.1700453. Review.
PMID: 28696328

Tissue-resident memory T cells live off the fat of the land.
Stolley JM, Masopust D.
Cell Res. 2017 Jul;27(7):847-848. doi: 10.1038/cr.2017.49. Epub 2017 Mar 31
PMID: 28361896

CD8αα intraepithelial lymphocytes arise from two main thymic precursors.
Ruscher R, Kummer RL, Lee YJ, Jameson SC, Hogquist KA.
Nat Immunol. 2017 Jul;18(7):771-779. doi: 10.1038/ni.3751. Epub 2017 May 22.
PMID: 28530714

Cytokine-mediated activation of human ex vivo-expanded Vγ9Vδ2 T cells.
Domae E, Hirai Y, Ikeo T, Goda S, Shimizu Y.
Oncotarget. 2017 Jul 11;8(28):45928-45942. doi: 10.18632/oncotarget.17498.
PMID:28521284

Combination therapeutics of Nilotinib and radiation in acute lymphoblastic leukemia as an effective method against drug-resistance.
Kaveh K, Takahashi Y, Farrar MA, Storme G, Guido M, Piepenburg J, Penning J, Foo J, Leder KZ, Hui SK.
PLoS Comput Biol. 2017 Jul 6;13(7):e1005482. doi: 10.1371/journal.pcbi.1005482. eCollection 2017 Jul.
PMID:28683103 

Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation.
Schuldt NJ, Auger JL, Spanier JA, Martinov T, Breed ER, Fife BT, Hogquist KA, Binstadt BA.
J Immunol. 2017 Jul 1;199(1):33-38. doi: 10.4049/jimmunol.1700406. Epub 2017 May 24.
PMID: 28539428

Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.
Seelig DM, Ito D, Forster CL, Yoon UA, Breen M, Burns LJ, Bachanova V, Lindblad-Toh K, O'Brien TD, Schmechel SC, Rizzardi AE, Modiano JF, Linden MA.
Leuk Lymphoma. 2017 Jul;58(7):1702-1710. doi: 10.1080/10428194.2016.1260122. Epub 2016 Dec 8.
PMID: 27931134

Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.
Im KS, Graef AJ, Breen M, Lindblad-Toh K, Modiano JF, Kim JH.
Vet Comp Oncol. 2017 Jun;15(2):315-327. doi: 10.1111/vco.12165. Epub 2015 Sep 3. Erratum in: Vet Comp Oncol. 2018 Sep;16(3):416.
PMID: 26337509

Sleeve Gastrectomy Drives Persistent Shifts in the Gut Microbiome.
Jahansouz C, Staley C, Bernlohr DA, Sadowsky MJ, Khoruts A, Ikramuddin S.
Surg Obes Relat Dis. 2017 Jun;13(6):916-924. doi: 10.1016/j.soard.2017.01.003. Epub 2017 Jan 4.
PMID: 28279578

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.
Katerndahl CD, Heltemes-Harris LM, Willette MJ, Henzler CM, Frietze S, Yang R, Schjerven H, Silverstein KA, Ramsey LB, Hubbard G, Wells AD, Kuiper RP, Scheijen B, van Leeuwen FN, Müschen M, Kornblau SM, Farrar MA.
Nat Immunol. 2017 Jun;18(6):694-704. doi: 10.1038/ni.3716. Epub 2017 Apr 3.
PMID: 28369050

Infection Followed by Graft-versus-Host Disease: Pathogenic Role of Antibiotics.
Rashidi A, Khoruts A, Weisdorf DJ.
Biol Blood Marrow Transplant. 2017 Jun;23(6):1038-1039. doi: 10.1016/j.bbmt.2017.02.016. Epub 2017 Feb 28. No abstract available.
PMID:28257799

Successful Resolution of Recurrent Clostridium difficile Infection using Freeze-Dried, Encapsulated Fecal Microbiota; Pragmatic Cohort Study.
Staley C, Hamilton MJ, Vaughn BP, Graiziger CT, Newman KM, Kabage AJ, Sadowsky MJ, Khoruts A.
Am J Gastroenterol. 2017 Jun;112(6):940-947. doi: 10.1038/ajg.2017.6. Epub 2017 Feb 14.
PMID: 28195180

T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction.
Smith MJ, Reichenbach DK, Parker SL, Riddle MJ, Mitchell J, Osum KC, Mohtashami M, Stefanski HE, Fife BT, Bhandoola A, Hogquist KA, Holländer GA, Zúñiga-Pflücker JC, Tolar J, Blazar BR.
JCI Insight. 2017 May 18;2(10). pii: 92056. doi: 10.1172/jci.insight.92056. [Epub ahead of print]
PMID:28515359 

Implications of Resident Memory T Cells for Transplantation.
Beura LK, Rosato PC, Masopust D.
Am J Transplant. 2017 May;17(5):1167-1175. doi: 10.1111/ajt.14101. Epub 2016 Dec 9. Review.
PMID: 27804207

Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease.
Khanna S, Vazquez-Baeza Y, González A, Weiss S, Schmidt B, Muñiz-Pedrogo DA, Rainey JF 3rd, Kammer P, Nelson H, Sadowsky M, Khoruts A, Farrugia SL, Knight R, Pardi DS, Kashyap PC.
Microbiome. 2017 May 15;5(1):55. doi: 10.1186/s40168-017-0269-3.
PMID:28506317 

Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy.
Wang H, Kwak D, Fassett J, Liu X, Yao W, Weng X, Xu X, Xu Y, Bache RJ, Mueller DL, Chen Y.
Basic Res Cardiol. 2017 May;112(3):25. doi: 10.1007/s00395-017-0615-4. Epub 2017 Mar 27.
PMID: 28349258

Community dynamics drive punctuated engraftment of the fecal microbiome following transplantation using freeze-dried, encapsulated fecal microbiota.
Staley C, Vaughn BP, Graiziger CT, Singroy S, Hamilton MJ, Yao D, Chen C, Khoruts A, Sadowsky MJ.
Gut Microbes. 2017 May 4;8(3):276-288. doi: 10.1080/19490976.2017.1299310. Epub 2017 Feb 28.
PMID:28282270

Analysis of gut microbiota - An ever changing landscape.
Sadowsky MJ, Staley C, Heiner C, Hall R, Kelly CR, Brandt L, Khoruts A.
Gut Microbes. 2017 May 4;8(3):268-275. doi: 10.1080/19490976.2016.1277313. Epub 2017 Jan 4.
PMID: 28051919

Fecal Microbiota Transplantation - Early Steps on a Long Journey Ahead.
Khoruts A.
Gut Microbes. 2017 May 4;8(3):199-204. doi: 10.1080/19490976.2017.1316447. Epub 2017 Apr 10. No abstract available.
PMID: 28394706

Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease.
Newman KM, Rank KM, Vaughn BP, Khoruts A.
Gut Microbes. 2017 May 4;8(3):303-309. doi: 10.1080/19490976.2017.1279377. Epub 2017 Jan 19.
PMID: 28102756

Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy.
Wang H, Kwak D, Fassett J, Liu X, Yao W, Weng X, Xu X, Xu Y, Bache RJ, Mueller DL, Chen Y.
Basic Res Cardiol. 2017 May;112(3):25. doi: 10.1007/s00395-017-0615-4. Epub 2017 Mar 27.
PMID: 28349258

Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.
Borgatti A, Koopmeiners JS, Sarver AL, Winter AL, Stuebner K, Todhunter D, Rizzardi AE, Henriksen JC, Schmechel S, Forster CL, Kim JH, Froelich J, Walz J, Henson MS, Breen M, Lindblad-Toh K, Oh F, Pilbeam K, Modiano JF, Vallera DA.
Mol Cancer Ther. 2017 May;16(5):956-965. doi: 10.1158/1535-7163.MCT-16-0637. Epub 2017 Feb 13.
PMID: 28193671

Synthesis and Biological Evaluation of Bile Acid Analogues Inhibitory to Clostridium difficile Spore Germination.
Stoltz KL, Erickson R, Staley C, Weingarden AR, Romens E, Steer CJ, Khoruts A, Sadowsky MJ, Dosa PI.
J Med Chem. 2017 Apr 27;60(8):3451-3471. doi: 10.1021/acs.jmedchem.7b00295. Epub 2017 Apr 12.
PMID: 28402634

Antigen-Presenting Cells in the Skin.
Kashem SW, Haniffa M, Kaplan DH.
Annu Rev Immunol. 2017 Apr 26;35:469-499. doi: 10.1146/annurev-immunol-051116-052215. Epub 2017 Feb 6.
PMID: 28226228

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies.
Murphy KA, James BR, Wilber A, Griffith TS.
J Vis Exp. 2017 Apr 12;(122). doi: 10.3791/55080.
PMID: 28448047

Do Memory B Cells Form Secondary Germinal Centers? It Depends.
Pape KA, Jenkins MK.
Cold Spring Harb Perspect Biol. 2017 Mar 20. pii: a029116. doi: 10.1101/cshperspect.a029116. [Epub ahead of print]
PMID: 28320756

Tissue resident memory T cells and viral immunity.
Rosato PC, Beura LK, Masopust D.
Curr Opin Virol. 2017 Feb;22:44-50. doi: 10.1016/j.coviro.2016.11.011. Epub 2016 Dec 14. Review.
PMID: 27987416

Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.
Wiesner DL, Smith KD, Kashem SW, Bohjanen PR, Nielsen K.
J Immunol. 2017 Feb 15;198(4):1627-1637. doi: 10.4049/jimmunol.1600821. 
PMID: 28069805

Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia.
Landry J, Martinov T, Mengistu H, Dhanwada J, Benck CJ, Kline J, Boo B, Swanson L, Tonc E, Daughters R, Fife BT, Chatterjea D.
PLoS One. 2017 Feb 3;12(2):e0169672. doi: 10.1371/journal.pone.0169672.
PMID: 28158195

Gut-sparing treatment of urinary tract infection in patients at high risk of Clostridium difficile infection.
Staley C, Vaughn BP, Graiziger CT, Sadowsky MJ, Khoruts A.
J Antimicrob Chemother. 2017 Feb;72(2):522-528. doi: 10.1093/jac/dkw499. 
PMID: 27999027

Cutting Edge: Adenosine A2a Receptor Signals Inhibit Germinal Center T Follicular Helper Cell Differentiation during the Primary Response to Vaccination.
Schmiel SE, Yang JA, Jenkins MK, Mueller DL.
J Immunol. 2017 Jan 15;198(2):623-628. doi: 10.4049/jimmunol.1601686.
PMID: 27986907

STAT5 and CD4 + T Cell Immunity.
Owen DL, Farrar MA.
F1000Res. 2017 Jan 11;6:32. doi: 10.12688/f1000research.9838.1. Review.
PMID:28163905

Retrieving short-term memories of flu.
Borges da Silva H, Jameson SC.
Sci Immunol. 2017 Jan 6;2(7). pii: eaam5330. doi: 10.1126/sciimmunol.aam5330. Epub 2017 Jan 6. Review.
PMID:28783668

Identification of MHC-Bound Peptides from Dendritic Cells Infected with Salmonella enterica Strain SL1344: Implications for a Nontyphoidal Salmonella Vaccine.
Karunakaran KP, Yu H, Jiang X, Chan Q, Goldberg MF, Jenkins MK, Foster LJ, Brunham RC.
J Proteome Res. 2017 Jan 6;16(1):298-306. doi: 10.1021/acs.jproteome.6b00926. Epub 2016 Nov 10.
PMID: 27802388

Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the indigenous microbiota.
Khoruts A, Hippen KL, Lemire AM, Holtan SG, Knights D, Young JH.
Transl Res. 2017 Jan;179:116-125. doi: 10.1016/j.trsl.2016.07.013. Review.
PMID: 27513211

Interaction of gut microbiota with bile acid metabolism and its influence on disease states.
Staley C, Weingarden AR, Khoruts A, Sadowsky MJ.
Appl Microbiol Biotechnol. 2017 Jan;101(1):47-64. doi: 10.1007/s00253-016-8006-6. Review.
PMID: 27888332

Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis.
López De Padilla CM, Crowson CS, Hein MS, Pendegraft RS, Strausbauch MA, Niewold TB, Ernste FC, Peterson E, Baechler EC, Reed AM.
J Rheumatol. 2017 Jan;44(1):117-124. doi: 10.3899/jrheum.160293.
PMID: 27803134

Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease.
Cabrera-Perez J, Badovinac VP, Griffith TS.
Exp Biol Med (Maywood). 2017 Jan;242(2):127-139. doi: 10.1177/1535370216669610. Epub 2016 Oct 4. Review.
PMID: 27633573

Complete Microbiota Engraftment Is Not Essential for Recovery from Recurrent Clostridium difficile Infection following Fecal Microbiota Transplantation.
Staley C, Kelly CR, Brandt LJ, Khoruts A, Sadowsky MJ.
MBio. 2016 Dec 20;7(6). pii: e01965-16. doi: 10.1128/mBio.01965-16.
PMID: 27999162

High-Resolution Analysis of Antibodies to Post-Translational Modifications Using Peptide Nanosensor Microarrays.
Lee JR, Haddon DJ, Gupta N, Price JV, Credo GM, Diep VK, Kim K, Hall DA, Baechler EC, Petri M, Varma M, Utz PJ, Wang SX.
ACS Nano. 2016 Dec 27;10(12):10652-10660. doi: 10.1021/acsnano.6b03786.
PMID: 27636738

Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo.
Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, Griffith TS, Legge KL, Badovinac VP.
J Immunol. 2016 Dec 1;197(11):4301-4311.
PMID: 27798171

Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior.
Scott MC, Tomiyasu H, Garbe JR, Cornax I, Amaya C, O'Sullivan MG, Subramanian S, Bryan BA, Modiano JF.
Dis Model Mech. 2016 Dec 1;9(12):1435-1444. Epub 2016 Nov 3.
PMID: 27874835

Simian Immunodeficiency Virus-Producing Cells in Follicles Are Partially Suppressed by CD8+ Cells In Vivo.
Li S, Folkvord JM, Rakasz EG, Abdelaal HM, Wagstaff RK, Kovacs KJ, Kim HO, Sawahata R, MaWhinney S, Masopust D, Connick E, Skinner PJ.
J Virol. 2016 Nov 28;90(24):11168-11180.
PMID: 27707919

Interaction of gut microbiota with bile acid metabolism and its influence on disease states.
Staley C, Weingarden AR, Khoruts A, Sadowsky MJ.
Appl Microbiol Biotechnol. 2016 Nov 25. [Epub ahead of print] Review.
PMID: 27888332

Resident memory T cells are a Notch above the rest.
Wijeyesinghe S, Masopust D.
Nat Immunol. 2016 Nov 16;17(12):1337-1338. doi: 10.1038/ni.3617. No abstract available.
PMID: 27849200

Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity.
Jiang TT, Martinov T, Xin L, Kinder JM, Spanier JA, Fife BT, Way SS.
Cell Rep. 2016 Nov 8;17(7):1783-1794. doi: 10.1016/j.celrep.2016.10.042.
PMID: 27829150

Implications of Resident Memory T Cells for Transplantation.
Beura LK, Rosato PC, Masopust D.
Am J Transplant. 2016 Nov 2. doi: 10.1111/ajt.14101. [Epub ahead of print]
PMID: 27804207

How MAIT cells get their start
Wang H, Hogquist KA.
Nat Immunol. 2016 Oct 19;17(11):1238-1240. doi: 10.1038/ni.3584. No abstract available.
PMID: 27760106

PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetes.
Martinov T, Spanier JA, Pauken KE, Fife BT.
Immunoendocrinology (Houst). 2016;3. pii: e1164.
PMID: 27656680

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer.
Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH.
Oncotarget. 2016 Oct 11;7(41):66540-66557. doi: 10.18632/oncotarget.11658.
PMID: 27572319

SIV-producing cells in follicles are partially suppressed by CD8+ cells in vivo.
Li S, Folkvord JM, Rakasz EG, Abdelaal HM, Wagstaff RK, Kovacs KJ, Kim HO, Sawahata R, MaWhinney S, Masopust D, Connick E, Skinner PJ.
J Virol. 2016 Oct 5. pii: JVI.01332-16.
PMID: 27707919

Understanding the mechanisms of faecal microbiota transplantation.
Khoruts A, Sadowsky MJ.
Nat Rev Gastroenterol Hepatol. 2016 Sep;13(9):508-16. doi: 10.1038/nrgastro.2016.98. Epub 2016 Jun 22. Review.
PMID: 27329806

Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst γδ T, Innate Lymphoid, and Th Cells.
Lee YJ, Starrett GJ, Lee ST, Yang R, Henzler CM, Jameson SC, Hogquist KA.
J Immunol. 2016 Aug 15;197(4):1460-70. doi: 10.4049/jimmunol.1600643. Epub 2016 Jul 6.
PMID: 27385777

Prospective studies of infectious mononucleosis in University students.
Grimm JM, Schmeling DO, Dunmire SK, Knight JA, Mullan BD, Ed JA, Brundage RC,Hogquist KA, Balfour Jr, HH.
Clinical & Translational Immunology (2016) 5 e94, published online 12 August 2016

Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection.
Fiege JK, Beura LK, Burbach BJ, Shimizu Y.
J Immunol. 2016 Sep 15;197(6):2079-89. doi: 10.4049/jimmunol.1501805. Epub 2016 Aug 12.
PMID: 27521337

Toward revision of antimicrobial therapies in hematopoietic stem cell transplantation: target the pathogens, but protect the indigenous microbiota.
Khoruts A, Hippen KL, Lemire AM, Holtan SG, Knights D, Young JH.
Transl Res. 2016 Jul 25. pii: S1931-5244(16)30128-1. doi: 10.1016/j.trsl.2016.07.013. [Epub ahead of print] Review.
PMID: 27513211

Autoimmune variant PTPN22 C1858T is associated with impaired responses to influenza virus vaccination.
Crabtree JN, He W, Guan W, Flage M, Miller MS, Peterson EJ.
J Infect Dis. 2016 Jul 15;214(2):248-57. doi: 10.1093/infdis/jiw126. Epub 2016 Mar 30.
PMID: 27034343

Skin Immunity to Candida albicans.
Kashem SW, Kaplan DH.
Trends Immunol. 2016 Jul;37(7):440-50. doi: 10.1016/j.it.2016.04.007. Epub 2016 May 10. Review.
PMID:27178391

Understanding the mechanisms of faecal microbiota transplantation.
Khoruts A, Sadowsky MJ.
Nat Rev Gastroenterol Hepatol. 2016 Jun 22. doi: 10.1038/nrgastro.2016.98. [Epub ahead of print] Review.
PMID: 27329806

Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Spanier JA, Frederick DR, Taylor JJ, Heffernan JR, Kotov DI, Martinov T, Osum KC, Ruggiero JL, Rust BJ, Landry SJ, Jenkins MK, McLachlan JB, Fife BT.
Nat Commun. 2016 Jun 13;7:11804. doi: 10.1038/ncomms11804.
PMID: 27292946

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.
Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW.
Cell Host Microbe. 2016 May 11;19(5):713-9. doi: 10.1016/j.chom.2016.04.003. Epub 2016 Apr 20.
PMID: 27107939

Normalizing the environment recapitulates adult human immune traits in laboratory mice.
Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.
Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20.
PMID: 27096360

Spontaneous partial loss of the OT-I transgene.
Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.
Nat Immunol. 2016 Apr 19;17(5):471. doi: 10.1038/ni.3411. No abstract available.
PMID: 27092794

Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.
Xing Y, Wang X, Jameson SC, Hogquist KA.
Nat Immunol. 2016 May;17(5):565-73. doi: 10.1038/ni.3419. Epub 2016 Apr 4.
PMID: 27043411

IL-15-Independent Maintenance of Tissue-Resident and Boosted Effector Memory CD8 T Cells.
Schenkel JM, Fraser KA, Casey KA, Beura LK, Pauken KE, Vezys V, Masopust D.
J Immunol. 2016 May 1;196(9):3920-6. doi: 10.4049/jimmunol.1502337. Epub 2016 Mar 21.
PMID: 27001957

Arthritis in KRN T cell receptor transgenic mice does not require interleukin-17 or Th17 cells.
Auger JL, Cowan HM, Engelson BJ, Kashem SW, Prinz I, Binstadt BA.
Arthritis Rheumatol. 2016 Feb 16. doi: 10.1002/art.39646. [Epub ahead of print]
PMID: 26882006

Fractionated radiotherapy combined with PD-1 pathway blockade promotes CD8 T cell-mediated tumor clearance for the treatment of advanced malignancies.
Martinov T, Fife BT.
Ann Transl Med. 2016 Feb;4(4):82. doi: 10.3978/j.issn.2305-5839.2016.01.13.
PMID: 27004229

Colonoscopic screening shows increased early incidence and progression of adenomas in cystic fibrosis.
Niccum DE, Billings JL, Dunitz JM, Khoruts A.
J Cyst Fibros. 2016 Feb 2. pii: S1569-1993(16)00009-6. doi: 10.1016/j.jcf.2016.01.002. [Epub ahead of print]
PMID: 26851188

Fas ligand based immunotherapy: A potent and effective neoadjuvant with checkpoint inhibitor properties, or a systemically toxic promoter of tumor growth?
Modiano JF, Bellgrau D.
Discov Med. 2016 Feb;21(114):109-16. Review.
PMID: 27011046

Most microbe-specific naïve CD4⁺ T cells produce memory cells during infection.
Tubo NJ, Fife BT, Pagan AJ, Kotov DI, Goldberg MF, Jenkins MK.
Science. 2016 Jan 29;351(6272):511-4. doi: 10.1126/science.aad0483.
PMID: 26823430

Changes in Colonic Bile Acid Composition following Fecal Microbiota Transplantation Are Sufficient to Control Clostridium difficile Germination and Growth.
Weingarden AR, Dosa PI, DeWinter E, Steer CJ, Shaughnessy MK, Johnson JR, Khoruts A, Sadowsky MJ.
PLoS One. 2016 Jan 20;11(1):e0147210. doi: 10.1371/journal.pone.0147210. eCollection 2016.
PMID: 26789728

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation.
Benck CJ, Martinov T, Fife BT, Chatterjea D.
J Vis Exp. 2016 Jan 25;(107). doi: 10.3791/53638.
PMID:26863129

Regulatory T Cell Induction and Retention in the Lungs Drives Suppression of Detrimental Type 2 Th Cells During Pulmonary Cryptococcal Infection.
Wiesner DL, Smith KD, Kotov DI, Nielsen JN, Bohjanen PR, Nielsen K.
J Immunol. 2016 Jan 1;196(1):365-74. doi: 10.4049/jimmunol.1501871. [Epub 2015 Nov 20.]
PMID:26590316

Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity.
Danahy DB, Strother RK, Badovinac VP, Griffith TS.
Crit Rev Immunol. 2016;36(1):57-74. doi: 10.1615/CritRevImmunol.2016017098. Review.
PMID: 27480902

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.
Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A.
Elife. 2015 Oct 30;4. pii: e09183. doi: 10.7554/eLife.09183.
PMID:26517880

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
Heltemes-Harris LM, Larson JD, Starr TK, Hubbard GK, Sarver AL, Largaespada DA, Farrar MA.
Oncogene. 2015 Oct 26. doi: 10.1038/onc.2015.405. [Epub ahead of print]
PMID:26500062

Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection.
Weingarden AR, Chen C, Zhang N, Graiziger CT, Dosa PI, Steer CJ, Shaughnessy MK, Johnson JR, Sadowsky MJ, Khoruts A.
J Clin Gastroenterol. 2015 Oct 17. [Epub ahead of print]
PMID:26485102

Infectious Mononucleosis.
Dunmire SK, Hogquist KA, Balfour HH.
Curr Top Microbiol Immunol. 2015;390:211-40. doi: 10.1007/978-3-319-22822-8_9.
PMID:26424648 

Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells.
Linehan JL, Dileepan T, Kashem SW, Kaplan DH, Cleary P, Jenkins MK.
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12782-7. doi: 10.1073/pnas.1513532112. Epub 2015 Sep 28.
PMID:26417101 

Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells.
Manlove LS, Berquam-Vrieze KE, Pauken KE, Williams RT, Jenkins MK, Farrar MA.
J Immunol. 2015 Oct 15; 195(8):4028-37. doi: 10.4049/jimmunol.1501291. Epub 2015 Sep 16.
PMID:26378075 

Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein.
Fiege JK, Burbach BJ, Shimizu Y.
J Immunol. 2015 Oct 1; 195(7):3119-28. doi: 10.4049/jimmunol.1402670. Epub 2015 Aug 28
PMID:26320248

Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response.
Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA.
Immunity. 2015 Sep 15;43(3):566-78. doi: 10.1016/j.immuni.2015.06.025. Epub 2015 Sep 8.
PMID:26362265 

Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b(+) Dermal Dendritic Cells and Drive Protective Cutaneous Immunity.
Kashem SW, Riedl MS, Yao C, Honda CN, Vulchanova L, Kaplan DH.
Immunity. 2015 Sep 15;43(3):515-26. doi: 10.1016/j.immuni.2015.08.016.  
PMID:26377898      

The Neonatal CD4+ T Cell Response to a Single Epitope Varies in Genetically Identical Mice.
Nelson RW, Rajpal MN, Jenkins MK.
J Immunol. 2015 Sep 1;195(5):2115-21. doi: 10.4049/jimmunol.1500405. Epub 2015 Jul 15.
PMID:26179899  

TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells.
Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.         
Nat Immunol. 2015 Aug 24. doi: 10.1038/ni.3237. [Epub ahead of print]                        
PMID:26301566     

T Cell Adolescence: Maturation Events Beyond Positive Selection.
Hogquist KA, Xing Y, Hsu FC, Shapiro VS.
J Immunol. 2015 Aug 15;195(4):1351-7. doi: 10.4049/jimmunol.1501050. Review.
PMID:26254267

The human T-cell repertoire grows up.  
Moon JJ, Jenkins MK. 
Immunol Cell Biol. 2015 Aug;93(7):601-2. doi: 10.1038/icb.2015.50. Epub 2015 May 5. No abstract available. 
PMID:25939281

Polymicrobial Sepsis Increases Susceptibility to Chronic Viral Infection and Exacerbates CD8+ T Cell Exhaustion.
Condotta SA, Khan SH, Rai D, Griffith TS, Badovinac VP.
J Immunol. 2015 Jul 1;195(1):116-25. doi: 10.4049/jimmunol.1402473. Epub 2015 May 15.
PMID: 25980007

Cutting edge: Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function. 
Yang JA, Tubo NJ, Gearhart MD, Bardwell VJ, Jenkins MK. 
J Immunol. 2015 Jun 15;194(12):5604-8. doi: 10.4049/jimmunol.1500201. Epub 2015 May 11.
PMID:25964495

Investigating influenza A virus infection: tools to track infection and limit tropism.
Fiege JK, Langlois RA.
J Virol. 2015 Jun;89(12):6167-70. doi: 10.1128/JVI.00462-15. Epub 2015 Apr 8. Review.
PMID: 25855737

The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse.
Laudenbach M, Baruffaldi F, Vervacke JS, Distefano MD, Titcombe PJ, Mueller DL, Tubo NJ, Griffith TS, Pravetoni M.
J Immunol. 2015 Jun 15;194(12):5926-36. doi: 10.4049/jimmunol.1500385. Epub 2015 May 13.
PMID:25972483                                                                                                                                                                                        

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.
Steinert EM, Schenkel JM, Fraser KA, Beura LK, Manlove LS, Igyártó BZ, Southern PJ, Masopust D.
Cell. 2015 May 7;161(4):737-49. doi: 10.1016/j.cell.2015.03.031.
PMID:25957682

Mast Cell Activation Disease and Microbiotic Interactions.
Afrin LB, Khoruts A.
Clin Ther. 2015 May 1;37(5):941-53. doi: 10.1016/j.clinthera.2015.02.008. Epub 2015 Mar 12. Review.
PMID:25773459

TCR ITAM multiplicity is required for the generation of follicular helper T-cells.
Hwang S, Palin AC, Li L, Song KD, Lee J, Herz J, Tubo N, Chu H, Pepper M, Lesourne R, Zvezdova E, Pinkhasov J, Jenkins MK, McGavern D, Love PE.
Nat Commun. 2015 May 11;6:6982. doi: 10.1038/ncomms7982.
PMID:25959494  

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.
Tonomura N, Elvers I, Thomas R, Megquier K, Turner-Maier J, Howald C, Sarver AL, Swofford R, Frantz AM, Ito D, Mauceli E, Arendt M, Noh HJ, Koltookian M, Biagi T, Fryc S, Williams C, Avery AC, Kim JH, Barber L, Burgess K, Lander ES, Karlsson EK, Azuma C, Modiano JF, Breen M, Lindblad-Toh K.
PLoS Genet. 2015 Feb 2;11(2):e1004922. doi: 10.1371/journal.pgen.1004922. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 May;11(5):e1005339.
PMID: 25642983

Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade.
Pauken KE, Nelson CE, Martinov T, Spanier JA, Heffernan JR, Sahli NL, Quarnstrom CF, Osum KC, Schenkel JM, Jenkins MK, Blazar BR, Vezys V, Fife BT.
J Immunol. 2015 Apr 15;194(8):3551-5. doi: 10.4049/jimmunol.1402262. Epub 2015 Mar 13.
PMID:25769925

Stimulation with Concanavalin-A Induces IL-17 Production by Canine Peripheral T Cells.
Ritt MG, Lindborg BA, O'Brien TD, Bisignano J, Modiano JF.
Vet Sci. 2015 Apr 10;2(2):43-51. doi: 10.3390/vetsci2020043.
PMID: 29061930

Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes.
Wüthrich M, Brandhorst TT, Sullivan TD, Filutowicz H, Sterkel A, Stewart D, Li M, Lerksuthirat T, LeBert V, Shen ZT, Ostroff G, Deepe GS Jr, Hung CY, Cole G, Walter JA, Jenkins MK, Klein B.
Cell Host Microbe. 2015 Apr 8;17(4):452-65. doi: 10.1016/j.chom.2015.02.009. Epub 2015 Mar 19.
PMID:25800545   

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.
Cabrera-Perez J, Condotta SA, James BR, Kashem SW, Brincks EL, Rai D, Kucaba TA, Badovinac VP, Griffith TS.
J Immunol. 2015 Feb 15;194(4):1609-20. doi: 10.4049/jimmunol.1401711. Epub 2015 Jan 16.
PMID: 25595784                                                                                                                                                    

Humoral immunity. Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell.
Taylor JJ, Pape KA, Steach HR, Jenkins MK.
Science. 2015 Feb 13;347(6223):784-7. doi: 10.1126/science.aaa1342. Epub 2015 Jan 29. 
PMID:25636798

Development of a novel anti-canine CD20 monoclonal antibody with diagnostic and therapeutic potential.
Ito D, Brewer S, Modiano JF, Beall MJ.
Leuk Lymphoma. 2015 Jan;56(1):219-25. doi: 10.3109/10428194.2014.914193. Epub 2014 Jun 16.
PMID: 24724777