Publications

The Center for Immunology produces an immense amount of research each year. The data produced is comprehensive and timely to research across the globe. Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities. The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.

2025 Publications

Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4+ T cells.
Venkatesh H, Granados Centeno E, Luo Q, Arroyo M, Heltemes Harris LM, Knutson TP, Qiu Y, Haaning A, Webber BR, Bachanova V, Farrar MA, Tracy SI.
Blood. 2025 Sep 4:blood.2024028194. doi: 10.1182/blood.2024028194. Online ahead of print.
PMID: 40906918

Reduction of Preexisting AAV9 Antibody Titers Before Onasemnogene Abeparvovec Administration in Twins With Spinal Muscular Atrophy.
Nelson RW, Cox CA, Stark M, Johnson AD, Sichmeller K, Earhart J, Ihinger JM, Stafki SA, Karachunski P, Kang PB.
Neurology. 2025 Aug 26;105(4):e213899. doi: 10.1212/WNL.0000000000213899. Epub 2025 Jul 24.
PMID: 40705999

Exploiting Viral Infection/Vaccination To Focus High Affinity T Cell Populations into Tumors Using Oncolytic Viro-immunotherapy.
Rios AV, Metko M, Tonne J, Thompson J, Kendall B, Chen A, Mudrick H, Masopust D, Irshad S, Barry M, Barry M, Diaz RM, Vile R.
Mol Ther. 2025 Aug 20:S1525-0016(25)00654-9. doi: 10.1016/j.ymthe.2025.08.023. Online ahead of print.
PMID: 40842156

CAR T_reg cells mediate linked suppression and infectious tolerance in islet transplantation in mice.
Wardell CM, Fung VCW, Chen E, Haque M, Tan DFH, Leca M, Gillies J, Spanier JA, Mojibian M, Fife BT, Levings MK.
Sci Transl Med. 2025 Aug 20;17(812):eadp6519. doi: 10.1126/scitranslmed.adp6519. Epub 2025 Aug 20.
PMID: 40834104

Humanized DRAGA mice are a valuable model to study novel immunotherapies for HIV-1.
Pumtang-On P, Thron LK, Goodarzi N, Davey BC, Sevcik EN, Coleman-Fuller N, Karim AF, Vezys V, Rao M, Moriarity BS, Pampusch MS, Rendahl AK, Casares SA, Skinner PJ.
J Immunol. 2025 Aug 13:vkaf185. doi: 10.1093/jimmun/vkaf185. Online ahead of print.
PMID: 40803333

Beyond the native repertoire.
Hickok GH, Stromnes IM.
Science. 2025 Jul 24;389(6758):349-351. doi: 10.1126/science.adz6423. Epub 2025 Jul 24.
PMID: 40705900

A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells.
Skeate JG, Slipek NJ, Lahr WS, Roy S, Wick BJ, Stelljes EM, Gilkey AK, Thenge PP, Diers MD, Kar B, Krueger JB, Niemeyer EM, Lonetree CL, Kluesner MG, Bell JB, Clement K, Provenzano P, Moriarity BS, Webber BR.
bioRxiv [Preprint]. 2025 Jul 16:2025.07.11.664404. doi: 10.1101/2025.07.11.664404.
PMID: 40791471

Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion.
Tuokkola JE, Reese LE, Wang Y, O'Connor CH, VanTreeck JG, Rumahorbo AH, Schwertfeger KL.
Breast Cancer Res. 2025 Jul 15;27(1):132. doi: 10.1186/s13058-025-02084-9.
PMID: 40665359

Maturation of thymocytes with a monoclonal TCR under control of Trac promoter elements in the absence of β-selection.
Tsai AK, Cruz-Hinojoza E, Ellefson MA, Burrack AL, Larsen BM, Martinez RJ, Stromnes IM.
Immunohorizons. 2025 Jul 15;9(8):vlaf035. doi: 10.1093/immhor/vlaf035.
PMID: 4066417

Total, not isoform-specific, Lyn expression by macrophages promotes TLR activation and restricts proliferation.
Lindstedt AJ, Greene JT, Freedman TS.
bioRxiv [Preprint]. 2025 Jul 10:2025.07.07.663098. doi: 10.1101/2025.07.07.663098.
PMID: 40672308

Whillock A, Smith P, Burger S, Sridhar A, Lindgren A, Berg J, Tsuda S, Mahajan S, Tilburgs T, Schuldt NJ.
Front Immunol. 2025 Jul 9;16:1616491. doi: 10.3389/fimmu.2025.1616491. eCollection 2025.
PMID: 40703520

Martinez RJ, Hogquist KA.
J Immunol. 2025 Jul 1;214(7):1468-1476. doi: 10.1093/jimmun/vkaf048.
PMID: 40184034

Mix MR, Kreitlow BL, Berton RR, Xu J, Fain CE, van de Wall S, Pewe LL, Hancox LS, Hassert MA, Kannan SK, Arumugam SA, Sievers CM, Buchanan GF, Griffith TS, Badovinac VP, Harty JT.
Nat Immunol. 2025 Jul;26(7):1087-1098. doi: 10.1038/s41590-025-02174-y. Epub 2025 Jun 13.
PMID: 40514419

The Cardiohepatic Axis in Metabolic Disease: Liver to Heart.
Hakeem A, van Berlo J, Revelo XS.
JACC Basic Transl Sci. 2025 Jul;10(7):101309. doi: 10.1016/j.jacbts.2025.05.004.
PMID: 40738521

Thymic Interferons: A Little Goes a Long Way.
Vobořil M, Hogquist KA.
Immunol Rev. 2025 Jul;332(1):e70038. doi: 10.1111/imr.70038.
PMID: 40439345

Bajaj JS, Fagan A, Gavis EA, Sterling RK, Gallagher ML, Lee H, Matherly SC, Siddiqui MS, Bartels A, Mousel T, Davis BC, Puri P, Fuchs M, Moutsoglou DM, Thacker LR, Sikaroodi M, Gillevet PM, Khoruts A.
J Hepatol. 2025 Jul;83(1):81-91. doi: 10.1016/j.jhep.2024.12.047. Epub 2025 Jan 10.
PMID: 39800192

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages.
Xu Y, Hillman H, Chang M, Barrow F, Ivanov S, Revelo XS, Williams JW.
Commun Biol. 2025 Jun 23;8(1):953. doi: 10.1038/s42003-025-08387-z.
PMID: 40550904

Thymic DC2 are heterogenous and include a novel population of transitional dendritic cells.
Vobořil M, Sulczewski FB, Martinez RJ, Ashby KM, Valerio MM, Idoyaga J, Hogquist KA.
bioRxiv [Preprint]. 2025 Jun 18:2025.06.13.659520. doi: 10.1101/2025.06.13.659520.
PMID: 40666966

Antigen-specific CD4+ T cells promote monocyte recruitment and differentiation into glycolytic lung macrophages to control Mycobacterium tuberculosis.
Becker SH, Ronayne CE, Bold TD, Jenkins MK.
PLoS Pathog. 2025 Jun 9;21(6):e1013208. doi: 10.1371/journal.ppat.1013208. eCollection 2025 Jun.
PMID: 40489538

In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8⁺ T cells from old mice.
Dahlquist KJV, Dehm EM, Smith DM, Lucas ED, Pierson M, Hamilton SE, Camell CD.
Geroscience. 2025 Jun 6. doi: 10.1007/s11357-025-01723-5. Online ahead of print.
PMID: 40478430

IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma.
Schmiechen ZC, Nanda HA, Burrack AL, Hickok GH, Butler JZ, Cruz-Hinojoza E, Maurice NJ, Geuenich MJ, Yu C, Tsai AK, Lonetree CL, Ellefson MA, Hilk AL, Larsen BM, Miller EA, Rizzo AB, Campbell KR, Shen SS, Stromnes IM. Cancer Immunol Res. 2025 Jun 4;13(6):847-866. doi: 10.1158/2326-6066.CIR-24-0758.
PMID: 40072469

TREM2 macrophages mediate the beneficial effects of bariatric surgery against MASH.
Fredrickson G, Florczak K, Barrow F, Mahmud S, Dietsche K, Wang H, Parthiban P, Hakeem A, Almutlaq R, Adeyi O, Herman A, Bartolomucci A, Staley C, Dong X, Jahansouz C, Williams JW, Mashek DG, Ikramuddin S, Revelo XS. Hepatology. 2025 Jun 1;81(6):1776-1791. doi: 10.1097/HEP.0000000000001098. Epub 2024 Sep 18.
PMID: 39292863

MACanalyzeR scRNAseq analysis tool reveals PPARγ^HIGH/GDF15^HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT.
Ninni A, Zaccaria F, Verteramo L, Sciarretta F, Silveira LS, Rosa-Neto JC, Carotti S, Nevi L, Grumati P, Patel S, Carrera G, Sgambato A, Lucchetti D, Colella F, Severi I, Senzacqua M, Giordano A, Bernardini S, Di Biagio C, Tortolici F, Rizzo G, Cochain C, Chiurchiù V, Ivanov S, Zhou B, Williams JW, Savage DB, Aquilano K, Lettieri-Barbato D.
Nat Commun. 2025 May 31;16(1):5063. doi: 10.1038/s41467-025-60295-2.
PMID: 40450001

Differential Virulence and Host-Specific Fitness of Regionally Distinct Human-Derived Powassan Virus Lineage 2 Strains.
Lange RE, Pritchard JC, Jaeger AS, Bold TD, White JL, Dean AB, Hull RC, St George K, Dupuis AP, Aliota MT, Ciota AT.
Am J Trop Med Hyg. 2025 May 13;113(1):106-116. doi: 10.4269/ajtmh.24-0776. Print 2025 Jul 2.
PMID: 40359924

Rabies vaccination induces a CD4+ TEM and CD4+CD8+ TEMRA TH1 phenotype in dogs.
Lang HP, Almeer FF, Jenkins MK, Friedenberg SG.
PLoS One. 2025 May 12;20(5):e0323823. doi: 10.1371/journal.pone.0323823. eCollection 2025.
PMID: 40354406

McNitt SA, Dick JK, Hernandez-Castaneda MA, Sangala J, Pierson M, Macchietto M, Burrack KS, Crompton PD, Seydel K, Hamilton SE, Hart GT.
JCI Insight. 2025 May 8;10(9):e183076. doi: 10.1172/jci.insight.183076. eCollection 2025 May 8.
PMID: 40337867

Divergent immediate and delayed effects of juvenile exposure to doxorubicin on the thymus in C57BL/6 mice.
George B, Dahlquist KJV, Grant MKO, Daniel MR, Smith DM, Ahlberg I, Sadak KT, Seelig D, Camell CD, Zordoky BN.
Sci Rep. 2025 May 3;15(1):15557. doi: 10.1038/s41598-025-98617-5.
PMID: 40319158

Wang H, Herman A, Barrow F, Abdel-Ghani A, Draxler M, Fredrickson G, Parthiban P, Seelig DM, Ikramuddin S, Revelo XS.
Hepatol Commun. 2025 Apr 21;9(5):e0668. doi: 10.1097/HC9.0000000000000668. eCollection 2025 May 1.
PMID: 40257356

Rehermann B, Graham AL, Masopust D, Hamilton SE.
Nat Rev Immunol. 2025 May;25(5):385-397. doi: 10.1038/s41577-024-01108-3. Epub 2024 Nov 19.
PMID: 39562646

Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease.
Martell M, Quarnstrom CF, Khoruts A, Vezys V, Staley C, Shmidt E.
Gastro Hep Adv. 2025 Apr 3;4(7):100670. doi: 10.1016/j.gastha.2025.100670. eCollection 2025.
PMID: 40520922

Walton AH, Mazer MB, Remy KE, Osborne DF, Davitt EB, Griffith TS, Gould RW, Badovinac VP, Brakenridge SC, Drewry AM, Ungaro RF, Rocha IL, Loftus TJ, Efron PA, Moldawer LL, Caldwell CC, Hotchkiss RS.
Sci Rep. 2025 Apr 18;15(1):13464. doi: 10.1038/s41598-025-92016-6.
PMID: 40251188

Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells.
Hildebrand JA, Daniels NR, Dehm EM, Fisher BD, Guter JK, Janse CJ, Lucas ED, Sangala JA, Tankersley TN, Hart GT, Hamilton SE.
PLoS Pathog. 2025 Mar 31;21(3):e1012993. doi: 10.1371/journal.ppat.1012993. eCollection 2025 Mar.
PMID: 40163479

Polymorphisms in Pfkelch13 domains before and after the introduction of artemisinin-based combination therapy in Southwest Nigeria.
Amusan A, Akinola O, Akano K, Hernández-Castañeda M, Dick JK, Sowunmi A, Hart G, Gbotosho G.
PLoS One. 2025 Mar 31;20(3):e0316479. doi: 10.1371/journal.pone.0316479. eCollection 2025.
PMID: 40163420

Best practices in islet transplantation in mice.
Meier RPH, Ben Nasr M, Fife BT, Finger EB, Fiorina P, Luo X, Bromberg JS.
Am J Transplant. 2025 Mar 13:S1600-6135(25)00137-6. doi: 10.1016/j.ajt.2025.03.008. Online ahead of print.
PMID: 40089068

Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8⁺ T cells to cytokine deficiency.

Jarjour NN, Dalzell TS, Maurice NJ, Wanhainen KM, Peng C, O'Flanagan SD, DePauw TA, Block KE, Valente WJ, Ashby KM, Masopust D, Jameson SC.
Immunity. 2025 Mar 11;58(3):616-631.e5. doi: 10.1016/j.immuni.2025.02.009. Epub 2025 Feb 28.
PMID: 40023156

Risk Factors for Antibiotic Exposure Post-Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection: A Prospective Multicenter Observational Study.
Hirsch W, Fischer M, Khoruts A, Allegretti JR, Kelly CR, Vaughn B.
Open Forum Infect Dis. 2025 Mar 7;12(3):ofaf130. doi: 10.1093/ofid/ofaf130. eCollection 2025 Mar.
PMID: 40103733

Husmann R, Lehman A, Nelson RW, Pragman AA.
Clin Chest Med. 2025 Mar;46(1):61-75. doi: 10.1016/j.ccm.2024.10.005. Epub 2024 Nov 29.
PMID: 39890293

Saavedra FM, Brotto DB, Joag V, Matson CA, Herzberg MC, Nesmiyanov PP, Vezys V, Masopust D, Stolley JM.
Mucosal Immunol. 2025 Feb 21:S1933-0219(25)00021-2. doi: 10.1016/j.mucimm.2025.02.003. Online ahead of print.
PMID: 39988203

B-cell interleukin 1 receptor 1 modulates the female adipose tissue immune microenvironment during aging.

Carey A, Pitcher LE, Jang IH, Nguyen K, Cholensky S, Robbins PD, Camell CD.
J Leukoc Biol. 2025 Feb 13;117(2):qiae219. doi: 10.1093/jleuko/qiae219.
PMID: 39378334

Review of Elevated Para-Cresol in Autism and Possible Impact on Symptoms.

Flynn CK, Adams JB, Krajmalnik-Brown R, Khoruts A, Sadowsky MJ, Nirmalkar K, Takyi E, Whiteley P.
Int J Mol Sci. 2025 Feb 11;26(4):1513. doi: 10.3390/ijms26041513.
PMID: 40003979

Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience.

Arnesen H, Birkeland S, Stendahl H, Neuhaus K, Masopust D, Boysen P, Carlsen H.
Discov Immunol. 2025 Feb 1;4(1):kyaf002. doi: 10.1093/discim/kyaf002. eCollection 2025.
PMID: 40065807

Viral Burden and Illness Severity During Acute SARS-CoV-2 Infection Predict Persistent Long COVID Symptoms.

Brandstetter Figueroa E, Frosch AEP, Burrack KS, Dileepan G, Goldsmith R, Harris M, Ikeogu N, Jibrell H, Thayalan S, Dewar RL, Shenoy C, Sereti I, Baker JV.
Open Forum Infect Dis. 2025 Jan 30;12(2):ofaf048. doi: 10.1093/ofid/ofaf048. eCollection 2025 Feb.
PMID: 39917335

A minority of Th1 and Tfh effector cells express survival genes shared by memory cell progeny that require IL-7 or TCR signaling to persist.

Osum KC, Becker SH, Krueger PD, Mitchell JS, Hong SW, Magill IR, Jenkins MK.
Cell Rep. 2025 Jan 28;44(1):115111. doi: 10.1016/j.celrep.2024.115111. Epub 2024 Dec 25.
PMID: 39723889

Reddi S, Senyshyn L, Ebadi M, Podlesny D, Minot SS, Gooley T, Kabage AJ, Hill GR, Lee SJ, Khoruts A, Rashidi A.
Nat Commun. 2025 Jan 25;16(1):1034. doi: 10.1038/s41467-025-56375-y.
PMID: 39863610

CD44 in myeloid cells is a major driver of liver inflammation and injury in alcohol-associated liver disease.
Rousseau D, Bonnafous S, Soysouvanh F, Sarrail D, Bourinet M, Strazzulla A, Patouraux S, Borderie A, Dolfi B, Gallerand A, Farrugia MA, Orian-Rousseau V, Xu Y, Williams JW, Ivanov S, Tran A, Anty R, Luci C, Gual P.
Hepatology. 2025 Jan 14. doi: 10.1097/HEP.0000000000001232. Online ahead of print.
PMID: 39808819

Deep profiling deconstructs features associated with memory CD8⁺ T cell tissue residence.
Scott MC, Steier Z, Pierson MJ, Stolley JM, O'Flanagan SD, Soerens AG, Wijeyesinghe SP, Beura LK, Dileepan G, Burbach BJ, Künzli M, Quarnstrom CF, Ghirardelli Smith OC, Weyu E, Hamilton SE, Vezys V, Shalek AK, Masopust D. Immunity. 2025 Jan 14;58(1):162-181.e10. doi: 10.1016/j.immuni.2024.11.007. Epub 2024 Dec 20.
PMID: 39708817

Protocol for applying Tumor Treating Fields in mouse models of cancer using the inovivo system.

Gates TJ, Zbidat S, Deniz K, Padmanabhan S, Ladner K, Sarkari A, Zhao X, Davidi S, Blatt R, Cahal S, Gabay M, Sellevoll M, Tzchori I, Porat Y, Haber A, Giladi M, Subramanian S, Lou E.
STAR Protoc. 2025 Jan 8;6(1):103535. doi: 10.1016/j.xpro.2024.103535. Online ahead of print.
PMID: 39792561

Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer.

Perez JM, Duda JM, Ryu J, Shetty M, Mehta S, Jagtap PD, Nelson AC, Winterhoff B, Griffin TJ, Starr TK, Thomas SN.
Sci Rep. 2025 Jan 4;15(1):813. doi: 10.1038/s41598-024-84874-3.
PMID: 39755759

Implantation of Islets Co-Seeded with Tregs in a Novel Biomaterial Reverses Diabetes in the NOD Mouse Model.

Elizondo DM, de Oliveira Rekowsky LL, de Sa Resende A, Seenarine J, da Silva RLL, Ali J, Yang D, de Moura T, Lipscomb MW.
Tissue Eng Regen Med. 2025 Jan;22(1):43-55. doi: 10.1007/s13770-024-00685-7. Epub 2024 Dec 30.
PMID: 39738937

Expand all

2024 Publications

Implantation of Islets Co-Seeded with Tregs in a Novel Biomaterial Reverses Diabetes in the NOD Mouse Model.
Elizondo DM, de Oliveira Rekowsky LL, de Sa Resende A, Seenarine J, da Silva RLL, Ali J, Yang D, de Moura T, Lipscomb MW.
Tissue Eng Regen Med. 2024 Dec 30. doi: 10.1007/s13770-024-00685-7. Online ahead of print.
PMID: 39738937

A minority of Th1 and Tfh effector cells express survival genes shared by memory cell progeny that require IL-7 or TCR signaling to persist.
Osum KC, Becker SH, Krueger PD, Mitchell JS, Hong SW, Magill IR, Jenkins MK.
Cell Rep. 2024 Dec 25;44(1):115111. doi: 10.1016/j.celrep.2024.115111. Online ahead of print.
PMID: 39723889

Deep profiling deconstructs features associated with memory CD8⁺ T cell tissue residence.
Scott MC, Steier Z, Pierson MJ, Stolley JM, O'Flanagan SD, Soerens AG, Wijeyesinghe SP, Beura LK, Dileepan G, Burbach BJ, Künzli M, Quarnstrom CF, Ghirardelli Smith OC, Weyu E, Hamilton SE, Vezys V, Shalek AK, Masopust D.
Immunity. 2024 Dec 3:S1074-7613(24)00522-3. doi: 10.1016/j.immuni.2024.11.007. Online ahead of print.
PMID: 39708817

Williams JW, Lutgens E.
Nat Cardiovasc Res. 2024 Nov 29. doi: 10.1038/s44161-024-00571-4. Online ahead of print.
PMID: 39613874

Rehermann B, Graham AL, Masopust D, Hamilton SE.
Nat Rev Immunol. 2024 Nov 19. doi: 10.1038/s41577-024-01108-3. Online ahead of print.
PMID: 39562646

NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Children.
Dick JK, Sangala JA, Krishna VD, Khaimraj A, Hamel L, Erickson SM, Hicks D, Soigner Y, Covill LE, Johnson AK, Ehrhardt MJ, Ernste K, Brodin P, Koup RA, Khaitan A, Baehr C, Thielen BK, Henzler CM, Skipper C, Miller JS, Bryceson YT, Wu J, John CC, Panoskaltsis-Mortari A, Orioles A, Steiner ME, Cheeran MCJ, Pravetoni M, Hart GT.
J Immunol. 2024 Nov 15;213(10):1452-1466. doi: 10.4049/jimmunol.2400395.
PMID: 39392378

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.

Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Gwilt KB, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I.
Cell. 2024 Oct 30:S0092-8674(24)01158-9. doi: 10.1016/j.cell.2024.10.010. Online ahead of print.
PMID: 39500322

Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice.
Gallerand A, Dolfi B, Stunault MI, Caillot Z, Castiglione A, Strazzulla A, Chen C, Heo GS, Luehmann H, Batoul F, Vaillant N, Dumont A, Pilot T, Merlin J, Zair FN, Gilleron J, Bertola A, Carmeliet P, Williams JW, Arguello RJ, Masson D, Dombrowicz D, Yvan-Charvet L, Doyen D, Haschemi A, Liu Y, Guinamard RR, Ivanov S.
Nat Commun. 2024 Oct 19;15(1):9027. doi: 10.1038/s41467-024-53267-5.
PMID: 39424804

Ferroptosis Mediated Inflammation Promotes Pulmonary Hypertension.
Kazmirczak F, Vogel NT, Prisco SZ, Patterson MT, Annis J, Moon RT, Hartweck LM, Mendelson JB, Kim M, Calixto Mancipe N, Markowski T, Higgins L, Guerrero C, Kremer B, Blake ML, Rhodes CJ, Williams JW, Brittain EL, Prins KW.
Circ Res. 2024 Oct 18. doi: 10.1161/CIRCRESAHA.123.324138. Online ahead of print.
PMID: 39421926

Frequency of chloroquine-resistant haplotype of Plasmodium falciparum (CVIET) in Ibadan, Southwest Nigeria 17 years post-chloroquine withdrawal.
Amusan A, Akinola O, Akano K, Hernández-Castañeda M, Dick JK, Sowunmi A, Hart G, Gbotosho G.
Acta Trop. 2024 Oct 15;260:107435. doi: 10.1016/j.actatropica.2024.107435. Online ahead of print.
PMID: 39413897

Surviving septic patients endotyped with a functional assay demonstrate active immune responses.
Price AD, Becker ER, Barrios EL, Mazer MB, McGonagill PW, Bergmann CB, Goodman MD, Gould RW, Rao M, Polcz VE, Kucaba TA, Walton AH, Miles S, Xu J, Liang M, Loftus TJ, Efron PA, Remy KE, Brakenridge SC, Badovinac VP, Griffith TS, Moldawer LL, Hotchkiss RS, Caldwell CC.
Front Immunol. 2024 Oct 14;15:1418613. doi: 10.3389/fimmu.2024.1418613. eCollection 2024.
PMID: 39469706

B-cell Interleukin 1 Receptor 1 (IL1R1) modulates the female adipose tissue immune microenvironment during aging.
Carey A, Pitcher LE, Jang IH, Nguyen K, Cholensky S, Robbins PD, Camell CD.
J Leukoc Biol. 2024 Oct 8:qiae219. doi: 10.1093/jleuko/qiae219. Online ahead of print.
PMID: 39378334

CD4⁺ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.
Mitchell JS, Spanier JA, Dwyer AJ, Knutson TP, Alkhatib MH, Qian G, Weno ME, Chen Y, Shaheen ZR, Tucker CG, Kangas TO, Morales MS, Silva N, Kaisho T, Farrar MA, Fife BT.
Immunity. 2024 Oct 8;57(10):2399-2415.e8. doi: 10.1016/j.immuni.2024.07.024. Epub 2024 Aug 29.
PMID: 39214091

Ungaro RF, Xu J, Kucaba TA, Rao M, Bergmann CB, Brakenridge SC, Efron PA, Goodman MD, Gould RW, Hotchkiss RS, Liang M, Mazer MB, McGonagill PW, Moldawer LL, Remy KE, Turnbull IR, Caldwell CC, Badovinac VP, Griffith TS.
J Immunol Methods. 2024 Oct;533:113743. doi: 10.1016/j.jim.2024.113743.

PMID: 39147231

Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.
Takaoka M, Zhao X, Lim HY, Magnussen CG, Ang O, Suffee N, Schrank PR, Ong WS, Tsiantoulas D, Sommer F, Mohanta SK, Harrison J, Meng Y, Laurans L, Wu F, Lu Y, Masters L, Newland SA, Denti L, Hong M, Chajadine M, Juonala M, Koskinen JS, Kähönen M, Pahkala K, Rovio SP, Mykkänen J, Thomson R, Kaisho T, Habenicht AJR, Clement M, Tedgui A, Ait-Oufella H, Zhao TX, Nus M, Ruhrberg C, Taleb S, Williams JW, Raitakari OT, Angeli V, Mallat Z.
Nature. 2024 Oct;634(8033):457-465. doi: 10.1038/s41586-024-07993-x. Epub 2024 Sep 4.
PMID: 39231480

Development and optimization of a diluted whole blood ELISpot assay to test immune function.

SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized patients.

Basting CM, Langat R, Broedlow CA, Guerrero CR, Bold TD, Bailey M, Velez A, Schroeder T, Short-Miller J, Cromarty R, Mayer ZJ, Southern PJ, Schacker TW, Safo SE, Bramante CT, Tignanelli CJ, Schifanella L, Klatt NR.
Microbiol Spectr. 2024 Sep 30:e0068024. doi: 10.1128/spectrum.00680-24. Online ahead of print.
PMID: 39345212

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages (LAMs).

Xu Y, Hillman H, Chang M, Ivanov S, Williams JW.
bioRxiv [Preprint]. 2024 Sep 26:2024.09.24.614807. doi: 10.1101/2024.09.24.614807.
PMID: 39386558

Ferroptosis Integrates Mitochondrial Derangements and Pathological Inflammation to Promote Pulmonary Hypertension.

Kazmirczak F, Vogel NT, Prisco SZ, Patterson MT, Annis J, Moon RT, Hartweck LM, Mendelson JB, Kim M, Mancipe NC, Markowski T, Higgins L, Guerrero C, Kremer B, Blake ML, Rhodes CJ, Williams JW, Brittain EL, Prins KW.
bioRxiv [Preprint]. 2024 Sep 23:2023.01.19.524721. doi: 10.1101/2023.01.19.524721.
PMID: 36712076

Loss of TREM2 diminishes CAA despite an overall increase of amyloid load in Tg-SwDI mice.
Zhong R, Xu Y, Williams JW, Li L.
Alzheimers Dement. 2024 Sep 23. doi: 10.1002/alz.14222. Online ahead of print.
PMID: 39308178

Protocol to examine murine visceral adipose tissue immune cells using fluorescence-based flow cytometry.
Carey A, Camell CD.
STAR Protoc. 2024 Sep 20;5(3):103227. doi: 10.1016/j.xpro.2024.103227. Epub 2024 Aug 10.
PMID: 39126656

Protocol for inducing monomicrobial sepsis in mice with uropathogenic E. coli.
Kim CY, Kannan SK, Badovinac VP, Griffith TS.
STAR Protoc. 2024 Sep 20;5(3):103206. doi: 10.1016/j.xpro.2024.103206. Epub 2024 Jul 27.
PMID: 39068653

TREM2 macrophages mediate the beneficial effects of bariatric surgery against MASH.
Fredrickson G, Florczak K, Barrow F, Mahmud S, Dietsche K, Wang H, Parthiban P, Hakeem A, Almutlaq R, Adeyi O, Herman A, Bartolomucci A, Staley C, Dong X, Jahansouz C, Williams JW, Mashek DG, Ikramuddin S, Revelo XS.
Hepatology. 2024 Sep 18. doi: 10.1097/HEP.0000000000001098.
PMID: 39292863

Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial.
Galiwango RM, Okech B, Park DE, Buchanan L, Shao Z, Bagaya B, Mpendo J, Joag V, Yegorov S, Nanvubya A, Biribawa VM, Namatovu T, Kato C, Kawoozo B, Ssetaala A, Muwanga M, Aziz M, Pham T, Huibner S, Tobian AAR, Liu CM, Prodger JL, Kaul R.
Cell Rep Med. 2024 Sep 17;5(9):101705. doi: 10.1016/j.xcrm.2024.101705. Epub 2024 Aug 29.
PMID: 39214083

Seefeld ML, Templeton EL, Lehtinen JM, Sinclair N, Yadav D, Hartwell BL.
Front Immunol. 2024 Sep 2;15:1419527. doi: 10.3389/fimmu.2024.1419527.
PMID: 39286244

Human ACE2 Gene Replacement Mice Support SARS-CoV-2 Viral Replication and Nonlethal Disease Progression.
Thiede JM, Dick JK, Jarjour NN, Krishna VD, Qian L, Sangala J, Benzow K, Karanjeet K, Chin S, Rainwater O, Cheeran MC, Hogquist KA, Jameson SC, Hart GT, Bold TD, Koob MD.
Immunohorizons. 2024 Sep 1;8(9):712-720. doi: 10.4049/immunohorizons.2400030.
PMID: 39287601

Novel chemokine biomarkers in melanoma^†.
Giubellino A, Hamilton SE.
J Pathol. 2024 Sep;264(1):1-3. doi: 10.1002/path.6323. Epub 2024 Jun 25.
PMID: 38922893

Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice.
Shih WC, Jang IH, Kruglov V, Dickey D, Cholensky S, Bernlohr DA, Camell CD.
Immun Ageing. 2024 Aug 26;21(1):57. doi: 10.1186/s12979-024-00461-0.
PMID: 39187841

Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model.
Dicovitsky RH, Schappa JT, Schulte AJ, Lang HP, Kuerbitz E, Roberts S, DePauw TA, Lewellen M, Winter AL, Stuebner K, Buettner M, Reid K, Bergsrud K, Pracht S, Chehadeh A, Feiock C, O'Sullivan MG, Carlson T, Armstrong AR, Meritet D, Henson MS, Weigel BJ, Modiano JF, Borgatti A, Vallera DA.
Toxins (Basel). 2024 Aug 26;16(9):376. doi: 10.3390/toxins16090376.
PMID: 39330834

Lang HP, Osum KC, Friedenberg SG.
Vet Immunol Immunopathol. 2024 Aug 21;275:110816. doi: 10.1016/j.vetimm.2024.110816.
PMID: 39173398

Antigen-specific T cell responses in autoimmune diabetes.

Dwyer AJ, Shaheen ZR, Fife BT.
Front Immunol. 2024 Aug 15;15:1440045. doi: 10.3389/fimmu.2024.1440045. eCollection 2024.
PMID: 39211046

Resident memory T cells and cancer.
Gavil NV, Cheng K, Masopust D.
Immunity. 2024 Aug 13;57(8):1734-1751. doi: 10.1016/j.immuni.2024.06.017.
PMID: 39142275

Roach SN, Shepherd FK, Mickelson CK, Fiege JK, Thielen BK, Pross LM, Sanders AE, Mitchell JS, Robertson M, Fife BT, Langlois RA.
Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2320303121. doi: 10.1073/pnas.2320303121.
PMID: 39008691

Sterile production of interferons in the thymus affects T cell repertoire selection.
Ashby KM, Vobořil M, Salgado OC, Lee ST, Martinez RJ, O'Connor CH, Breed ER, Xuan S, Roll CR, Bachigari S, Heiland H, Stetson DB, Kotenko SV, Hogquist KA.
Sci Immunol. 2024 Jul 26;9(97):eadp1139. doi: 10.1126/sciimmunol.adp1139.
PMID: 39058762

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells.

Matson AW, Hullsiek R, Dixon KJ, Wang S, Lindstedt AJ, Friess RR, Phung SK, Freedman TS, Felices M, Truckenbrod EN, Wu J, Miller JS, Walcheck B.
J Immunother Cancer. 2024 Jul 24;12(7):e008959. doi: 10.1136/jitc-2024-008959.
PMID: 39053944

iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma.
Dixon KJ, Snyder KM, Khaw M, Hullsiek R, Davis ZB, Matson AW, Shirinbak S, Hancock B, Bjordahl R, Hosking M, Miller JS, Valamehr B, Wu J, Walcheck B.
Front Immunol. 2024 Jul 19;15:1407567. doi: 10.3389/fimmu.2024.1407567.
PMID: 39100677

C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle.

Rojo MD, Bandyopadhyay I, Burke CM, Sturtz AD, Phillips ES, Matherne MG, Embrey SJ, LaRue R, Qiu Y, Schwertfeger KL, Machado HL.
Life Sci Alliance. 2024 Jul 18;7(10):e202302516. doi: 10.26508/lsa.202302516.
PMID: 39025525

An exercise in relaxation: right ventricular diastolic function predicts exercise capacity in pulmonary arterial hypertension.
Patterson MT, Prins KW.
Eur Respir J. 2024 Jul 18;64(1):2401142. doi: 10.1183/13993003.01142-2024.
PMID: 39025515

Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency.
Wilkie H, Das M, Pelovitz T, Bainter W, Woods B, Alasharee M, Sobh A, Baris S, Eltan SB, Al-Herz W, Barbouche MR, Ben-Mustapha I, Ben-Ali M, Sallam MTH, Awad A, Lotfy S, El Marsafy A, Ezzelarab M, Farrar M, Schmidt BAR, NandyMazumdar M, Guttman-Yassky E, Sheets A, Vidic KM, Murphy G, Schlievert PM, Chou J, Leyva-Castillo JM, Janssen E, Timilshina M, Geha RS.
J Allergy Clin Immunol. 2024 Jul;154(1):143-156. doi: 10.1016/j.jaci.2023.12.020.
PMID: 38185418

PD1 blockade improves survival and CD8⁺ cytotoxic capacity, without increasing inflammation, during normal microbial experience in old mice.
Dahlquist KJV, Huggins MA, Yousefzadeh MJ, Soto-Palma C, Cholensky SH, Pierson M, Smith DM, Hamilton SE, Camell CD.
Nat Aging. 2024 Jul;4(7):915-925. doi: 10.1038/s43587-024-00620-4. Epub 2024 Apr 30.
PMID: 38689133

Circulating KLRG1⁺ long-lived effector memory T cells retain the flexibility to become tissue resident.
Lucas ED, Huggins MA, Peng C, O'Connor C, Gress AR, Thefaine CE, Dehm EM, Kubota Y, Jameson SC, Hamilton SE.
Sci Immunol. 2024 Jun 28;9(96):eadj8356. doi: 10.1126/sciimmunol.adj8356.
PMID: 38941479

Vardam-Kaur T, Banuelos A, Gabaldon-Parish M, Macedo BG, Salgado CL, Wanhainen KM, Zhou MH, van Dijk S, Santiago-Carvalho I, Beniwal AS, Leff CL, Peng C, Tran NL, Jameson SC, Borges da Silva H.
iScience. 2024 Jun 17;27(7):110290. doi: 10.1016/j.isci.2024.110290.
PMID: 39045105

Maurice NJ, Dalzell TS, Jarjour NN, DePauw TA, Jameson SC.
bioRxiv [Preprint]. 2024 Jun 12:2024.06.10.598293. doi: 10.1101/2024.06.10.598293.
PMID: 38915668

Mi T, Soerens AG, Alli S, Kang TG, Vasandan AB, Wang Z, Vezys V, Kimura S, Iacobucci I, Baylin SB, Jones PA, Hiner C, Mueller A, Goldstein H, Mullighan CG, Zebley CC, Masopust D, Youngblood B.
Nat Aging. 2024 Jun 12. doi: 10.1038/s43587-024-00649-5.
PMID: 38867059

CD8⁺ T cell tolerance: It doesn't translate.

Block KE, Jameson SC.
Immunity. 2024 Jun 11;57(6):1184-1186. doi: 10.1016/j.immuni.2024.05.014.
PMID: 38865962

Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion.
Kim JH, Schulte AJ, Sarver AL, Lee D, Angelos MG, Frantz AM, Forster CL, O'Brien TD, Cornax I, O'Sullivan MG, Cheng N, Lewellen M, Oseth L, Kumar S, Bullman S, Pedamallu CS, Goyal SM, Meyerson M, Lund TC, Breen M, Lindblad-Toh K, Dickerson EB, Kaufman DS, Modiano JF.
Cancer Res Commun. 2024 Jun 11;4(6):1467-1480. doi: 10.1158/2767-9764.CRC-23-0441.
PMID: 38757809

Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8⁺ T cells.

Jarjour NN, Dalzell TS, Maurice NJ, Wanhainen KM, Peng C, DePauw TA, Block KE, Valente WJ, Ashby KM, Masopust D, Jameson SC.
bioRxiv [Preprint]. 2024 Jun 3:2024.05.31.596695. doi: 10.1101/2024.05.31.596695.
PMID: 38895229

Elfstrum AK, Rumahorbo AH, Reese LE, Nelson EV, McCluskey BM, Schwertfeger KL.
Cancer Res Commun. 2024 May 31;4(5):1380-1397. doi: 10.1158/2767-9764.CRC-24-0205.
PMID: 38717149

Leveraging dirty mice that have microbial exposure to improve preclinical models of human immune status and disease.

Liu Q, Pickett T, Hodge D, Rios C, Arnold M, Dong G, Hamilton SE, Rehermann B.
Nat Immunol. 2024 May 15. doi: 10.1038/s41590-024-01842-9.
PMID: 38750319.

Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
Rasmussen DM, Semonis MM, Greene JT, Muretta JM, Thompson AR, Toledo Ramos S, Thomas DD, Pomerantz WCK, Freedman TS, Levinson NM.
Elife. 2024 May 14;13:RP95481. doi: 10.7554/eLife.95481.
PMID: 38742856

Successful Treatment of Recurrent Clostridioides difficile Infection Using a Novel, Drinkable, Oral Formulation of Fecal Microbiota.
Sadowsky MJ, Matson M, Mathai PP, Pho M, Staley C, Evert C, Weldy M, Khoruts A.
Dig Dis Sci. 2024 May;69(5):1778-1784. doi: 10.1007/s10620-024-08351-7.
PMID: 38457115

Cutting Edge: First Lung Infection Permanently Enlarges Lymph Nodes and Enhances New T Cell Responses.
Stolley JM, Scott MC, O'Flanagan SD, Künzli M, Matson CA, Weyu E, Langlois RA, Vezys V, Masopust D.
J Immunol. 2024 Apr 15:ji2400010. doi: 10.4049/jimmunol.2400010.
PMID: 38619284

Short Report: CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation.
Wardell CM, Fung VCW, Chen E, Haque M, Gillies J, Spanier JA, Mojibian M, Fife BT, Levings MK.
bioRxiv [Preprint]. 2024 Apr 10:2024.04.06.588414. doi: 10.1101/2024.04.06.588414.
PMID: 38645184

Peptide targeting improves the delivery and therapeutic index of glucocorticoids to treat rheumatoid arthritis.
Wu X, Guo H, Gao H, Li Y, Hu X, Kowalke MA, Li YX, Wei Y, Zhao J, Auger J, Binstadt BA, Pang HB.
J Control Release. 2024 Apr;368:329-343. doi: 10.1016/j.jconrel.2024.02.040.
PMID: 38431094

Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.
Osinski V, Yellamilli A, Firulyova MM, Zhang MJ, Peck AL, Auger JL, Faragher JL, Marath A, Voeller RK, O'Connell TD, Zaitsev K, Binstadt BA.
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):807-821. doi: 10.1161/ATVBAHA.123.320326.
PMID: 38269589

Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis.
Carey A, Nguyen K, Kandikonda P, Kruglov V, Bradley C, Dahlquist KJV, Cholensky S, Swanson W, Badovinac VP, Griffith TS, Camell CD.
Cell Rep. 2024 Mar 15;43(3):113967. doi: 10.1016/j.celrep.2024.113967.
PMID: 38492219

IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production.
Bravo M, Dileepan T, Dolan M, Hildebrand J, Wolford J, Hanson ID, Hamilton SE, Frosch AE, Burrack KS.
J Immunol. 2024 Mar 15;212(6):992-1001. doi: 10.4049/jimmunol.2300525.
PMID: 38305633

Mouse Models of Sepsis.
Kannan SK, Kim CY, Heidarian M, Berton RR, Jensen IJ, Griffith TS, Badovinac VP.
Curr Protoc. 2024 Mar;4(3):e997. doi: 10.1002/cpz1.997.
PMID: 38439603

Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer.
Elfstrum AK, Bapat AS, Schwertfeger KL.
Cancer Med. 2024 Feb;13(3):e7053. doi: 10.1002/cam4.7053.
PMID: 38426622

A guide to thymic selection of T cells.
Ashby KM, Hogquist KA.
Nat Rev Immunol. 2024 Feb;24(2):103-117. doi: 10.1038/s41577-023-00911-8.
PMID: 37464188

To die or not to die: Gasdermins in intestinal health and disease.
Lin Z, Chen Q, Ruan HB.
Semin Immunol. 2024 Feb;71:101865. doi: 10.1016/j.smim.2024.101865.
PMID: 38232665

Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination.
Sanders AE, Arnesen H, Shepherd FK, Putri DS, Fiege JK, Pierson MJ, Roach SN, Carlsen H, Masopust D, Boysen P, Langlois RA.
mSphere. 2024 Jan 29:e0065423. doi: 10.1128/msphere.00654-23.
PMID: 38286428

Centrosomal Protein 55 (CEP55) Drives Immune Exclusion and Resistance to Immune Checkpoint Inhibitors in Colorectal Cancer.
Wangmo D, Gates TJ, Zhao X, Sun R, Subramanian S.
Vaccines (Basel). 2024 Jan 8;12(1):63. doi: 10.3390/vaccines12010063.
PMID: 38250876

Treg cell dysfunction and cutaneous exposure to S. aureus underlie eczema in DOCK8 deficiency.
Wilkie H, Das M, Pelovitz T, Bainter W, Woods B, Alasharee M, Sobh A, Baris S, Eltan SB, Al-Herz W, Barbouche MR, Ben-Mustapha I, Ben-Ali M, Sallam MTH, Awad A, Lotfy S, El Marsafy A, Ezzelarab M, Farrar M, Schmidt BAR, NandyMazumdar M, Guttman-Yassky E, Sheets A, Vidic KM, Murphy G, Schlievert PM, Chou J, Leyva-Castillo JM, Janssen E, Timilshina M, Geha RS.
J Allergy Clin Immunol. 2024 Jan 5:S0091-6749(24)00005-8. doi: 10.1016/j.jaci.2023.12.020.
PMID: 38185418

Long- and short-term effects of fecal microbiota transplantation on antibiotic resistance genes: results from a randomized placebo-controlled trial.
Rashidi A, Ebadi M, Rehman TU, Elhusseini H, Kazadi D, Halaweish H, Khan MH, Hoeschen A, Cao Q, Luo X, Kabage AJ, Lopez S, Holtan SG, Weisdorf DJ, Liu C, Ishii S, Khoruts A, Staley C.
Gut Microbes. 2024 Jan-Dec;16(1):2327442. doi: 10.1080/19490976.2024.2327442.
PMID: 38478462

Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa.
Mandarino Alves A, Lecchi C, Lopez S, Stornetta A, Mathai PP, Villalta PW, Ishii S, Balskus EP, Balbo S, Khoruts A.
Gut Microbes. 2024 Jan-Dec;16(1):2387877. doi: 10.1080/19490976.2024.2387877. Epub 2024 Aug 12.
PMID: 39133871

2015-2024 Publications

Past CFI Publications

Wall of Honor

To honor the Center for Immunology faculty with 200 or more citations on one paper we have created a wall of honor located on the second floor of WMBB.

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2015-2024 Publications

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Wall of Honor

2024 Publications

2015-2024 Publications