The Center for Immunology produces an immense amount of research each year.  The data produced is comprehensive and timely to research across the globe.  Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities.  The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.


 To honor the Center for Immunology faculty with 200 or more citations on one paper we have created our wall of honor. 


2022-23 Publications


2023 Publications

2022 Publications

Fecal microbiota transplantation across the lifespan: balancing efficacy, safety, and innovation.
Gulati AS, Nicholson MR, Khoruts A, Kahn SA. Am J Gastroenterol. 2022 Dec 29. doi: 10.14309/ajg.0000000000002167. Online ahead of print.
PMID: 36580630
Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.
Lee RD, Knutson TP, Munro SA, Miller JT, Heltemes-Harris LM, Mullighan CG, Jepsen K, Farrar MA.
Nat Immunol. 2022 Dec;23(12):1763-1776. doi: 10.1038/s41590-022-01343-7. Epub 2022 Oct 31.
PMID: 36316474
Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803.
Harwood OE, Balgeman AJ, Weaver AJ, Ellis-Connell AL, Weiler AM, Erickson KN, Matschke LM, Golfinos AE, Vezys V, Skinner PJ, Safrit JT, Edlefsen PT, Reynolds MR, Friedrich TC, O'Connor SL.
J Virol. 2022 Dec 14;96(23):e0142422. doi: 10.1128/jvi.01424-22. Epub 2022 Nov 15.
PMID: 36377872
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells.
Künzli M, O'Flanagan SD, LaRue M, Talukder P, Dileepan T, Stolley JM, Soerens AG, Quarnstrom CF, Wijeyesinghe S, Ye Y, McPartlan JS, Mitchell JS, Mandl CW, Vile R, Jenkins MK, Ahmed R, Vezys V, Chahal JS, Masopust D.
Sci Immunol. 2022 Dec 9;7(78):eadd3075. doi: 10.1126/sciimmunol.add3075. Epub 2022 Dec 2.
PMID: 36459542
Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate.
Burrack AL, Spartz EJ, Rollins MR, Miller EA, Firulyova M, Cruz E, Goldberg MF, Wang IX, Nanda H, Shen S, Zaitsev K, Stromnes IM.
Cancer Immunol Immunother. 2022 Dec 6. doi: 10.1007/s00262-022-03338-7. Online ahead of print.
PMID: 36472588
Genetic Engineering of Immune Evasive Stem Cell-Derived Islets.
Sackett SD, Kaplan SJ, Mitchell SA, Brown ME, Burrack AL, Grey S, Huangfu D, Odorico J.
Transpl Int. 2022 Dec 5;35:10817. doi: 10.3389/ti.2022.10817. eCollection 2022.
PMID: 36545154
Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells.
Sjaastad FV, Huggins MA, Lucas ED, Skon-Hegg C, Swanson W, Martin MD, Salgado OC, Xu J, Pierson M, Dileepan T, Kucaba TA, Hamilton SE, Griffith TS.
J Immunol. 2022 Dec 1;209(11):2149-2159. doi: 10.4049/jimmunol.2200324.
PMID: 36426978

Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia.
Beura LK, Scott MC, Pierson MJ, Joag V, Wijeyesinghe S, Semler MR, Quarnstrom CF, Busman-Sahay K, Estes JD, Hamilton SE, Vezys V, O'Connor DH, Masopust D.
J Immunol. 2022 Nov 1;209(9):1691-1702. doi: 10.4049/jimmunol.2200320. Epub 2022 Sep 19.
PMID: 36122933

Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8+ T cell subsets.
Jarjour NN, Wanhainen KM, Peng C, Gavil NV, Maurice NJ, Borges da Silva H, Martinez RJ, Dalzell TS, Huggins MA, Masopust D, Hamilton SE, Jameson SC.
Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2209021119. doi: 10.1073/pnas.2209021119. Epub 2022 Oct 19.
PMID: 36260745

Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells.
Sjaastad FV, Huggins MA, Lucas ED, Skon-Hegg C, Swanson W, Martin MD, Salgado OC, Xu J, Pierson M, Dileepan T, Kucaba TA, Hamilton SE, Griffith TS.
J Immunol. 2022 Oct 17:ji2200324. doi: 10.4049/jimmunol.2200324. Online ahead of print.
PMID: 36253051

Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development.
Hicks D, Baehr C, Silva-Ortiz P, Khaimraj A, Luengas D, Hamid FA, Pravetoni M.
Hum Vaccin Immunother. 2022 Oct 4:2122507. doi: 10.1080/21645515.2022.2122507. Online ahead of print.
PMID: 36194773

Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing.
Owen DL, La Rue RS, Munro SA, Farrar MA.
J Immunol. 2022 Oct 1;209(7):1300-1313. doi: 10.4049/jimmunol.2200089. Epub 2022 Aug 29.
PMID: 36038290

The B side of B cells in NAFLD.
Barrow F, Revelo XS.
Hepatology. 2022 Oct;76(4):914-916. doi: 10.1002/hep.32481. Epub 2022 Apr 7.
PMID: 35340064

Correction to: Functional virus‑specific memory T cells survey glioblastoma.
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC.
Cancer Immunol Immunother. 2022 Oct;71(10):2577-2579. doi: 10.1007/s00262-022-03168-7.
PMID: 35179625

Editorial: Immune mechanisms of inflammation in NASH.
Hirsova P, Revelo XS.
Front Endocrinol (Lausanne). 2022 Sep 21;13:1039238. doi: 10.3389/fendo.2022.1039238. eCollection 2022.
PMID: 36213275

Effectiveness and Safety of Colonic and Capsule Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.
Vaughn BP, Fischer M, Kelly CR, Allegretti JR, Graiziger C, Thomas J, McClure E, Kabage AJ, Khoruts A.
Clin Gastroenterol Hepatol. 2022 Sep 17:S1542-3565(22)00880-1. doi: 10.1016/j.cgh.2022.09.008. Online ahead of print.
PMID: 36126907

Non-criteria antiphospholipid antibodies and pediatric rheumatic disease: a case series.
Mahmud SA, Bullock DR, Correll CK, Hobday PM, Riskalla MM, Vehe RK, Binstadt BA.
Pediatr Rheumatol Online J. 2022 Aug 20;20(1):70. doi: 10.1186/s12969-022-00732-4.
PMID: 35987646

Functional virus-specific memory T cells survey glioblastoma. 
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC. 
Cancer Immunol Immunother. 2022 Aug;71(8):1863-1875. doi: 10.1007/s00262-021-03125-w. Epub 2022 Jan 10.
PMID: 35001153

Natural Killer Cell Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Against Plasmodium falciparum-Infected Red Blood Cells.
Dick JK, Hart GT.
Methods Mol Biol. 2022;2470:641-657. doi: 10.1007/978-1-0716-2189-9_48.
PMID: 35881380

Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion.
Breed ER, Vobořil M, Ashby KM, Martinez RJ, Qian L, Wang H, Salgado OC, O'Connor CH, Hogquist KA.
Nat Immunol. 2022 Jul;23(7):1042-1051. doi: 10.1038/s41590-022-01218-x. Epub 2022 May 30.
PMID: 35637352

Targeted sequencing of candidate gene regions for myelofibrosis in dogs.
Campbell AG, Seelig DM, Beckman JD, Minor KM, Heinrich DA, Friedenberg SG, Modiano JF, Furrow E.
J Vet Intern Med. 2022 Jul;36(4):1237-1247. doi: 10.1111/jvim.16476. Epub 2022 Jul 11.
PMID: 35815881

Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction.
Hong SW, Krueger PD, Osum KC, Dileepan T, Herman A, Mueller DL, Jenkins MK.
Nature. 2022 Jul;607(7920):762-768. doi: 10.1038/s41586-022-04916-6. Epub 2022 Jul 6.
PMID: 35794484

Retinoic acid signaling acts as a rheostat to balance Treg function.
Thangavelu G, Andrejeva G, Bolivar-Wagers S, Jin S, Zaiken MC, Loschi M, Aguilar EG, Furlan SN, Brown CC, Lee YC, Hyman CM, Feser CJ, Panoskaltsis-Mortari A, Hippen KL, MacDonald KP, Murphy WJ, Maillard I, Hill GR, Munn DH, Zeiser R, Kean LS, Rathmell JC, Chi H, Noelle RJ, Blazar BR.
Cell Mol Immunol. 2022 Jul;19(7):820-833. doi: 10.1038/s41423-022-00869-y. Epub 2022 May 17.
PMID: 35581350

Combining nilotinib and PD-L1 blockade reverses CD4+ T-cell dysfunction and prevents relapse in acute B-cell leukemia.
Tracy SI, Venkatesh H, Hekim C, Heltemes-Harris LM, Knutson TP, Bachanova V, Farrar MA.
Blood. 2022 Jul 28;140(4):335-348. doi: 10.1182/blood.2021015341.
PMID: 35275990

An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism.
Zhang Z, Salgado OC, Liu B, Moazzami Z, Hogquist KA, Farrar MA, Ruan HB.
Front Immunol. 2022 Jul 8;13:874863. doi: 10.3389/fimmu.2022.874863. eCollection 2022.
PMID: 35874700 

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.
Wanhainen KM, Peng C, Zhou MH, Macedo BG, O'Flanagan S, Yang T, Kelekar A, Burbach BJ, Borges da Silva H, Jameson SC.
Cancer Immunol Res. 2022 Jul 1;10(7):871-884. doi: 10.1158/2326-6066.CIR-21-0691.
PMID: 35588154

Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease.
Pape KA, Dileepan T, Matchett WE, Ellwood C, Stresemann S, Kabage AJ, Kozysa D, Evert C, Matson M, Lopez S, Krueger PD, Graiziger CT, Vaughn BP, Shmidt E, Rhein J, Schacker TW, Bold TD, Langlois RA, Khoruts A, Jenkins MK.
JCI Insight. 2022 Jun 22;7(12):e159618. doi: 10.1172/jci.insight.159618.
PMID: 35730567

Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer.
Wenzel AT, Champa D, Venkatesh H, Sun S, Tsai CY, Mesirov JP, Bui JD, Howell SB, Harismendy O.
NPJ Syst Biol Appl. 2022 Jun 17;8(1):20. doi: 10.1038/s41540-022-00230-z.
PMID: 35715421

CD47 Promotes Autoimmune Valvular Carditis by Impairing Macrophage Efferocytosis and Enhancing Cytokine Production.
Meier LA, Faragher JL, Osinski V, Auger JL, Voeller R, Marath A, Binstadt BA.
J Immunol. 2022 Jun 15;208(12):2643-2651. doi: 10.4049/jimmunol.2100903. Epub 2022 Jun 3.
PMID: 35867674

Unravelling the sex-specific diversity and functions of adrenal gland macrophages.
Dolfi B, Gallerand A, Firulyova MM, Xu Y, Merlin J, Dumont A, Castiglione A, Vaillant N, Quemener S, Gerke H, Stunault MI, Schrank PR, Kim SH, Zhu A, Ding J, Gilleron J, Magnone V, Barbry P, Dombrowicz D, Duranton C, Wakkach A, Blin-Wakkach C, Becher B, Pagnotta S, Argüello RJ, Rantakari P, Chakarov S, Ginhoux F, Zaitsev K, Kim KW, Yvan-Charvet L, Guinamard RR, Williams JW, Ivanov S.
Cell Rep. 2022 Jun 14;39(11):110949. doi: 10.1016/j.celrep.2022.110949.
PMID: 35705045

Macrophage Fate Mapping.
Xu Y, Schrank PR, Williams JW.
Curr Protoc. 2022 Jun;2(6):e456. doi: 10.1002/cpz1.456.
PMID: 35687806

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.
Teigen L, Mathai PP, Lopez S, Matson M, Elkin B, Kozysa D, Kabage AJ, Hamilton M, Vaughn BP, Sadowsky MJ, Khoruts A.
Clin Nutr. 2022 Jun;41(6):1153-1162. doi: 10.1016/j.clnu.2022.03.028. Epub 2022 Apr 5.
PMID: 35500315

Embracing the heterogeneity of natural viruses in mouse studies.
Fiege JK, Langlois RA.
J Gen Virol. 2022 Jun;103(6). doi: 10.1099/jgv.0.001758.PMID: 35737518

Parabiosis in Mice to Study Tissue Residency of Immune Cells.
Wang H, Gavil NV, Koewler N, Masopust D, Jameson SC.
Curr Protoc. 2022 May;2(5):e446. doi: 10.1002/cpz1.446.
PMID: 35612420

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine. 
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21
PMID: 35446142

Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats.
Baehr C, Robinson C, Kassick A, Jahan R, Gradinati V, Averick SE, Runyon SP, Pravetoni M.
ACS Omega. 2022 May 4;7(19):16584-16592. doi: 10.1021/acsomega.2c00820. eCollection 2022 May 17.
PMID: 35601290

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Mills LJ, Scott MC, Shah P, Cunanan AR, Deshpande A, Auch B, Curtin B, Beckman KB, Spector LG, Sarver AL, Subramanian S, Richmond TA, Modiano JF.
Bone. 2022 May;158:115716. doi: 10.1016/j.bone.2020.115716. Epub 2020 Oct 27.
PMID: 33127576

γδ Thymocyte Maturation and Emigration in Adult Mice. 
Joannou K, Golec DP, Wang H, Henao-Caviedes LM, May JF, Kelly RG, Chan R, Jameson SC, Baldwin TA.
J Immunol. 2022 May 1;208(9):2131-2140. doi: 10.4049/jimmunol.2100360. Epub 2022 Apr 8. 
PMID: 35396221

Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Chen J, Farrugia G, Redinbo MR, Grover M.
Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038/s41564-022-01103-1. Epub 2022 Apr 28.
PMID: 35484230

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine.
Roach SN, Fiege JK, Shepherd FK, Wiggen TD, Hunter RC, Langlois RA.
J Virol. 2022 May 11;96(9):e0035222. doi: 10.1128/jvi.00352-22. Epub 2022 Apr 21.
PMID: 35446142

Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.
Baehr CA, Wu MM, Pandit SG, Arias-Umana J, AuCoin D, Pravetoni M.
J Pharmacol Exp Ther. 2022 May;381(2):129-136. doi: 10.1124/jpet.121.001048. Epub 2022 Feb 13.
PMID: 35153198

A dominant function of LynB kinase in preventing autoimmunity. 
Brian BF 4th, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS. 
Sci Adv. 2022 Apr 22;8(16):eabj5227. doi: 10.1126/sciadv.abj5227. Epub 2022 Apr 22. 
PMID: 35452291

Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.
Crouse B, Wu MM, Gradinati V, Kassick AJ, Song D, Jahan R, Averick S, Runyon S, Comer SD, Pravetoni M.
ACS Pharmacol Transl Sci. 2022 Apr 20;5(5):331-343. doi: 10.1021/acsptsci.1c00260. eCollection 2022 May 13.
PMID: 35592436

Brown adipose tissue involution associated with progressive restriction in progenitor competence.
Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB.
Cell Rep. 2022 Apr 12;39(2):110575. doi: 10.1016/j.celrep.2022.110575.
PMID: 35417710

The Conundrum of Lung Disease and Drug Hypersensitivity-like Reactions in Systemic Juvenile Idiopathic Arthritis.
Binstadt BA, Nigrovic PA.
Arthritis Rheumatol. 2022 Apr 12. doi: 10.1002/art.42137. Online ahead of print.
PMID: 35413159

Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. 
Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. 
Immunity. 2022 Apr 12;55(4):623-638.e5. doi: 10.1016/j.immuni.2022.03.009. Epub 2022 Apr 5.PMID: 35385697

Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer.
Burrack AL, Schmiechen ZC, Patterson MT, Miller EA, Spartz EJ, Rollins MR, Raynor JF, Mitchell JS, Kaisho T, Fife BT, Stromnes IM. 
JCI Insight. 2022 Apr 8;7(7):e151593. doi: 10.1172/jci.insight.151593. 
PMID: 35393950

SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
Brian BF 4th, Sjaastad FV, Freedman TS.
Sci Rep. 2022 Apr 7;12(1):5875. doi: 10.1038/s41598-022-09589-9. 
PMID: 35393453