Publications
The Center for Immunology produces an immense amount of research each year. The data produced is comprehensive and timely to research across the globe. Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities. The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.
2023 Publications
Allergen exposure functionally alters influenza-specific CD4+ Th1 memory cells in the lung.
Rüterbusch MJ, Hondowicz BD, Takehara KK, Pruner KB, Griffith TS, Pepper M.
J Exp Med. 2023 Nov 6;220(11):e20230112. doi: 10.1084/jem.20230112. Epub 2023 Sep 12.
PMID: 37698553
The role of interferon in the thymus.
Martinez RJ, Hogquist KA.
Curr Opin Immunol. 2023 Sep 20;84:102389. doi: 10.1016/j.coi.2023.102389. Online ahead of print.
PMID: 37738858
Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection.
King CR, Liu Y, Amato KA, Schaack GA, Mickelson C, Sanders AE, Hu T, Gupta S, Langlois RA, Smith JA, Mehle A.
Cell Host Microbe. 2023 Sep 13;31(9):1552-1567.e8. doi: 10.1016/j.chom.2023.08.001. Epub 2023 Aug 30.
PMID: 37652009
APLs and Oranges: Induction of T Cell Anergy by Altered Peptide Ligands.
Jarjour NN, Jameson SC.
J Immunol. 2023 Sep 1;211(5):709-710. doi: 10.4049/jimmunol.2300225.
PMID: 37603860
The Calm after the Storm: Implications of Sepsis Immunoparalysis on Host Immunity.
Silva EE, Skon-Hegg C, Badovinac VP, Griffith TS.
J Immunol. 2023 Sep 1;211(5):711-719. doi: 10.4049/jimmunol.2300171.
PMID: 37603859
Advancing Cancer Immunotherapy: From Molecular Mechanisms to Clinical Applications.
Zhao X, Starr T, Subramanian S.
Cancers (Basel). 2023 Aug 21;15(16):4197. doi: 10.3390/cancers15164197.
PMID: 37627225
Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes.
Schrodt MV, Behan-Bush RM, Liszewski JN, Humpal-Pash ME, Boland LK, Scroggins SM, Santillan DA, Ankrum JA.
Stem Cell Res Ther. 2023 Aug 17;14(1):206. doi: 10.1186/s13287-023-03443-z.
PMID: 37592321
Cytotoxic CD4 T cells in the mucosa and in cancer.
Venkatesh H, Tracy SI, Farrar MA.
Front Immunol. 2023 Aug 16;14:1233261. doi: 10.3389/fimmu.2023.1233261. eCollection 2023.
PMID: 37654482
Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes in mice.
Spanier JA, Fung V, Wardell CM, Alkhatib MH, Chen Y, Swanson LA, Dwyer AJ, Weno ME, Silva N, Mitchell JS, Orban PC, Mojibian M, Verchere CB, Fife BT, Levings MK.
J Clin Invest. 2023 Aug 10:e168601. doi: 10.1172/JCI168601. Online ahead of print.
PMID: 37561596
Pre-transplant and longitudinal changes in faecal microbiome characteristics are associated with subsequent development of chronic graft-versus-host disease.
El Jurdi N, Holtan SG, Hoeschen A, Velguth J, Hillmann B, Betts BC, MacMillan ML, Weisdorf DJ, Khoruts A, Rashidi A, Shields-Cutler R.
Br J Haematol. 2023 Aug 8. doi: 10.1111/bjh.19016. Online ahead of print.
PMID: 37553783
TB granuloma: CD30 co-stimulation for CD4+ T cell co-operation.
Gress AR, Bold TD.
J Exp Med. 2023 Aug 7;220(8):e20230547. doi: 10.1084/jem.20230547. Epub 2023 May 9.
PMID: 37158981
Virtual memory is a big hairy deal
Kedl RM, Jameson SC.
Nat Immunol. 2023 Aug;24(8):1215-1216. doi: 10.1038/s41590-023-01564-4.
PMID: 37429991
Author Correction: A guide to thymic selection of T cells.
Ashby KM, Hogquist KA.
Nat Rev Immunol. 2023 Aug 1. doi: 10.1038/s41577-023-00927-0. Online ahead of print.
PMID: 37528192
A guide to thymic selection of T cells.
Ashby KM, Hogquist KA.
Nat Rev Immunol. 2023 Jul 18. doi: 10.1038/s41577-023-00911-8. Online ahead of print.
PMID: 37464188
Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma.
Patterson MT, Burrack AL, Xu Y, Hickok GH, Schmiechen ZC, Becker S, Cruz-Hinojoza E, Schrank PR, Kennedy AE, Firulyova MM, Miller EA, Zaitsev K, Williams JW, Stromnes IM.
Cell Rep. 2023 Jul 25;42(7):112732. doi: 10.1016/j.celrep.2023.112732. Online ahead of print.
PMID: 37402168
Macrophages Remember When Your Heart Was Broken.
Souza-Neto F, Revelo XS, van Berlo JH.
JACC Basic Transl Sci. 2023 Jul 24;8(7):798-800. doi: 10.1016/j.jacbts.2023.02.008. eCollection 2023 Jul.
PMID: 37547070
A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models.
Crouse B, Miller SM, Muelken P, Hicks L, Vigliaturo JR, Marker CL, Guedes AGP, Pentel PR, Evans JT, LeSage MG, Pravetoni M.
NPJ Vaccines. 2023 Jul 24;8(1):107. doi: 10.1038/s41541-023-00697-9.
PMID: 37488109
Influence of Testosterone in Neglected Tropical Diseases: Clinical Aspects in Leprosy and In Vitro Experiments in Leishmaniasis.
de Oliveira Rekowsky LL, de Oliveira DT, Cazzaniga RA, Magalhães LS, Albuquerque LF, Araujo JMS, Tenório MDL, Machado TC, Lipscomb MW, Dos Santos PL, Ribeiro de Jesus A, Bezerra-Santos M, da Silva RLL.
Trop Med Infect Dis. 2023 Jul 10;8(7):357. doi: 10.3390/tropicalmed8070357.
PMID: 37505653
A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice.
Miller SM, Crouse B, Hicks L, Amin H, Cole S, Bazin HG, Burkhart DJ, Pravetoni M, Evans JT.
NPJ Vaccines. 2023 Jul 10;8(1):97. doi: 10.1038/s41541-023-00694-y.
PMID: 37429853
Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa.
Stolley JM, Scott MC, Joag V, Dale AJ, Johnston TS, Saavedra F, Gavil NV, Lotfi-Emran S, Soerens AG, Weyu E, Pierson MJ, Herzberg MC, Zhang N, Vezys V, Masopust D.
J Exp Med. 2023 Jul 3;220(7):e20221853. doi: 10.1084/jem.20221853. Epub 2023 Apr 25.
PMID: 37097449
Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques.
Jaeger AS, Crooks CM, Weiler AM, Bliss MI, Rybarczyk S, Richardson A, Einwalter M, Peterson E, Capuano S 3rd, Barkhymer A, Becker JT, Greene JT, Freedman TS, Langlois RA, Friedrich TC, Aliota MT.
Sci Adv. 2023 Jun 30;9(26):eadg3444. doi: 10.1126/sciadv.adg3444. Epub 2023 Jun 30.
PMID: 37390207
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates.
Tkachev V, Vanderbeck A, Perkey E, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Koch U, Radtke F, Ludewig B, Burbach B, Shimizu Y, Panoskaltsis-Mortari A, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS, Maillard I.
Sci Transl Med. 2023 Jun 28;15(702):eadd1175. doi: 10.1126/scitranslmed.add1175. Epub 2023 Jun 28.
PMID: 37379368
Detection of Antibody-Dependent Cell-Mediated Cytotoxicity-Supporting Antibodies by NK-92-CD16A Cell Externalization of CD107a: Recognition of Antibody Afucosylation and Assay Optimization.
Cruz Amaya J, Walcheck B, Smith-Gagen J, Lombardi VC, Hudig D.
Antibodies (Basel). 2023 Jun 27;12(3):44. doi: 10.3390/antib12030044.
PMID: 37489366
A paradigm shift: AMPK negatively regulates ULK1 activity.
Park JM, Kim DH.
Autophagy. 2023 Jun 20:1-3. doi: 10.1080/15548627.2023.2223465. Online ahead of print.
PMID: 37339275
Chronic antigen in solid tumors drives a distinct program of T cell residence.
Gavil NV, Scott MC, Weyu E, Smith OC, O'Flanagan SD, Wijeyesinghe S, Lotfi-Emran S, Shiao SL, Vezys V, Masopust D.
Sci Immunol. 2023 Jun 8;8(84):eadd5976. doi: 10.1126/sciimmunol.add5976. Epub 2023 Jun 2.
PMID: 37267383
Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression.
Faragher J, Auger JL, Osinski V, Meier LA, Engelson BJ, Firulyova MM, Gonzalez-Torres MI, Brombacher F, Zaitsev K, Marath A, Binstadt BA.
Arterioscler Thromb Vasc Biol. 2023 Jun;43(6):943-957. doi: 10.1161/ATVBAHA.122.319025. Epub 2023 Apr 6
PMID: 37021574
Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate.
Burrack AL, Spartz EJ, Rollins MR, Miller EA, Firulyova M, Cruz E, Goldberg MF, Wang IX, Nanda H, Shen S, Zaitsev K, Stromnes IM.
Cancer Immunol Immunother. 2023 Jun;72(6):1461-1478. doi: 10.1007/s00262-022-03338-7. Epub 2022 Dec 6.
PMID: 36472588
CD4+ T cell memory.
Künzli M, Masopust D.
Nat Immunol. 2023 Jun;24(6):903-914. doi: 10.1038/s41590-023-01510-4. Epub 2023 May 8.
PMID: 37156885
Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML.
Rashidi A, Ebadi M, Rehman TU, Elhusseini H, Kazadi D, Halaweish H, Khan MH, Hoeschen A, Cao Q, Luo X, Kabage AJ, Lopez S, Holtan SG, Weisdorf DJ, Khoruts A, Staley C.
J Clin Oncol. 2023 May 26:JCO2202366. doi: 10.1200/JCO.22.02366. Online ahead of print.
PMID: 37235836
Redefining the role of AMPK in autophagy and the energy stress response.
Park JM, Lee DH, Kim DH.
Nat Commun. 2023 May 24;14(1):2994. doi: 10.1038/s41467-023-38401-z.
PMID: 37225695
Distinct mechanisms of PTEN inactivation in dogs and humans highlight convergent molecular events that drive cell division in the pathogenesis of osteosarcoma.
Sarver AL, Mills LJ, Makielski KM, Temiz NA, Wang J, Spector LG, Subramanian S, Modiano JF.
Cancer Genet. 2023 May 20;276-277:1-11. doi: 10.1016/j.cancergen.2023.05.001. Online ahead of print.
PMID: 37267683
Leveraging mice with diverse microbial exposures for advances in osteoimmunology.
Little-Letsinger SE, Hamilton SE.
Front Endocrinol (Lausanne). 2023 May 10;14:1168552. doi: 10.3389/fendo.2023.1168552. eCollection 2023.
PMID: 37251680
Prolonged Elevations of Factor VIII and von Willebrand Factor Antigen After Multisystem Inflammatory Syndrome in Children.
Boucher AA, Knutson S, Young L, Evans MD, Braunlin E, Zantek ND, Sharon B, Binstadt BA, Ryan M, Greene R, Mahmud S, Marmet J, Fischer G, Steiner ME.
J Pediatr Hematol Oncol. 2023 May 1;45(4):e427-e432. doi: 10.1097/MPH.0000000000002583. Epub 2022 Oct 24.
PMID: 36730963
IL-4 Predicts the Efficacy of a Candidate Antioxycodone Vaccine and Alters Vaccine-Specific Antibody-Secreting Cell Proliferation in Mice.
Crouse B, Baehr C, Hicks D, Pravetoni M.
J Immunol. 2023 May 1;210(9):1272-1280. doi: 10.4049/jimmunol.2200605.
PMID: 36939374
Effectiveness and Safety of Colonic and Capsule Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection.
Vaughn BP, Fischer M, Kelly CR, Allegretti JR, Graiziger C, Thomas J, McClure E, Kabage AJ, Khoruts A.
Clin Gastroenterol Hepatol. 2023 May;21(5):1330-1337.e2. doi: 10.1016/j.cgh.2022.09.008. Epub 2022 Sep 17.
PMID: 36126907
Natural Microbial Exposure from the Earliest Natural Time Point Enhances Immune Development by Expanding Immune Cell Progenitors and Mature Immune Cells.
Burger S, Stenger T, Pierson M, Sridhar A, Huggins MA, Kucaba TA, Griffith TS, Hamilton SE, Schuldt NJ.
J Immunol. 2023 Apr 19:ji2300061. doi: 10.4049/jimmunol.2300061. Online ahead of print.
PMID: 37074206
FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome.
Zhang N, Harsch B, Zhang MJ, Gyberg DJ, Stevens JA, Wagner BM, Mendelson J, Patterson MT, Orchard DA, Healy CL, Williams JW, Townsend D, Shearer GC, Murphy KA, O'Connell TD.
J Lipid Res. 2023 Apr 17:100374. doi: 10.1016/j.jlr.2023.100374. Online ahead of print.
PMID: 37075982
Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production.
Dahlvang JD, Dick JK, Sangala JA, Kennedy PR, Pomeroy EJ, Snyder KM, Moushon JM, Thefaine CE, Wu J, Hamilton SE, Felices M, Miller JS, Walcheck B, Webber BR, Moriarity BS, Hart GT.
J Immunol. 2023 Apr 15;210(8):1108-1122. doi: 10.4049/jimmunol.2200488.
PMID: 36881874
HLA DRB1*15 and Eosinophilia are Common Among Patients with Systemic Juvenile Idiopathic Arthritis.
Arthritis Care Res (Hoboken). 2023 Apr 13. doi: 10.1002/acr.25132. Online ahead of print.
PMID: 37052526
Gates TJ, Yuan C, Shetty M, Kaiser T, Nelson AC, Chauhan A, Starr TK, Staley C, Subramanian S.
Cancers (Basel). 2023 Apr 12;15(8):2260. doi: 10.3390/cancers15082260.
PMID: 37190186
Stromnes IM.
Cancer Immunol Res. 2023 Apr 3;11(4):400. doi: 10.1158/2326-6066.CIR-23-0145.
PMID: 36897261
Targeting the NF-κB pathway enhances responsiveness of mammary tumors to JAK inhibitors.
Bapat AS, O'Connor CH, Schwertfeger KL.
Sci Rep. 2023 Apr 1;13(1):5349. doi: 10.1038/s41598-023-32321-0.
PMID: 37005447
ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer.
Bae SY, Bergom HE, Day A, Greene JT, Sychev ZE, Larson G, Corey E, Plymate SR, Freedman TS, Hwang JH, Drake JM. Front Endocrinol (Lausanne). 2023 Mar 29;14:1093332. doi: 10.3389/fendo.2023.1093332. eCollection 2023.
PMID: 37065756
Anti-Strychnine Immunoconjugate Reduces the Effects of Strychnine-Induced Toxicity in Mice.
Baehr C, Kassick AJ, Vigliaturo J, Luengas D, Khaimraj A, Pravetoni M, Averick SE, Raleigh MD.
ACS Chem Neurosci. 2023 Apr 5;14(7):1291-1298. doi: 10.1021/acschemneuro.2c00797. Epub 2023 Mar 23.
PMID: 36952479
Toward a general model of CD4+ T cell subset specification and memory cell formation.
Osum KC, Jenkins MK.
Immunity. 2023 Mar 14;56(3):475-484. doi: 10.1016/j.immuni.2023.02.010.
PMID: 36921574
A new hope; the M. tuberculosis strikes back.
Bold TD.
Cell Host Microbe. 2023 Mar 8;31(3):321-322. doi: 10.1016/j.chom.2023.02.004.
PMID: 36893727
O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors.
Zhang Z, Huang Z, Awad M, Elsalanty M, Cray J, Ball LE, Maynard JC, Burlingame AL, Zeng H, Mansky KC, Ruan HB.
Elife. 2023 Mar 2;12:e85464. doi: 10.7554/eLife.85464.
PMID: 36861967
Type III interferon drives thymic B cell activation and regulatory T cell generation.
Martinez RJ, Breed ER, Worota Y, Ashby KM, Vobořil M, Mathes T, Salgado OC, O'Connor CH, Kotenko SV, Hogquist KA.
Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2220120120. doi: 10.1073/pnas.2220120120. Epub 2023 Feb 21.
PMID: 36802427
Tissue resident memory T cells trigger rapid exudation and local antibody accumulation.
Rosato PC, Lotfi-Emran S, Joag V, Wijeyesinghe S, Quarnstrom CF, Degefu HN, Nedellec R, Schenkel JM, Beura LK, Hangartner L, Burton DR, Masopust D.
Mucosal Immunol. 2023 Feb;16(1):17-26. doi: 10.1016/j.mucimm.2022.11.004. Epub 2023 Jan 16.
PMID: 36657662
FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells.
Zhao Q, Hu J, Kong L, Jiang S, Tian X, Wang J, Hashizume R, Jia Z, Fowlkes NW, Yan J, Xia X, Yi SF, Dao LH, Masopust D, Heimberger AB, Li S.
Nat Commun. 2023 Feb 10;14(1):735. doi: 10.1038/s41467-023-36430-2.
PMID: 36759517
Germline T cell receptor exchange results in physiological T cell development and function.
Rollins MR, Raynor JF, Miller EA, Butler JZ, Spartz EJ, Lahr WS, You Y, Burrack AL, Moriarity BS, Webber BR, Stromnes IM.
Nat Commun. 2023 Feb 1;14(1):528. doi: 10.1038/s41467-023-36180-1.
PMID: 36726009
Resident memory T cells develop regional dialects.
Maurice NJ, Jameson SC.
Nat Immunol. 2023 Feb;24(2):209-210. doi: 10.1038/s41590-022-01416-7.
PMID: 36658239
Functional T cells are capable of supernumerary cell division and longevity.
Soerens AG, Künzli M, Quarnstrom CF, Scott MC, Swanson L, Locquiao JJ, Ghoneim HE, Zehn D, Youngblood B, Vezys V, Masopust D.
Nature. 2023 Feb;614(7949):762-766. doi: 10.1038/s41586-022-05626-9. Epub 2023 Jan 18.
PMID: 36653453
Characterization of Hyaluronan Localization in the Developing Mammary Gland and Mammary Tumors.
Witschen PM, Elfstrum AK, Nelson AC, Schwertfeger KL.
J Mammary Gland Biol Neoplasia. 2023 Jan 27;28(1):1. doi: 10.1007/s10911-023-09528-y.
PMID: 36723776
Fecal Microbiota Transplantation Across the Lifespan: Balancing Efficacy, Safety, and Innovation.
Gulati AS, Nicholson MR, Khoruts A, Kahn SA.
Am J Gastroenterol. 2023 Jan 25. doi: 10.14309/ajg.0000000000002167. Online ahead of print.
PMID: 36580630
Single-cell transcriptomes and T cell receptors of vaccine-expanded apolipoprotein B-specific T cells.
Nettersheim FS, Ghosheh Y, Winkels H, Kobiyama K, Durant C, Armstrong SS, Brunel S, Roy P, Dileepan T, Jenkins MK, Zajonc DM, Ley K.
Front Cardiovasc Med. 2023 Jan 5;9:1076808. doi: 10.3389/fcvm.2022.1076808. eCollection 2022.
PMID: 36684560
Impact of diet on hydrogen sulfide production: implications for gut health.
Teigen L, Biruete A, Khoruts A.
Curr Opin Clin Nutr Metab Care. 2023 Jan 1;26(1):55-58. doi: 10.1097/MCO.0000000000000881. Epub 2022 Sep 27.
PMID: 36542535
Tumor-derived extracellular vesicles in the colorectal cancer immune environment and immunotherapy.
2022 Publications
Wall of Honor
To honor the Center for Immunology faculty with 200 or more citations on one paper we have created a wall of honor located on the second floor of WMBB.