Publications

The Center for Immunology produces an immense amount of research each year.  The data produced is comprehensive and timely to research across the globe.  Our research is supported by Government, Commercial and Industrial grants and private funds and is produced in our state of the art research facilities.  The research is carried out by faculty members, visiting scholars, post-doctoral fellows, graduate, and undergraduate students and technicians. The Center for Immunology also has a strong collaboration history with colleagues at other Universities and research companies worldwide.

CFI Publications

2026 Publications

IL-4-STAT6 signaling delays protective CD8+ T cell bystander activation by antagonizing IL-18 sensing. 
Maurice NJ, Dalzell TS, Tankersley TN, Rhee KH, Block KE, Jarjour NN, DePauw TA, Wall SM, Hamilton SE, Jameson SC.
Nat Immunol. 2026 Feb 10. doi: 10.1038/s41590-026-02430-9. Online ahead of print.
PMID: 41667619

Distinct spatial organization governs oral mucosal immunity. 
Theofilou VI, Fraser D, Kanasi E, Brenchley L, Greenwell-Wild T, Adade EE, Valm AM, Douagi I, Belkaid Y, Tran DT, Williams DW, Moutsopoulos NM.
Nat Immunol. 2026 Feb 9. doi: 10.1038/s41590-025-02398-y. Online ahead of print.
PMID: 41663813

Decidual CD4 Effector Memory and Resident Memory T Cells Respond to Cord Blood Allo-Antigens.
Koenig ZT, Eswar S, Tsuda S, Schuldt N, Chougnet CA, Forde B, Andorf S, Tilburgs T.
Am J Reprod Immunol. 2026 Feb;95(2):e70213. doi: 10.1111/aji.70213.
PMID: 41618722
 

When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA. 
Stuttgen GM, Chang M, Williams JW.
Circ Res. 2026 Jan 30;138(3):e327969. doi: 10.1161/CIRCRESAHA.125.327969. Epub 2026 Jan 29.
PMID: 41610191

Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza. 
Zhang Q, Conrad TS, Moncada-Velez M, Jiang K, Cupic A, Eaton J, Hutchinson K, Gervais A, Chen R, Puel A, Bastard P, Cobat A, Sokol T, Langlois RA, Miorin L, García-Sastre A, Vanchiere JA, Casanova JL. 
J Exp Med. 2026 Mar 2;223(3):e20251962. doi: 10.1084/jem.20251962. Epub 2025 Dec 5. 
PMID: 41348320
 
CSF Hypo-Inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis. 
Wilt AL, Meya DB, Cresswell FV, Wele A, Kabahubya M, Kagimu E, Gakuru J, Mugabi T, Kimuda S, Namombwe S, Tukundane A, Okafor EC, Okurut S, Scriven JE, Dai B, Engen N, Bahr NC, Boulware DR, Bold TD.
J Infect Dis. 2026 Jan 12:jiag032. doi: 10.1093/infdis/jiag032. Online ahead of print.
PMID: 41527237
 

Toll-Like Receptor 7/8 Antagonist Promotes Interleukin-10-Mediated Anti-inflammatory Therapy.
Funk GA, Xie J, Kucaba TA, Griffith TS, Ferguson DM, Kim H.
ACS Pharmacol Transl Sci. 2025 Dec 11;9(1):114-125. doi: 10.1021/acsptsci.5c00604. eCollection 2026 Jan 9.
PMID: 41536275

A host-adapted commensal fungus from pet store mice drives type 2 immunity and cross-kingdom protection. 
Han G, Yunker R, Hasan MH, Bruce A, Baldaro K, Pacia J, Jarjour NN, Beura LK, Vaishnava S.
bioRxiv [Preprint]. 2026 Jan 6:2025.04.30.651489. doi: 10.1101/2025.04.30.651489.
PMID: 41542591

Altered natural killer cell function in children with severe malaria.
Turyasingura G, Mellencamp KA, Namazzi R, Opoka RO, John CC, Hart GT.
Immunohorizons. 2026 Jan 6;10(1):vlaf070. doi: 10.1093/immhor/vlaf070.
PMID: 41491654

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells.
Vobořil M, Sulczewski FB, Martinez RJ, Ashby KM, Valerio MM, Idoyaga J, Hogquist KA.
J Exp Med. 2026 Jan 5;223(1):e20250733. doi: 10.1084/jem.20250733. Epub 2025 Oct 22. 
PMID: 41123595

A Novel Imidazoquinoline With TLR 7/8, STING, and Inflammasome Activity Demonstrates Antitumor Efficacy in Mouse Melanoma and Neu-Driven Mammary Adenocarcinoma. 
Bhatnagar S, Revuri V, Merali C, Wang B, Schultz JR, Larson P, Yu D, Prabha S, Griffith TS, Ferguson D, Merali S, Panyam J.
J Immunother. 2026 Jan 1;49(1):1-14. doi: 10.1097/CJI.0000000000000571. 
PMID: 40765175
 

Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection.
Rivera-Cardona J, Mahajan T, Thayer EA, Kakuturu NR, Teo QW, Lederer J, Rowland EF, Heimburger K, Sun J, McDonald CA, Mickelson CK, Langlois RA, Wu NC, Milenkovic O, Maslov S, Brooke CB.
Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2509560123. doi: 10.1073/pnas.2509560123. Epub 2025 Dec 30.
PMID: 41468430

 

Expand all

2025 Publications

2025 Publications

Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection.
Rivera-Cardona J, Mahajan T, Thayer EA, Kakuturu NR, Teo QW, Lederer J, Rowland EF, Heimburger K, Sun J, McDonald CA, Mickelson CK, Langlois RA, Wu NC, Milenkovic O, Maslov S, Brooke CB.
Proc Natl Acad Sci U S A. 2026 Jan 6;123(1):e2509560123. doi: 10.1073/pnas.2509560123. Epub 2025 Dec 30.
PMID: 41468430

Epidermal resident memory T cell fitness requires antigen encounter in the skin.
Weiss ES, Hirai T, Li H, Liu A, Baker S, Magill I, Gillis J, Zhang YR, Ramcke T, Kurihara K; ImmGen Consortium OpenSource T cell Project; Masopust D, Anandasabapathy N, Singh H, Zemmour D, Mackay LK, Kaplan DH.
Elife. 2025 Dec 30;14:RP107096. doi: 10.7554/eLife.107096.
PMID: 41468295

The Sixth Annual Symposium of the Midwest Aging Consortium.
Sturmlechner I, Ashiqueali SA, Martini H, Valdivieso K, Franco AC, Guthikonda P, Dosch AJ, Prieto LI, Asmussen NC, Latham AS, Redden JT, Leitschuh EA, Mashek DG, Passos JF, Rodriguez-Lopez J, Blake Monroe T, Bernlohr DA, Robbins PD, Knopf BA, Lamming DW, Johnston MJ, Brown-Borg HM, Tye SA, Rhoads TW, Gate DM, Childs BG, Baker DJ, Li X, Jang IH, Camell CD, Miller Z, Phatnani H, Konopka AR, Haak AJ, Vanegas-Avendano N, Akula RN, Limkar AR, Ricke WA, Leiser SF, Correia J, Bai H, Olszewski S, Seldeen KL, Budinger GRS, Morales-Nebreda LC, Winter DR, Mccrady-Spitzer SK, Anderson RM, Mihaylova MM, Rojas M, Mora AL, Lebrasseur NK, Schafer MJ.
J Gerontol A Biol Sci Med Sci. 2025 Dec 22:glaf280. doi: 10.1093/gerona/glaf280. Online ahead of print.
PMID: 41429578

Chronic NK cell activation results in a dysfunctional, tissue resident-like state mediated by KLF2 deficiency.
Myers JA, Huang RS, Phung SK, Chacón JM, Bendzick L, Weis A, Shetty M, DePauw TA, Khaw MJ, Abrahante JE, O'Flanagan SD, Ashby KM, Lozada JR, Jameson SC, Hwang JH, Cichocki F, Felices M, Miller JS.
Blood. 2025 Dec 18;146(25):3059-3071. doi: 10.1182/blood.2024027763.
PMID: 40857665

More Than a Cleanup Crew: The Expanding Biology of Efferocytosis.
Pandit R, Hillman H, Williams JW, Yurdagul A Jr.
Arterioscler Thromb Vasc Biol. 2025 Dec 18. doi: 10.1161/ATVBAHA.125.323211. Online ahead of print.
PMID: 41410050

The challenges and opportunities in the expanding horizons of microbiota transplant therapies.

Khoruts A.
Gut Microbes. 2025 Dec;17(1):2559032. doi: 10.1080/19490976.2025.2559032. Epub 2025 Nov 3.
PMID: 41181931
 
Use of proximity ligation shotgun metagenomics to investigate the dynamics of plasmids and bacteriophages in the gut microbiome following fecal microbiota transplantation.

Bryson S, Sisson Z, Nelson B, Grove J, Reister E, Liachko I, Auch B, Graiziger C, Khoruts A.
Gut Microbes. 2025 Dec;17(1):2559019. doi: 10.1080/19490976.2025.2559019. Epub 2025 Sep 15.
PMID: 40948444
 
Metagenomic source tracking after microbiota transplant therapy.
Hoops SL, Moutsoglou D, Vaughn BP, Khoruts A, Knights D. 
Gut Microbes. 2025 Dec;17(1):2487840. doi: 10.1080/19490976.2025.2487840. Epub 2025 Apr 14. 
PMID: 40229213
 

Effect of fecal microbiota transplantation on gut microbiota functional profile in recipients of allogeneic hematopoietic cell transplantation. 

Ebadi M, Reddi S, Senyshyn L, Minot SS, Gooley T, Kabage AJ, Lee SJ, Hill GR, Khoruts A, Rashidi A. 
Gut Microbes. 2025 Dec;17(1):2551882. doi: 10.1080/19490976.2025.2551882. Epub 2025 Aug 27. 
PMID: 40867077
 
GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging.

Jang IH, Carey A, Kruglov V, Nguyen K, Misialek JR, Cholensky SH, Smith DM, Bai S, Nottoli T, Bernlohr DA, Lutsey PL, Camell CD
Nat Aging. 2025 Dec 15. doi: 10.1038/s43587-025-01034-6. Online ahead of print.
PMID: 41398392
 
Breast Cancer Progression by the FGF/FGFR Axis: A Metabolic Perspective. 

Tuokkola JE, Schwertfeger KL.
J Mammary Gland Biol Neoplasia. 2025 Dec 10. doi: 10.1007/s10911-025-09594-4. Online ahead of print. 
PMID: 41369841
 

Functional genomics for improving adoptive T-cell transfer therapies.
Skeate JG, Lee CJ, Stewart C, Fischbach MJ, Kar B, Tsai AK, Kenderian SS, Stromnes IM, Largaespada DA, Moriarity BS, Rogers LM.
J Immunother Cancer. 2025 Dec 9;13(12):e013286. doi: 10.1136/jitc-2025-013286. 
PMID: 41365534

CD69 Regulates Gingival Inflammation and Microbiome in Periodontitis.
Saavedra FM, Fischer L, Bittner-Eddy PD, Johnstone KF, Stolley JM, Williams DW, Herzberg MC, Costalonga M. 
J Dent Res. 2025 Nov 26:220345251383827. doi: 10.1177/00220345251383827. Online ahead of print. 
PMID: 41299866

NK cell immunotherapy administered at the time of HIV recrudescence is associated with viral control.
Liliana Kopeck Thron, Pongthorn Pumtang-on, Jae Woong Chang, Maxwell E Cantor, Ian Gorrell-Brown, Kelsie L Becklin, Zoe E Quinn, Ahmad F Karim, Aaron K Rendahl, Mary S Pampusch, Sofia A Casares, Vaiva Vezys, Branden Moriarity, Pamela J. Skinner
bioRxiv [Preprint]. 2025 Nov 19:2025.11.19.688897. doi: 10.1101/2025.11.19.688897. 
PMID: 41332665

A special collection on targeting the immune system-Editorial. 

Rothlin C, Gutkind JS. 
J Pharmacol Exp Ther. 2025 Nov 21;392(12):103771. doi: 10.1016/j.jpet.2025.103771. Online ahead of print. 
PMID: 41273897
 
Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells. 

Haniuda K, Edner NM, Makita Y, Appiah S, Watts TH, Wu GF, Dileepan T, Gommerman JL. 
Cell. 2025 Nov 17:S0092-8674(25)00812-8. doi: 10.1016/j.cell.2025.07.022. Online ahead of print. 
PMID: 41253146
 
IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell-dependent and NK cell-independent manner in a murine model of pancreatic ductal adenocarcinoma. 

Burrack AL, Tsai AK, Ellefson MA, Schmiechen ZC, Larsen BM, Burrack KS, Stromnes IM. 
J Immunol. 2025 Nov 18:vkaf314. doi: 10.1093/jimmun/vkaf314. Online ahead of print.
PMID: 41254945
 

T cell nomenclature: from subsets to modules.
Masopust D, Soerens AG, Quarnstrom CF, Ahmed R. 
Nat Rev Immunol. 2025 Nov 18. doi: 10.1038/s41577-025-01246-2. Online ahead of print. 
PMID: 41254225  

Guidelines for T cell nomenclature. 

Masopust D, Awasthi A, Bosselut R, Brooks DG, Buggert M, Chamoto K, Cui W, Dong C, Farber DL, Gebhardt T, Gerlach C, Goldrath A, Greenberg PD, Hale JS, Hayday A, Homann D, Iannacone M, Jameson SC, Jenkins MK, Joshi NS, Kaech SM, Kallies A, Kamphorst AO, Kaplan MH, Klenerman P, Künzli M, Lanzavecchia A, Lauer GM, Lugli E, Luster AD, Mackay LK, McElrath MJ, Mueller SN, Ndhlovu Z, Ndung'u T, Ohashi PS, Oxenius A, Pantaleo G, Pepper M, Picker LJ, Quarnstrom CF, Reyes-Terán G, Roederer M, Rosato PC, de Oca GS, Sallusto F, Schumacher TN, Schwartz DM, Shin EC, Soerens AG, Thommen DS, Vezys V, Viola JPB, Walker BD, Watts TH, Weaver CT, Wherry EJ, Xue HH, Youngblood B, Ahmed R. 
Nat Rev Immunol. 2025 Nov 18. doi: 10.1038/s41577-025-01238-2. Online ahead of print. 
PMID: 41254224  
 
Mechanisms of Innate Immune Modulation by High-Fat Diet: Implications for Obesity and Asthma. 

Caslin HL, Williams JW. 
Curr Allergy Asthma Rep. 2025 Nov 10;25(1):51. doi: 10.1007/s11882-025-01232-7. 
PMID: 41212444
 

Lyn expression in macrophages promotes TLR activation and restricts proliferation in an isoform-independent manner.
Lindstedt AJ, Greene JT, Xu Y, Williams JW, Freedman TS.
J Leukoc Biol. 2025 Nov 4;117(11):qiaf140. doi: 10.1093/jleuko/qiaf140. 
PMID: 41054812

Thymic Dendritic Cells Revisited.
Vobořil M, Xuan S, Hogquist KA. 
Immunol Rev. 2025 Nov;336(1):e70076. doi: 10.1111/imr.70076. 
PMID: 41251667

CD44 in myeloid cells is a major driver of liver inflammation and injury in alcohol-associated liver disease.
Rousseau D, Bonnafous S, Soysouvanh F, Sarrail D, Bourinet M, Strazzulla A, Patouraux S, Borderie A, Dolfi B, Gallerand A, Farrugia MA, Orian-Rousseau V, Xu Y, Williams JW, Ivanov S, Tran A, Anty R, Luci C, Gual P.
Hepatology. 2025 Nov 1;82(5):1211-1228. doi: 10.1097/HEP.0000000000001232.
PMID: 39808819

 

Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer.
Callaway MK, Noonan BJ, Schwertfeger KL, Provenzano PP. 
Matrix Biol. 2025 Nov;141:114-126. doi: 10.1016/j.matbio.2025.09.004. Epub 2025 Sep 18. 
PMID: 40975454

Discovery Stack Pilot: Feasibility and Outcomes of a Scientist-Designed Peer Review Model Separating Quality and Impact
Maureen A. McGargill, Beiyun C. Liu, Michael S. Kuhns, Daniel Mucida, Isabella Rauch, Lauren B. Rodda, Meghan A. Koch, Hugo Gonzalez, Ken Cadwell, Tanya S. Freedman, Tiffany C. Scharschmidt, Richard Sever, Jose Ordovas-Montanes, Sara Suliman, Andrew Oberst, Brooke Runnette, Matthew F. Krummel
bioRxiv 2025.10.31.685758; doi:10.1101/2025.10.31.685758

Monitoring Response to Combinatorial Immunotherapies by Tracking both T Cells and Natural Killer Cells In Vivo via ImmunoPET-Raman Multimodal Gold Nanostars.
Cutshaw GP, Kothadiya S, Uthaman S, Pandya DN, Wen X, Mathew A, Sinha A, Antony I, Vilgelm AE, Wadas TJ, Mitchell JS, Bardhan R. 
ACS Appl Mater Interfaces. 2025 Oct 29;17(43):59051-59066. doi: 10.1021/acsami.5c11312. Epub 2025 Oct 16. 
PMID: 41099635

Gut microbial composition modulates food-specific CD4+ T cells in food allergy

Alexa R Weingarden, Flannery S Dahlberg, Caroline N Broude, Xiandong Meng, Sunit Jain, Allison M Weakley, Ashley V Cabrera, Thamotharampillai Dileepan, Michael A Fischbach, Marc K Jenkins
bioRxiv 2025.10.27.684919; doi: 10.1101/2025.10.27.684919
 
Quantifying Nuance within Sepsis-Associated Immune Suppression toward Diagnostic Certainty. 

Caldwell CC, Maile R, Mazer MB, McGonagill PW, Bergmann CB, Gould RW, Rao M, Hernández-Ríos M, Ungaro RF, Loftus TJ, Efron PA, Remy KE, Brakenridge SC, Badovinac VP, Griffith TS, Hotchkiss RS, Moldawer LL. 
Shock. 2025 Oct 21. doi: 10.1097/SHK.0000000000002745. Online ahead of print. 
PMID: 41166166
 
The multi-omic basis for hepatic encephalopathy recurrence: Analysis of the THEMATIC trial.
Bajaj JS, Fagan A, Sterling RK, Sikaroodi M, Gallagher ML, Lee H, Matherly SC, Bartels A, Mousel T, Davis BC, Puri P, Fuchs M, Thacker LR, McGinley JP, Khoruts A, Gillevet PM.
JHEP Rep. 2025 Oct 18;8(1):101634. doi: 10.1016/j.jhepr.2025.101634. eCollection 2026 Jan.
PMID: 41503571

 
Primate resident memory T cells activate humoral and stromal immunity. 

Joag V, Bimber BN, Quarnstrom CF, Bollimpelli VS, Schenkel JM, Fraser KA, Bertogliat M, Soerens AG, Stolley JM, O'Flanagan SD, Rosato PC, Gavil NV, Künzli M, Mitchell JS, Legere T, Jean S, Upadhyay AA, Kang CY, Gibbs J, Yewdell JW, Fife BT, Park H, Hansen SG, Bosinger SE, Barber GN, Skinner PJ, Vezys V, Hunter E, Picker LJ, Amara RR, Masopust D. 
Immunity. 2025 Oct 14;58(10):2541-2555.e6. doi: 10.1016/j.immuni.2025.09.009. 
PMID: 41092897
 
Cutting the Gordian knot: Untangling gasdermin C from pyroptosis. 

Lin Z, Ruan HB. 
Immunity. 2025 Oct 14;58(10):2359-2361. doi: 10.1016/j.immuni.2025.09.015. 
PMID: 41092892
 
Macrophage-Derived CCL24 Promotes Cardiac Fibrosis Via Fibroblast CCR3. 

Parthiban P, Barrow F, Wang H, Chalise U, Araujo N, Souza-Neto F, Nguyen H, Draxler M, Pallais JP, Yucel D, Liu H, Ciske E, Fehrenbach P, Hakeem A, Lee SH, Herman A, Rothenberg ME, Dudley S, van Berlo JH, Revelo XS. 
Circ Res. 2025 Oct 10;137(9):1140-1156. doi: 10.1161/CIRCRESAHA.125.326599. Epub 2025 Sep 16. 
PMID: 40955564
 

Sepsis prevents the development of experimental type 1 diabetes.
Stegnjaić G, Mićanović D, Saksida T, Despotović S, Griffith TS, Badovinac VP, Miljković Đ, Stanisavljević S. 
Front Immunol. 2025 Oct 9;16:1658960. doi: 10.3389/fimmu.2025.1658960. eCollection 2025. 
PMID: 41142792

SMAD4 mutation drives gut microbiome shifts toward tumor progression in colorectal cancer.
Gates TJ, Wangmo D, Bergerud KMB, Keel BM, Staley C, Subramanian S. 
Discov Oncol. 2025 Oct 9;16(1):1841. doi: 10.1007/s12672-025-02580-6. 
PMID: 41065880

Collagen-Based Tumor Spheroid Model for Investigating Tumor-Macrophage Interactions through Extracellular Matrix Remodeling.
Zhang L, Abdi S, Szafraniec HM, Provenzano PP, Schwertfeger KL, Wood DK. 
bioRxiv [Preprint]. 2025 Oct 3:2025.10.01.679587. doi: 10.1101/2025.10.01.679587. 
PMID: 41256421

The potential impacts of human genetics on virus emergence.
Langlois RA, Casanova JL. 
Proc Natl Acad Sci U S A. 2025 Sep 30;122(39):e2504318122. doi: 10.1073/pnas.2504318122. Epub 2025 Sep 19. 
PMID: 40971407

Foreign epitope-specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope.
Krueger PD, Osum KC, Fife BT, Jenkins MK. 
J Immunol. 2025 Sep 27:vkaf254. doi: 10.1093/jimmun/vkaf254. Online ahead of print. 
PMID: 41014584

Extended Survival in a Dog with Primary Bone Hemangiosarcoma Following Treatment with Neoadjuvant Oncolytic Virotherapy and Standard of Care.
Labé C, Chehadeh A, Winter A, Pracht S, Stuebner KM, Lewellen M, Eskander B, O'Sullivan MG, Tabaran AF, Ober C, Henson MS, Seelig D, Russell SJ, Modiano JF, Naik S, Makielski KM. 
Vet Sci. 2025 Sep 23;12(10):921. doi: 10.3390/vetsci12100921. 
PMID: 41150061

Differential migration mechanics and immune responses of glioblastoma subtypes.
Shamsan GA, Liu CJ, Braman BC, Li R, Rathe SK, Sarver AL, Ghaderi N, McMahon MM, Klank RL, Tschida BR, McFarren SJ, Rosato PC, Masopust D, Sarkaria JN, Clark HB, Rosenfeld SS, Largaespada DA, Odde DJ. 
bioRxiv [Preprint]. 2025 Sep 22:2022.06.26.497270. doi: 10.1101/2022.06.26.497270. 
PMID: 41040354

Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4+ T cells.
Venkatesh H, Granados Centeno E, Luo Q, Arroyo M, Heltemes Harris LM, Knutson TP, Qiu Y, Haaning A, Webber BR, Bachanova V, Farrar MA, Tracy SI. 
Blood. 2025 Sep 4:blood.2024028194. doi: 10.1182/blood.2024028194. Online ahead of print. 
PMID: 40906918

Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation.
Gonzalez-Hurtado E, Leveau C, Li K, Mishra M, Qu R, Goldberg EL, Sidorov S, Damani-Yokota P, Yeung ST, Khairallah C, Gonzalez D, Shepard TM, Camell C, Artyomov MN, Kluger Y, Khanna KM, Dixit VD. 
Nat Aging. 2025 Sep;5(9):1828-1843. doi: 10.1038/s43587-025-00952-9. Epub 2025 Sep 2. 
PMID: 40897908

Remodeling the sarcoma microenvironment by simultaneous targeting of urokinase-type plasminogen activator receptors and epidermal growth factor receptors to promote antitumor activity.
Schulte AJ, Lewellen M, Durose W, Nolan E, Taghizadeh L, Todhunter D, Bush C, Lang HP, Brown ME, DePauw TA, Makielski KM, Kim JH, Burt LE, Overn P, Forster CL, Seelig DM, O'Sullivan MG, Weigel BJ, Murugan P, Cutter GR, Lund TC, Vallera DA, Modiano JF. 
J Pharmacol Exp Ther. 2025 Sep;392(9):103674. doi: 10.1016/j.jpet.2025.103674. Epub 2025 Aug 18. 
PMID: 40914989

Reduction of Preexisting AAV9 Antibody Titers Before Onasemnogene Abeparvovec Administration in Twins With Spinal Muscular Atrophy.
Nelson RW, Cox CA, Stark M, Johnson AD, Sichmeller K, Earhart J, Ihinger JM, Stafki SA, Karachunski P, Kang PB. 
Neurology. 2025 Aug 26;105(4):e213899. doi: 10.1212/WNL.0000000000213899. Epub 2025 Jul 24. 
PMID: 40705999

Exploiting Viral Infection/Vaccination To Focus High Affinity T Cell Populations into Tumors Using Oncolytic Viro-immunotherapy.
Rios AV, Metko M, Tonne J, Thompson J, Kendall B, Chen A, Mudrick H, Masopust D, Irshad S, Barry M, Barry M, Diaz RM, Vile R. 
Mol Ther. 2025 Aug 20:S1525-0016(25)00654-9. doi: 10.1016/j.ymthe.2025.08.023.  
PMID: 40842156

CAR Treg cells mediate linked suppression and infectious tolerance in islet transplantation in mice.
Wardell CM, Fung VCW, Chen E, Haque M, Tan DFH, Leca M, Gillies J, Spanier JA, Mojibian M, Fife BT, Levings MK. 
Sci Transl Med. 2025 Aug 20;17(812):eadp6519. doi: 10.1126/scitranslmed.adp6519. Epub 2025 Aug 20. 
PMID: 40834104

Humanized DRAGA mice are a valuable model to study novel immunotherapies for HIV-1.
Pumtang-On P, Thron LK, Goodarzi N, Davey BC, Sevcik EN, Coleman-Fuller N, Karim AF, Vezys V, Rao M, Moriarity BS, Pampusch MS, Rendahl AK, Casares SA, Skinner PJ. 
J Immunol. 2025 Aug 13:vkaf185. doi: 10.1093/jimmun/vkaf185. Online ahead of print. 
PMID: 40803333

Beyond the native repertoire.
Hickok GH, Stromnes IM. 
Science. 2025 Jul 24;389(6758):349-351. doi: 10.1126/science.adz6423. Epub 2025 Jul 24. 
PMID: 40705900

A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells.
Skeate JG, Slipek NJ, Lahr WS, Roy S, Wick BJ, Stelljes EM, Gilkey AK, Thenge PP, Diers MD, Kar B, Krueger JB, Niemeyer EM, Lonetree CL, Kluesner MG, Bell JB, Clement K, Provenzano P, Moriarity BS, Webber BR. 
bioRxiv [Preprint]. 2025 Jul 16:2025.07.11.664404. doi: 10.1101/2025.07.11.664404. 
PMID: 40791471

Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion.
Tuokkola JE, Reese LE, Wang Y, O'Connor CH, VanTreeck JG, Rumahorbo AH, Schwertfeger KL. 
Breast Cancer Res. 2025 Jul 15;27(1):132. doi: 10.1186/s13058-025-02084-9. 
PMID: 40665359

Maturation of thymocytes with a monoclonal TCR under control of Trac promoter elements in the absence of β-selection.
Tsai AK, Cruz-Hinojoza E, Ellefson MA, Burrack AL, Larsen BM, Martinez RJ, Stromnes IM. 
Immunohorizons. 2025 Jul 15;9(8):vlaf035. doi: 10.1093/immhor/vlaf035. 
PMID: 4066417

Total, not isoform-specific, Lyn expression by macrophages promotes TLR activation and restricts proliferation.
Lindstedt AJ, Greene JT, Freedman TS. 
bioRxiv [Preprint]. 2025 Jul 10:2025.07.07.663098. doi: 10.1101/2025.07.07.663098. 
Update in: J Leukoc Biol. 2025 Nov 4;117(11):qiaf140. doi: 10.1093/jleuko/qiaf140.
PMID: 40672308

Natural microbial exposure populates the maternal fetal interface with diverse T cells. 

Whillock A, Smith P, Burger S, Sridhar A, Lindgren A, Berg J, Tsuda S, Mahajan S, Tilburgs T, Schuldt NJ. 
Front Immunol. 2025 Jul 9;16:1616491. doi: 10.3389/fimmu.2025.1616491. eCollection 2025.
PMID: 40703520
 

PDL1 checkpoint blockade synergizes with Nilotinib but not Dasatinib to prevent Leukemia relapse.
Morgan EC, Venkatesh H, Centeno EG, Heltemes-Harris LM, Hubbard G, Maiers TL, Dileepan T, Tracy SI, Farrar MA. 
bioRxiv [Preprint]. 2025 Jul 5:2025.07.02.662848. doi: 10.1101/2025.07.02.662848. 
PMID: 40631161Dasatinib

Sterile production of interferons in the thymus. 

Martinez RJ, Hogquist KA.
J Immunol. 2025 Jul 1;214(7):1468-1476. doi: 10.1093/jimmun/vkaf048.
PMID: 40184034
 
Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes. 

Mix MR, Kreitlow BL, Berton RR, Xu J, Fain CE, van de Wall S, Pewe LL, Hancox LS, Hassert MA, Kannan SK, Arumugam SA, Sievers CM, Buchanan GF, Griffith TS, Badovinac VP, Harty JT. 
Nat Immunol. 2025 Jul;26(7):1087-1098. doi: 10.1038/s41590-025-02174-y. Epub 2025 Jun 13. 
PMID: 40514419
 
The Cardiohepatic Axis in Metabolic Disease: Liver to Heart.
Hakeem A, van Berlo J, Revelo XS. 
JACC Basic Transl Sci. 2025 Jul;10(7):101309. doi: 10.1016/j.jacbts.2025.05.004. 
PMID: 40738521

 

Thymic Interferons: A Little Goes a Long Way.
Vobořil M, Hogquist KA. 
Immunol Rev. 2025 Jul;332(1):e70038. doi: 10.1111/imr.70038. 
PMID: 40439345

Microbiota transplant for hepatic encephalopathy in cirrhosis: The THEMATIC trial.
Bajaj JS, Fagan A, Gavis EA, Sterling RK, Gallagher ML, Lee H, Matherly SC, Siddiqui MS, Bartels A, Mousel T, Davis BC, Puri P, Fuchs M, Moutsoglou DM, Thacker LR, Sikaroodi M, Gillevet PM, Khoruts A.
J Hepatol. 2025 Jul;83(1):81-91. doi: 10.1016/j.jhep.2024.12.047. Epub 2025 Jan 10.
PMID: 39800192

Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages.
Xu Y, Hillman H, Chang M, Barrow F, Ivanov S, Revelo XS, Williams JW. 
Commun Biol. 2025 Jun 23;8(1):953. doi: 10.1038/s42003-025-08387-z. 
PMID: 40550904

Thymic DC2 are heterogeneous and include a novel population of transitional dendritic cells.
Vobořil M, Sulczewski FB, Martinez RJ, Ashby KM, Valerio MM, Idoyaga J, Hogquist KA. 
bioRxiv [Preprint]. 2025 Jun 18:2025.06.13.659520. doi: 10.1101/2025.06.13.659520. 
PMID: 40666966

Antigen-specific CD4+ T cells promote monocyte recruitment and differentiation into glycolytic lung macrophages to control Mycobacterium tuberculosis.
Becker SH, Ronayne CE, Bold TD, Jenkins MK. 
PLoS Pathog. 2025 Jun 9;21(6):e1013208. doi: 10.1371/journal.ppat.1013208. eCollection 2025 Jun. 
PMID: 40489538

In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8+ T cells from old mice.
Dahlquist KJV, Dehm EM, Smith DM, Lucas ED, Pierson M, Hamilton SE, Camell CD. 
Geroscience. 2025 Jun 6. doi: 10.1007/s11357-025-01723-5. Online ahead of print. 
PMID: 40478430

IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma.
Schmiechen ZC, Nanda HA, Burrack AL, Hickok GH, Butler JZ, Cruz-Hinojoza E, Maurice NJ, Geuenich MJ, Yu C, Tsai AK, Lonetree CL, Ellefson MA, Hilk AL, Larsen BM, Miller EA, Rizzo AB, Campbell KR, Shen SS, Stromnes IM. Cancer Immunol Res. 2025 Jun 4;13(6):847-866. doi: 10.1158/2326-6066.CIR-24-0758. 
PMID: 40072469

TREM2 macrophages mediate the beneficial effects of bariatric surgery against MASH.
Fredrickson G, Florczak K, Barrow F, Mahmud S, Dietsche K, Wang H, Parthiban P, Hakeem A, Almutlaq R, Adeyi O, Herman A, Bartolomucci A, Staley C, Dong X, Jahansouz C, Williams JW, Mashek DG, Ikramuddin S, Revelo XS. Hepatology. 2025 Jun 1;81(6):1776-1791. doi: 10.1097/HEP.0000000000001098. Epub 2024 Sep 18. 
PMID: 39292863

Triggering mouth-resident antiviral CD8+ T cells potentiates experimental periodontitis. 

Saavedra FM, Brotto DB, Joag V, Matson CA, Herzberg MC, Nesmiyanov PP, Vezys V, Masopust D, Stolley JM. 
Mucosal Immunol. 2025 Jun;18(3):620-630. doi: 10.1016/j.mucimm.2025.02.003. Epub 2025 Feb 21. 
PMID: 39988203
 

MACanalyzeR scRNAseq analysis tool reveals PPARγHIGH/GDF15HIGH lipid-associated macrophages facilitate thermogenic expansion in BAT.
Ninni A, Zaccaria F, Verteramo L, Sciarretta F, Silveira LS, Rosa-Neto JC, Carotti S, Nevi L, Grumati P, Patel S, Carrera G, Sgambato A, Lucchetti D, Colella F, Severi I, Senzacqua M, Giordano A, Bernardini S, Di Biagio C, Tortolici F, Rizzo G, Cochain C, Chiurchiù V, Ivanov S, Zhou B, Williams JW, Savage DB, Aquilano K, Lettieri-Barbato D. 
Nat Commun. 2025 May 31;16(1):5063. doi: 10.1038/s41467-025-60295-2. 
PMID: 40450001

Differential Virulence and Host-Specific Fitness of Regionally Distinct Human-Derived Powassan Virus Lineage 2 Strains.
Lange RE, Pritchard JC, Jaeger AS, Bold TD, White JL, Dean AB, Hull RC, St George K, Dupuis AP, Aliota MT, Ciota AT.
Am J Trop Med Hyg. 2025 May 13;113(1):106-116. doi: 10.4269/ajtmh.24-0776. Print 2025 Jul 2. 
PMID: 40359924

Rabies vaccination induces a CD4+ TEM and CD4+CD8+ TEMRA TH1 phenotype in dogs.
Lang HP, Almeer FF, Jenkins MK, Friedenberg SG. 
PLoS One. 2025 May 12;20(5):e0323823. doi: 10.1371/journal.pone.0323823. eCollection 2025. 
PMID: 40354406

Phenotype and function of IL-10-producing NK cells in individuals with malaria experience. 

McNitt SA, Dick JK, Hernandez-Castaneda MA, Sangala J, Pierson M, Macchietto M, Burrack KS, Crompton PD, Seydel K, Hamilton SE, Hart GT. 
JCI Insight. 2025 May 8;10(9):e183076. doi: 10.1172/jci.insight.183076. eCollection 2025 May 8. 
PMID: 40337867
 

Divergent immediate and delayed effects of juvenile exposure to doxorubicin on the thymus in C57BL/6 mice.
George B, Dahlquist KJV, Grant MKO, Daniel MR, Smith DM, Ahlberg I, Sadak KT, Seelig D, Camell CD, Zordoky BN. 
Sci Rep. 2025 May 3;15(1):15557. doi: 10.1038/s41598-025-98617-5. 
PMID: 40319158

Single-cell RNA sequencing reveals a reprogramming of hepatic immune cells and a protective role for B cells in MASH-driven HCC. 

Wang H, Herman A, Barrow F, Abdel-Ghani A, Draxler M, Fredrickson G, Parthiban P, Seelig DM, Ikramuddin S, Revelo XS. 
Hepatol Commun. 2025 Apr 21;9(5):e0668. doi: 10.1097/HC9.0000000000000668. eCollection 2025 May 1. 
PMID: 40257356
 
Integrating natural commensals and pathogens into preclinical mouse models. 

Rehermann B, Graham AL, Masopust D, Hamilton SE. 
Nat Rev Immunol. 2025 May;25(5):385-397. doi: 10.1038/s41577-024-01108-3. Epub 2024 Nov 19. 
PMID: 39562646
 
Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease.
Martell M, Quarnstrom CF, Khoruts A, Vezys V, Staley C, Shmidt E. 
Gastro Hep Adv. 2025 Apr 3;4(7):100670. doi: 10.1016/j.gastha.2025.100670. eCollection 2025. 
PMID: 40520922

 
Determining potential immunomodulatory drug efficacy in sepsis using ELISpot. 

Walton AH, Mazer MB, Remy KE, Osborne DF, Davitt EB, Griffith TS, Gould RW, Badovinac VP, Brakenridge SC, Drewry AM, Ungaro RF, Rocha IL, Loftus TJ, Efron PA, Moldawer LL, Caldwell CC, Hotchkiss RS. 
Sci Rep. 2025 Apr 18;15(1):13464. doi: 10.1038/s41598-025-92016-6. 
PMID: 40251188
 
The hypervirulent Type-1/Type-17 phenotype of Cryptococcus neoformans clinical isolates is specific to A/J mice. 

Ding M, Jackson KM, Harris-Gordon M, Dileepan T, Meya DB, Nielsen K. 
Infect Immun. 2025 Apr 8;93(4):e0058524. doi: 10.1128/iai.00585-24. Epub 2025 Mar 3. 
PMID: 40029251
 

Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells.
Hildebrand JA, Daniels NR, Dehm EM, Fisher BD, Guter JK, Janse CJ, Lucas ED, Sangala JA, Tankersley TN, Hart GT, Hamilton SE. 
PLoS Pathog. 2025 Mar 31;21(3):e1012993. doi: 10.1371/journal.ppat.1012993. eCollection 2025 Mar. 
PMID: 40163479

Polymorphisms in Pfkelch13 domains before and after the introduction of artemisinin-based combination therapy in Southwest Nigeria.Amusan A, Akinola O, Akano K, Hernández-Castañeda M, Dick JK, Sowunmi A, Hart G, Gbotosho G. 
PLoS One. 2025 Mar 31;20(3):e0316479. doi: 10.1371/journal.pone.0316479. eCollection 2025. 
PMID: 40163420

Best practices in islet transplantation in mice.
Meier RPH, Ben Nasr M, Fife BT, Finger EB, Fiorina P, Luo X, Bromberg JS. 
Am J Transplant. 2025 Mar 13:S1600-6135(25)00137-6. doi: 10.1016/j.ajt.2025.03.008. Online ahead of print. 
PMID: 40089068

Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency.
Jarjour NN, Dalzell TS, Maurice NJ, Wanhainen KM, Peng C, O'Flanagan SD, DePauw TA, Block KE, Valente WJ, Ashby KM, Masopust D, Jameson SC. 
Immunity. 2025 Mar 11;58(3):616-631.e5. doi: 10.1016/j.immuni.2025.02.009. Epub 2025 Feb 28. 
PMID: 40023156

Risk Factors for Antibiotic Exposure Post-Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection: A Prospective Multicenter Observational Study.
Hirsch W, Fischer M, Khoruts A, Allegretti JR, Kelly CR, Vaughn B. 
Open Forum Infect Dis. 2025 Mar 7;12(3):ofaf130. doi: 10.1093/ofid/ofaf130. eCollection 2025 Mar. 
PMID: 40103733

Evaluation of Inborn Errors of Immunity Among Patients with Opportunistic Pulmonary Infection. 

Husmann R, Lehman A, Nelson RW, Pragman AA. 
Clin Chest Med. 2025 Mar;46(1):61-75. doi: 10.1016/j.ccm.2024.10.005. Epub 2024 Nov 29. 
PMID: 39890293
 
B-cell interleukin 1 receptor 1 modulates the female adipose tissue immune microenvironment during aging. 

Carey A, Pitcher LE, Jang IH, Nguyen K, Cholensky S, Robbins PD, Camell CD.
 J Leukoc Biol. 2025 Feb 13;117(2):qiae219. doi: 10.1093/jleuko/qiae219. 
PMID: 39378334

Review of Elevated Para-Cresol in Autism and Possible Impact on Symptoms. 

Flynn CK, Adams JB, Krajmalnik-Brown R, Khoruts A, Sadowsky MJ, Nirmalkar K, Takyi E, Whiteley P. 
Int J Mol Sci. 2025 Feb 11;26(4):1513. doi: 10.3390/ijms26041513. 
PMID: 40003979
 
Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience. 

Arnesen H, Birkeland S, Stendahl H, Neuhaus K, Masopust D, Boysen P, Carlsen H. 
Discov Immunol. 2025 Feb 1;4(1):kyaf002. doi: 10.1093/discim/kyaf002. eCollection 2025. 
PMID: 40065807
 
Viral Burden and Illness Severity During Acute SARS-CoV-2 Infection Predict Persistent Long COVID Symptoms. 

Brandstetter Figueroa E, Frosch AEP, Burrack KS, Dileepan G, Goldsmith R, Harris M, Ikeogu N, Jibrell H, Thayalan S, Dewar RL, Shenoy C, Sereti I, Baker JV. 
Open Forum Infect Dis. 2025 Jan 30;12(2):ofaf048. doi: 10.1093/ofid/ofaf048. eCollection 2025 Feb. 
PMID: 39917335
 
A minority of Th1 and Tfh effector cells express survival genes shared by memory cell progeny that require IL-7 or TCR signaling to persist. 

Osum KC, Becker SH, Krueger PD, Mitchell JS, Hong SW, Magill IR, Jenkins MK. 
Cell Rep. 2025 Jan 28;44(1):115111. doi: 10.1016/j.celrep.2024.115111. Epub 2024 Dec 25. 
PMID: 39723889
 
Reddi S, Senyshyn L, Ebadi M, Podlesny D, Minot SS, Gooley T, Kabage AJ, Hill GR, Lee SJ, Khoruts A, Rashidi A. 
Nat Commun. 2025 Jan 25;16(1):1034. doi: 10.1038/s41467-025-56375-y. 
PMID: 39863610

CD44 in myeloid cells is a major driver of liver inflammation and injury in alcohol-associated liver disease. 
Rousseau D, Bonnafous S, Soysouvanh F, Sarrail D, Bourinet M, Strazzulla A, Patouraux S, Borderie A, Dolfi B, Gallerand A, Farrugia MA, Orian-Rousseau V, Xu Y, Williams JW, Ivanov S, Tran A, Anty R, Luci C, Gual P. 
Hepatology. 2025 Jan 14. doi: 10.1097/HEP.0000000000001232. Online ahead of print. 
PMID: 39808819

Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence.
Scott MC, Steier Z, Pierson MJ, Stolley JM, O'Flanagan SD, Soerens AG, Wijeyesinghe SP, Beura LK, Dileepan G, Burbach BJ, Künzli M, Quarnstrom CF, Ghirardelli Smith OC, Weyu E, Hamilton SE, Vezys V, Shalek AK, Masopust D. Immunity. 2025 Jan 14;58(1):162-181.e10. doi: 10.1016/j.immuni.2024.11.007. Epub 2024 Dec 20. 
PMID: 39708817

Protocol for applying Tumor Treating Fields in mouse models of cancer using the Inovivo system. 

Gates TJ, Zbidat S, Deniz K, Padmanabhan S, Ladner K, Sarkari A, Zhao X, Davidi S, Blatt R, Cahal S, Gabay M, Sellevoll M, Tzchori I, Porat Y, Haber A, Giladi M, Subramanian S, Lou E. 
STAR Protoc. 2025 Jan 8;6(1):103535. doi: 10.1016/j.xpro.2024.103535. Online ahead of print. 
PMID: 39792561
 
Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer. 

Perez JM, Duda JM, Ryu J, Shetty M, Mehta S, Jagtap PD, Nelson AC, Winterhoff B, Griffin TJ, Starr TK, Thomas SN. 
Sci Rep. 2025 Jan 4;15(1):813. doi: 10.1038/s41598-024-84874-3. 
PMID: 39755759
 
Implantation of Islets Co-Seeded with Tregs in a Novel Biomaterial Reverses Diabetes in the NOD Mouse Model. 

Elizondo DM, de Oliveira Rekowsky LL, de Sa Resende A, Seenarine J, da Silva RLL, Ali J, Yang D, de Moura T, Lipscomb MW. 
Tissue Eng Regen Med. 2025 Jan;22(1):43-55. doi: 10.1007/s13770-024-00685-7. Epub 2024 Dec 30. 
PMID: 39738937

2015-2025 Publications

2015-2025 Publications

Past CFI Publications

Wall of Honor

Graphic highlighting CFI colleagues whose publications have received a high number of citations

To honor the Center for Immunology faculty with 200 or more citations on one paper we have created a wall of honor located on the second floor of WMBB.

View the Wall of Honor