Lin Yee Chen

Professor of Medicine
Director, Lillehei Heart Institute
Fred C. and Katherine B. Andersen Chair in Adult Cardiology
Faculty, PhD Program in Epidemiology
Faculty, MS in Clinical Research


Administrator Info
Name: Mayna Xiong
Mail: 2231 6th Street SE, Room 4-165 CCRB, 2812 (Campus Delivery Code), Minneapolis, MN 55455

Research Summary

Dr. Chen is a tenured Professor of Medicine, an ABIM board-certified cardiac electrophysiologist, and an NIH-funded physician-scientist. His patient-oriented research on atrial fibrillation and atrial myopathy is focused on 3 themes: (1) To identify novel risk factors for atrial fibrillation and atrial myopathy, and discover new strategies to prevent both conditions, (2) To characterize the relationship of atrial fibrillation and atrial myopathy to cardiovascular and neurocognitive outcomes such as stroke and dementia, and to elucidate the underlying mechanisms, and (3) To discover novel strategies to prevent atrial fibrillation and atrial myopathy-related stroke and dementia. As an Atherosclerosis Risk in Communities (ARIC), Multi-Ethnic Study of Atherosclerosis (MESA), and Hispanic Community Health Study/Study of Latinos (HCHS/SOL) investigator, he conducts some of his research using data from these cohort studies. Currently, he is the PI of 5 NIH R01/RF1-funded projects, which are all focused on atrial fibrillation and atrial myopathy. In addition, he is the PI of a K24 grant, an NIH grant that expands his capacity in mentoring junior physician-scientists and scientists who are conducting patient-oriented research in cardiovascular science. Dr. Chen was elected to the American Society for Clinical Investigation in 2024.

Clinical Summary

As a physician, he provides compassionate, evidence-based, and state-of-the-art care to patients with arrhythmias, which includes performing catheter ablation to maintain sinus rhythm in patients with atrial fibrillation (pulmonary vein isolation). Other procedures that he performs include Biventricular ICD implantation, ICD implantation, PVC ablation, supraventricular tachycardia ablation, and ventricular tachycardia ablation.

Honors and Recognition

Academic Health Center Faculty Research Development Award, University of Minnesota
Selected Publications

Selected Publications

Wang, W., Zhang, M. J., Inciardi, R. M., Norby, F. L., Johansen, M. C., Parikh, R., Van't Hof, J. R., Alonso, A., Soliman, E. Z., Mosley, T. H., Gottesman, R. F., Shah, A. M., Solomon, S. D., Chen, L. Y., 2022. Association of Echocardiographic Measures of Left Atrial Function and Size with Incident Dementia. JAMA - Journal of the American Medical Association, 327 (12): 1138-1148.
doi: PubMed ID: 35315884.
Wang, W., Norby, F. L., Zhang, M. J., Reyes, J. L., Shah, A. M., Soliman, E. Z., Lutsey, P. L., Alonso, A., Solomon, S. D., Inciardi, R. M., Chen, L. Y., 2021. Differences in Left Atrial Size and Function and Supraventricular Ectopy Between Black and White Participants in the ARIC Study.. Journal of the American Heart Association, 10 (21): e021723.
doi: PubMed ID: 34713724.
Harding, B. N., Norby, F. L., Heckbert, S. R., McKnight, B., Psaty, B. M., Soliman, E. Z., Floyd, J. S., Chen, L. Y., 2021. Longitudinal Measures of Blood Pressure and Subclinical Atrial Arrhythmias: The MESA and the ARIC Study.. Journal of the American Heart Association, 10 (11): e020260.
doi: PubMed ID: 34014105.
Rooney, M. R., Norby, F. L., Maheshwari, A., Lutsey, P. L., Dudley, Jr, S. C., Soliman, E. Z., Loehr, L. R., Mosley, T. H., Coresh, J., Alonso, A., Chen, L. Y., 2021. Frequent Premature Atrial Contractions Are Associated With Poorer Cognitive Function in the Atherosclerosis Risk in Communities (ARIC) Study.. Mayo Clinic proceedings, 96 (5): 1147-1156.
Chen, L. Y., Soliman, E. Z., 2019. P Wave Indices-Advancing Our Understanding of Atrial Fibrillation-Related Cardiovascular Outcomes.. Frontiers in cardiovascular medicine, 6 53.
doi: PubMed ID: 31131284.