Non-invasive Neuromodulation Lab (NNL)

The Non-invasive Neuromodulation Laboratories are supported by MnDRIVE (Minnesota's Discovery, Research and InnoVation Economy) which is a landmark partnership between the University of Minnesota and the State of Minnesota. Services provided include technical support, equipment operation training, data collection assistance, data processing and analysis and custom hardware/software systems to fit specialized experiment designs.

The Non-invasive Neuromodulation Laboratories are equipped with the most advanced non-invasive neuromodulation devices/systems, including:

  • Transcranial Magnetic Stimulation, TMS: The Magstim BiStim² and Magstim 200² set (The Magstim Co. Ltd., Carmarthenshire, UK)
  • Repetitive TMS, rTMS: The Magstim Rapid2 (The Magstim Co. Ltd., Carmarthenshire, UK)
  • Electromyogram, EMG acquisition system: 4-ch bipolar EMG pre-amplifier (Y03-2, Motion Lab Systems, Inc., Baton Rouge, LA) (Gain: 300, band-pass filter: 20~2000Hz)
  • Transcranial Direct/Alternative Current Stimulation, tDCS/tACS: Starstim NE wireless alternative/direct current stimulation system with 8-ch wireless EEG amplifier (Neuroelectrics SL, Massachusetts, USA)
  • Electroencephalogram, EEG acquisition system: 64-ch Brain Products BrainAMP ExG amplification system (Brain Products GmbH, Gilching, Germany)
  • Electrical stimulator: 2-ch Grass S88X constant current isolated stimulator (Natus Neurology Incorporated - Grass Products, Rhode Island, USA)
  • Neuronavigation system: frameless stereotactic BrainSight II neuronavigation system (Rogue Research Inc, Quebec, Canada)
  • Medical grade isolation transformer: ISB-100W medical grade isolation transformer (Power Sources Unlimited, Inc, Massachusetts, USA)
  • System control platform: including data acquisition system: NI 9234 Analog-to-digital converter (National Instruments, Austin, TX) with a sampling rate up to 100K Hz with a quantification resolution of 24-bit. Real-time data monitoring and analysis system powered by LabVIEW (v2012, National Instruments, Austin, TX). Equipment communication and control system powered by LabVIEW (v2012, National Instruments, Austin, TX)

The primary Non-invasive Neuromodulation Laboratory has a space of 500 square feet for experiments and consenting paperwork. The secondary Non-invasive Neuromodulation Laboratory has the space of approximately 120 square feet for experiments and consenting paperwork and is located in a child-friendly area of the building. All operating hours allow for clinical nurse support and free participant parking. With equipment and facilities, the Non-invasive Neuromodulation Laboratories are able to conduct almost all of the non-invasive TMS excitability assessments and neuromodulation paradigms including:

  • Cortical excitability assessment:
    • Single pulse: basic excitability assessment including single pulse test, S-R curve, CSP and cortical grid mapping.
    • Paired-pulse: SICI, ICF, SICF, LICI, IHI, I-wave curve, ISI curve, CI curve and SAI.
  • Neuromodulation interventions:
    • Low-frequency rTMS (inhibitory) and sham
    • High-frequency rTMS (facilitatory) and sham
    • PAS intervention which combines low-frequency rTMS with peripheral electrical stimulation. We can easily record the N20 SEP by customized fast EEG acquisition method, and use the N20 as a reference to induce LTD-/LTD-like PAS neuromodulation intervention (inhibitory and facilitatory respectively)
    • tDCS (StarStim, Neuroelectrics, Barcelona, Spain)
    • tACS (StarStim, Neuroelectrics, Barcelona, Spain)
  • Sensory function evaluation:
    • N20 SEP latency
    • Temporal discrimination test
    • Electrical stimulation perceptual threshold
  • Customized experiment protocol:
  • The system control platform is highly customizable to any new/tailored protocol design.

Research Team

Director

Kelvin Lim, MD

Steering Committee

Kelvin Lim, MD
Bernadette Gillick, PhD
Alex Opitz, PhD

Lab Manager

Mo Chen, PhD

Staff

Alana Lieske

Participating UMN Faculty PIs

  • Alex Opitz, PhD, Biomedical Engineering
  • Bernadette T. Gillick, PT, PhD, Department of Rehabilitation Medicine
  • Colum MacKinnon, PhD, Department of Neurology
  • Dawn A Lowe, PhD, Department of Rehabilitation Medicine
  • Jeffrey Wozniak, MD, Department of Psychiatry
  • Juergen Konczak, PhD, School of Kinesiology
  • Kelvin Lim, MD, Department of Psychiatry
  • Manda Keller-Ross, PT, PhD, Department of Rehabilitation Medicine
  • Michael Kotlyar, PharmD, College of Pharmacy
  • Ziad Nahas, MD, Department of Psychiatry
  • Christine Conelea, PhD, LP, Department of Psychiatry
  • Suma Jacob, MD, PhD, Department of Psychiatry
  • Thomas Henry, MD, Department of Neurology
  • Clayton Cook, PhD, Educational Psychology