Nichole Klatt
,
Credentials
PhD

Professor of Surgery
Director, Division of Surgical Outcomes and Precision Medicine Research
Biography

Bio

Dr. Nichole (Nikki) Klatt is a Professor and the Director of the Division of Surgical Outcomes and Precision Medicine Research in the Department of Surgery, University of Minnesota. Prior to this she was an associate professor, vice chair of research, and the Adrienne Arsht Endowed Chair in Pediatric clinical research in the Department of Pediatrics, Miller School of Medicine, and Sylvester Cancer Center of University of Miami from 2018-2020. Dr. Klatt was also an associate professor in the Department of Pharmaceutics at the University of Washington from 2012- 2018. Dr. Klatt received her PhD from Emory University in Immunology and Molecular Pathogenesis in 2009, and was also a visiting PhD candidate at the University of Pennsylvania from 2006-2008. Dr. Klatt performed her postdoctoral research in the Laboratory of Molecular Microbiology at the National Institutes of Health from 2009-2012. The goal of Dr. Klatt's research laboratory is to understand mechanisms of microbiome, mucosal dysfunction and drug metabolism to improve human health.

Research Summary

The goal of Dr. Klatt's research laboratory is to understand mechanisms of the microbiome, mucosal dysfunction and drug metabolism to improve human health.

Selected Publications

Selected Publications

Ibrahim, S., Lowe, J. R., Bramante, C. T., Shah, S., Klatt, N. R., Sherwood, N., Aronne, L., Puskarich, M., Tamariz, L., Palacio, A., Bomberg, E., Usher, M., King, S., Benson, B., Vojta, D., Tignanelli, C., Ingraham, N., 2021. Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit.. Frontiers in endocrinology, 12 587801.
doi: https://doi.org/10.3389/fendo.2021.587801 PubMed ID: 34367059.
Nganou-Makamdop, K., Talla, A., Sharma, A. A., Darko, S., Ransier, A., Laboune, F., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Fourati, S., Schmidt, T. E., Arumugam, S., Lima, N. S., Moon, D., Callisto, S., Schoephoerster, J., Tomalka, J., Mugyenyi, P., Ssali, F., Muloma, P., Ssengendo, P., Leda, A. R., Cheu, R. K., Flynn, J. K., Morou, A., Brunet-Ratnasingham, E., Rodriguez, B., Lederman, M. M., Kaufmann, D. E., Klatt, N. R., Kityo, C., Brenchley, J. M., Schacker, T. W., Sekaly, R. P., Douek, D. C., 2021. Translocated microbiome composition determines immunological outcome in treated HIV infection.. Cell, 184 (15): 3899-3914.e16.
doi: https://doi.org/10.1016/j.cell.2021.05.023 PubMed ID: 34237254.
Jones, R., Kroll, K., Broedlow, C., Schifanella, L., Smith, S., Hueber, B., Shah, S. V., Ram, D. R., Manickam, C., Varner, V., Klatt, N. R., Reeves, R. K., 2021. Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.. Scientific reports, 11 (1): 14507.
doi: https://doi.org/10.1038/s41598-021-93918-x PubMed ID: 34267278.
Gustin, A., Cromarty, R., Schifanella, L., Klatt, N. R., 2021. Microbial mismanagement: how inadequate treatments for vaginal dysbiosis drive the HIV epidemic in women. Seminars in Immunology, United States:
Klatt, N. R., Broedlow, C., Osborn, J. M., Gustin, A. T., Dross, S., O'Connor, M. A., Coronado, E., Barnette, P., Hensley-McBain, T., Zevin, A. S., Muir, R., Roederer, A., Wangari, S., Iwayama, N., Ahrens, C. Y., Smedley, J., Moats, C., Lynch, R. M., Haddad, E. K., Haigwood, N. L., Fuller, D. H., Manuzak, J. A., 2021. Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques.. NPJ vaccines, 6 (1): 34.
doi: https://doi.org/10.1038/s41541-021-00298-4 PubMed ID: 33707443.
Tapia, G. R., Glynn, T. R., Miller, C., Manuzak, J. A., Broedlow, C. A., Mcgaugh, A., Cherenack, E. M., Bauermeister, J. A., Grov, C., Dilworth, S. E., Parisi, R., Martinez, D., Klatt, N. R., Carrico, A. W., 2021. Syndemics and pre-exposure prophylaxis are independently associated with rectal immune dysregulation in sexual minority men.. AIDS (London, England),
Berard, A. R., Miller, C., Araínga, M., Broedlow, C. A., Noël-Romas, L., Schifanella, L., Hensley-McBain, T., Roederer, A., Driscoll, C., Coronado, E., Manuzak, J., McKinnon, L. R., Villinger, F. J., Hope, T. J., Burgener, A. D., Klatt, N. R., 2021. SIV susceptibility, immunology and microbiome in the female genital tract of adolescent versus adult pigtail macaques.. AIDS research and human retroviruses,
doi: https://doi.org/10.1089/AID.2020.0271 PubMed ID: 33446027.
Bowman, E. R., Cameron, C., Richardson, B., Kulkarni, M., Gabriel, J., Kettelhut, A., Hornsby, L., Kwiek, J. J., Turner, A. N., Malvestutto, C., Bazan, J., Koletar, S. L., Doblecki-Lewis, S., Lederman, M. M., Cameron, M., Klatt, N. R., Lake, J. E., Funderburg, N. T., 2020. <i>In Vitro</i> Exposure of Leukocytes to HIV Preexposure Prophylaxis Decreases Mitochondrial Function and Alters Gene Expression Profiles.. Antimicrobial agents and chemotherapy, 65 (1):
doi: https://doi.org/10.1128/AAC.01755-20 PubMed ID: 33020165.
Cheu, R. K., Gustin, A. T., Lee, C., Schifanella, L., Miller, C. J., Ha, A., Kim, C., Rodriguez, V. J., Fischl, M., Burgener, A. D., Arnold, K. B., Alcaide, M. L., Klatt, N. R., 2020. Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism.. PLoS pathogens, 16 (12): e1009024.
Lee, C. Y., Cheu, R. K., Lemke, M. M., Gustin, A. T., France, M. T., Hampel, B., Thurman, A. R., Doncel, G. F., Ravel, J., Klatt, N. R., Arnold, K. B., 2020. Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis.. Nature communications, 11 (1): 6147.
doi: https://doi.org/10.1038/s41467-020-19880-w PubMed ID: 33262350.
Sherrill-Mix, S., Connors, K., Aldrovandi, G. M., Brenchley, J. M., Boucher, C., Bushman, F. D., Collman, R. G., Dandekar, S., Klatt, N. R., Lagenaur, L. A., Paredes, R., Tachedjian, G., Turpin, J. A., Landay, A. L., Ghosh, M., 2020. A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop.. AIDS research and human retroviruses, 36 (11): 886-895.
doi: https://doi.org/10.1089/AID.2020.0121 PubMed ID: 32777940.
Hope, T. J., Klatt, N. R., Sacha, J. B., Cannon, P. M., 2020. Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research.. AIDS research and human retroviruses, 36 (11): 883-885.
doi: https://doi.org/10.1089/AID.2020.0253 PubMed ID: 33050710.
Om, K., Paquin-Proulx, D., Montero, M., Peachman, K., Shen, X., Wieczorek, L., Beck, Z., Weiner, J. A., Kim, D., Li , Y., Mdluli, T., Shubin, Z., Bryant, C., Sharma, V., Tokarev, A., Dawson, P., White, Y., Appelbe, O., Klatt, N. R., Tovanabutra, S., Estes, J. D., Matyas, G. R., Ferrari, G., Alving, C. R., Tomaras, G. D., Ackerman, M. E., Michael, N. L., Robb, M. L., Polonis, V., Rolland, M., Eller, M. A., Rao, M., Bolton, D. L., 2020. Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.. PLoS pathogens, 16 (9): e1008764.
Martino, C., Kellman, B. P., Sandoval, D. R., Clausen, T. M., Marotz, C. A., Song, S. J., Wandro, S., Zaramela, L. S., Salido Benítez, R. A., Zhu, Q., Armingol, E., Vázquez-Baeza, Y., McDonald, D., Sorrentino, J. T., Taylor, B., Belda-Ferre, P., Liang, C., Zhang, Y., Schifanella, L., Klatt, N. R., Havulinna, A. S., Jousilahti, P., Huang, S., Haiminen, N., Parida, L., Kim, H. C., Swafford, A. D., Zengler, K., Cheng, S., Inouye, M., Niiranen, T., Jain, M., Salomaa, V., Esko, J. D., Lewis, N. E., Knight, R., 2020. Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity.. bioRxiv : the preprint server for biology,
doi: https://doi.org/10.1101/2020.08.17.238444 PubMed ID: 32839779.
SahBandar, I. N., Chew, G. M., Corley, M. J., Pang APS, Tsai, N., Hanks, N., Khadka, V. S., Klatt, N. R., Hensley-McBain, T., Somsouk, M., Vujkovic-Cvijin, I., Chow, D. C., Shikuma, C. M., Ndhlovu, L. C., 2020. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.. AIDS (London, England), 34 (10): 1451-1460.
Manuzak, J. A., Zevin, A. S., Cheu, R., Richardson, B., Modesitt, J., Hensley-McBain, T., Miller, C., Gustin, A. T., Coronado, E., Gott, T., Fang, M., Cartwright, M., Wangari, S., Agricola, B., May, D., Smith, E., Hampel, H. B., Gale, M., Cameron, C. M., Cameron, M. J., Smedley, J., Klatt, N. R., 2020. Correction: Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques.. Mucosal immunology, 13 (3): 558.
doi: https://doi.org/10.1038/s41385-020-0274-x PubMed ID: 32094503.
Bar, K. J., Coronado, E., Hensley-McBain, T., O'Connor, M. A., Osborn, J. M., Miller, C., Gott, T. M., Wangari, S., Iwayama, N., Ahrens, C. Y., Smedley, J., Moats, C., Lynch, R. M., Haddad, E. K., Haigwood, N. L., Fuller, D. H., Shaw, G. M., Klatt, N. R., Manuzak, J. A., 2019. Simian-Human Immunodeficiency Virus SHIV.CH505 infection of rhesus macaques results in persistent viral replication and induces intestinal immunopathology. Journal of Virology, 93 (18): e00372-19.
doi: https://doi.org/10.1128/JVI.00372-19 PubMed ID: 31217249.
Jabs, D. A., Van Natta, M. L., Trang, G., Jones, N. G., Milush, J. M., Cheu, R. K., Klatt, N. R., Won Pak, J., Danis, R. P., Hunt, P. W., 2019. Association of systemic inflammation with retinal vascular caliber in patients with AIDS. Investigational Ophthalmology and Visual Science,
Hensley-McBain, T., Wu, M. C., Manuzak, J. A., Cheu, R. K., Gustin, A., Driscoll, C. B., Zevin, A. S., Miller, C. J., Coronado, E., Smith, E., Chang, J., Gale, M., Somsouk, M., Burgener, A. D., Hunt, P. W., Hope, T. J., Collier, A. C., Klatt, N. R., 2019. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection . PLoS Pathogens,
Jabs, D. A., Van Natta, M. L., Trang, G., Jones, N. G., Milush, J. M., Cheu, R., Klatt, N. R., Danis, R. P., Hunt, P. W., 2019. Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.. American journal of ophthalmology, 199 230-237.
doi: https://doi.org/10.1016/j.ajo.2018.12.002 PubMed ID: 30552890.
Shah, S. V., Manickam, C., Ram, D. R., Kroll, K., Itell, H., Permar, S. R., Barouch, D. H., Klatt, N. R., Reeves, R. K., 2018. CMV primes functional alternative signaling in adaptive Δg NK cells but is subverted by lentivirus infection in rhesus macaques. Cell Reports,
Hensley-McBain, T., Berard, A. R., Manuzak, J. A., Miller, C. J., Zevin, A. S., Polacino, P., Gile, J., Agricola, B., Cameron, M., Hu, S. L., Estes, J. D., Reeves, R. K., Smedley, J., Keele, B. F., Burgener, A. D., Klatt, N. R., 2018. Intestinal damage precedes mucosal immune dysfunction in SIV infection . Mucosal Immunology, 11 (5): 1429-1440.
Guillén , Y., Noguera-Julian , M., Rivera, J., Casadellà, M., Zevin, A. S., Rocafort, M., Parera, M., Rodríguez, C., Arumí, M., Carrillo, J., Mothe, B., Estany, C., Coll, J., Bravo, I., Herrero, C., Saz, J., Sirera, G., Torrella, A., Navarro, J., Crespo, M., Negredo, E., Brander, C., Blanco, J., Calle, M. L., Klatt, N. R., Clotet, B., Paredes, R., 2018. Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection . Mucosal Immunology, 10.1038/s41385-018-0083-7,
O'Connor, M. A., Tisoncik-Go, J., Lewi, T. B., Miller, C. J., Bratt, D., Moats, C. R., Edlefsen, P. T., Smedley, J., Klatt, N. R., Gale Jr. , M., Fuller, D. H., 2018. Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. Nature Communications , 9 (1): 3371.
Manuzak, J. A., Gott, T. M., Kirkwood, J. S., Coronado, E., Hensley-McBain, T., Miller, C., Cheu, R. K., Collier, A. C., Funderburg, N. T., Martin, J. N., Wu, M. C., Isoherranen, N., Hunt, P. W., Klatt, N. R., 2018. Heavy cannabis use associated with reduction in activated and inflammatory immune cell frequencies in antiretroviral therapy-treated human immunodeficiency virus-infected individuals. Clinical Infectious Diseases , 66 (12): 1872-1882.
Klatt, N. R., Manuzak, J. A., 2018. Microbial effects on immunity in HIV: Virus, gender or sexual preference induced?. EBioMedicine , 31 7-8.
Fisher, B. S., Green, R. R., Brown, R. R., Wood, M. P., Hensley-McBain, T., Fisher, C., Chang, J., Miller, A. D., Bosche, W. J., Lifson, J. D., Mavigner, M., Miller, C. J., Gale Jr. , M., Silvestri, G., Chahroudi, A., Klatt, N. R., Sodora, D. L., 2018. Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART. PLoS Pathogens, 14 (2): e1006871.
Hensley-McBain, T., Klatt, N. R., 2018. The dual role of neutrophils in HIV infection . Current HIV/AIDS Report , 15 (1): 1-10.
Zevin, A. S., Hensley-McBain, T., Miller, C., Smith, E., Langevin, S., Klatt, N. R., 2017. Antibiotic treatment disrupts bacterial communities in the colon and rectum of simian immunodeficiency virus-infected macaques.. FEMS microbiology letters, 364 (23):
doi: https://doi.org/10.1093/femsle/fnx228 PubMed ID: 29088370.
Zevin, A. S., Hensley-McBain, T., Miller, C., Smith, E., Langevin, S., Klatt, N. R., 2017. Antibiotic treatment disrupts bacterial communities in the colon and rectum of SIV-infected macaques. FEMS Microbiology Letters, 364 (23):
PubMed ID: 29088370.
Williams, B., Ghosh, M., Boucher CAB, Bushman, F., Carrington-Lawrence, S., Collman, R. G., Dandekar, S., Dang, Q., Malaspina, A., Paredes, R., Wilson, C. C., Nowak, P., Klatt, N. R., Lagenaur, L., Landay, A. L., 2017. A Summary of the Second Annual HIV Microbiome Workshop.. AIDS research and human retroviruses, 33 (12): 1258-1264.
doi: https://doi.org/10.1089/aid.2017.0137 PubMed ID: 28899105.
Pinto-Cardoso, S., Klatt, N. R., Reyes-Teran, G., 2017. impact of antiretroviral drugs on the microbiome: Unknown answers to important questions. Current Opinon in HIV and AIDS ,
PubMed ID: 29028667.
Klatt, N. R., Hunt, P. W., 2017. MicroRNAs: Novel tools to block gut inflammation in HIV?. AIDS, 31 (14): 2017.
Klatt*, N. R., Cheu, R., Birse, K., Zevin, A. S., Perner, M., Romas, L., Grobler, A., Westmacott, G., Xie, I. Y., Butler, J., Mansoor, L., McKinnon, L., Passmore, J., Abdool Karim, Q., Abdool Karim, S., Burgener*, A. D., 2017. Vaginal bacteria modify HIV Tenofovir microbicide efficacy in African women . Science, 356 (6341): 938-945.
PubMed ID: 28572388.
Zevin, A. S., Moats, C., May, D., Wangari, S., Miller, C., Ahrens, J., Iwayama, N., Brown, M., Bratt, D., Klatt, N. R., Smedley, J., 2017. Laparoscopic technique for serial collection of liver and mesenteric lymph nodes in macaques . Journal of Visualized Experiments , (123):
PubMed ID: 28518089.
Peterson, C. W., Benne, C., Polacino, P., Kaur, J., McAllister, C. E., Filali-Mouhim, A., Obenza, W., Pecor, T. A., Huang, M. L., Baldessari, A., Murnane, R. D., Woolfrey, A. E., Jerome, K. R., Hu, S. L., Klatt, N. R., DeRosa, S., Sékaly, R. P., Kiem, H. P., 2017. Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation . JCL Insight , 2 (4): e91230.
PubMed ID: 28239658.
Zevin, A. S., Xie, I. Y., Birse, K., Arnold, K., Romas, L., Westmacott, G., Novak, R. M., McCorrister, S., McKinnon, L. R., Cohen, C. R., Mackelprang , R., Lingappa, J., Lauffenburger, D. A., Klatt, N. R., Burgener, A. B., 2016. Microbiome composition and function drives wound-healing impairment in the female genital tract . PLoS Pathogens, 12 (9): e1005889.
PubMed ID: 27656899.
Ortiz, A. M., Carnathan, D. G., Yu, J., Sheehan, K. M., Kim, P., Reynaldi, A., Vanderford, T. H., Klatt, N. R., Brenchley, J. M., Davenport, M. P., Silvestri, G., 2016. Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys.. PloS one, 11 (5): e0156352.
Ortiz, A. M., Carnathan, D. G., Sheehan, K. M., Reynaldi, K. P., Vanderford, T. H., Klatt, N. R., Brenchley, J. M., Davenport, M. P., Silvestri, G., 2016. Analysis of the in vivo turnover of CD4+ T cell subset in chronically SIV-infected sooty mangabeys . PLoS One , 11 (5): e0156352.
PubMed ID: 27227993.
Hensley-McBain, T., Zevin, A. S., Manuzak, J., Smith, E., Gile, J., Miller, C., Agricola, B., Katzke, M., Reeves, R. K., Kraft, C. S., Langevin, S., Klatt, N. R., 2016. The effects of fecal microbial transplantation on microbiome and immunity in SIV-infected macaques . Journal of Virology , 90 (10): 4981-4989.
PubMed ID: 26937040.
Hensley-McBain, T., Zevin, A. S., Manuzak, J., Smith, E., Gile, J., Miller, C., Agricola, B., Katze, M., Reeves, R. K., Kraft, C. S., Langevin, S., Klatt, N. R., 2016. Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques.. Journal of virology, 90 (10): 4981-4989.
doi: https://doi.org/10.1128/JVI.00099-16 PubMed ID: 26937040.
Manuzak, J. A., Hensley-McBain, T., Zevin, A. S., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Estes, J. D., Langevin, S., Reeves, R. K., Haddad, E. K., Klatt, N. R., 2016. Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.. Journal of immunology (Baltimore, Md. : 1950), 196 (5): 2401-9.
doi: https://doi.org/10.4049/jimmunol.1502470 PubMed ID: 26826246.
Manuzak, J. A., Hensley-McBain, T., Zevin, A. S., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Estes, J. D., Langevin, S., Reeves, K. R., Haddad, E. K., Klatt, N. R., 2016. Enhancement of microbiota in healthy macaques results in robust beneficial modulation of mucosal and systemic immune function . The Journal of Immunology ,
PubMed ID: 26826246.
Zevin, A. S., McKinnon, L., Burgener, A., Klatt, N. R., 2015. Microbial translocation and microbiome dysbiosis in HIV-associated immune activation . Current Opinion in HIV and AIDS,
PubMed ID: 26679414.
Vujkovic-Cvijin, I., Swainson, L., Chu, S. N., Ortiz, A. M., Santee, C. A., Petriello, A., Dunham, R. M., Fadrosh, D. W., Lin, D. L., Faruqi, A. A., Huang, Y., Apetrei, C., Pandrea, I., Hecht, F. M., Pilcher, C. D., Klatt, N. R., Brenchley, J. M., Lynch, S. V., McCune, J. M., 2015. Gut-resident lactobacillus abundance associates with iDO1 inhibition and Th17 dynamics in SIV-infected macaques. Cell Reports , 13 (8): 1589-1597.
Burgener, A., McGowan, I., Klatt, N. R., 2015. HIV and mucosal barrier interactions: Consequences for transmission and pathogenesis . Current Opinions in Immunology , 36 22-30.
Reeves, R. K., Burgener, A., Klatt, N. R., 2015. Targeting the GI tract to develop novel therapies for HIV. Clinical Pharmacology and Therapeutics, 98 (4): 381-386.
Ortiz, A. M., Klase, Z. A., DiNapoli, S. R., Vujkovic-Cvijin, I., Carmack, K., Perkins, M. R., Calantone, N., Vinton, C. L., Riddick, N. E., Gallagher, J., Klatt, N. R., McCune, J. M., Estes, J. D., Paiardini, M., Brenchley, J. M., 2015. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal immunology ,
Hao, X. P., Lucero, C. M., Turkbey, B., Bernardo, M. L., Morcock, D. R., Deleage, C., Trubey, C. M., Smedley, J., Klatt, N. R., Giavedoni, L. D., Kristoff, J., Xu, A., Del Prete, G. Q., Keele, B. F., Rao, S. S., Alvord, W. G., Choyke, P. L., Lifson, J. D., Brenchley, J. M., Apetrei, C., Pandrea, I., Estes, J. D., 2015. Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection . Nature Communications, 6 8020.
Evans, T. I., Li, H., Schafer, J. L., Klatt, N. R., Hao, X. P., Traslavina, R. P., Estes, J. D., Brenchley, J. M., Reeves, R. K., 2015. SIV-induced translocation of bacterial products in the liver mobilizes myeloid dendritic and natural killer cells associated with liver damage. The journal of Infectious Diseases ,
Klase, Z., Ortiz, A., Deleage, C., Mudd, J. C., Quinones, M., Schwartzman, E., Klatt, N. R., Canary, L., Estes, J. D., Brenchley, J. M., 2015. Dysbiotic bacteria translocate in progresive SIV infection .
Li, H., Richert-Spuhler, L. E., Evans, T. I., Gillis, J., Connole, M., Estes, J. D., Keele, B. F., Klatt, N. R., Reeves, R. K., 2014. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection . PLoS Pathogens , 10 (12): e1004551.
Perkins, M. R., Briant, J. A., Calantone, N., Whitted, S., Vinton, C. L., Klatt, N. R., Ourmanov, I., Ortiz, A. M., Hirsch, V. M., Brenchley, J. M., 2014. Homeostatic cytokines include CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD88aa T cells. Journal of Virology , 88 (18): 10714-10724.
Carlson, J. M., Schaefer, M., Monaco, D. C., Batorsky, R., Claiborne, D. T., Prince, J., Deymier, M. J., Ende, Z. S., Klatt, N. R., DeZiel, C. E., Lin, T. H., Peng, J., Seese, A. M., Shapiro, R., Frater, J., Ndung'u, T., Tang, J., Goepfert, P., Gilmour, J., Price, M. A., Kilembe, W., Heckerman, D., Goulder, P. J., Allen, T. M., Allen, S., Hunter, E., 2014. HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck . Science , 345 (6193): 1254031.
Klatt, N. R., Bosinger, S. E., Peck, M., Richert-Spuhler, L. E., Heigele, A., Gile, J. P., Patel, N., Taaffe, J., Julg, B., Camerini, D., Torti, C., Martin, J. N., Deeks, S. G., Sinclair, E., Hecht, F. M., Lederman, M. M., Paiardini, M., Kirchhoff, F., Brenchley, J. M., Hunt, P. W., Silvestri, G., 2014. Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. PLoS Pahogens , 10 e1004345.
Fuller, D. H., Richert-Spuhler, L. E., Klatt, N. R., 2014. HIV vaccine trial exploits a dual and central role for innate immunity . Journal of Virology ,
Petrovas, C., Yamamoto, T., Price, D. A., Rao, S. S., Klatt, N. R., Brenchley, J. M., Douek, D. C., Gostick, E., Angermann, B. R., Grossman, Z., Macallan, D. C., Meier-Schellersheim, M., Koup, R. A., 2013. High production rates sustain in vivo levels of PD-1 high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance . Journal of Virology , 87 (17): 9836-9844.
Klatt, N. R., Chomont, N., Douek, D. C., Deeks, S. G., 2013. Immune activation and HIV persistence: implications for curative approaches to HIV infection.. Immunological reviews, 254 (1): 326-42.
doi: https://doi.org/10.1111/imr.12065 PubMed ID: 23772629.
Klatt, N. R., Chomont, N., Douek, D. C., Deeks, S. G., 2013. Immune activation and persistence: Implications for curative approaches to HIV infection. Immunological Reviews , 254 (1): 326-342.
Canary, L. A., Vinton, C. L., Morcock, D. R., Pierce, J., Estes, J. D., Brenchley, J. M., Klatt, N. R., 2013. Rate of AIDS progression is associated with pre-existing microbial translocation in pigtail macaques . 190 (6): 2959-2965.
Lugli, E., Dominguez, M., Gattinoni, L., Chattopadhay, P. K., Bolton, D. L., Song, K., Klatt, N. R., Brenchley, J. M., Vaccari, M., Price, D. A., Waldmann, T. A., Restifo, N. P., Franchini, G., Roederer, M., 2013. Superior T memory stem cell persistence supports long-lived T cell memory . The Journal of Clinical Investigation , 123 (2): 594-599.
Klatt, N. R., Canary, L. A., Sun, X., Vinton, C. L., Funderburg, N. T., Morcock, D. R., Quiñones, M., Deming, C. B., Perkins, M., Hazuda, D. J., Miller, M. D., Lederman, M. M., Segre, J. A., Lifson, J. D., Haddad, E. K., Estes, J. D., Brenchley, J. M., 2013. Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.. The Journal of clinical investigation, 123 (2): 903-7.
doi: https://doi.org/10.1172/JCI66227 PubMed ID: 23321668.
Klatt, N. R., Canary, L. C., Sun, X., Vinton, C. L., Funderberg, N. T., Deming, C., Quinones, M., Perkins, M., Hazuda, D. J., Miller, M. D., Lederman, M. M., Segre, J. A., Lifson, J. D., Haddad, E. K., Estes, J. D., Brenchley, J. M., 2013. Probiotic and prebiotic supplementation of antiretroviral therapy improves gastrointestinal immunity in SIV-infected macaques . The journal of Clinical Investigation ,
Lederman, M. M., Funderberg, N. T., Sekaly, R. P., Klatt, N. R., Hunt, P. W., 2013. Residual immune dysregulation syndrome in treated HIV infection . Advances in Immunology , 119 51-83.
Bosinger, S. E., Jochems, S. P., Folkner, K. A., Hayes, T. L., Klatt, N. R., Silvestri, G., 2013. Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239.. Journal of virology, 87 (1): 433-43.
doi: https://doi.org/10.1128/JVI.01746-12 PubMed ID: 23097439.
Klatt, N. R., Estes, J. D., Sun, X., Harris, L. D., Ortiz, A. M., Cervasi, B., Yokomizo, L. K., Vinton, C. L., Tabb, B., Canary, L. A., Dang, Q., Hirsch, V. M., Lifson, J. D., Alter, G., Belkaid, Y., Silvestri, G., Milner, J. D., Paiardini, M., Haddad, E. K., Brenchley, J. M., 2012. Loss of mucosal IL-17+ and IL-22+ lymphocytes after SIV infection is associated with loss of CD103+ DCs and damage to the mucosal barrier . Mucosal Immunology, 5 (6): 646-657.
Bosinger, S. E., Jochems, S. P., Folkner, K. A., Hayes, T. L., Klatt, N. R., Silvestri, G., 2012. Transcriptional profiling of experimental CD8+ lymphocyte depletion in rhesus macaques infected with SIVmac239. Journal of Virology ,
Klatt, N. R., Funderburg, N. T., Brenchley, J. M., 2012. Microbial translocation, immune activation and HIV disease . Trends in Microbiology ,
Klatt, N. R., Silvestri, G., 2012. CD4+ T cells and HIV: A paradoxical pas de deux . Science Translational Medicine , 123 (4): 123-124.
Klatt, N. R., Estes, J. D., Brenchley, J. M., 2012. Nonpathogenic SIV infections. Cold Spring Harbor Perspectives in Medicine 2 (1): a007153.
Klatt, N. R., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., Swerczek, J., Cronise-Santis, H., Lafont, B., Brenchley, J. M., 2012. Dynamics of SIVmac239 infection in pigtail macaques. Journal of Virology , 86 (2): 1203-1213.
Klatt, N. R., Silvestri, G., Hirsch, V., 2012. Nonpathogenic simian immunodeficiency virus infections.. Cold Spring Harbor perspectives in medicine, 2 (1): a007153.
Klatt, N. R., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., Cronise, H. E., Swerczek, J. M., Lafont, B. A., Picker, L. J., Silvestri, G., Brenchley, J. M., 2012. Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques.. Journal of virology, 86 (2): 1203-13.
doi: https://doi.org/10.1128/JVI.06033-11 PubMed ID: 22090099.
Klatt, N. R., Estes, J. D., Brenchley, J. M., 2011. Cover Image: Confocal immunofluorescent image of a jejunum section stained for cytokeratin of an acutely SIV-infected rhesus macaque. AIDS Res Hum Retroviruses ,
Klatt, N. R., Vinton, C. L., Lynch, R. M., Ho, J., Darrah, P., Estes, J. D., Seder, R. A., Moir, S. L., Brenchley, J. M., 2011. SIV infection of rhesus macaques results in dysfunctional T and B cell responses to neo and recall Leishmania vaccination . Blood , 118 (22): 5803-5812.
Klatt, N. R., Vinton, C. L., Lynch, R. M., Canary, L. A., Ho, J., Darrah, P. A., Estes, J. D., Seder, R. A., Moir, S. L., Brenchley, J. M., 2011. SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.. Blood, 118 (22): 5803-12.
Ortiz, A. M., Klatt, N. R., Carnathan, P., Li, B., Derdeyn, C., Lawson, B., Ryzhova, E., Gonzalez-Scarano, F., Paiardini, M., Ratcliffe, S., Else, J., Brenchley, J. M., Silvestri, G., 2011. Depletion of CD4+ T-cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. The Journal of Clinical Investigation , 121 (11): 4433-4445.
Ortiz, A. M., Klatt, N. R., Li , B., Yi, Y., Tabb, B., Hao, X. P., Sternberg, L., Lawson, B., Carnathan, P. M., Cramer, E. M., Engram, J. C., Little, D. M., Ryzhova, E., Gonzalez-Scarano, F., Paiardini, M., Ansari, A. A., Ratcliffe, S., Else, J. G., Brenchley, J. M., Collman, R. G., Estes, J. D., Derdeyn, C. A., Silvestri, G., 2011. Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.. The Journal of clinical investigation, 121 (11): 4433-45.
doi: https://doi.org/10.1172/JCI46023 PubMed ID: 22005304.
Vinton, C. L., Klatt, N. R., Harrs, L. D., Judith, A. B., Sanders-Beer, B. E., Herbert, R., Woodward, R., Silvestri, G., Pandrea, I., Apetrei, C., Hirsch, V. M., Brenchley, J. M., 2011. Maintenance of CD4-like immunological function by CD4- T cells in multiple natural hosts for SIV . Journal of Virology , 85 (17): 8702-8708.
Vinton, C., Klatt, N. R., Harris, L. D., Briant, J. A., Sanders-Beer, B. E., Herbert, R., Woodward, R., Silvestri, G., Pandrea, I., Apetrei, C., Hirsch, V. M., Brenchley, J. M., 2011. CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.. Journal of virology, 85 (17): 8702-8.
doi: https://doi.org/10.1128/JVI.00332-11 PubMed ID: 21715501.
Vanderford, T. H., Bleckwehl, C., Klatt, N. R., Engram, J. C., Dunham, R. M., Sumpter, B., Feinberg, M., Garber, D., Betts, M., Silvestri, G., 2011. Viral cytotoxic T lymphocyte escape mutants become fixed in plasma before rectal mucosa during acute SIV infection of rhesus macaques . PLoS Pathogens , 7 (5): e1002048.
Vanderford, T. H., Bleckwehl, C., Engram, J. C., Dunham, R. M., Klatt, N. R., Feinberg, M. B., Garber, D. A., Betts, M. R., Silvestri, G., 2011. Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.. PLoS pathogens, 7 (5): e1002048.
Elemans, M., Seich al Basatena, N., Klatt, N. R., Gkekas, C., Silvestri, G., Asquith, B., 2011. Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo. PLoS Computational Biology, 7 (9): e1002200.
Harris, L. D., Klatt, N. R., Vinton, C., Briant, J. A., Tabb, B., Ladell, K., Lifson, J., Estes, J. D., Price, D. A., Hirsch, V. M., Brenchley, J. M., 2010. Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.. Blood, 116 (20): 4148-57.
Knox, K. S., Vinton, C., Hage, C. A., Kohli, L. M., Twigg, 3rd, H. L., Klatt, N. R., Zwickl, B., Waltz, J., Goldman, M., Douek, D. C., Brenchley, J. M., 2010. Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy.. Journal of virology, 84 (18): 9010-8.
doi: https://doi.org/10.1128/JVI.01138-10 PubMed ID: 20610726.
Engram, J. C., Cervasi, B., Borghans, J. A., Klatt, N. R., Gordon, S. N., Chahroudi, A., Else, J. G., Mittler, R. S., Sodora, D. L., de Boer, R. J., Brenchley, J. M., Silvestri, G., Paiardini, M., 2010. Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.. Blood, 116 (5): 748-58.
Harris, L. D., Tabb, B., Sodora, D. L., Paiardini, M., Klatt, N. R., Douek, D. C., Silvestri, G., Muller-Trutwin, M., Vasile-Pandrea, I., Apetrei, C., Hirsch, V., Lifson, J., Brenchley, J. M., Estes, J. D., 2010. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques . Journal of Virology , 84 7886-7891.
Klatt, N. R., Shudo, E., Ortiz, A. M., Engram, J. C., Paiardini, M., Lawson, B., Miller, M. D., Else, J., Pandrea, I., Estes, J. D., Apetrei, C., Schmitz, J. E., Ribeiro, R. M., Perelson, A. S., Silvestri, G., 2010. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS Pathogens, 6 e1000747.
Klatt, N. R., Harris, L. D., Vinton, C. L., Sung, H., Briant, J. A., Tabb, B., Morcock, D., McGinty, J. W., Lifson, J. D., Lafont, B. A., Martin, M. A., Levine, A. D., Estes, J. D., Brenchley, J. M., 2010. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection . Mucosal Immunology , 3 387-398.
Engram, J. C., Cervasi, B., Borghans, J. A., Klatt, N. R., Gordon, S. N., Chahroudi, A., Else, J., Mittler, R. S., Sodora, D. L., de Boer, R. J., Brenchley, J. M., Silvestri, G., Paiardini, M., 2010. Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in non-human primates . Blood , 5 748-758.
Knox, K. S., Vinton, C., Hage, C. A., Kohli, L. M., Twigg III, H. L., Klatt, N. R., Zwicki, B., Waltz, J., Goldman, M., Douek, D. C., Brenchley, J. M., 2010. Reconstitution of CD4 T cells in BAL after initiation of highly active antiretroviral therapy . journal of Virology, 18 9010-9018.
Klatt, N. R., Brenchley, J. M., 2010. Th17 cell dynamics in HIV infection . Current Opinions in HIV and AIDS , 5 135-140.
Lasaro, M. O., Haut, L. H., Zhou, X., Xiang, Z., Zhou, D., Li, Y., Giles-Davis, W., Li, H., Engram, J. C., Dimenna, L. J., Bian, A., Sazanovich, M., Parzych, E. M., Kurupati, R., Small, J. C., Wu, T. L., Leskowitz, R. M., Klatt, N. R., Brenchley, J. M., Garber, D. A., Lewis, M., Ratcliffe, S. J., Betts, M. R., Silvestri, G., Ertl, H. C., 2010. Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques. Molecular Therapy , (2): 417-426.
Harris, L. D., Klatt, N. R., Vinton, C. L., Briant, J. A., Tabb, B., Ladell, K., Lifson, J., Estes, J. D., Price, D. A., Hirsch, V. M., Brenchley, J. M., 2010. Mechanisms underlying gamma-delta T cell subset perturbations in SIV-infected Asian rhesus macaques . Blood , 116 (20): 4148-4157.
Estes, J. D., Harris, L. D., Klatt, N. R., Tabb, B., Pittaluga, S., Paiardini, M., Barclay, G. R., Smedley, J., Pung, R., Oliveira, K. M., Hirsch, V. M., Silvestri, G., Douek, D. C., Miller, C. J., Haase, A. T., Lifson, J., Brenchley, J. M., 2010. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathogens , 6 e1001052.
Bosinger, S. E., Li, Q., Gordon, S. N., Klatt, N. R., Duan, L., Xu, L., Francella, N., Sidahmed, A., Smith, A. J., Cramer, E. M., Zeng, M., Masopust, D., Carlis, J. V., Ran, L., Vanderford, T. H., Paiardini, M., Isett, R. B., Baldwin, D. A., Else, D. A., Staprans, S. I., Silvestri, G., Haase, A. T., Kelvin, D. J., 2009. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. The Journal of Clinical Investigation , 119 3556-3572.
Engram, J. C., Dunham, R. M., Makedonas, G., Vanderford, T. H., Sumpter, B., Klatt, N. R., Ratcliffe, S. J., Garg, S., Paiardini, M., McQuoid, M., Altman, J. D., Staprans, S. I., Betts, M. R., Garber, D. A., Feinberg, M. B., Silvestri, G., 2009. Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression. Journal of Immunology , 183 706-717.
Paiardini, M., Cervasi, B., Engram, J. C., Gordon, S. N., Klatt, N. R., Muthukumar, A., Else, J., Mittler, R. S., Staprans, S. I., Sodora, D. L., Silvestri, G., 2009. Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: Implications for AIDS pathogenesis. Blood, 113 612-621.
Beaumier, C. M., Harris, L. D., Goldstein, S., Klatt, N. R., Whitted, S., McGinty, J., Apetrei, C., Pandrea, I., Hirsch, V. M., Brenchley, J. M., 2009. CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection . Natural Medicine , 15 879-885.
Klatt, N. R., Villinger, F., Bostik, P., Gordon, S. N., Pereira, L., Engram, J. C., Mayne, A., Dunham, R. M., Lawson, B., Ratcliffe, S. J., Sodora, D. L., Else, J., Reimann, K., Staprans, S. I., Haase, A. T., Estes, J. D., Silvestri, G., Ansari, A. A., 2008. Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.. The Journal of clinical investigation, 118 (6): 2039-49.
doi: https://doi.org/10.1172/JCI33814 PubMed ID: 18497876.
Klatt, N. R., Villinger, F., Bostik, P., Gordon, S. N., Pereira, L., Engram, J. C., Mayne, A., Dunham, R. M., Lawson, B., Ratcliffe, S. J., Sodora, D. L., Else, J., Reimann, K., Staprans, S. I., Haase, A. T., Estes, J. D., Silvestri, G., Ansari, A. A., 2008. Availability of activated CD4+ T cells dictates the level of viremia in naturaly SIV-infected sooty mangabeys. The Journal of Clinical Investigation , 118 2039-2049.
Dunham, R. M., Cervasi, B., Brenchley, J. M., Albrecht, H., Weintrob, A., Sumpter, B., Engram, J., Gordon, S., Klatt, N. R., Frank, I., Sodora, D. L., Douek, D. C., Paiardini, M., Silvestri, G., 2008. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. Journal of Immunology, 180 5582-5592.
Gordon, S. N., Dunham, R. M., Engram, J. C., Estes, J., Wang, Z., Klatt, N. R., Paiardini, M., Pandrea, I. V., Apetrei, C., Sodora, D. L., Lee, H. Y., Haase, A. T., Miller, M. D., Kaur, A., Staprans, S. I., Perelson, A. S., Feinberg, M. B., Silvestri, G., 2008. Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: Implications for AIDS pathogenesis. journal of Virology, 82 3725-3735.
Klatt, N. R., Chahroudi, A., Silvestri, G., 2008. Human immunodeficiency viruses (Retroviridae): Pathogenesis. Encyclopedia of Virology
Gordon, S. N., Klatt, N. R., Bosinger, S. E., Brenchley, J. M., Milush, J. M., Engram, J. C., Dunham, R. M., Paiardini, M., Klucking, S., Danesh, A., Strobert, E. A., Apetrei, C., Pandrea, I. V., Kelvin, D., Douek, D. C., Staprans, S. I., Sodora, D. L., Silvestri, G., 2007. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. Journal of Immunology , 179 3026-3034.
Sumpter, B., Dunham, R., Gordon, S., Engram, J., Hennessy, M., Kinter, A., Paiardini, M., Cervasi, B., Klatt, N. R., McClure, H., Milush, J. M., Staprans, S., Sodora, D. L., Silvestri, G., 2007. Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: Implications for AIDS pathogenesis. Journal of Immunology, 178 1680-1691.
Selected Presentations

Selected Presentations

Klatt, N. R., (Keynote/Plenary Speaker) "Potential Role of the Microbiome in HIV Vaccination", Keystone Symposia: HIV Pathogenesis and Cure; HIV Vaccines, Keystone Symposia, June 01, 2021.
Klatt, N. R., (Author & Presenter) "Novel metabolism-mediated mechanisms of microbiome influence on human disease", Microbiome Supergroup Monthly Seminar, University of Minnesota Medical School, April 28, 2021.
Klatt, N. R., (Speaker) "Microbiome in Human Health and Disease", Department of Surgery Forum: Research Spotlight, University of Minnesota Medical School, January 01, 2021.
Klatt, N. R., (Speaker) "Mechanisms Underlying Microbiome Influence on Human Disease", Department of Surgery Grand Rounds, University of Minnesota Medical School, December 01, 2020.
Klatt, N. R., (Chair) "Mechanisms of microbiome influence in human health", Cytokines 2020 - 8th Annual Meeting of the International Cytokine & Interferon Society, International Cytokine & Interferon Society, November 01, 2020.
Contact

Contact

Administrative Contact

klat0037@umn.edu