Nikki Klatt, PhD

Professor and the Director of the Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery

Nikki Klatt

Contact Info

klat0037@umn.edu

Office Address:
Microbiology Research Facility,
Room 2-136
689 SE 23rd Av, Minneapolis, MN 55455

Administrative Assistant Name
Ngoc (Natalie) Ha, MPH

Administrative Phone
612-301-8604

Administrative Email
ngoch@umn.edu

Professor and the Director of the Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery

Faculty, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program


Doctor of Philosophy, Immunology and Molecular Pathogenesis

Emory University, Atlanta, GA

Summary

Dr. Nichole (Nikki) Klatt is a Professor and the Director of the Division of Surgical Outcomes and Precision Medicine Research in the Department of Surgery, University of Minnesota. Prior to this she was an associate professor, vice chair of research, and the Adrienne Arsht Endowed Chair in Pediatric clinical research in the Department of Pediatrics, Miller School of Medicine, and Sylvester Cancer Center of University of Miami from 2018-2020. Dr. Klatt was also an associate professor in the Department of Pharmaceutics at the University of Washington from 2012- 2018. Dr. Klatt received her PhD from Emory University in Immunology and Molecular Pathogenesis in 2009, and was also a visiting PhD candidate at the University of Pennsylvania from 2006-2008. Dr. Klatt performed her postdoctoral research in the Laboratory of Molecular Microbiology at the National Institutes of Health from 2009-2012. The goal of Dr. Klatt’s research laboratory is to understand mechanisms of microbiome, mucosal dysfunction and drug metabolism to improve human health.

Research

Research Summary/Interests

The goal of Dr. Klatt’s research laboratory is to understand mechanisms of the microbiome, mucosal dysfunction and drug metabolism to improve human health.

Publications

Cheu RK, Gustin AT, Lee C, Schifanella L, Miller CJ, Ha A, Kim C, Rodriguez VJ, Fischl M, Burgener AD, Arnold KB, Alcaide ML, Klatt NR. Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism. PLoS Pathog. 2020 Dec 3;16(12):e1009024. doi: 10.1371/journal.ppat.1009024. PMID: 33270801; PMCID: PMC7714160.

Manuzak JA, Zevin AS, Cheu R, Richardson B, Modesitt J, Hensley-McBain T, Miller C, Gustin AT, Coronado E, Gott T, Fang M, Cartwright M, Wangari S, Agricola B, May D, Smith E, Hampel HB, Gale M, Cameron CM, Cameron MJ, Smedley J, Klatt NR. Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques. Mucosal Immunol. 2019 Dec 4. doi: 10.1038/s41385-019-0238-1. PMID: 31797911

Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection. PLoS Pathog. 2019 Apr 11. doi:10.1371/journal.ppat.1007672.

Hensley-McBain T, Berard AR, Manuzak JA, Miller CJ, Zevin AS, Polacino P, Gile J, Agricola B, Cameron M, Hu SL, Estes JD, Reeves RK, Smedley J, Keele BF, Burgener AD, Klatt NR. Intestinal damage precedes mucosal immune dysfunction in SIV infection. Mucosal Immunol. 2018 Sep;11(5):1429-1440. doi: 10.1038/s41385-018-0032-5. Epub 2018 Jun 15.

Klatt, N.R.*, Cheu, R., Birse, K., Zevin, A.S., Perner, M., Romas, L., Grobler, A., Westmacott, G. Xie, I.Y., Butler, J., Mansoor, L., McKinnon, L., Passmore, J., Abdool Karim, Q., Abdool Karim, S., Burgener, A.D.* Vaginal Bacteria Modify HIV Tenofovir Microbicide Efficacy in African Women. Science. 2017 Jun2;356(6341):938-945 PMID: 28572388.

Hensley-McBain, T., Zevin, A.S., Manuzak, J., Smith, E., Gile, J., Miller, C., Agricola, B., Katze, M., Reeves, R.K., Kraft, C.S., Langevin, S., Klatt, N.R. The effects of fecal microbial transplantation on microbiome and immunity in SIV-infected macaques. J Virol. 2016 Apr 29:90(10)4981-9. PMID 26937040.

anuzak, J.A., Hensley-McBain, T., Zevin, A.S., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Estes J.D., Langevin, S., Reeves K.R., Haddad E.K., Klatt, N.R. Enhancement of Microbiota in Healthy Macaques Results in Robust Beneficial Modulation of Mucosal and Systemic Immune Function. J Immunol. 2016 Jan 29. Pii:1502470. PMID 26826246.

Klatt, N.R., Chomont, N., Douek, D.C., Deeks, S.G. Immune activation and persistence: Implications for curative approaches to HIV infection. Immunol Rev. 2013 Jul;254(1):326-429.

Klatt, N.R., Canary, L.C., Sun, X., Vinton, C.L., Funderburg, N.T., Deming, C., Quinones, M. Perkins, M., Hazuda, D.J., Miller, M.D., Lederman, M.M., Segre, J.A., Lifson, J.D., Haddad, E.K., Estes, J.D., Brenchley, J.M. Probiotic and prebiotic supplementation of antiretroviral therapy improves gastrointestinal immunity in SIV-infected macaques. J Clin Invest. 2013 Jan 16.

Klatt N.R., Shudo E., Ortiz A.M., Engram J.C., Paiardini M., Lawson B., Miller M.D., Else J., Pandrea I., Estes J.D., Apetrei, C., Schmitz, J.E., Ribeiro, R.M., Perelson, A.S., Silvestri, G. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS Pathog 2010, 6:e1000747.

Klatt N.R., Villinger .F, Bostik P., Gordon S.N., Pereira L., Engram J.C., Mayne A., Dunham R.M., Lawson B., Ratcliffe S.J., Sodora, D.L., Else, J., Reimann, K., Staprans, S.I., Haase, A.T., Estes, J.D., Silvestri, G., Ansari, A.A. Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. J Clin Invest 2008, 118:2039-2049.