The University Imaging Centers (UIC) is a network of shared research facilities located on the University of Minnesota-Twin Cities campuses: Snyder Hall on the St. Paul campus, Jackson Hall on the Minneapolis East Bank campus, and the Cancer and Cardiovascular Research Building located in the Biomedical Discovery District on the East Bank campus. The UIC offers equipment and support for light and electron microscopy, multiplex ion beam imaging, tissue clearing, in-vivo imaging from subcellular to whole animals, image analysis & visualization, slide scanning, large format poster printing, and 3D printing. Services range from training users to independently operate equipment to full service imaging, and sample processing.
Operating under the direction of Mark Sanders, the UIC has seven full-time staff members, three part-time, as well as multiple undergraduate employees that can assist in experimental design, probe and labeling selection, sample handling, tissue clearing, as well as data analysis and interpretation.
The University Imaging Centers is supported by the Medical School and College of Biological Sciences and is advised by a 13-member University-wide Advisory Panel.
University Imaging Centers: Nikon Center of Excellence
The University Imaging Centers is a Nikon Center of Excellence(link is external). Nikon recognizes the UIC as a state-of-the-art microscopy resource that is mutually beneficial for both the University and Nikon. As a Nikon Center of Excellence, the UIC makes cutting-edge imaging tools accessible to the local scientific community and serves as a platform for the free exchange of ideas, methodologies, and technologies between investigators and Nikon toward the mutual goals of advancing research and developing new technologies. Nikon firmly believes that these types of partnerships between Academia and Industry are critically important for the rapid advancement of science and technology.
Optical Systems include:
- Laser scanning confocal microscopes with multiphoton capabilities (two)
- Single photon confocal microscopes (six, three with spectral unmixing)
- Super resolution Structured Illumination microscope (SIM)
- Spinning disk confocal microscope
- Total Internal Reflection Fluorescence (TIRF) Microscope
- Fluorescent spectral meso-confocal microscope
- Automated widefield microscopes
- High speed ribbon confocal microscope
- Light Sheet microscope
Also available at UIC facilities
- Spectral scans
- High-content widefield and confocal plate imaging
- FRET (Fluorescence Resonance Energy Transfer)
- FRAP (Fluorescence Recover After Photobleaching)
- FLIM (Fluorescence Lifetime Imaging)
- SHG (Second Harmonic Generation) Imaging
- Multi-channel live cell time-lapse
- Small animal/ bioluminescence / fluorescence
- BSL-2 cabinets
- Phosphor / fluorescence scanners for molecular biology
- Bioluminescence and fluorescence in-vivo small animal imagers
- Multiplexed Ion Beam Imaging (MIBI)
- diSPIM light sheet
- Tissue clearing
- Large format poster printing
- 3D printing
- Brightfield and fluorescence slide scanning.
The University Imaging Centers operate on the following fundamental mission goals:
- Maximize the availability of advanced imaging technologies and methodologies to faculty, staff, students, and external users.
- Bring expertise in new imaging technologies to users.
- Educate the University community about new imaging technologies.
- Promote interaction between developers of new imaging technology and potential users.