Christopher Staley
,
Credentials
PhD

Assistant Professor
Biography

Bio

The intestinal microbiota is a vital organ critical to the development, functioning, and health of the human the host. Our research focus is to characterize how disruptions in this community affect the onset and progression of diseases and conditions e.g., obesity, colorectal cancer, and inflammatory bowel diseases. By applying microbial ecology principles and leveraging next-generation sequencing technologies, our goal is to develop targeted, microbiota-based therapies to improve patient outcomes.

Research Summary

Microbial community dynamics related to obesity and type 2 diabetes Fecal microbiota transplantation therapies Patterns of dysbiosis related to health outcomes Network modeling of microbial communities Personalized microbiota therapeutics Microbiota interactions in solid and non-solid cancers

Education

PhD, University of South Florida
Major: Biology
Minor: Environmental and Ecological Microbiology
BS, University of South Florida
Major: Microbiology

Fellowships, Residencies, and Visiting Engagements

Research Associate, Residency
University of Minnesota
Post-doctoral Associate, Residency
University of Minnesota

Honors and Recognition

Microbial and Plant Genomics Institute Travel Award, University of Minnesota
2014
USEPA Scientific and Technological Achievement Award – Level II
2013

Professional Memberships

Masonic Cancer Center, University of Minnesota
BioTechnology Institute, University of Minnesota
American Society for Microbiology
Selected Presentations

Selected Presentations

Rashidi, A., (Author & Presenter), Kaiser, T., (Author), Shields-Cutler, R., (Author), Graiziger, C., (Author), Rehman, T., (Author), Holtan, S. G., (Author), Weisdorf, D. J., (Author), Knights, D. B., (Author), Khoruts, A., (Author), Staley, C. M., (Author) "Outpatient-to-Inpatient Transition Causes Marked Dysbiosis in Allogeneic Hematopoietic Cell Transplantation Recipients", Transplantation & Cellular Therapy Meetings, Center for International Blood & Marrow Transplant Research, Houston, Texas, United States. February 22, 2019.
Staley, C. M. "Validation of a Human Microbiota-Associated Mouse Model to Study Obesity", Research Animal Resources, University of Minnesota, November 16, 2018.
Stornetta, A., Kimmell, C., Hamilton, M., Kaiser, T., Staley, C. M., Khoruts, A., Wagner, J., MacMillan, M., Balbo, S. "Aldehyde Exposure in the Oral Cavity of Subjects with Fanconi Anemia", Fanconi Anemia Research Fund Symposium, Newport Beach, California, September 27, 2018.
Weiskerger, C., Brandão, J. S., Robinson, C., Staley, C. M., Kleinheinz, G., Nshimyiamana, J. P., Kinzelmen, J., Nevers, M. B., Sadowsky, M. J., Phanikumar, M. S., Whitman, R., Edge, T. A., Piggot, A., Boehm, A., Aslan, A., Badgley, B., Heaney, C., Symonds, E., Solo-Gabriele, H., Fleisher, J., Harwood, J., Yamahara, K., Vogel, L., Jordao, M. L., Avolio, L., Merilainen, P., Pitkanen, T., Ahmed, W., Staley, Z., Klaus, J. "Effects of a Changing Earth of Microbial Dynamics and Human Health Risks in the Water/Sand Continuum", International Association for Great Lakes Research 61st Conference on Great Lakes Research, Toronto, Canada. June 18, 2018.
Sadowsky, M., Brown, C., Staley, C. M. "Use of DNA Sequence Technology to Determine Sources and Sinks of Microbes in Waterways", International Association for Great Lakes Research 61st Conference on Great Lakes Research, Toronto, Canada. June 18, 2018.
Harwood, V., Ahmed, W., Hamilton, K. A., Lobos, A., Hughes, B., Staley, C. M., Sadowsky, M. J. "QMRA Links Risk of Gastroenteritis from Viral Pathogens to Microbial Source Tracking Markers in Sewage", Water Microbioogy Conference, University of North Carolina, Chapel Hill, North Carolina, May 22, 2018.
Staley, C. M. "Restoration of Intestinal microbiota Diversity by Encapsulated Fecal Microbiota Transplantation to Treat Clostridium difficile Infection", Surgical Critical Care Fellowship Program, University of Minnesota, March 22, 2018.
Staley, C. M. "The Role of the Intestinal Microbiota in Human Health Outcomes", Brown Bag Talk, University of Minnesota, Medical School, Department of Surgery, February 23, 2018.
Staley, C. M. "Changes in the Intestinal Microbial Community Associated with Obesity and Insulin Resistance", Resident Seminar, University of Minnesota, Medical School, Department of Surgery, December 14, 2017.
Sinigalliano, C., Gramer, L., Lee, H. W., Gidley, M., Lopez, J., Staley, C. M., Chun, C., Sadowsky, M., Putman, N., Hendee, J., Rosales, S. "Drivers of Reef Microbiome Community Structure: Next-Generation Sequencing, Microbial Source Tracking, Gene Flow, and Physical Habitat", European Coral Reef Symposium, Oxford, United Kingdom. December 13, 2017.
Sadowsky, M. J., Staley, C. M., Khoruts, A. "Freeze-dried and Encapsulation Microbiota Successfully Cures Recurrent Clostridium difficile Infection", The Human Miccrobiome: Emerging Themes at the Horizon of the 21st Century, Bethesda, Maryland, August 16, 2017.
Staley, C. M., Romão, D., Ferreira, F., Rodrigues, R., Sabino, R., Veríssimo, C., Wang, P., Brandão, J., Sadowsky, M. J. "Next-Generation Sequencing and Culture-Based Techniques Offer Complementary Insights into Fungi and Prokaryotes in Beach Sands", American Society for Microbiology Microbe Meeting, New Orleans, Louisiana, June 01, 2017.
Staley, C. M. "Evaluation of Structure-Function Relationships in Next-Generation Sequence Data", PLPA 5999: Plant Pathology Workshop, University of Minnesota, April 26, 2017.
Jahansouz, C., Staley, C. M., Xu, H., Hertzel, A., Hahn, W., Krumm, Z., Leslie, D., Bernlohr, D., Sadowsky, M., Khoruts, A., Ikramuddin, S. "The Vertical Sleeve Gastrectomy is Responsible for Dominant Shifts in Gut Microbiota", American Society for Metabolic and Bariatric Surgery Obesity Week, New Orleans, Louisiana, October 31, 2016.
Brown, C. M., Staley, C. M., Wang, P., Chun, C. L., Sadowsky, M. J. "A High-Throughput Sequencing Approach for Determining Sources of Fecal Bacteria in the Lake Superior Watershed", American Society for Microbiology Microbe Meeting, Boston, Massachusetts, June 16, 2016.
Hall, R., Heine, C., Oh, S., Staley, C. M., Hamilton, M., Khoruts, A., Kelly, C., Brandt, L., Sadowsky, M. "Workflow for Processing High-Throughput, Single Molecule, Real-Time Sequencing Data, for Analyzing the Microbiome of Patients Undergoing Fecal Microbiota Transplantation", American Society for Microbiology Microbe Meeting, Boston, Massachusetts, June 16, 2016.
Heiner, C., Oh, S., Hall, R., Staley, C. M., Hamilton, M., Khoruts, A., Kelly, C., Brandt, L., Sadowsky, M. "WGS SMRT Sequencing of Patient Samples from a Fecal Microbiota Transplant Trial", American Society for Microbiology Microbe Meeting, Boston, Massachusetts, June 16, 2016.
Pasa-Tolic, L., Ferrieri, A., Ansong, C., Brewer, H., Norbeck, A., Markillie, M., Ferrieri, R., Tringe, S. G., Sadowsky, M., Staley, C. M., Cui, Y., Stacey, G. "The Dynamic Nature of the Arabidopsis Rhizosphere Microbiota", American Society for Microbiology Microbe Meeting, Boston, Massachusetts, June 16, 2016.
Staley, C. M., Sadowsky, M. J. "Regional Similarity and Consistent Patterns of Local Variation in Beach Sand Bacterial Communities throughout the Northern Hemisphere", American Society for Microbiology Microbe Meeting, Boston, Massachusetts, June 16, 2016.
Pasa-Tolic, L., Ferrieri, A., Ansong, C. K., Brewer, H. M., Norbeck, A. D., Cui, Y., Staley, C. M., Tfaily, M., Chu, R., Shaw, J., Markillie, M. L., Ferrieri, R. A., Tringe, S. G., Sadowsky, M. J., Stacey, G. "Integrated Omics Reveals Dynamic Nature of the Arabidopsis Rhizosphere Microbiome", 64th Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, June 05, 2016.
Li, X., Harwood, V. J., Nayak, B., Staley, C. M., Sadowsky, M. J., Weidhaas, J. "A Customized DNA Microarray for Microbial Source Tracking in Environmental Systems", 2016 Recreational Waters Conference, New Orleans, Louisiana, April 12, 2016.
Ahmed, W., Staley, C. M., Sadowsky, M. J., Gyawali, P., Sidhu, J. S., Beale, D., Toze, S. "Application of Genetic Markers and Sequencing for the Identification of Fecal Pollution in an Urban River", 18th International Symposium on Health-Related Water Microbiology, Lisbon, Portugal. September 13, 2015.
Solo-Gabriele, H. M., Harwood, V. J., Kay, D., Fujioka, R. S., Sadowsky, M. J., Whitman, R. L., Wither, A., Canica, M., da Fonsec, R. C., Duarte, A., Edge, T. A., Gargaté, M. J., Gunde-cimerman, N., Hagen, F., McLellan, S. L., Silva, A., Babič, M. N., Prada, S., Rodrigues, R., Romão, D., Sabino, R., Samson, R. A., Segal, R., Staley, C. M., Taylor, H. D., Veríssimo, C., Viegas, C., Barroso, H., Brandão, J. "Beach Sand and the Potential for Infectious Disease Transmission: Observations and Recommendations", 18th International Symposium on Health-Related Water Microbiology, Lisbon, Portugal. September 13, 2015.
Staley, C. M., Gould, T. J., Wang, P., Phillips, J., Cotner, J. B., Sadowsky, M. J. "Evaluation of Water Sampling Methodologies for Metagenomic Characterization of Bacterial Community Structure", American Society of Microbiology General Meeting, New Orleans, Louisiana, May 30, 2015.
Fernandez, A. L., Sheaffer, C. C., Sadowsky, M., Wyse, D., Staley, C. M. "Cover Crop and Fertilizer Effects on Soil Bacterial Community Structure and Function in Organic Farming Systems", American Society of Agronomy | Crop Science Society of America | Soil Science Society of America International Annual Meeting, Long Beach, California, November 02, 2014.
Staley, C. M., Gould, T. J., Wang, P., Phillips, J., Cotner, J. B., Sadowsky, M. J. "Species Sorting Dynamics in the Bacterial Community of the Upper Mississippi River are Influenced by Land Use and Sediment Resuspension", American Society for Microbiology General Meeting, Boston, Massachusetts, May 17, 2014.
Staley, C. M., Unno, T., Gould, T. J., Jarvis, B., Phillips, J., Cotner, J. B., Sadowsky, M. J. "Relationship Between Land Use and Anthropogenic Factors Influencing Bacterial Community Structure in the Upper Mississippi River", American Society for Microbiology General Meeting, Denver, Colorado, May 18, 2013.
Young, S., Nayak, B., Staley, C. M., Sadowsky, M. J., Harwood, V. J. "Characterization of the Microbial Community in Alligator Fecal Samples Using a Metagenomics-Based Approach", American Society for Microbiology General Meeting, Denver, Colorado, May 18, 2013.
Heisel, T., Podgorski, H., Staley, C. M., Badgley, B., Sadowsky, M. J., Gale, C. A. "Molecular Strategy To Evaluate the Impact of Fungal Microbiomes on Infant Health", Pediatric Academic Societies Annual Meeting, Washington, District of Columbia, May 04, 2013.
Schoen, M. E., Staley, C. M., Gordon, K. V., Harwood, V. J. "Microbial Risk Assessment of Sewage-Impacted Waters: Potential Use of Microbial Source Tracking Assays", International Society of Exposure Sciences, Seattle, Washington, October 28, 2012.
Harwood, V. J., Gordon, K. V., Staley, C. M. "Case Studies and Caveats: Microbial Source Tracking In Coastal Waters", Coastal and Estuarine Research Foundation, Daytona Beach, Florida, November 06, 2011.
Staley, C. M., Harwood, V. J. "Characterization of Vibrio sinaloensis and Differentiation form Vibrio vulnificus", Southeastern Branch American Society for Microbiology, Gainesville, Florida, October 20, 2011.
Gordon, K. V., Staley, C. M., Harwood, V. J. "Persistence of Human-Associated Microbial Markers on a Simulated Tidally-Influenced Estuarine Beach", Southeastern Branch American Society for Microbiology, Gainesville, Florida, October 20, 2011.
Chase, E., Staley, C. M., Hunting, J., Harwood, V. J. "Microbial Source Tracking Methods Identify Human and Ruminant Sources of Fecal Pollution in an Ephemeral Florida River", Southeastern Branch American Society for Microbiology, Gainesville, Florida, October 20, 2011.
Staley, C. M., Harwood, V. J. "Differential Expression of A Sodium-Phosphate Symporter Gene Among Vibrio vulnificus Strains", American Society for Microbiology General Meeting, New Orleans, Louisiana, May 21, 2011.
Gordon, K. V., Staley, C. M., Harwood, V. J. "Persistence of Human-Associated Microbial Markers on a Simulated Tidally-Influenced Estuarine Beach", American Society for Microbiology General Meeting, New Orleans, Louisiana, May 21, 2011.
Staley, C. M., Harwood, V. J. "Expression of A Sodium-Dependent Phosphate Cotransporter May Be Linked to Host Colonization in Vibrio vulnificus Strains", Integrative Biology Seminar Series, University of South Florida, Tampa, Florida, April 07, 2011.
Harwood, V. J., Gordon, K. V., Staley, C. M. "Performance Criteria and Field Testing of QPCR Methods for Human-Associated Microbial Source Tracking Markers and Fecal Indicator Bacteria in Fresh and Salt Surface Waters", EPA National Beach Conference, Miami, Florida, March 15, 2011.
Staley, C. M., Harwood, V. J. "Analysis of the Relationship of Water Quality and Physical Parameters to Vibrio vulnificus Abundance and Virulence Factor Distribution", Vibrios in the Environment, Biloxi, Mississippi, November 06, 2010.
Staley, C. M., Reckhow, K., Lukasik, J., Harwood, V. J. "Assessment of Sources of Human Pathogens and Fecal Contamination in a Florida Freshwater Lake", American Society for Microbiology General Meeting, San Diego, California, May 23, 2010.
Staley, Z. R., Staley, C. M., Wapnick, C., Harwood, V. J. "A Weight of Evidence Approach Allows More Accurate Assessment of Sources of Fecal Indicator Bacteria in Surface Waters", Water Environment Federation TMDL Conference, Minneapolis, Minnesota, August 09, 2009.
Staley, C. M., Fowler, J., Harwood, V. J. "Analysis of the Distribution of Putative Virulence Markers and Virulence Factors in Vibrio vulnificus Strains", American Society for Microbiology General Meeting, Philadelphia, Pennsylvania, May 17, 2009.
Staley, C. M., Harwood, V. J. "Evaluation of a Potential Virulence Marker in Vibrio vulnificus", Southeastern Branch American Society for Microbiology, Jacksonville, Florida, November 06, 2008.
Wapnick, C. M., Harwood, V. J., Staley, C. M., Singleton, T. "A Cost-Effective Method for Assessing Fecal Contamination in Florida Tributaries", StormCon, Orlando, Florida, August 03, 2008.
Staley, C. M., Harwood, V. J. "A Conserved Hypothetical Protein May Aid in Typing Vibrio vulnificus", American Society for Microbiology General Meeting, Boston, Massachusetts, June 01, 2008.
Wapnick, C., Staley, C. M. "A Guide for Assessing Fecal Contamination in Northeast Florida Tributaries", Southeast Stormwater Association Annual Meeting, Nashville, Tennessee, October 24, 2007.
Staley, C. M., Harwood, V. J. "Characterization of a Putative Virulence Marker in Vibrio vulnificus Unique to Clinically-Associated Strains", American Society for Microbiology General Meeting, Toronto, Canada. May 21, 2007.
McQuaig, S., Brownell, M., Staley, C. M., Harwood, V. J. "Application of Microbial Source Tracking Methods for Human-Associated Sewage at Sites Suspected of Contamination by Compromised wastewater Handling Systems", American Society for Microbiology General Meeting, Toronto, Canada. May 21, 2007.
Staley, C. M., Harwood, V. J. "Characterization of a Putative Virulence Marker in Vibrio vulnificus Unique to Clinically-Associated Strains", Southeastern Branch American Society for Microbiology, Kennesaw, Georgia, November 02, 2006.
Staley, C. M., Harwood, V. J. "Vibrio vulnificus Populations in Oyster Tissues Using BOX-PCR", American Society for Microbiology General Meeting, Orlando, Florida, May 21, 2006.
Staley, C. M., Harwood, V. J. "Analysis of Vibrio vulnificus Population Distribution in Oyster Tissues Using BOX-PCR", Undergraduate Research Symposium, University of South Florida, Tampa, Florida, January 01, 2006.
Staley, C. M., Harwood, V. J. "Analysis of Vibrio vulnificus Populations in Oyster Tissues Using BOX-PCR", Southeastern Branch American Society for Microbiology, St. Pete Beach, Florida, October 27, 2005.
Contact

Contact

Address

Mayo Mail Code 195
420 Delaware St, SE
Minneapolis, MN 55455

Administrative Contact

Kelli Tourand |  612-624-4581 | toura018@umn.edu