Nichole Klatt, PhD

Ibrahim, S., Lowe, J. R., Bramante, C. T., Shah, S., Klatt, N. R., Sherwood, N., Aronne, L., Puskarich, M., Tamariz, L., Palacio, A., Bomberg, E., Usher, M., King, S., Benson, B., Vojta, D., Tignanelli, C., Ingraham, N., 2021. Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit.. Frontiers in endocrinology, 12: 587801.
doi: https://doi.org/10.3389/fendo.2021.587801
PubMed ID: 34367059

Nganou-Makamdop, K., Talla, A., Sharma, A. A., Darko, S., Ransier, A., Laboune, F., Chipman, J. G., Beilman, G. J., Hoskuldsson, T., Fourati, S., Schmidt, T. E., Arumugam, S., Lima, N. S., Moon, D., Callisto, S., Schoephoerster, J., Tomalka, J., Mugyenyi, P., Ssali, F., Muloma, P., Ssengendo, P., Leda, A. R., Cheu, R. K., Flynn, J. K., Morou, A., Brunet-Ratnasingham, E., Rodriguez, B., Lederman, M. M., Kaufmann, D. E., Klatt, N. R., Kityo, C., Brenchley, J. M., Schacker, T. W., Sekaly, R. P., Douek, D. C., 2021. Translocated microbiome composition determines immunological outcome in treated HIV infection.. Cell, 184 (15): 3899-3914.e16.
doi: https://doi.org/10.1016/j.cell.2021.05.023
PubMed ID: 34237254

Jones, R., Kroll, K., Broedlow, C., Schifanella, L., Smith, S., Hueber, B., Shah, S. V., Ram, D. R., Manickam, C., Varner, V., Klatt, N. R., Reeves, R. K., 2021. Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.. Scientific reports, 11 (1): 14507.
doi: https://doi.org/10.1038/s41598-021-93918-x
PubMed ID: 34267278

Gustin, A., Cromarty, R., Schifanella, L., Klatt, N. R., 2021. Microbial mismanagement: how inadequate treatments for vaginal dysbiosis drive the HIV epidemic in women. Seminars in Immunology, United States.

Klatt, N. R., Broedlow, C., Osborn, J. M., Gustin, A. T., Dross, S., O'Connor, M. A., Coronado, E., Barnette, P., Hensley-McBain, T., Zevin, A. S., Muir, R., Roederer, A., Wangari, S., Iwayama, N., Ahrens, C. Y., Smedley, J., Moats, C., Lynch, R. M., Haddad, E. K., Haigwood, N. L., Fuller, D. H., Manuzak, J. A., 2021. Effects of persistent modulation of intestinal microbiota on SIV/HIV vaccination in rhesus macaques.. NPJ vaccines, 6 (1): 34.
doi: https://doi.org/10.1038/s41541-021-00298-4
PubMed ID: 33707443

Tapia, G. R., Glynn, T. R., Miller, C., Manuzak, J. A., Broedlow, C. A., Mcgaugh, A., Cherenack, E. M., Bauermeister, J. A., Grov, C., Dilworth, S. E., Parisi, R., Martinez, D., Klatt, N. R., Carrico, A. W., 2021. Syndemics and pre-exposure prophylaxis are independently associated with rectal immune dysregulation in sexual minority men.. AIDS (London, England),
doi: https://doi.org/10.1097/QAD.0000000000002866
PubMed ID: 33710016

Berard, A. R., Miller, C., Araínga, M., Broedlow, C. A., Noël-Romas, L., Schifanella, L., Hensley-McBain, T., Roederer, A., Driscoll, C., Coronado, E., Manuzak, J., McKinnon, L. R., Villinger, F. J., Hope, T. J., Burgener, A. D., Klatt, N. R., 2021. SIV susceptibility, immunology and microbiome in the female genital tract of adolescent versus adult pigtail macaques.. AIDS research and human retroviruses,
doi: https://doi.org/10.1089/AID.2020.0271
PubMed ID: 33446027

Bowman, E. R., Cameron, C., Richardson, B., Kulkarni, M., Gabriel, J., Kettelhut, A., Hornsby, L., Kwiek, J. J., Turner, A. N., Malvestutto, C., Bazan, J., Koletar, S. L., Doblecki-Lewis, S., Lederman, M. M., Cameron, M., Klatt, N. R., Lake, J. E., Funderburg, N. T., 2020. In Vitro Exposure of Leukocytes to HIV Preexposure Prophylaxis Decreases Mitochondrial Function and Alters Gene Expression Profiles.. Antimicrobial agents and chemotherapy, 65 (1)
doi: https://doi.org/10.1128/AAC.01755-20
PubMed ID: 33020165

Cheu, R. K., Gustin, A. T., Lee, C., Schifanella, L., Miller, C. J., Ha, A., Kim, C., Rodriguez, V. J., Fischl, M., Burgener, A. D., Arnold, K. B., Alcaide, M. L., Klatt, N. R., 2020. Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism.. PLoS pathogens, 16 (12): e1009024.
doi: https://doi.org/10.1371/journal.ppat.1009024
PubMed ID: 33270801

Lee, C. Y., Cheu, R. K., Lemke, M. M., Gustin, A. T., France, M. T., Hampel, B., Thurman, A. R., Doncel, G. F., Ravel, J., Klatt, N. R., Arnold, K. B., 2020. Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis.. Nature communications, 11 (1): 6147.
doi: https://doi.org/10.1038/s41467-020-19880-w
PubMed ID: 33262350

Sherrill-Mix, S., Connors, K., Aldrovandi, G. M., Brenchley, J. M., Boucher, C., Bushman, F. D., Collman, R. G., Dandekar, S., Klatt, N. R., Lagenaur, L. A., Paredes, R., Tachedjian, G., Turpin, J. A., Landay, A. L., Ghosh, M., 2020. A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop.. AIDS research and human retroviruses, 36 (11): 886-895.
doi: https://doi.org/10.1089/AID.2020.0121
PubMed ID: 32777940

Hope, T. J., Klatt, N. R., Sacha, J. B., Cannon, P. M., 2020. Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research.. AIDS research and human retroviruses, 36 (11): 883-885.
doi: https://doi.org/10.1089/AID.2020.0253
PubMed ID: 33050710

Om, K., Paquin-Proulx, D., Montero, M., Peachman, K., Shen, X., Wieczorek, L., Beck, Z., Weiner, J. A., Kim, D., Li , Y., Mdluli, T., Shubin, Z., Bryant, C., Sharma, V., Tokarev, A., Dawson, P., White, Y., Appelbe, O., Klatt, N. R., Tovanabutra, S., Estes, J. D., Matyas, G. R., Ferrari, G., Alving, C. R., Tomaras, G. D., Ackerman, M. E., Michael, N. L., Robb, M. L., Polonis, V., Rolland, M., Eller, M. A., Rao, M., Bolton, D. L., 2020. Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge.. PLoS pathogens, 16 (9): e1008764.
doi: https://doi.org/10.1371/journal.ppat.1008764
PubMed ID: 32881968

Martino, C., Kellman, B. P., Sandoval, D. R., Clausen, T. M., Marotz, C. A., Song, S. J., Wandro, S., Zaramela, L. S., Salido Benítez, R. A., Zhu, Q., Armingol, E., Vázquez-Baeza, Y., McDonald, D., Sorrentino, J. T., Taylor, B., Belda-Ferre, P., Liang, C., Zhang, Y., Schifanella, L., Klatt, N. R., Havulinna, A. S., Jousilahti, P., Huang, S., Haiminen, N., Parida, L., Kim, H. C., Swafford, A. D., Zengler, K., Cheng, S., Inouye, M., Niiranen, T., Jain, M., Salomaa, V., Esko, J. D., Lewis, N. E., Knight, R., 2020. Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity.. bioRxiv : the preprint server for biology,
doi: https://doi.org/10.1101/2020.08.17.238444
PubMed ID: 32839779

SahBandar, I. N., Chew, G. M., Corley, M. J., Pang APS, Tsai, N., Hanks, N., Khadka, V. S., Klatt, N. R., Hensley-McBain, T., Somsouk, M., Vujkovic-Cvijin, I., Chow, D. C., Shikuma, C. M., Ndhlovu, L. C., 2020. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade.. AIDS (London, England), 34 (10): 1451-1460.
doi: https://doi.org/10.1097/QAD.0000000000002557
PubMed ID: 32675558

Manuzak, J. A., Zevin, A. S., Cheu, R., Richardson, B., Modesitt, J., Hensley-McBain, T., Miller, C., Gustin, A. T., Coronado, E., Gott, T., Fang, M., Cartwright, M., Wangari, S., Agricola, B., May, D., Smith, E., Hampel, H. B., Gale, M., Cameron, C. M., Cameron, M. J., Smedley, J., Klatt, N. R., 2020. Correction: Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques.. Mucosal immunology, 13 (3): 558.
doi: https://doi.org/10.1038/s41385-020-0274-x
PubMed ID: 32094503

Bar, K. J., Coronado, E., Hensley-McBain, T., O'Connor, M. A., Osborn, J. M., Miller, C., Gott, T. M., Wangari, S., Iwayama, N., Ahrens, C. Y., Smedley, J., Moats, C., Lynch, R. M., Haddad, E. K., Haigwood, N. L., Fuller, D. H., Shaw, G. M., Klatt, N. R., Manuzak, J. A., 2019. Simian-Human Immunodeficiency Virus SHIV.CH505 infection of rhesus macaques results in persistent viral replication and induces intestinal immunopathology. Journal of Virology, 93 (18): e00372-19.
doi: https://doi.org/10.1128/JVI.00372-19
PubMed ID: 31217249

Jabs, D. A., Van Natta, M. L., Trang, G., Jones, N. G., Milush, J. M., Cheu, R. K., Klatt, N. R., Won Pak, J., Danis, R. P., Hunt, P. W., 2019. Association of systemic inflammation with retinal vascular caliber in patients with AIDS. Investigational Ophthalmology and Visual Science,
doi: https://doi.org/10.1167/iovs.18-26070

Hensley-McBain, T., Wu, M. C., Manuzak, J. A., Cheu, R. K., Gustin, A., Driscoll, C. B., Zevin, A. S., Miller, C. J., Coronado, E., Smith, E., Chang, J., Gale, M., Somsouk, M., Burgener, A. D., Hunt, P. W., Hope, T. J., Collier, A. C., Klatt, N. R., 2019. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection . PLoS Pathogens,
doi: https://doi.org/10.1371/journal.ppat.1007672

Jabs, D. A., Van Natta, M. L., Trang, G., Jones, N. G., Milush, J. M., Cheu, R., Klatt, N. R., Danis, R. P., Hunt, P. W., 2019. Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.. American journal of ophthalmology, 199: 230-237.
doi: https://doi.org/10.1016/j.ajo.2018.12.002
PubMed ID: 30552890

Shah, S. V., Manickam, C., Ram, D. R., Kroll, K., Itell, H., Permar, S. R., Barouch, D. H., Klatt, N. R., Reeves, R. K., 2018. CMV primes functional alternative signaling in adaptive Δg NK cells but is subverted by lentivirus infection in rhesus macaques. Cell Reports,
doi: https://doi.org/10.1016/j.celrep.2018.11.020

Hensley-McBain, T., Berard, A. R., Manuzak, J. A., Miller, C. J., Zevin, A. S., Polacino, P., Gile, J., Agricola, B., Cameron, M., Hu, S. L., Estes, J. D., Reeves, R. K., Smedley, J., Keele, B. F., Burgener, A. D., Klatt, N. R., 2018. Intestinal damage precedes mucosal immune dysfunction in SIV infection . Mucosal Immunology, 11 (5): 1429-1440.
doi: https://doi.org/10.1038/s41385-018-0032-5

Guillén , Y., Noguera-Julian , M., Rivera, J., Casadellà, M., Zevin, A. S., Rocafort, M., Parera, M., Rodríguez, C., Arumí, M., Carrillo, J., Mothe, B., Estany, C., Coll, J., Bravo, I., Herrero, C., Saz, J., Sirera, G., Torrella, A., Navarro, J., Crespo, M., Negredo, E., Brander, C., Blanco, J., Calle, M. L., Klatt, N. R., Clotet, B., Paredes, R., 2018. Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection . Mucosal Immunology, 10.1038/s41385-018-0083-7, .

O'Connor, M. A., Tisoncik-Go, J., Lewi, T. B., Miller, C. J., Bratt, D., Moats, C. R., Edlefsen, P. T., Smedley, J., Klatt, N. R., Gale Jr. , M., Fuller, D. H., 2018. Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques. Nature Communications , 9 (1): 3371.
doi: https://doi.org/10.1038/s41467-018-05826-w

Manuzak, J. A., Gott, T. M., Kirkwood, J. S., Coronado, E., Hensley-McBain, T., Miller, C., Cheu, R. K., Collier, A. C., Funderburg, N. T., Martin, J. N., Wu, M. C., Isoherranen, N., Hunt, P. W., Klatt, N. R., 2018. Heavy cannabis use associated with reduction in activated and inflammatory immune cell frequencies in antiretroviral therapy-treated human immunodeficiency virus-infected individuals. Clinical Infectious Diseases , 66 (12): 1872-1882.

Klatt, N. R., Manuzak, J. A., 2018. Microbial effects on immunity in HIV: Virus, gender or sexual preference induced?. EBioMedicine , 31: 7-8.
doi: https://doi.org/10.1016/j.ebiom.2018.04.008

Fisher, B. S., Green, R. R., Brown, R. R., Wood, M. P., Hensley-McBain, T., Fisher, C., Chang, J., Miller, A. D., Bosche, W. J., Lifson, J. D., Mavigner, M., Miller, C. J., Gale Jr. , M., Silvestri, G., Chahroudi, A., Klatt, N. R., Sodora, D. L., 2018. Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART. PLoS Pathogens, 14 (2): e1006871.
doi: https://doi.org/10.1371/journal.ppat.1006871

Hensley-McBain, T., Klatt, N. R., 2018. The dual role of neutrophils in HIV infection . Current HIV/AIDS Report , 15 (1): 1-10.
doi: https://doi.org/10.1007/s11904-018-0370-7

Zevin, A. S., Hensley-McBain, T., Miller, C., Smith, E., Langevin, S., Klatt, N. R., 2017. Antibiotic treatment disrupts bacterial communities in the colon and rectum of simian immunodeficiency virus-infected macaques.. FEMS microbiology letters, 364 (23)
doi: https://doi.org/10.1093/femsle/fnx228
PubMed ID: 29088370

Zevin, A. S., Hensley-McBain, T., Miller, C., Smith, E., Langevin, S., Klatt, N. R., 2017. Antibiotic treatment disrupts bacterial communities in the colon and rectum of SIV-infected macaques. FEMS Microbiology Letters, 364 (23)
PubMed ID: 29088370

Williams, B., Ghosh, M., Boucher CAB, Bushman, F., Carrington-Lawrence, S., Collman, R. G., Dandekar, S., Dang, Q., Malaspina, A., Paredes, R., Wilson, C. C., Nowak, P., Klatt, N. R., Lagenaur, L., Landay, A. L., 2017. A Summary of the Second Annual HIV Microbiome Workshop.. AIDS research and human retroviruses, 33 (12): 1258-1264.
doi: https://doi.org/10.1089/aid.2017.0137
PubMed ID: 28899105

Pinto-Cardoso, S., Klatt, N. R., Reyes-Teran, G., 2017. impact of antiretroviral drugs on the microbiome: Unknown answers to important questions. Current Opinon in HIV and AIDS ,
PubMed ID: 29028667

Klatt, N. R., Hunt, P. W., 2017. MicroRNAs: Novel tools to block gut inflammation in HIV?. AIDS, 31 (14): 2017.

Klatt*, N. R., Cheu, R., Birse, K., Zevin, A. S., Perner, M., Romas, L., Grobler, A., Westmacott, G., Xie, I. Y., Butler, J., Mansoor, L., McKinnon, L., Passmore, J., Abdool Karim, Q., Abdool Karim, S., Burgener*, A. D., 2017. Vaginal bacteria modify HIV Tenofovir microbicide efficacy in African women . Science, 356 (6341): 938-945.
PubMed ID: 28572388

Zevin, A. S., Moats, C., May, D., Wangari, S., Miller, C., Ahrens, J., Iwayama, N., Brown, M., Bratt, D., Klatt, N. R., Smedley, J., 2017. Laparoscopic technique for serial collection of liver and mesenteric lymph nodes in macaques . Journal of Visualized Experiments , (123)
PubMed ID: 28518089

Peterson, C. W., Benne, C., Polacino, P., Kaur, J., McAllister, C. E., Filali-Mouhim, A., Obenza, W., Pecor, T. A., Huang, M. L., Baldessari, A., Murnane, R. D., Woolfrey, A. E., Jerome, K. R., Hu, S. L., Klatt, N. R., DeRosa, S., Sékaly, R. P., Kiem, H. P., 2017. Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation . JCL Insight , 2 (4): e91230.
PubMed ID: 28239658

Zevin, A. S., Xie, I. Y., Birse, K., Arnold, K., Romas, L., Westmacott, G., Novak, R. M., McCorrister, S., McKinnon, L. R., Cohen, C. R., Mackelprang , R., Lingappa, J., Lauffenburger, D. A., Klatt, N. R., Burgener, A. B., 2016. Microbiome composition and function drives wound-healing impairment in the female genital tract . PLoS Pathogens, 12 (9): e1005889.
PubMed ID: 27656899

Ortiz, A. M., Carnathan, D. G., Yu, J., Sheehan, K. M., Kim, P., Reynaldi, A., Vanderford, T. H., Klatt, N. R., Brenchley, J. M., Davenport, M. P., Silvestri, G., 2016. Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys.. PloS one, 11 (5): e0156352.
doi: https://doi.org/10.1371/journal.pone.0156352
PubMed ID: 27227993

Ortiz, A. M., Carnathan, D. G., Sheehan, K. M., Reynaldi, K. P., Vanderford, T. H., Klatt, N. R., Brenchley, J. M., Davenport, M. P., Silvestri, G., 2016. Analysis of the in vivo turnover of CD4+ T cell subset in chronically SIV-infected sooty mangabeys . PLoS One , 11 (5): e0156352.
PubMed ID: 27227993

Hensley-McBain, T., Zevin, A. S., Manuzak, J., Smith, E., Gile, J., Miller, C., Agricola, B., Katzke, M., Reeves, R. K., Kraft, C. S., Langevin, S., Klatt, N. R., 2016. The effects of fecal microbial transplantation on microbiome and immunity in SIV-infected macaques . Journal of Virology , 90 (10): 4981-4989.
PubMed ID: 26937040

Hensley-McBain, T., Zevin, A. S., Manuzak, J., Smith, E., Gile, J., Miller, C., Agricola, B., Katze, M., Reeves, R. K., Kraft, C. S., Langevin, S., Klatt, N. R., 2016. Effects of Fecal Microbial Transplantation on Microbiome and Immunity in Simian Immunodeficiency Virus-Infected Macaques.. Journal of virology, 90 (10): 4981-4989.
doi: https://doi.org/10.1128/JVI.00099-16
PubMed ID: 26937040

Manuzak, J. A., Hensley-McBain, T., Zevin, A. S., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Estes, J. D., Langevin, S., Reeves, R. K., Haddad, E. K., Klatt, N. R., 2016. Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function.. Journal of immunology (Baltimore, Md. : 1950), 196 (5): 2401-9.
doi: https://doi.org/10.4049/jimmunol.1502470
PubMed ID: 26826246

Manuzak, J. A., Hensley-McBain, T., Zevin, A. S., Miller, C., Cubas, R., Agricola, B., Gile, J., Richert-Spuhler, L., Patilea, G., Estes, J. D., Langevin, S., Reeves, K. R., Haddad, E. K., Klatt, N. R., 2016. Enhancement of microbiota in healthy macaques results in robust beneficial modulation of mucosal and systemic immune function . The Journal of Immunology ,
PubMed ID: 26826246

Zevin, A. S., McKinnon, L., Burgener, A., Klatt, N. R., 2015. Microbial translocation and microbiome dysbiosis in HIV-associated immune activation . Current Opinion in HIV and AIDS,
PubMed ID: 26679414

Vujkovic-Cvijin, I., Swainson, L., Chu, S. N., Ortiz, A. M., Santee, C. A., Petriello, A., Dunham, R. M., Fadrosh, D. W., Lin, D. L., Faruqi, A. A., Huang, Y., Apetrei, C., Pandrea, I., Hecht, F. M., Pilcher, C. D., Klatt, N. R., Brenchley, J. M., Lynch, S. V., McCune, J. M., 2015. Gut-resident lactobacillus abundance associates with iDO1 inhibition and Th17 dynamics in SIV-infected macaques. Cell Reports , 13 (8): 1589-1597.
doi: https://doi.org/10.1016/j.celrep.2015.10.026

Burgener, A., McGowan, I., Klatt, N. R., 2015. HIV and mucosal barrier interactions: Consequences for transmission and pathogenesis . Current Opinions in Immunology , 36: 22-30.
doi: https://doi.org/10.1016/j.coi.2015.06.004

Reeves, R. K., Burgener, A., Klatt, N. R., 2015. Targeting the GI tract to develop novel therapies for HIV. Clinical Pharmacology and Therapeutics, 98 (4): 381-386.
doi: https://doi.org/10.1002/cpt.186

Ortiz, A. M., Klase, Z. A., DiNapoli, S. R., Vujkovic-Cvijin, I., Carmack, K., Perkins, M. R., Calantone, N., Vinton, C. L., Riddick, N. E., Gallagher, J., Klatt, N. R., McCune, J. M., Estes, J. D., Paiardini, M., Brenchley, J. M., 2015. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal immunology ,
doi: https://doi.org/10.1038/mi.2015.75

Hao, X. P., Lucero, C. M., Turkbey, B., Bernardo, M. L., Morcock, D. R., Deleage, C., Trubey, C. M., Smedley, J., Klatt, N. R., Giavedoni, L. D., Kristoff, J., Xu, A., Del Prete, G. Q., Keele, B. F., Rao, S. S., Alvord, W. G., Choyke, P. L., Lifson, J. D., Brenchley, J. M., Apetrei, C., Pandrea, I., Estes, J. D., 2015. Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection . Nature Communications, 6: 8020.
doi: https://doi.org/10.1038/ncomms9020

Evans, T. I., Li, H., Schafer, J. L., Klatt, N. R., Hao, X. P., Traslavina, R. P., Estes, J. D., Brenchley, J. M., Reeves, R. K., 2015. SIV-induced translocation of bacterial products in the liver mobilizes myeloid dendritic and natural killer cells associated with liver damage. The journal of Infectious Diseases ,

Klase, Z., Ortiz, A., Deleage, C., Mudd, J. C., Quinones, M., Schwartzman, E., Klatt, N. R., Canary, L., Estes, J. D., Brenchley, J. M., 2015. Dysbiotic bacteria translocate in progresive SIV infection .
doi: https://doi.org/10.1038/mi.2014.128

Li, H., Richert-Spuhler, L. E., Evans, T. I., Gillis, J., Connole, M., Estes, J. D., Keele, B. F., Klatt, N. R., Reeves, R. K., 2014. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection . PLoS Pathogens , 10 (12): e1004551.
doi: https://doi.org/10.1371

Perkins, M. R., Briant, J. A., Calantone, N., Whitted, S., Vinton, C. L., Klatt, N. R., Ourmanov, I., Ortiz, A. M., Hirsch, V. M., Brenchley, J. M., 2014. Homeostatic cytokines include CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD88aa T cells. Journal of Virology , 88 (18): 10714-10724.
doi: https://doi.org/10.1128/JVI.01331-14

Carlson, J. M., Schaefer, M., Monaco, D. C., Batorsky, R., Claiborne, D. T., Prince, J., Deymier, M. J., Ende, Z. S., Klatt, N. R., DeZiel, C. E., Lin, T. H., Peng, J., Seese, A. M., Shapiro, R., Frater, J., Ndung'u, T., Tang, J., Goepfert, P., Gilmour, J., Price, M. A., Kilembe, W., Heckerman, D., Goulder, P. J., Allen, T. M., Allen, S., Hunter, E., 2014. HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck . Science , 345 (6193): 1254031.
doi: https://doi.org/10.1126/science.1254031

Klatt, N. R., Bosinger, S. E., Peck, M., Richert-Spuhler, L. E., Heigele, A., Gile, J. P., Patel, N., Taaffe, J., Julg, B., Camerini, D., Torti, C., Martin, J. N., Deeks, S. G., Sinclair, E., Hecht, F. M., Lederman, M. M., Paiardini, M., Kirchhoff, F., Brenchley, J. M., Hunt, P. W., Silvestri, G., 2014. Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. PLoS Pahogens , 10: e1004345.
doi: https://doi.org/10.1371/jounral.ppat.1004345

Fuller, D. H., Richert-Spuhler, L. E., Klatt, N. R., 2014. HIV vaccine trial exploits a dual and central role for innate immunity . Journal of Virology ,
doi: https://doi.org/10.1128/JVI.02140-14

Petrovas, C., Yamamoto, T., Price, D. A., Rao, S. S., Klatt, N. R., Brenchley, J. M., Douek, D. C., Gostick, E., Angermann, B. R., Grossman, Z., Macallan, D. C., Meier-Schellersheim, M., Koup, R. A., 2013. High production rates sustain in vivo levels of PD-1 high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance . Journal of Virology , 87 (17): 9836-9844.
doi: https://doi.org/10.1128/JVI.01001-13

Klatt, N. R., Chomont, N., Douek, D. C., Deeks, S. G., 2013. Immune activation and HIV persistence: implications for curative approaches to HIV infection.. Immunological reviews, 254 (1): 326-42.
doi: https://doi.org/10.1111/imr.12065
PubMed ID: 23772629

Klatt, N. R., Chomont, N., Douek, D. C., Deeks, S. G., 2013. Immune activation and persistence: Implications for curative approaches to HIV infection. Immunological Reviews , 254 (1): 326-342.

Canary, L. A., Vinton, C. L., Morcock, D. R., Pierce, J., Estes, J. D., Brenchley, J. M., Klatt, N. R., 2013. Rate of AIDS progression is associated with pre-existing microbial translocation in pigtail macaques . 190 (6): 2959-2965.
doi: https://doi.org/10.4049/jimmunol.1202319

Lugli, E., Dominguez, M., Gattinoni, L., Chattopadhay, P. K., Bolton, D. L., Song, K., Klatt, N. R., Brenchley, J. M., Vaccari, M., Price, D. A., Waldmann, T. A., Restifo, N. P., Franchini, G., Roederer, M., 2013. Superior T memory stem cell persistence supports long-lived T cell memory . The Journal of Clinical Investigation , 123 (2): 594-599.
doi: https://doi.org/10.1172/JCI66327

Klatt, N. R., Canary, L. A., Sun, X., Vinton, C. L., Funderburg, N. T., Morcock, D. R., Quiñones, M., Deming, C. B., Perkins, M., Hazuda, D. J., Miller, M. D., Lederman, M. M., Segre, J. A., Lifson, J. D., Haddad, E. K., Estes, J. D., Brenchley, J. M., 2013. Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.. The Journal of clinical investigation, 123 (2): 903-7.
doi: https://doi.org/10.1172/JCI66227
PubMed ID: 23321668

Klatt, N. R., Canary, L. C., Sun, X., Vinton, C. L., Funderberg, N. T., Deming, C., Quinones, M., Perkins, M., Hazuda, D. J., Miller, M. D., Lederman, M. M., Segre, J. A., Lifson, J. D., Haddad, E. K., Estes, J. D., Brenchley, J. M., 2013. Probiotic and prebiotic supplementation of antiretroviral therapy improves gastrointestinal immunity in SIV-infected macaques . The journal of Clinical Investigation ,

Lederman, M. M., Funderberg, N. T., Sekaly, R. P., Klatt, N. R., Hunt, P. W., 2013. Residual immune dysregulation syndrome in treated HIV infection . Advances in Immunology , 119: 51-83.

Bosinger, S. E., Jochems, S. P., Folkner, K. A., Hayes, T. L., Klatt, N. R., Silvestri, G., 2013. Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239.. Journal of virology, 87 (1): 433-43.
doi: https://doi.org/10.1128/JVI.01746-12
PubMed ID: 23097439

Klatt, N. R., Estes, J. D., Sun, X., Harris, L. D., Ortiz, A. M., Cervasi, B., Yokomizo, L. K., Vinton, C. L., Tabb, B., Canary, L. A., Dang, Q., Hirsch, V. M., Lifson, J. D., Alter, G., Belkaid, Y., Silvestri, G., Milner, J. D., Paiardini, M., Haddad, E. K., Brenchley, J. M., 2012. Loss of mucosal IL-17+ and IL-22+ lymphocytes after SIV infection is associated with loss of CD103+ DCs and damage to the mucosal barrier . Mucosal Immunology, 5 (6): 646-657.
doi: https://doi.org/10.1038/mi.2012.38

Bosinger, S. E., Jochems, S. P., Folkner, K. A., Hayes, T. L., Klatt, N. R., Silvestri, G., 2012. Transcriptional profiling of experimental CD8+ lymphocyte depletion in rhesus macaques infected with SIVmac239. Journal of Virology ,

Klatt, N. R., Funderburg, N. T., Brenchley, J. M., 2012. Microbial translocation, immune activation and HIV disease . Trends in Microbiology ,
doi: https://doi.org/S0966-842X

Klatt, N. R., Silvestri, G., 2012. CD4+ T cells and HIV: A paradoxical pas de deux . Science Translational Medicine , 123 (4): 123-124.

Klatt, N. R., Estes, J. D., Brenchley, J. M., 2012. Nonpathogenic SIV infections. Cold Spring Harbor Perspectives in Medicine 2 (1): a007153.

Klatt, N. R., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., Swerczek, J., Cronise-Santis, H., Lafont, B., Brenchley, J. M., 2012. Dynamics of SIVmac239 infection in pigtail macaques. Journal of Virology , 86 (2): 1203-1213.

Klatt, N. R., Silvestri, G., Hirsch, V., 2012. Nonpathogenic simian immunodeficiency virus infections.. Cold Spring Harbor perspectives in medicine, 2 (1): a007153.
doi: https://doi.org/10.1101/cshperspect.a007153
PubMed ID: 22315718

Klatt, N. R., Canary, L. A., Vanderford, T. H., Vinton, C. L., Engram, J. C., Dunham, R. M., Cronise, H. E., Swerczek, J. M., Lafont, B. A., Picker, L. J., Silvestri, G., Brenchley, J. M., 2012. Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques.. Journal of virology, 86 (2): 1203-13.
doi: https://doi.org/10.1128/JVI.06033-11
PubMed ID: 22090099

Klatt, N. R., Estes, J. D., Brenchley, J. M., 2011. Cover Image: Confocal immunofluorescent image of a jejunum section stained for cytokeratin of an acutely SIV-infected rhesus macaque. AIDS Res Hum Retroviruses ,

Klatt, N. R., Vinton, C. L., Lynch, R. M., Ho, J., Darrah, P., Estes, J. D., Seder, R. A., Moir, S. L., Brenchley, J. M., 2011. SIV infection of rhesus macaques results in dysfunctional T and B cell responses to neo and recall Leishmania vaccination . Blood , 118 (22): 5803-5812.

Klatt, N. R., Vinton, C. L., Lynch, R. M., Canary, L. A., Ho, J., Darrah, P. A., Estes, J. D., Seder, R. A., Moir, S. L., Brenchley, J. M., 2011. SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.. Blood, 118 (22): 5803-12.
doi: https://doi.org/10.1182/blood-2011-07-365874
PubMed ID: 21960586

Ortiz, A. M., Klatt, N. R., Carnathan, P., Li, B., Derdeyn, C., Lawson, B., Ryzhova, E., Gonzalez-Scarano, F., Paiardini, M., Ratcliffe, S., Else, J., Brenchley, J. M., Silvestri, G., 2011. Depletion of CD4+ T-cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques. The Journal of Clinical Investigation , 121 (11): 4433-4445.

Ortiz, A. M., Klatt, N. R., Li , B., Yi, Y., Tabb, B., Hao, X. P., Sternberg, L., Lawson, B., Carnathan, P. M., Cramer, E. M., Engram, J. C., Little, D. M., Ryzhova, E., Gonzalez-Scarano, F., Paiardini, M., Ansari, A. A., Ratcliffe, S., Else, J. G., Brenchley, J. M., Collman, R. G., Estes, J. D., Derdeyn, C. A., Silvestri, G., 2011. Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.. The Journal of clinical investigation, 121 (11): 4433-45.
doi: https://doi.org/10.1172/JCI46023
PubMed ID: 22005304

Vinton, C. L., Klatt, N. R., Harrs, L. D., Judith, A. B., Sanders-Beer, B. E., Herbert, R., Woodward, R., Silvestri, G., Pandrea, I., Apetrei, C., Hirsch, V. M., Brenchley, J. M., 2011. Maintenance of CD4-like immunological function by CD4- T cells in multiple natural hosts for SIV . Journal of Virology , 85 (17): 8702-8708.

Vinton, C., Klatt, N. R., Harris, L. D., Briant, J. A., Sanders-Beer, B. E., Herbert, R., Woodward, R., Silvestri, G., Pandrea, I., Apetrei, C., Hirsch, V. M., Brenchley, J. M., 2011. CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.. Journal of virology, 85 (17): 8702-8.
doi: https://doi.org/10.1128/JVI.00332-11
PubMed ID: 21715501

Vanderford, T. H., Bleckwehl, C., Klatt, N. R., Engram, J. C., Dunham, R. M., Sumpter, B., Feinberg, M., Garber, D., Betts, M., Silvestri, G., 2011. Viral cytotoxic T lymphocyte escape mutants become fixed in plasma before rectal mucosa during acute SIV infection of rhesus macaques . PLoS Pathogens , 7 (5): e1002048.

Vanderford, T. H., Bleckwehl, C., Engram, J. C., Dunham, R. M., Klatt, N. R., Feinberg, M. B., Garber, D. A., Betts, M. R., Silvestri, G., 2011. Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques.. PLoS pathogens, 7 (5): e1002048.
doi: https://doi.org/10.1371/journal.ppat.1002048
PubMed ID: 21625590

Elemans, M., Seich al Basatena, N., Klatt, N. R., Gkekas, C., Silvestri, G., Asquith, B., 2011. Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo. PLoS Computational Biology, 7 (9): e1002200.

Harris, L. D., Klatt, N. R., Vinton, C., Briant, J. A., Tabb, B., Ladell, K., Lifson, J., Estes, J. D., Price, D. A., Hirsch, V. M., Brenchley, J. M., 2010. Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.. Blood, 116 (20): 4148-57.
doi: https://doi.org/10.1182/blood-2010-05-283549
PubMed ID: 20660793

Knox, K. S., Vinton, C., Hage, C. A., Kohli, L. M., Twigg, 3rd, H. L., Klatt, N. R., Zwickl, B., Waltz, J., Goldman, M., Douek, D. C., Brenchley, J. M., 2010. Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy.. Journal of virology, 84 (18): 9010-8.
doi: https://doi.org/10.1128/JVI.01138-10
PubMed ID: 20610726

Engram, J. C., Cervasi, B., Borghans, J. A., Klatt, N. R., Gordon, S. N., Chahroudi, A., Else, J. G., Mittler, R. S., Sodora, D. L., de Boer, R. J., Brenchley, J. M., Silvestri, G., Paiardini, M., 2010. Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.. Blood, 116 (5): 748-58.
doi: https://doi.org/10.1182/blood-2010-01-263814
PubMed ID: 20484087

Harris, L. D., Tabb, B., Sodora, D. L., Paiardini, M., Klatt, N. R., Douek, D. C., Silvestri, G., Muller-Trutwin, M., Vasile-Pandrea, I., Apetrei, C., Hirsch, V., Lifson, J., Brenchley, J. M., Estes, J. D., 2010. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques . Journal of Virology , 84: 7886-7891.

Klatt, N. R., Shudo, E., Ortiz, A. M., Engram, J. C., Paiardini, M., Lawson, B., Miller, M. D., Else, J., Pandrea, I., Estes, J. D., Apetrei, C., Schmitz, J. E., Ribeiro, R. M., Perelson, A. S., Silvestri, G., 2010. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS Pathogens, 6: e1000747.

Klatt, N. R., Harris, L. D., Vinton, C. L., Sung, H., Briant, J. A., Tabb, B., Morcock, D., McGinty, J. W., Lifson, J. D., Lafont, B. A., Martin, M. A., Levine, A. D., Estes, J. D., Brenchley, J. M., 2010. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection . Mucosal Immunology , 3: 387-398.

Engram, J. C., Cervasi, B., Borghans, J. A., Klatt, N. R., Gordon, S. N., Chahroudi, A., Else, J., Mittler, R. S., Sodora, D. L., de Boer, R. J., Brenchley, J. M., Silvestri, G., Paiardini, M., 2010. Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in non-human primates . Blood , 5: 748-758.

Knox, K. S., Vinton, C., Hage, C. A., Kohli, L. M., Twigg III, H. L., Klatt, N. R., Zwicki, B., Waltz, J., Goldman, M., Douek, D. C., Brenchley, J. M., 2010. Reconstitution of CD4 T cells in BAL after initiation of highly active antiretroviral therapy . journal of Virology, 18: 9010-9018.

Klatt, N. R., Brenchley, J. M., 2010. Th17 cell dynamics in HIV infection . Current Opinions in HIV and AIDS , 5: 135-140.

Lasaro, M. O., Haut, L. H., Zhou, X., Xiang, Z., Zhou, D., Li, Y., Giles-Davis, W., Li, H., Engram, J. C., Dimenna, L. J., Bian, A., Sazanovich, M., Parzych, E. M., Kurupati, R., Small, J. C., Wu, T. L., Leskowitz, R. M., Klatt, N. R., Brenchley, J. M., Garber, D. A., Lewis, M., Ratcliffe, S. J., Betts, M. R., Silvestri, G., Ertl, H. C., 2010. Vaccine-induced T cells provide partial protection against high-dose rectal SIVmac239 challenge of rhesus macaques. Molecular Therapy , (2): 417-426.

Harris, L. D., Klatt, N. R., Vinton, C. L., Briant, J. A., Tabb, B., Ladell, K., Lifson, J., Estes, J. D., Price, D. A., Hirsch, V. M., Brenchley, J. M., 2010. Mechanisms underlying gamma-delta T cell subset perturbations in SIV-infected Asian rhesus macaques . Blood , 116 (20): 4148-4157.

Estes, J. D., Harris, L. D., Klatt, N. R., Tabb, B., Pittaluga, S., Paiardini, M., Barclay, G. R., Smedley, J., Pung, R., Oliveira, K. M., Hirsch, V. M., Silvestri, G., Douek, D. C., Miller, C. J., Haase, A. T., Lifson, J., Brenchley, J. M., 2010. Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections. PLoS Pathogens , 6: e1001052.

Bosinger, S. E., Li, Q., Gordon, S. N., Klatt, N. R., Duan, L., Xu, L., Francella, N., Sidahmed, A., Smith, A. J., Cramer, E. M., Zeng, M., Masopust, D., Carlis, J. V., Ran, L., Vanderford, T. H., Paiardini, M., Isett, R. B., Baldwin, D. A., Else, D. A., Staprans, S. I., Silvestri, G., Haase, A. T., Kelvin, D. J., 2009. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. The Journal of Clinical Investigation , 119: 3556-3572.

Engram, J. C., Dunham, R. M., Makedonas, G., Vanderford, T. H., Sumpter, B., Klatt, N. R., Ratcliffe, S. J., Garg, S., Paiardini, M., McQuoid, M., Altman, J. D., Staprans, S. I., Betts, M. R., Garber, D. A., Feinberg, M. B., Silvestri, G., 2009. Vaccine-induced, simian immunodeficiency virus-specific CD8+ T cells reduce virus replication but do not protect from simian immunodeficiency virus disease progression. Journal of Immunology , 183: 706-717.

Paiardini, M., Cervasi, B., Engram, J. C., Gordon, S. N., Klatt, N. R., Muthukumar, A., Else, J., Mittler, R. S., Staprans, S. I., Sodora, D. L., Silvestri, G., 2009. Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: Implications for AIDS pathogenesis. Blood, 113: 612-621.

Beaumier, C. M., Harris, L. D., Goldstein, S., Klatt, N. R., Whitted, S., McGinty, J., Apetrei, C., Pandrea, I., Hirsch, V. M., Brenchley, J. M., 2009. CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection . Natural Medicine , 15: 879-885.

Klatt, N. R., Villinger, F., Bostik, P., Gordon, S. N., Pereira, L., Engram, J. C., Mayne, A., Dunham, R. M., Lawson, B., Ratcliffe, S. J., Sodora, D. L., Else, J., Reimann, K., Staprans, S. I., Haase, A. T., Estes, J. D., Silvestri, G., Ansari, A. A., 2008. Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.. The Journal of clinical investigation, 118 (6): 2039-49.
doi: https://doi.org/10.1172/JCI33814
PubMed ID: 18497876

Klatt, N. R., Villinger, F., Bostik, P., Gordon, S. N., Pereira, L., Engram, J. C., Mayne, A., Dunham, R. M., Lawson, B., Ratcliffe, S. J., Sodora, D. L., Else, J., Reimann, K., Staprans, S. I., Haase, A. T., Estes, J. D., Silvestri, G., Ansari, A. A., 2008. Availability of activated CD4+ T cells dictates the level of viremia in naturaly SIV-infected sooty mangabeys. The Journal of Clinical Investigation , 118: 2039-2049.

Dunham, R. M., Cervasi, B., Brenchley, J. M., Albrecht, H., Weintrob, A., Sumpter, B., Engram, J., Gordon, S., Klatt, N. R., Frank, I., Sodora, D. L., Douek, D. C., Paiardini, M., Silvestri, G., 2008. CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection. Journal of Immunology, 180: 5582-5592.

Gordon, S. N., Dunham, R. M., Engram, J. C., Estes, J., Wang, Z., Klatt, N. R., Paiardini, M., Pandrea, I. V., Apetrei, C., Sodora, D. L., Lee, H. Y., Haase, A. T., Miller, M. D., Kaur, A., Staprans, S. I., Perelson, A. S., Feinberg, M. B., Silvestri, G., 2008. Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: Implications for AIDS pathogenesis. journal of Virology, 82: 3725-3735.

Klatt, N. R., Chahroudi, A., Silvestri, G., 2008. Human immunodeficiency viruses (Retroviridae): Pathogenesis. Encyclopedia of Virology

Gordon, S. N., Klatt, N. R., Bosinger, S. E., Brenchley, J. M., Milush, J. M., Engram, J. C., Dunham, R. M., Paiardini, M., Klucking, S., Danesh, A., Strobert, E. A., Apetrei, C., Pandrea, I. V., Kelvin, D., Douek, D. C., Staprans, S. I., Sodora, D. L., Silvestri, G., 2007. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. Journal of Immunology , 179: 3026-3034.

Sumpter, B., Dunham, R., Gordon, S., Engram, J., Hennessy, M., Kinter, A., Paiardini, M., Cervasi, B., Klatt, N. R., McClure, H., Milush, J. M., Staprans, S., Sodora, D. L., Silvestri, G., 2007. Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: Implications for AIDS pathogenesis. Journal of Immunology, 178: 1680-1691.