Amar Singh, PhD

Assistant Professor,

Amar Singh

Contact Info

singh423@umn.edu

Administrative Assistant Name
Kelly Swenson

Administrative Phone
612-626-5697

Administrative Email
malon187@umn.edu

Assistant Professor


PhD, Immunology - All India Institute of Medical Sciences (AIIMS), New Delhi, India

M.S., Biotechnology - Jawaharlal Nehru University, New Delhi, India

Summary

Role of Regulatory T and B cells in Allo and Xeno Immunity, Phenotype of Induction Maintenance and Loss of Tolerance

My work primarily focused on understanding the development of the xeno/alloimmune response and how it leads to intraportal porcine islets graft rejection. My main goal is to understand the role of regulatory T and B cells in islets xeno/alloimmunity and immune phenotype of induction, maintenance and loss of tolerance. Our preliminary work showed instrumental role of lymphocytes with regulatory phenotypes in the maintenance of porcine islet xenografts in macaques immunosuppressed with costimulation blocking biologics. I am also characterizing B cell subpopulations, their function and association with in islets graft function. Other areas of my research include identify the main mediator of cellular islet xenograft rejection and understanding the role of CD8 effector memory T cells. My special interests include development of improved therapeutics and more precise monitoring techniques so that immune therapies can be tailor-made to the transplant recipients. A recent new direction of my work is the analysis of donor reactive lymphocytes turnover using novel TCR tracking approach to understand the interplay of tolerance and cellular islet xeno /allo-graft rejection.

Research

Publications

Publications:

Singh A, Dey A B, Mohan A, Sharma PK and Mitra DK. Foxp3+ regulatory T cells among tuberculosis patients: Impact on prognosis and restoration of antigen specific IFN-? producing T cells. PLoS ONE. 2012;7 (9): e44728.

Abstracts:

IPITA, International Meeting , Australia , 2015
Singh A, Suarez-Pinzon WL, Naqvi RA, Burlak C, Graham ML, Hering BJ
Circulating CD8+ effector memory T cells – A candidate biomarker for imminent rejection of porcine islet xenografts in nonhuman primates.

Singh A, Suarez-Pinzon WL, Naqvi RA, Burlak C, Graham ML, Hering BJ
T and B Cell Signatures Associated with Survival and Rejection of Intraportal Porcine Islet Xenografts in Immunosuppressed Cynomolgus