Satoshi Miyairi
,
Credentials
MD, PhD

Assistant Professor, Pediatric Cardiothoracic Surgery
Biography

Bio

Dr. Miyairi received his Doctor of Medicine license in 2008 and his Doctor in Philosophy license in 2017, both in Japan. His fellowship was at Children’s National Medical Center with the Department of Cardiovascular surgery in Washington D.C. Following his fellowship he was a Clinical Instructor at Stanford University School of Medicine with the Department of Cardiothoracic surgery, Division of Pediatric Cardiac Surgery in California.

He has been working in the field of congenital cardiac surgery, from neonate to ACHD. His focus is also on transplant Immunology, and surgical Therapy of Heart Failure.

His clinical interests are Heart transplant, Mechanical Circulatory Support, TOF/PA/MAPCAs and early primary repair of neonatal heart defect

Research Summary

Transplant Immunology, VAD Therapy

Clinical Summary

Heart transplant, Mechanical Circulatory Support, TOF/PA/MAPCAs and early primary repair of neonatal heart defect

Education

PhD , Tokyo Women's Medical University
MD, University of the Ryukyus

Fellowships, Residencies, and Visiting Engagements

Clinical Instructor,
Stanford University School of Medicine, Department of Cardiothoracic Surgery, Division of Pediatric Cardiac Surgery
Clinical Fellow,
Children's National Medical Center, Department of Cardiovascular Surgery
Assistant Professor,
Asahikawa Medical University, Department of Surgery, Division of Cardiac Surgery
Research Fellow,
Cleveland Clinic - Lerner Research Institute, Department of Inflammation and Immunity
Clinical Fellow,
Tokyo Women's Medical University, Department of Cardiovascular Surgery
Clinical Fellow,
Seirei Hamamatsu General Hospital, Department of Cardiovascular Surgery
Senior Resident,
Tokyo Women's Medical University, Department of Cardiovascular Surgery
Junior Resident,
Tokyo Women's Medical University, The Medical Training Center for Graduates

Licensures and Certifications

Standard ECFMG certificate in Apr. 2019,
Doctor of Philosophy (Ph.D.) in Mar. 2017 Japanese Board Certified Surgeon in Jan. 2017,
Japanese Board Certified Cardiovascular Surgeon in Jan. 2023,
Doctor of Medicine (M.D.) in Mar. 2008 ,

Honors and Recognition

Young Investigator Award for the American Transplant Congress (ATC)
2018

Professional Memberships

American Society of Transplantation
Japanese Society for Immunology
American Society of Transplant Surgeons
Japanese Society of Pediatric Cardiology and Cardiac Surgery
Japanese Society for Cardiovascular Surgery
Japanese Association for Thoracic Surgery
Japanese Circulation Society
Japan Surgical Society
Selected Publications

Selected Publications

Miyairi S, Koide M, Kunii Y, Tsuda K, Ohashi Y, Harada T. Redo mitral valve replacement using the valve-on-valve method. Asian Cardiovasc Thorac Ann 2015;23(6):707-709.
Miyairi S, Koide M, Kunii Y. A case of cryptogenic thoracic aortic aneurysm with tetralogy of Fallot. J Thorac Cardiovasc Surg 2014;147(3):1088.
Miyairi S, Hirai T, Ishii R, Okumi M, Nunoda S, Yamazaki K, Ishii Y, Tanabe K. Donor bone marrow cells are essential for iNKT cell-mediated Foxp3+ Treg cell expansion in a murine model of transplantation tolerance. Eur J Immunol. 2017 Apr;47(4):734-742.
Hirai T, Ishii R, Miyairi S, Ikemiyagi M, Omoto K, Ishii Y et al. Clonal Deletion Established via Invariant NKT Cell Activation and Costimulatory Blockade Requires In Vivo Expansion of Regulatory T Cells. Am J Transplant 2016;16(2):426-439.
Miyairi S, Ueda D, Yagiasawa T, Okada D, Kesler K, Tanabe K, Dvorina N, Valuj skikh A, Baldwin WM 3rd, Fairchild RL. Recipient myeloperoxidase-producing cells regulate antibody-mediated acute versus chronic kidney allograft rejection. JCI Insight. 2021;6(13):e148747.
Ikemiyagi M, Hirai T, Ishii R, Miyairi S, Okumi M, Tanabe K. Transitional B Cells Predominantly Reconstituted After a Desensitization Therapy Using Rituximab Before Kidney Transplantation. Ther Apher Dial. 2017 Apr;21(2):139-149.
Yagisawa T, Tanaka T, Miyairi S, Tanabe K, Dvorina N, Yokoyama WM, Valujskikh A, Baldwin WM 3rd, Fairchild RL. In the absence of natural killer cell activation donor-specific antibody mediates chronic, but not acute, kidney allograft rejection. Kidney Int. 2019 Feb;95(2):350-362.
Tsuda K, Koide M, Kunii Y, Watanabe K, Miyairi S, Ohashi Y et al. Simplified model for end-stage liver disease score predicts mortality for tricuspid valve surgery. Interact Cardiovasc Thorac Surg 2013;16(5):630-635.
Katsumata H, Miyairi S, Ikemiyagi M, Hirai T, Fukuda H, Kanzawa T, Ishii R, Saiga K, Ishii Y, Omoto K, Okumi M, Yokoo T, Tanabe K. Evaluation of the impact of conventional immunosuppressant on the establishment of murine transplantation tolerance - an experimental study. Transpl Int. 2019 Apr;32(4):443-453.
Katsumata H, Ikemiyagi M, Hirai T, Kanzawa T, Ishii R, Miyairi S, Fukuda H, Saiga K, Okumi M, Ishii Y, Yokoo T, Tanabe K. Impact of activated invariant natural killer T cells on the expansion of regulatory T cell precursors in murine thymocytes in vitro. Immunol Lett. 2019 Feb;206:41-48.
Nicosia M, Miyairi S, Beavers A, Farr GW, McGuirk PR, Pelletier MF, Valujskikh A. Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking. Sci Rep. 2019 May 15;9(1):7417.
Miyairi S, Valujskikh A, Baldwin WM 3rd, Fairchild RL. Natural Killer Cells: Critical effectors during antibody-mediated rejection of solid organ allografts. Transpl. 2021 Feb 1;105(2):284-290.
Miyairi S, Takeyoshi D, Ishikawa N, Kamiya H. Edge-to-edge repair of the systolic anterior motion of mitral valve and cardiac myectomy of the abnormally positioned papillary muscles in an infant with COL4A1 mutation. Journal of Surg Case Report. 2021 Jun. Vol 2021(6), rjab240.
Harada T, Koide M, Kunii Y, Watanabe K, Tsuda K, Miyairi S et al. [Adult coarctation of aorta repaired under partial selective cerebral perfusion]. Kyobu Geka 2013;66(6):469-472.
Iida S, Miyairi S, Su CA, Abe T, Abe R, Tanabe K, Dvorina N, Baldwin WM 3rd, Fairchild RL. Peritransplant VLA-4 blockade inhibits endogenous memory CD8 T cell infiltration into high-risk cardiac allografts and CTLA-4Ig resistant rejection. Am J Transplant. 2019 Apr;19(4):998-1010.
Tsuda K, Koide M, Kunii Y, Watanabe K, Miyairi S, Ohashi Y et al. Rupture of right sinus of Valsalva aneurysm into the pulmonary artery. Gen Thorac Cardiovasc Surg 2013.
Ishii R, Hirai T, Miyairi S, Omoto K, Okumi M, Ishii Y, Tanabe K. iNKT cell activation plus T-cell transfer establishes complete chimerism in a murine sublethal bone marrow transplant model. Am J Transplant. 2018 Feb;18(2):328-340.
Iizuka K, Saito H, Nishinaka T, Kobayashi Y, Ikeda C, Seta H, Houki R, Masuda N, Miyairi S, Tomari H, Saito S, Yamazaki K. Re-operation of an aortic pericardial bioprosthesis 23-years after implantation; report of a case. Kyoubu Geka. 2010; 63(13): 1169-72.
Kanzawa T, Tokita D, Saiga K, Yamanaka T, Ishigooka H, Fukuda H, Katsumata H, Miyairi S, Ishii R, Hirai T, Imai T, Okumi M, Tanabe K. Role of Fractalkine- CX3CR1 axis in acute rejection of mouse heart allografts subjected to ishemia reperfusion injury. Transpl Int 2022 Feb 1;35:10157.
Contact

Contact

Address

Pediatric Cardiac Surgery
Academic Office Building
2450 Riverside Ave S A0510
Minneapolis, MN 55454

Administrative Contact

Jessy Anderson | and08788@umn.edu | 612-625-2646