Christopher Tignanelli, MD

Assistant Professor
Division of Critical Care/Acute Care Surgery, Department of Surgery

Christopher Tignanelli

Contact Info

Office Phone 612-625-7911

Fax 612-626-0439

Mailing Address:
420 Delaware St SE, MMC 195
Minneapolis, MN 55455

Administrative Phone

Assistant Professor
Division of Critical Care/Acute Care Surgery
, Department of Surgery

Affiliate Faculty, Institute for Health Informatics

MD, New Jersey Medical School (2005 – 2009), Newark NJ

Residency, University of North Carolina (2009 – 2016), Chapel Hill, NC

Fellowship in Surgical Critical Care, University of Michigan (2016 – 2017), Ann Arbor MI

MS, Clinical Research (2020, anticipated), School of Public Health, University of Minnesota

BS, Bioinformatics, The College of William and Mary, 2005

T32 Research Fellowship, University of North Carolina (2012 – 2014), Chapel Hill, NC


I wholeheartedly enjoy caring for patients with critical illness and emergency surgical conditions. My approach is to provide high quality evidenced-based emergency surgical and critical care to those in need. I treat every patient like I would my own family member.


  • Trauma
  • Surgical Critical Care
  • ECMO
  • Emergency general surgery

Awards & Recognition

  • 2017 - TQIP Annual Scientific Meeting Performance Improvement Abstract Award - Winner
  • 2017 - Surgical Critical Care Program Director Society (SCCPDS) Excellence in Research Award – Honorable Mention
  • 2017 - Association of Academic Surgery (AAS) - Best Overall Manuscript Submission by an AAS Resident or Fellow. Paper titled: “A comparison of a homemade central line simulator to commercial models”
  • 2015 - Winner of Herbert J. Proctor Award for Excellence in Surgical Research
  • 2014 - Winner of John William Pope Clinical Fellowship for combining excellence in clinical practice as a physician and as a researcher in the laboratory

Professional Associations

  • Surgical Infection Society
  • Society of Critical Care Medicine
  • Association for Academic Surgery
  • American College of Surgeons


Research Summary/Interests

  • Quality Improvement
  • Patient Safety
  • Trauma Systems Research
  • Surgical Outcomes

Research Funding Grants

  • Medical School/UMF Research Equipment Startup Award 5/2018
    Characterizing Barriers to Guideline Concordant Care for Patients with Complex Solid Organ Injuries
    Principal Investigator

  • CHAAMPS Disparity Scholars Program (CDSP) 2017 Award 11/2017
    Disparities in Clinical Outcomes After Injury
    Principal Investigator


Google Scholar Publication List

Tignanelli CJ, Weinberg A, Napolitano LM. Optimal methods to secure ECMO bicaval dual lumen cannulae: what works? ASAIO.

Skube SJ, Katz SA, Chipman JG, Tignanelli CJ. Acute kidney injury and sepsis. Surg Infect. 2018 Feb/Mar; 19(2):216-224. Epub 2018 Jan 5.

Tignanelli CJ, Vander Kolk WE, Mikhail JN, Delano MJ, Hemmila. MR. Non-Compliance with ACS-COT recommended criteria for full trauma team activation is associated with undertriage deaths. J Trauma Acute Care Surg. 2018 Feb; 84(2):287-294. Epub 2017 Nov 11.

Tignanelli CJ, Joseph B, Jakubus JL, Iskander GA, George BC, Hemmila MR. Variability in management of blunt liver trauma and contribution of level of ACS-COT verification status on mortality. J Trauma Acute Care Surg. 2018 Feb; 84(2):273-279. Epub 2017 Dec 1.

Tignanelli CJ, Wiktor, AJ, Vatsaas CJ, Sachdev G, Heung M, Park PK, Raghavendran K, Napolitano LM. Outcomes of acute kidney injury in patients with severe ARDS due to influenza a (H1N1) pdm09 virus. Am J Crit Care. 2018 Jan; 27(1):67-73.

Tignanelli CJ, Cherry-Bukowiec J. Hospital based nutrition support: A review of the latest evidence. J Clin Nutr Diet. 2017 Sept 30; 3(22).

J Grudziak MD, B Herndon MD, RD DAncel MD, H Arora MBBS, CJ Tignanelli MD, MR Phillips MD, JR Crowner, NA True, AC Kiser, HP Goodell BS, Murty BS, Ashton MD, MO Meyers MD, SP Montgomery MD. Standardized, interdepartmental, simulation-based central line insertion course closes an education gap and improves intern comfort with the procedure. Am Surg. 2017 Jun 1; 83(6):536-540.

Brown RF, Tignanelli C*, Grudziak J, Summerlin-Long S, Laux J, Kister A, Montgomery SP. A comparison of a homemade central line simulator to commercial models. J Surg Res. 2017 Jun 15; 214:203-208. Epub 2017 Mar 6. [*co-first authors]

Tignanelli CJ, Embree GGR, Barzin A. House-staff led interdisciplinary morbidity and mortality conference promotes systematic improvement. J Surg Res. 2017 Jun 15; 214:124-130. Epub 2017 Mar 6.

Tignanelli CJ, Andrews AG, Sieloff KM, Pleva MR, Reichert HA, Wooley JA, Napolitano LM, Cherry-Bukowiec JR. Are predictive energy expenditure equations in ventilated surgery patients accurate? J Intensive Care Med. Epub 2017 Jan 1.

Tignanelli CJ, Herrera Loeza SG, Yeh JJ. KRAS and PIK3CA mutation frequencies in patient-derived xenograft models of pancreatic and colorectal cancer are reflective of patient tumors and stable across passages. Am Surg. 2014 Sep; 80 (9): 873-877.

Torphy RJ, Tignanelli CJ, Kamande JW, Moffitt RA, Herrera Loeza SG, Soper SA, Yeh JJ. Circulating tumor cells as a biomarker of response to treatment in patient-derived xenograft mouse models of pancreatic adenocarcinoma, PLoS One. 2014 Feb 19; 9(2):e89474.

Damrauer JS, Hoadley KA, Chism DD, Fan C, Tignanelli CJ, Wobker SE, Yeh JJ, Milowsky MI, Iyer G, Paker JS,Kim WY. Instrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology. PNAS. 2014 Jan; 111(8): 3110-3115.

Jackson JM, Witek MA, Hupert ML, Brady C, Pullagurla S, Kamande J, Aufforth RD, Tignanelli CJ, Torphy RJ, Yeh JJ, Soper SA. UV Activation of polymeric high aspect ratio microstructures: ramifications in antibody surface loading for circulating tumor cell selection. Lab Chip. 2014 Jan 7; 14 (1):106-117.

Mazzag B,Tignanelli CJ, Smith GD. The effects of residual Ca2+ on the stochastic gating of Ca2+ -regulated Ca2+ channel models. J Theor Biol. 2005 Jul 7; 235 (1): 121-150.


Board Certifications

General Surgery

Clinical Interests

Trauma, Surgical Critical Care, ECMO, Emergency general surgery