Faculty
Director, Division of Pediatric Rheumatology, Allergy, & Immunology
Bryce Binstadt, MD, PhD
Professor
Rheumatology Faculty
Bio
Bryce A. Binstadt, MD, PhD, is an Professor of Pediatrics in the Division of Pediatric Rheumatology, Allergy, and Immunology and a Distinguished University Teaching Professor. Dr. Binstadt cares for children with arthritis, systemic lupus erythematosus, dermatomyositis, and related rheumatologic disorders. He heads a laboratory in the University of Minnesota's Center for Immunology focused on understanding the pathogenesis of autoimmune diseases with particular emphasis on immune-mediated cardiovascular disease. He is the Director of the Pediatric Rheumatology Fellowship Training Program, an Associate Director of the Medical Scientist Training Program (MD/PhD), and Director of the Pediatric Physician Scientist Training Program.
Dr. Binstadt received his MD degree from Mayo Medical School and his PhD in Immunology from Mayo Graduate School in Rochester, MN. He then completed his residency in the Boston Combined Residency Program in Pediatrics at Boston Children's Hospital and Boston Medical Center, followed by fellowship training in Pediatric Rheumatology at Boston Children's Hospital. He served as an attending physician in the Rheumatology Program at Boston Children's Hospital/Harvard Medical School as well as a research fellow in the Section on Immunology and Immunogenetics at the Joslin Diabetes Center for two years before joining the faculty at the University of Minnesota in 2007. Dr. Binstadt is board-certified in Pediatrics and Pediatric Rheumatology.
Research Summary
Autoimmunity, Innate Immunity
The Binstadt Laboratory is broadly interested in autoimmune and rheumatic disease pathogenesis.
The main area of investigation focuses on how systemic autoimmune diseases lead to cardiovascular inflammation and damage. We use the K/BxN T cell receptor (TCR) transgenic mouse model. K/BxN mice spontaneously develop both inflammatory arthritis and autoimmune valvular carditis, similar to patients with rheumatic heart disease or systemic lupus erythematosus. Current projects seek to understand how macrophages, fibroblasts, and endothelial cells promote progression of cardiac valve inflammation and fibrosis.
A second project focuses on developing and testing novel inhibitors of the arthritis-promoting cytokine TNF.
A new collaborative project explores cardiovascular inflammation that occurs in lysosomal storage diseases, particularly mucopolysaccharidosis type I (MPS-I).
Current Funding Sources:
- National Institutes of Health (NIH)
- American College of Rheumatology/Rheumatology Research Foundation
Clinical Summary
Juvenile dermatomyositis; Juvenile rheumatoid arthritis; Pediatric autoimmune diseases; Systemic lupus erythematosus
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Honors and Recognition
Contact
Address
Pediatric Rheumatology, Allergy, & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Honors and Recognition
Contact
Address
Pediatric Rheumatology, Allergy, & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Bio
Colleen Correll is an Associate Professor in the Division of Pediatric Rheumatology. After earning her medical degree from Rush Medical College in Chicago, Dr. Correll completed her residency in Pediatrics at the Medical College of Wisconsin in Milwaukee. She moved to Minnesota in 2011 to complete both her Pediatric Rheumatology Fellowship and a Master's Degree in Epidemiology. Dr. Correll has been a faculty member at the University of Minnesota since 2014.
Research Summary
Dr. Correll's research interests are in the epidemiology of pediatric rheumatic diseases, including impact on service and educational planning for community providers, as well as studies of risk factors associate with rheumatic diseases.
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Honors and Recognition
Contact
Address
Pediatric Rheumatology, Allergy, & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Contact
Address
Pediatric Rheumatology, Allergy & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Bio
Patricia Hobday, MD, is a 2013 graduate of the Division of Pediatric Rheumatology Fellowship Program at the University of Minnesota.
Dr. Hobday received her MD degree from Mayo Medical School in Rochester, Minnesota. She completed Pediatric residency at the University of Minnesota and went on to complete an additional year as Chief resident. She is board-certified in Pediatrics.
At the University of Minnesota, Dr. Hobday cares for children arthritis and other related conditions such as dermatomyositis and systemic lupus erythematosus.
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Honors and Recognition
Contact
Address
Pediatric Rheumatology, Allergy, & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Bio
Shawn Mahmud is a Pediatric Rheumatologist who completed MD/PhD (MSTP), residency, and fellowship training at the University of Minnesota. He provides care to children with autoimmune and autoinflammatory diseases including juvenile idiopathic arthritis, systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease, chronic noninfectious osteitis, vasculitis, and others. He has a long-standing interest in immunology, specifically CD4+ T cell biology. During his graduate training, Dr. Mahmud made contributions to our understanding of how regulatory T cells develop in the thymus. His current focus is in developing peptide:MHCII tetramer-based approaches to identify, track, and phenotype important antigen-specific populations of CD4+ T cells in human disease.
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Contact
Address
Pediatric Rheumatology, Allergy, & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Bio
Dr. Mona Riskalla is an Assistant Professor of Pediatrics at the University of Minnesota (UMN). She has also taken on the role of Co-Director for the Pediatric Uveitis Program at Minnesota Lions Children's Eye Clinic. Dr. Riskalla received her MD degree from Michigan State University. She completed her Pediatric residency at the University of Michigan and her Fellowship in Pediatric Rheumatology at the University of Michigan. Additionally, she has an MS in Biostatistics/Clinical Research Design and Statistical Analysis from the University of Michigan.
Clinical Summary
Juvenile Idiopathic Arthritis; Juvenile Myositis; Systemic Lupus Erythematosus; Inflammatory Eye Disease; Uveitis
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Honors and Recognition
Contact
Address
Pediatric Rheumatology, Allergy, & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Immunology Faculty
Bio
Ryan Nelson is a graduate of the MD/PhD training program at the University of Minnesota. He completed pediatrics residency and Allergy/Immunology fellowship training at Boston Children’s Hospital. As a physician-scientist, he provides care for patients with primary immunodeficiencies, immune dysregulation disorders, and allergic diseases. His research interests focus on CD4+ T cell specificity, functional diversity, trafficking, and memory. He aims to build a translational research program using new approaches to define factors influencing human variability in adaptive immunity to pathogens and maladaptive responses to allergens and self tissues. The goal of this work is to uncover pathways that inform better therapies for patients with immune disorders.
Education
Fellowships, Residencies, and Visiting Engagements
Licensures and Certifications
Contact
Address
Pediatric Rheumatology, Allergy & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454
Research Faculty
Bio
Nathan Schuldt, PhD, is an Assistant Professor in the Department of Pediatrics in the Division of Pediatric Rheumatology. Dr. Schuldt runs a laboratory at the University of Minnesota's Center for Immunology. His laboratory investigates the origins of autoimmune diseases like type 1 diabetes (T1D) and multiple sclerosis (MS). Dr. Schuldt has particular interest in T cell development, tolerance, and fate decisions.
Dr. Schuldt earned his PhD in Genetics in 2012 at Michigan State University training in the laboratory of Andrea Amalfitano, DO, PhD. His graduate studies focused on the interactions between adenovirus and the immune system with the goal of improving adenovirus-based vectors for gene therapy and vaccination. He joined the University of Minnesota Center for Immunology in 2012 as a Postdoctoral Fellow.
Research Summary
Multiple immune tolerance mechanisms prevent self-reactive T cells from becoming pathogenic. Autoimmunity occurs when these mechanisms break down. Thymic selection, also referred to as central tolerance, is the first prevention a self-reactive T cell encounters. During this process antigen recognizing T cell receptors (TCRs) are tested against various self-peptides, those that react too strongly are either deleted or shuttled into the regulatory T cell lineage. My research aims to understand how self-reactive T cells escape this process and initiate autoimmune disease.
One hypothesized method is through the expression of two different TCRs on a single T cells. An estimated 10-20% of all T cells express two functionally recombined TCRs. We hypothesize that this dual TCR expression can limit deletion and regulatory T cell commitment of strongly self-reactive T cells in the thymus. This could explain how self-reactive T cells escape the thymus and enter the periphery as pathogenic T cells. Dual TCR expression is hypothesized to play important roles in several other immune contexts including allo-responses in graft rejection, allergy, and protective immunity. We have developed new tools in our lab that allow us to detect and study dual TCR T cells in several immune contexts.
A second area of interest for the lab is neonatal immune development. At birth, the adaptive immune system is underdeveloped and may function differently than that of adults. As a result, infections are common in neonates and infants. The Schuldt Lab has begun a collaboration to investigate how early microbial exposure influences the development of adaptive immunity. Improved understanding of neonatal adaptive immunity could lead to improved vaccine platforms.
Education
Fellowships, Residencies, and Visiting Engagements
Honors and Recognition
Contact
Address
Pediatric Rheumatology, Allergy, & ImmunologyAcademic Office Building
2450 Riverside Ave S AO-10
Minneapolis, MN 55454